γ-aminobutyric acid transporter-1 is involved in anxiety-like behaviors and cognitive function in knockout mice.

abstract：:Chinese herbal extracts are being used increasingly to treat osteoarthritis (OA) in recent years. Baicalin (BA) is an active component of Scutellaria baicalensis Georgi extracts and protects chondrocytes against damage. The aim of the present study was to examine the mechanism of action of BA on chondrocytes from mous...

journal_title：Experimental and therapeutic medicine

authors： Wang P,Zhu P,Liu R,Meng Q,Li S

更新日期：2020-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial proliferation and inflammation. Intra-articular corticosteroid injections are commonly used for the treatment of arthritis affecting one or two joints. Although corticosteroid injections are fast-acting, repeated usage can result in se...

journal_title：Experimental and therapeutic medicine

authors： Cho HK,Park GY,Sung WJ,Kawk SG,Jung WB

更新日期：2020-11-01 00:00:00

abstract：:The aim of the present study was to investigate the functional status of dendritic cells (DCs) in nasal polyps (NP) and their interactions with T lymphocytes. The interactions between DC and T lymphocytes in the pathogenesis of NP was also studied. The expression of cluster of differentiation (CD)1a and CD83 in NP was...

journal_title：Experimental and therapeutic medicine

authors： Lin X,Zhuang X,Li C,Wang X

更新日期：2018-06-01 00:00:00

abstract：:The aim of this study was to investigate the effects of advanced glycation end-products (AGEs) on podocyte adhesion and the underlying mechanisms. Immortalized mouse podocytes were exposed to various conditions and podocyte adhesion was evaluated using a hexosaminidase assay. The expression levels of integrin-linked k...

journal_title：Experimental and therapeutic medicine

authors： Cheng C,Zheng Z,Shi C,Liu X,Ye Z,Lou T

更新日期：2013-12-01 00:00:00

abstract：:As a strategy to prevent the well-known immunosuppressant effects of cyclophosphamide (CY), the immunomodulatory activity of the polysaccharide isolated from Urtica macrorrhiza Hand.-Mazz. (UMHMPS) was investigated in the present study. The chemical properties of UMHMPS, including total carbohydrates, uronic acid, pro...

journal_title：Experimental and therapeutic medicine

authors： Wang Z,Li Y,Wang C,Xia H,Liang Y,Li Z

更新日期：2019-09-01 00:00:00

abstract：:Effects of antithrombotic agents on the bleeding risk after transurethral resection of the prostate (TURP) were assessed in patients with benign prostatic hyperplasia (BPH). Controlled clinical trials on the effects of perioperative anticoagulant therapy on postoperative bleeding in BPH patients published during Janua...

journal_title：Experimental and therapeutic medicine

authors： He Q,Yu Y,Gao F

更新日期：2020-10-01 00:00:00

abstract：:Primary lung enteric adenocarcinoma is a rare type of invasive lung carcinoma. Its morphology and immunohistochemistry are those of colorectal carcinoma, but there is no associated primary colorectal carcinoma. The present study describes the case of a 53-year-old female who presented with an irritating cough and a ma...

journal_title：Experimental and therapeutic medicine

authors： Lin LI,Xu CW,Zhang BO,Liu RR,Ge FJ,Zhao CH,Jia RU,Qin QH,Stojsic J,Wang Y,Xu JM

更新日期：2016-01-01 00:00:00

abstract：:Atrial remodeling is considered to be any persistent change in atrial structure or function, and is responsible for the development and perpetuation of atrial fibrillation (AF). Oxidative stress and intracellular pH regulation may also be linked to AF; however it remains unclear whether eicosapentaenoic acid (EPA) or ...

journal_title：Experimental and therapeutic medicine

authors： Tong M,Wang J,Ji Y,Chen X,Wang J,Wang S,Ruan L,Cui H,Zhou Y,Zhang Q,Watanabe E

更新日期：2017-09-01 00:00:00

abstract：:Assisted reproductive technology (ART) including in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) have been shown to be associated with abnormal genomic imprinting, thus increasing the incidence of imprinting disorders such as Beckwith-Wiedemann syndrome (BWS) and Angelman syndrome (AS) in ART-...

journal_title：Experimental and therapeutic medicine

authors： Zheng HY,Shi XY,Wang LL,Wu YQ,Chen SL,Zhang L

更新日期：2011-07-01 00:00:00

abstract：:Lung cancer, a major health problem affecting the epithelial lining of the lower respiratory tract, is considered to be one of the deadliest types of cancer in males and females and it is well-known that smoking is the chief cause of lung cancer. In addition to smoking and environmental factors, genetic susceptibility...

journal_title：Experimental and therapeutic medicine

authors： Baykara O,Tansarikaya M,Demirkaya A,Kaynak K,Tanju S,Toker A,Buyru N

更新日期：2013-02-01 00:00:00

abstract：:Previous studies have demonstrated that autophagy induced by caloric restriction (CR) is neuroprotective against cerebral ischemia. However, it has not been determined whether intermittent fasting (IF), a variation of CR, can exert autophagy-related neuroprotection against cerebral ischemia. Therefore, the neuroprotec...

journal_title：Experimental and therapeutic medicine

authors： Jeong JH,Yu KS,Bak DH,Lee JH,Lee NS,Jeong YG,Kim DK,Kim JJ,Han SY

更新日期：2016-11-01 00:00:00

abstract：:The aim of the present study was to investigate the expression levels and clinical significance of Toll-like receptor (TLR) 3 and 4 in peripheral blood mononuclear cells (PBMCs) collected from children with Henoch-Schönlein purpura (HSP) nephritis. The randomized controlled trial was conducted between August 2011 and ...

journal_title：Experimental and therapeutic medicine

authors： Chang H,Yu DS,Liu XQ,Zhang QY,Cheng N,Zhang SQ,Qu ZH

更新日期：2014-06-01 00:00:00

abstract：:The diaphragm is an important respiratory organ. The aim of this study was to quantitatively evaluate the longitudinal deformation of the right hemidiaphragm in normal subjects using two-dimensional strain ultrasound speckle tracking. Twenty-one healthy subjects were enrolled in this study. GE Healthcare Vivid E9 equi...

journal_title：Experimental and therapeutic medicine

authors： Ye X,Xiao H,Bai W,Liang Y,Chen M,Zhang S

更新日期：2013-08-01 00:00:00

abstract：:Tumor hypoxia contributes to the development of resistance to chemotherapeutic drugs in several human cancer cell lines. Atovaquone, an anti-malaria drug approved by the US Food and Drug Administration, has recently demonstrated anti-cancer effects in vitro and in vivo in several cancer models. To assess the potential...

journal_title：Experimental and therapeutic medicine

authors： Fu C,Xiao X,Xu H,Lu W,Wang Y

更新日期：2020-12-01 00:00:00

abstract：:Tuberculosis is highly infectious and has a high incidence worldwide. Therefore, effective treatment is essential for the disease. The immune function and inflammatory factors can reflect the therapeutic effect of pulmonary tuberculosis to some extent. Thus, the aim of the present study was to investigate the clinical...

journal_title：Experimental and therapeutic medicine

authors： Cheng C,Pan W,Li X,Qu H

更新日期：2020-09-01 00:00:00

abstract：:A standard systemic therapy for patients with human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer (ABC) is yet to be identified. Sorafenib has been developed for the treatment of solid tumors, including breast cancer, as an oral multikinase inhibitor with antiangiogenic and antiproliferativ...

journal_title：Experimental and therapeutic medicine

authors： Tan QX,Qin QH,Lian B,Yang WP,Wei CY

更新日期：2014-05-01 00:00:00

abstract：:The present study aimed to investigate the influence of mouse nerve growth factor (mNGF) on glial fibrillary acidic protein (GFAP) expression in neonatal rats with hypoxic-ischemic brain damage (HIBD). A total of 60 7-day-old neonatal rats were randomly divided into control, HIBD and mNGF groups (n=20). The rats in th...

journal_title：Experimental and therapeutic medicine

authors： Yin X,Dong L,Wei W,Wang Y,Chai Y,Feng Z

更新日期：2013-02-01 00:00:00

abstract：:Pilocytic astrocytoma (PA) is a rare glioma, which generally occurs in children and young adults. In adult patients, the majority of PA tumors are supratentorial. Due to the low morbidity rate of the disease in adults, PA is frequently misdiagnosed and mistreated. In the present study, this rare disease was successful...

journal_title：Experimental and therapeutic medicine

authors： Zhao Y,Feng L,Wei Q,Gao L

更新日期：2015-12-01 00:00:00

abstract：:Bacterial infection is a key factor in airway inflammation. The present study describes the time-dependent changes in the leukocyte counts and cytokine levels of the bronchoalveolar lavage fluid (BALF) following subacute airway inflammation induced by lipopolysaccharide (LPS), a major component of the outer membranes ...

journal_title：Experimental and therapeutic medicine

authors： Liu L,Chen L,Wang Y,Yang H,Chen Y,Xu X,Zhou H,Jiang F,Li T,Wang J

更新日期：2012-12-01 00:00:00

abstract：:The aim of this study was to analyze the techniques for intraocular lens (IOL) implantation in patients with coloboma of the iris. A retrospective cohort study was used to analyze the degree of iris coloboma and the characteristics of the crystalline lens in 56 patients with iris coloboma. The patients with a lesser d...

journal_title：Experimental and therapeutic medicine

authors： Li J,Li Y,Hu Z,Kong L

更新日期：2014-06-01 00:00:00

abstract：:The aim of the present investigation was to compare the effects of cyclic compression, perfusion, dexamethasone (DEX) and bone morphogenetic protein-7 (BMP-7) on the proliferation and differentiation of human bone marrow stromal cells (hBMSCs) in polyurethane scaffolds in a perfusion bioreactor. Polyurethane scaffolds...

journal_title：Experimental and therapeutic medicine

authors： Teng S,Liu C,Guenther D,Omar M,Neunaber C,Krettek C,Jagodzinski M

更新日期：2016-06-01 00:00:00

abstract：:Shen-Zhi-Ling (SZL) oral liquid is a traditional Chinese medicine formula that is mainly used for the clinical treatment of mild to moderate Alzheimer's disease (AD). The aim of the present study was to investigate the effects and underlying mechanisms of SZL treatment on AD. APP/PS1 transgenic mice were utilized to e...

journal_title：Experimental and therapeutic medicine

authors： Xing S,Shen D,Chen C,Wu B,Chi H

更新日期：2017-09-01 00:00:00

abstract：:Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant tumor that accounts for 3% of all tumors of the nasal cavity. The incidence of ENB is 0.4 cases per million in the general population, and the most common symptoms are nasal obstruction and epistaxis. Previous studies have indicate...

journal_title：Experimental and therapeutic medicine

authors： Sabongi JG,Gonçalves MC,Alves CD,Alves J,Scapulatempo-Neto C,Moriguchi SM

更新日期：2016-11-01 00:00:00

abstract：:The aim of the present study was to investigate the prevalence rate of hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-positive individuals and to study the infection status of HCV RNA in HIV-infected individuals who did not have anti-HCV antibodies in the Guangxi province of China, in order to...

journal_title：Experimental and therapeutic medicine

authors： Wu SZ,Wei JL,Xu B,Wei PH,Yang Y,Qin B,Xie ZC

更新日期：2017-03-01 00:00:00

abstract：:The aim of the present study was to clarify the association between lipid metabolism and the atherosclerosis in early-stage chronic renal failure at the molecular level and to explore the efficacy of decorin on chronic renal failure. Sprague Dawley rats receiving 5/6 nephrectomy and Sham surgery were divided into cont...

journal_title：Experimental and therapeutic medicine

authors： Ma HB,Wang R,Yu KZ,Yu C

更新日期：2015-02-01 00:00:00

abstract：:Colorectal cancer (CRC) develops from the colon or rectum and is the fourth highest inducer of cancer mortality. In the present study, cancer tissues and normal tissues were extracted from patients with CRC who were treated in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine (Jinan, China...

journal_title：Experimental and therapeutic medicine

authors： Jia B,Xia L,Cao F

更新日期：2018-03-01 00:00:00

abstract：:The present multicentre, prospective, open-label, single treatment arm study (Val-Perfect) examined the efficacy and tolerability of once-daily valsartan monotherapy (80 mg for two weeks, followed by 160 mg for eight weeks) in 195 Chinese patients with mild to moderate hypertension, using office, home, and ambulatory ...

journal_title：Experimental and therapeutic medicine

authors： Sun N,Feng Y,Gao P,Chen X,Qi L,Zhang S,Dong Y,Yang X,Li X,Chen Y,Liu L

更新日期：2017-03-01 00:00:00

abstract：:The present prospective, randomized, double-blinded, controlled study aimed to investigate the efficacy and safety of dexmedetomidine (DEX) combined with butorphanol for patient-controlled intravenous analgesia (PCIA) following total laparoscopic hysterectomy. A total of 88 patients undergoing total laparoscopic hyste...

journal_title：Experimental and therapeutic medicine

authors： Du J,Li JW,Jin J,Shi CX,Ma JH

更新日期：2018-11-01 00:00:00

abstract：:Granulomatosis with polyangiitis (GPA) is a systemic form of vasculitis that involves small to medium sized vessels and is associated with high morbidity and mortality. GPA presents a continuous and difficult clinical diagnostic concern, due to the rarity of the disease and the diversity of the manifestations. This ca...

journal_title：Experimental and therapeutic medicine

authors： Lu CW,Liu XF,Luan Y,Lu CB,Zhou DD,Guo LM,Sun YB,Chen SN,Wu YL,Hao JL

更新日期：2017-06-01 00:00:00

abstract：:The ChrT gene encodes a chromate reductase enzyme which catalyzes the reduction of Cr(VI). The chromate reductase is also known as flavin mononucleotide (FMN) reductase (FMN_red). The aim of the present study was to clone the full-length ChrT DNA from Serratia sp. CQMUS2 and analyze the deduced amino acid sequence and...

journal_title：Experimental and therapeutic medicine

authors： Deng P,Tan X,Wu Y,Bai Q,Jia Y,Xiao H

更新日期：2015-03-01 00:00:00