Effect of mouse nerve growth factor on the expression of glial fibrillary acidic protein in hippocampus of neonatal rats with hypoxic-ischemic brain damage.

abstract：:Matrine is an active component of Leguminosae plants and is thought to exhibit anti-tumor effects. However, the effects of matrine on drug-resistant cancer have not been fully elucidated. The present study aimed to investigate the effects of matrine on vincristine (VCR)-resistant retinoblastoma (RB) cells and to asses...

journal_title：Experimental and therapeutic medicine

authors： Zhao B,Li B,Liu Q,Gao F,Zhang Z,Bai H,Wang Y

更新日期：2020-09-01 00:00:00

abstract：:Previous clinical trials have investigated the effect of glucocorticoid therapy in acute respiratory distress syndrome (ARDS), with controversial results, particularly with regard to the early administration of low dose glucocorticoid. The present meta-analysis aimed to assess whether the application of glucocorticoid...

journal_title：Experimental and therapeutic medicine

authors： Yang ZG,Lei XL,Li XL

更新日期：2017-04-01 00:00:00

abstract：:Shen-Zhi-Ling (SZL) oral liquid is a traditional Chinese medicine formula that is mainly used for the clinical treatment of mild to moderate Alzheimer's disease (AD). The aim of the present study was to investigate the effects and underlying mechanisms of SZL treatment on AD. APP/PS1 transgenic mice were utilized to e...

journal_title：Experimental and therapeutic medicine

authors： Xing S,Shen D,Chen C,Wu B,Chi H

更新日期：2017-09-01 00:00:00

abstract：:Vascular calcification (VC) caused by chronic kidney disease (CKD)-mineral and bone disorder is a common complication of CKD. Recent studies have demonstrated that menaquinone-4 (MK-4) is negativly associated with VC in patients with CKD. Furthermore, we have previously shown that runt-related transcription factor 2 (...

journal_title：Experimental and therapeutic medicine

authors： Cui L,Xu J,Zhang J,Zhang M,Zhang S,Bai Y

更新日期：2018-10-01 00:00:00

abstract：:Hepatic stellate cells (HSCs) have been demonstrated to have immunoinhibitory activity. The aim of this study was to investigate the role of HSCs in the development of immunotolerance following liver transplantation. A rat liver transplantation tolerance model [donor Lewis into recipient Dark Agouti (DA)] and rejectio...

journal_title：Experimental and therapeutic medicine

authors： Jiang Z,Chen Y,Feng X,Jiang J,Chen T,Xie H,Zhou L,Zheng S

更新日期：2013-01-01 00:00:00

abstract：:The CC chemokine receptor 9 (CCR9) and its natural secreted ligand CC motif chemokine ligand 25 (CCL25) have been implicated in cancer metastasis. However, their metastatic potential in non-small cell lung cancer (NSCLC) remains unclear. In the present study, immunohistochemistry was used to detect the expression and ...

journal_title：Experimental and therapeutic medicine

authors： Niu Y,Tang D,Fan L,Gao W,Lin H

更新日期：2020-06-01 00:00:00

abstract：:The activation of monocytes and macrophages is associated with steroid-resistant (SR) asthma. Interleukin-35 (IL-35) is an important anti-inflammatory cytokine, but its regulatory effects on monocytes in patients with SR asthma is not fully understood. Based on clinical response to oral prednisolone, 34 patients with ...

journal_title：Experimental and therapeutic medicine

authors： Qian L,Xu D,Xue F,Li M,Wang X,Liu G

更新日期：2020-05-01 00:00:00

abstract：:The present study aimed to investigate the effect of the traditional Chinese medicine Qingre Baidu mixture (QBM) on the regulation of various parameters, including the morphology of bacterial biofilms, the bacterial density sensing system, the self-induction of the molecule autoinducer (AI)-2 and the hypoxia-inducible...

journal_title：Experimental and therapeutic medicine

authors： Shan W,Wang Y,Zhang Z,Xing J,Xu J,Xiao W,Shen Y,Guo S,Que H

更新日期：2019-05-01 00:00:00

abstract：:Osteoarthritis (OA) is the most common motor system disease in the elderly, with a high incidence and a huge social and economic burden. Therefore, it is urgent to study its potential pathogenesis to improve the therapeutic effect of the disease. In this study, we constructed a number of regulator-mediated OA dysfunct...

journal_title：Experimental and therapeutic medicine

authors： Wang F,Guo Z,Yuan Y

更新日期：2020-01-01 00:00:00

abstract：:Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting were investigated. Eighty patients undergoing systemic anesthesia with extracorporeal coronary artery bypass grafting in The People's Hospital of Guangxi Zhuang Autonomous Region from January 2015 to A...

journal_title：Experimental and therapeutic medicine

authors： Gong Z,Li J,Zhong Y,Guan X,Huang A,Ma L

更新日期：2018-12-01 00:00:00

abstract：:The aim of this study was to validate the feasibility of modified frontolateral partial laryngectomy without tracheotomy using animal experiments. The glottic area before and after surgery of 6 excised canine larynges and 10 canine larynges in vivo were compared to observe whether the glottic area following modified f...

journal_title：Experimental and therapeutic medicine

authors： Xu H,Dong P,Sun Z,Xie J

更新日期：2013-02-01 00:00:00

abstract：:Sepsis is a type of systemic inflammatory response syndrome with high morbidity and mortality. Skeletal muscle dysfunction is one of the major complications of sepsis that may also influence the outcome of sepsis. The aim of the present study was to explore and identify potential mechanisms and therapeutic targets of ...

journal_title：Experimental and therapeutic medicine

authors： Yang F,Wang Y

更新日期：2018-06-01 00:00:00

abstract：:The present study determined the expression of microRNA (miR)-663 in hypertrophic scar (HS) tissues and investigate the regulatory mechanisms of miR-663 in HS. A total of 51 patients diagnosed with HS between December 2013 and February 2016 were included in the present study. HS tissues (experimental group) and HS-adj...

journal_title：Experimental and therapeutic medicine

authors： Chen Q,Zhao T,Xie X,Yu D,Wu L,Yu W,Sun W

更新日期：2018-08-01 00:00:00

abstract：:Osteopontin (OPN), a secreted phosphorylated glycoprotein, has been found to be involved in carcinogenesis, progression and metastasis of several types of cancers. The aim of the present study was to investigate the immunohistochemical expression of OPN in colorectal carcinoma (CRC) and its relationship with clinicopa...

journal_title：Experimental and therapeutic medicine

authors： Li J,Yang GZ,Zhu ZM,Zhou ZY,Li L

更新日期：2012-04-01 00:00:00

abstract：:Stress-related mucosal disease (SRMD) is a common complication in patients in the intensive care unit (ICU). The aim of the present study was to investigate the possible mechanisms for the pathogenesis of SRMD. In total, 38 patients with SRMD were enrolled from an ICU, as well as 15 healthy volunteers. The disease sev...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Zhao Q,Shi H,Qi F,Shi N,Bai D,Li X,Yuan H,Zuo X

更新日期：2020-11-01 00:00:00

abstract：:β-elemene is a novel, plant-derived anticancer drug, which has been used to target multiple solid tumor types. Hyperthermia is an adjuvant therapeutic modality to treat cancer. However, the underlying mechanisms associated with the efficacy of these two treatments are largely unknown. The aim of the present study was ...

journal_title：Experimental and therapeutic medicine

authors： Wu Z,Wang T,Zhang Y,Zheng Z,Yu S,Jing S,Chen S,Jiang H,Ma S

更新日期：2017-06-01 00:00:00

abstract：:The diagnostic criteria of osteoporosis were established based on bone mineral density (BMD). Therefore, BMD measured by dual energy X-ray absorptiometry has been recognized as the gold standard to diagnose osteoporosis. However, discrepancies between fracture risk and BMD have been recognized. Bone is composed of col...

journal_title：Experimental and therapeutic medicine

authors： Suzuki Y,Maruyama-Nagao A,Sakuraba K,Kawai S

更新日期：2017-05-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2018.6297.]. ...

journal_title：Experimental and therapeutic medicine

authors： Jia L,Wang L,Liu W,Qian G,Jiang X,Zhang Z

更新日期：2018-12-01 00:00:00

abstract：:Gastrointestinal (GI) mucormycosis is a rare and life-threatening invasive fungal infection. GI mucormycosis occur in all parts of the alimentary tract, with the stomach being the most common site. Diabetes mellitus and other types of conditions associated with immunodeficiency, including hematologic malignancies, sol...

journal_title：Experimental and therapeutic medicine

authors： Lee SH,Son YG,Sohn SS,Ryu SW

更新日期：2014-08-01 00:00:00

abstract：:The aim of this study was to investigate the effects of heat stress on the expression of the coxsackievirus and adenovirus receptor (CAR) in mouse skin keratinocytes. Twenty BALB/c mice were randomly divided into two groups: the sham heat (control) and scald groups. Skin specimens were obtained 6 h after the treatment...

journal_title：Experimental and therapeutic medicine

authors： Deng X,Jia C,Chen F,Liu J,Zhou Z

更新日期：2013-10-01 00:00:00

abstract：:Point mutations in oncogenes and tumor suppressor genes occur at early stages in the carcinogenic process. Point mutations in ras family oncogenes are the most common mutational events in several types of human cancer, and are available as molecular markers for the detection of cancer cells in carcinogenicity bioassay...

journal_title：Experimental and therapeutic medicine

authors： Yano Y,Yano T,Kinoshita A,Matoba A,Hasuma T,Wanibuchi H,Morimura K,Otani S,Fukushima S

更新日期：2010-07-01 00:00:00

abstract：:The aim of the study was to detect the expression of interleukin-1β (IL-1β) in serum of patients with perimenopausal non-organic sleep disorder (PNSD) and to study the relationship between IL-1β and the severity of insomnia and liver depression, so as to benefit the prevention of PNSD. A total of 268 cases of perimeno...

journal_title：Experimental and therapeutic medicine

authors： Li H,Chen Y,Wu H,Huang J,Ma K,Zheng J,Lv S

更新日期：2019-01-01 00:00:00

abstract：:Mitochondrial factor and cell cytokines play important roles in the incidence of vascular dementia (VD), but their correlations with inflammatory and mitochondrial factors and the role of both in the kidney essence deficiency pattern and phlegm turbidity blocking orifice pattern are not clear. This study was aimed at ...

journal_title：Experimental and therapeutic medicine

authors： Sun L

更新日期：2018-01-01 00:00:00

abstract：:Previous studies have suggested that 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) prevents progression of non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet. The present study aimed to evaluate whether TSG could reverse NAFLD induced by a methionine and choline-deficient (MCD) diet and identi...

journal_title：Experimental and therapeutic medicine

authors： Han M,Zhang T,Gu W,Yang X,Zhao R,Yu J

更新日期：2018-08-01 00:00:00

abstract：:Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are an effective treatment for advanced non-small cell lung cancer. The objective of the present study was to compare the efficacy of gefitinib and erlotinib in patients with pulmonary adenocarcinoma, whose tumor EGFR mutation status was known. Pu...

journal_title：Experimental and therapeutic medicine

authors： Wu WS,Chen YM,Tsai CM,Shih JF,Chiu CH,Chou KT,Lai SL,Wu CH,Luo YH,Huang CY,Lee YC,Perng RP,Whang-Peng J

更新日期：2012-02-01 00:00:00

abstract：:Successful islet isolation is crucial for islet transplantation and cell treatment for type 1 diabetes. Current isolation methods are able to obtain 500-1,000 islets per rat, which results in a waste of ≥50% of total islets. In the present study, a facile mechanical shaking method for improving islet yield (up to 1,50...

journal_title：Experimental and therapeutic medicine

authors： Yin N,Chen T,Yu Y,Han Y,Yan F,Zheng Z,Chen Z

更新日期：2016-12-01 00:00:00

abstract：:Malignant hyperthermia (MH) is a rare life threatening inherited disorder that is triggered by drugs used for general anesthesia in susceptible persons. The symptoms include rapid increase of body temperature and severe muscle contractions. The present study includes 3 cases of MH and highlights the timely identificat...

journal_title：Experimental and therapeutic medicine

authors： Pan T,Ji W,Nie M,Li Y

更新日期：2016-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-coding RNAs that are key regulators of gene expression by directly binding to the 3'-untranslated region of their target mRNAs, resulting in translational repression or degradation of mRNA. It has been demonstrated that miRNAs have key roles in a variety of human malignancies, includi...

journal_title：Experimental and therapeutic medicine

authors： He Y,Yu B

更新日期：2017-05-01 00:00:00

abstract：:In order to evaluate the efficacy and tolerability of oxycodone in moderate-severe cancer-related pain, we conducted a systematic review of randomized controlled trials (RCTs). Publications addressing the efficacy and tolerability of oxycodone in moderate-severe cancer-related pain were selected from the Cochrane libr...

journal_title：Experimental and therapeutic medicine

authors： Wang YM,Liu ZW,Liu JL,Zhang L

更新日期：2012-08-01 00:00:00

abstract：:E-cadherin is a key cell adhesion molecule implicated in tumor suppression that is frequently altered in hepatocellular carcinoma (HCC), particularly in hepatitis B virus-related tumors. Here, we report that the epigenetic drugs 5-azacytidine and trichostatin A up-regulated E-cadherin expression in HCC cells. The depl...

journal_title：Experimental and therapeutic medicine

authors： Qiu X,Qiao F,Su X,Zhao Z,Fan H

更新日期：2010-05-01 00:00:00