Abstract:
:Chronic myelogenous leukemia (CML) is a condition characterized by a balanced genetic translocation, t (9;22) (q34;q11.2), which leads to a fusion of the Abelson oncogene (ABL) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2. This rearrangement is referred to as the Philadelphia chromosome. At a molecular level, this translocation results in the formation of the BCR-ABL fusion oncogene, which translates into a BCR-ABL oncoprotein. Imatinib, nilotinib and dasatinib are three tyrosine kinase inhibitors that have been approved by the US Food and Drug Administration for the treatment of patients diagnosed with CML in the chronic phase (CML-CP). The present study describes the case of a patient with imatinib-resistant CML who, following two months of treatment with nilotinib, no longer exhibited detectable BCR-ABL fusion genes or M244V mutations. This suggests that nilotinib may be effective for treating CML cases in which the BCR-ABL fusion protein has an M244V mutation.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Shen X,Zhang M,Shen Y,Shi W,Liu W,Wei WUdoi
10.3892/etm.2015.2707subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1479-1482issue
4eissn
1792-0981issn
1792-1015pii
ETM-0-0-2707journal_volume
10pub_type
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