S-adenosyl methionine regulates calcium channels and inhibits uterine smooth muscle contraction in rats with infectious premature delivery through the transient receptor protein 3/protein kinase Cβ/C-kinase-activated protein phosphatase-1 inhibitor of 17

abstract：:Many studies have focused on the identification of therapeutic targets for the treatment of certain types of cancer. Wogonin is a natural flavonoid compound that exhibits a potent anti-cancer effect. The underlying mechanism of wogonin may therefore reveal an effective way to identify novel therapeutic targets. In the...

journal_title：Experimental and therapeutic medicine

authors： Wang SJ,Zhao JK,Ren S,Sun WW,Zhang WJ,Zhang JN

更新日期：2019-01-01 00:00:00

abstract：:The present prospective, randomized, double-blinded, controlled study aimed to investigate the efficacy and safety of dexmedetomidine (DEX) combined with butorphanol for patient-controlled intravenous analgesia (PCIA) following total laparoscopic hysterectomy. A total of 88 patients undergoing total laparoscopic hyste...

journal_title：Experimental and therapeutic medicine

authors： Du J,Li JW,Jin J,Shi CX,Ma JH

更新日期：2018-11-01 00:00:00

abstract：:Nitrogen mustards are chemical agents that are similar to sulfur mustards, with similar toxicities. The present study describes a case of nitrogen mustard-induced acute respiratory failure and myelosuppression in a 33-year-old man. The patient, who was accidentally exposed to nitrogen mustard hydrochloride in a pharma...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Zhang Z,Chen S,Zhao D,Zhang F,Hu Z,Xiao F,Ma X

更新日期：2015-10-01 00:00:00

abstract：:Cnidium officinale Makino and Capsella bursa-pastoris are used as traditional herbs with diverse medicinal effects, including the inhibition of inflammation, reduction of blood pressure and as diuretics, however, the anti-cancer effects of C. officinale Makino and C. bursa-pastoris are poorly defined. The aims of this...

journal_title：Experimental and therapeutic medicine

authors： Lee KE,Shin JA,Hong IS,Cho NP,Cho SD

更新日期：2013-03-01 00:00:00

abstract：:Enamel matrix derivative (EMD) is a commercially available protein extract, mainly comprising amelogenins. A number of other polypeptides have been identified in EMD, mostly growth factors, which promote cementogenesis and osteogenesis during the regeneration processes through the regulation of cell proliferation, dif...

journal_title：Experimental and therapeutic medicine

authors： Wyganowska-Świątkowska M,Urbaniak P,Nohawica MM,Kotwicka M,Jankun J

更新日期：2015-06-01 00:00:00

abstract：:MicroRNAs (miRs), a class of small non-coding RNAs, function as key regulators in gene expression through binding to the 3'-untranslated region (UTR) of their target mRNA, which further leads to translational repression or mRNA degradation. Recently, miR-138 has been found to have a tumor suppressive role in a variety...

journal_title：Experimental and therapeutic medicine

authors： Yuan Z,Mo H,Mo L,He J,Wu Z,Lin X

更新日期：2017-06-01 00:00:00

abstract：:The present study evaluated the association between different Mycoplasma pneumoniae (M. pneumonia) genotypes and clinical features of pediatric patients. Subjects were children diagnosed with community-acquired pneumonia at the Children's Hospital of Soochow University (Suzhou, China) from January 2012 to December 201...

journal_title：Experimental and therapeutic medicine

authors： Fan L,Li D,Zhang L,Hao C,Sun H,Shao X,Xu J,Chen Z

更新日期：2017-09-01 00:00:00

abstract：:This meta-analysis was performed to evaluate the efficacy and safety of parecoxib sodium for acute postoperative pain. PubMed, Cochrane Central Register of Controlled Trials, EBSCO, Springer, Ovid and Chinese National Knowledge Infrastructure (CNKI) databases were searched from January 1999 to January 2013 to comprehe...

journal_title：Experimental and therapeutic medicine

authors： Wei W,Zhao T,Li Y

更新日期：2013-08-01 00:00:00

abstract：:MicroRNAs (miRs) are a class of endogenous small non-coding RNAs that have been revealed to negatively mediate the expression of their target genes at the post-transcriptional level. Recently, particular miRs have demonstrated an involvement in the pathogenesis of Alzheimer's disease (AD). However, the specific role o...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Xing H,Guo S,Zheng Z,Wang H,Xu D

更新日期：2016-08-01 00:00:00

abstract：:Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is closely associated with organ injury. The aim of the present study was to investigate the change of ALDH2 expression in a rat model of sepsis-induced acute renal injury, and to observe the effect of ALDH2 inhibition on the kidney. A model of sepsis syndrome was establi...

journal_title：Experimental and therapeutic medicine

authors： Hu JF,Wang HX,Li HH,Hu J,Yu Y,Gao Q

更新日期：2017-09-01 00:00:00

abstract：:Embelin is a small-molecule inhibitor extracted from plants of the Myrsinaceae family demonstrating specific inhibition of the X-linked inhibitor of apoptosis protein (XIAP) to affect the proliferation and apoptosis of various types of tumor cells. However, the mechanism of action for this effect remains unclear. The ...

journal_title：Experimental and therapeutic medicine

authors： Taghiyev A,Sun D,Gao ZM,Liang R,Wang L

更新日期：2012-10-01 00:00:00

abstract：:Osteoarthritis (OA) is one of the most prevalent causes of joint disease. However, the pathological mechanisms of OA have remained to be completely elucidated, and further investigation into the underlying mechanisms of OA development and the identification of novel therapeutic targets are urgently required. In the pr...

journal_title：Experimental and therapeutic medicine

authors： Gao X,Sun Y,Li X

更新日期：2019-10-01 00:00:00

abstract：:The present study aimed to investigate the effect of the traditional Chinese medicine Qingre Baidu mixture (QBM) on the regulation of various parameters, including the morphology of bacterial biofilms, the bacterial density sensing system, the self-induction of the molecule autoinducer (AI)-2 and the hypoxia-inducible...

journal_title：Experimental and therapeutic medicine

authors： Shan W,Wang Y,Zhang Z,Xing J,Xu J,Xiao W,Shen Y,Guo S,Que H

更新日期：2019-05-01 00:00:00

abstract：:The Krüppel-associated box zinc-finger protein 545 (ZNF545) was recently identified as a tumor suppressor in esophageal squamous cell carcinoma (ESCC). However, the role of ZNF545 in the tumorigenesis of esophageal cancer cells expressing loss-of-function mutant p53 has not been elucidated. In the present study, the r...

journal_title：Experimental and therapeutic medicine

authors： Fan Y,Wang Y,Fu S,Liu D,Lin S

更新日期：2019-09-01 00:00:00

abstract：:The effects of atrial fibrillation on complications and prognosis of patients receiving emergency percutaneous coronary intervention after acute myocardial infarction (AMI) were investigated. Eighty AMI patients treated with interventional vascular recanalization in the Affiliated Hospital of Weifang Medical Universit...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Zhang L,Zheng H,Chen H

更新日期：2018-10-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a rare but highly aggressive type of malignancy. MicroRNA (miR)-25 has been demonstrated to be involved in the genesis of numerous cancer types. The aim of the present study was to investigate the prognostic value and functional role of miR-25 in CCA. The expression of miR-25 was determined...

journal_title：Experimental and therapeutic medicine

authors： Liu H,Ma L,Wang J

更新日期：2019-10-01 00:00:00

abstract：:The present study was designed to observe the initiation of mitophagy in tumor cells after ultrasound treatment in the presence of curcumin under transmission electron microscopy. Nasopharyngeal carcinoma CNE2 cells were incubated with 10 μM curcumin and then exposed to ultrasound for 8 sec at an intensity of 0.46 W/c...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Leung AW,Luo J,Xu C

更新日期：2012-01-01 00:00:00

abstract：:Chitosan, a naturally derived polymer, has been shown to possess antimicrobial and anti-inflammatory properties; however, little is known about the effect of chitosan on the immune responses and glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) and lactate dehydrogenase (LDH) activities in n...

journal_title：Experimental and therapeutic medicine

authors： Yeh MY,Shih YL,Chung HY,Chou J,Lu HF,Liu CH,Liu JY,Huang WW,Peng SF,Wu LY,Chung JG

更新日期：2016-04-01 00:00:00

abstract：:Hyponatremia is a risk factor associated with poor prognosis in patients with heart failure (HF) with reduced ejection fraction. However, whether hyponatremia has a similar role in patients with HF with preserved ejection fraction (HFpEF) has remained controversial. Therefore, the present study aimed to investigate th...

journal_title：Experimental and therapeutic medicine

authors： Su Y,Ma M,Zhang H,Pan X,Zhang X,Zhang F,Lv Y,Yan C

更新日期：2020-11-01 00:00:00

abstract：:The effectiveness of therapy combining dihydroartemisinin (DHA) and small interfering RNA targeting Notch1 (siNotch1) in T-cell lymphoma remains unknown. The present study explored the potential and possible mechanisms of combined dihydroarteminin, and siNotch1 therapy for T-cell lymphoma. It was demonstrated that the...

journal_title：Experimental and therapeutic medicine

authors： Huo L,Wei W,Wu S,Zhao X,Zhao C,Zhao H,Sun L

更新日期：2018-03-01 00:00:00

abstract：:Chronic hepatitis B virus (CHB) infection is a burden on global healthcare and is associated with a higher risk of serious sequelae, including cirrhosis and hepatocellular carcinoma. The clinical application of entecavir as a treatment for CHB has produced positive outcomes, and so is an attractive form of pharmacolog...

journal_title：Experimental and therapeutic medicine

authors： Gai XD,Wu WF

更新日期：2017-10-01 00:00:00

abstract：:Chrysin is a major active ingredient of flavonoids, known to exhibit protective effects against various types of cancer. However, the anticancer role of chrysin against hepatocellular carcinoma (HCC) and the underlying molecular mechanisms remain unclear. In order to evaluate the effects of chrysin on cell viability a...

journal_title：Experimental and therapeutic medicine

authors： Zhang Q,Ma S,Liu B,Liu J,Zhu R,Li M

更新日期：2016-07-01 00:00:00

abstract：:The transient receptor potential melastatin 2 (TRPM2) channel, a Ca2+ permeable channel activated by cAMP, is expressed on pancreatic β-cells and is responsible for the regulation of insulin secretion. It is known that glucose-stimulated insulin secretion (GSIS) can be potentiated by glucagon like peptide-1 (GLP-1), a...

journal_title：Experimental and therapeutic medicine

authors： Pang B,Kim S,Li D,Ma Z,Sun B,Zhang X,Wu Z,Chen L

更新日期：2017-11-01 00:00:00

abstract：:The aim of this study was to analyze the changes in serum protein levels in the progression of hepatitis B using isobaric tags for relative and absolute quantitation (iTRAQ) analysis, in addition to comparing the serum protein levels of patients with chronic hepatitis B (CHB), patients with hepatitis B virus-induced a...

journal_title：Experimental and therapeutic medicine

authors： Peng L,Liu J,Li YM,Huang ZL,Wang PP,Gu YR,Zheng YB,Gao ZL

更新日期：2013-11-01 00:00:00

abstract：:This study describes the case of a 41-year-old woman admitted for anterograde memory loss, right facial grimacing and right arm posturing that had begun 1 month previously. Cranial magnetic resonance-diffusion weighted imaging and -fluid-attenuated inversion recovery imaging revealed a hyperintense signal in the left ...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Li M,Li G,Zhou C,Zhang R

更新日期：2016-01-01 00:00:00

abstract：:Human osteoarthritis (OA) has been reclassified as a systemic musculoskeletal disorder involving activation of the innate and adaptive immune systems. Elevated pro-inflammatory cytokines may serve a key function in the development of the disease. 1,25-Dihydroxyvitamin D3 and dexamethasone (vitD3/Dex) may inhibit infla...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Zhang J,Fang Y,Cao W,Xu B,Chen X

更新日期：2019-01-01 00:00:00

abstract：:A major consequence of obstructive jaundice (OJ) in clinical practice is the development of severe liver injury, and at present, no effective treatments have been developed to protect against it. Preconditioning with damage-associated molecular pattern (DAMP) molecules has been demonstrated to protect multiple organs ...

journal_title：Experimental and therapeutic medicine

authors： Zhou YX,Ni Y,Liu YB,Liu X

更新日期：2014-07-01 00:00:00

abstract：:The present study investigated the effect of the phytochemical genistein on the proliferation and differentiation of MCF-7 and 3T3-L1 cells via the regulation of estrogen receptor-α (ERα) expression and the induction of apoptosis. When MCF-7 human breast cancer cells were treated with 50, 100, 150 and 200 μM genistein...

journal_title：Experimental and therapeutic medicine

authors： Choi EJ,Jung JY,Kim GH

更新日期：2014-08-01 00:00:00

abstract：:The present retrospective study aimed to investigate the prognostic factors for critically ill patients with an Acinetobacter baumannii (A. baumannii) infection. A total of 37 patients from the intensive care unit (ICU) were enrolled in the study. Data was collected from patients, including age, gender, ethnicity, A. ...

journal_title：Experimental and therapeutic medicine

authors： Xiao D,Wang L,Zhang D,Xiang D,Liu Q,Xing X

更新日期：2017-04-01 00:00:00

abstract：:Esophageal submucosal tumors are occasionally detected incidentally during a gastrointestinal survey. In the present study, a case of esophageal leiomyoma is reported, which was incidentally detected by chest radiography during an annual survey of mass-screening for lung cancer. The patient underwent a laparoscopic lo...

journal_title：Experimental and therapeutic medicine

authors： Tadano S,Kondo T,Watanabe M,Takayashiki N,Shiozawa T,Ohara G,Kagohashi K,Kurishima K,Satoh H

更新日期：2014-12-01 00:00:00