Acetylpuerarin inhibits oxygen-glucose deprivation-induced neuroinflammation of rat primary astrocytes via the suppression of HIF-1 signaling.

abstract：:Achondroplasia (ACH) is a hereditary dwarfism caused by the disturbed proliferation and differentiation of growth plate chondrocytes, followed by impaired endochondral bone growth. ACH is caused by mutations in the gene encoding the transmembrane receptor, fibroblast growth factor receptor 3 (FGFR3). In total, >90% of...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Tang X,Cheng J,Wang L,Yang X,Wang Y

更新日期：2015-05-01 00:00:00

abstract：:To investigate the effects of propofol on myocardial ischemia reperfusion in rats with type 2 diabetes, male adult rats were divided into five groups: Sham-operation (CC), ischemia-reperfusion (CI), low-dose propofol (LP), moderate-dose propofol (MP) and high-dose propofol (HP). The LP, MP and HP groups were administe...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Zhang K,Qi X,Yang G,Wang H,Zhang Z,Yang B

更新日期：2020-04-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus, which causes coronavirus disease 2019 (COVID-19) and affects children less frequently than adults. According to Professor Vana Papaevangelou, Professor of Paediatrics at the University of Athens School of Medicine, children comprise o...

journal_title：Experimental and therapeutic medicine

authors： Mammas IN,Theodoridou M,Spandidos DA

更新日期：2020-12-01 00:00:00

abstract：:Phthalates are confirmed to have toxic effects on the reproductive system and are likely to have further damaging actions in humans. The present study explored the molecular mechanisms of the toxic effect of mono-(2-ethylhexyl) phthalate (MEHP) on mouse Sertoli cells. Cell apoptosis and proliferation assays were used ...

journal_title：Experimental and therapeutic medicine

authors： Wang L,Dou T,Li S,Liu Y

更新日期：2019-04-01 00:00:00

abstract：:The present study analyzed the ultrasonic features of papillary thyroid microcarcinoma (PTMC) and papillary thyroid non-microcarcinoma (non-PTMC) with the aim of improving the diagnostic value of ultrasonography. The ultrasonic features of 328 patients with papillary thyroid carcinoma (PTC), as confirmed by pathology,...

journal_title：Experimental and therapeutic medicine

authors： Zhang XL,Qian LX

更新日期：2014-10-01 00:00:00

abstract：:The present study aimed to investigate the effect of triptolide (TL) on ulcerative colitis (UC) and explore the potential association between the therapeutic effects of TL and IL-1β expression using a 4,4-dimethyl-4-silapentane-1-sulfonic acid (DSS)-induced mouse model to simulate human UC. A total of 70 BALB/c female...

journal_title：Experimental and therapeutic medicine

authors： Zhang H,Gong C,Qu L,Ding X,Cao W,Chen H,Zhang B,Zhou G

更新日期：2016-09-01 00:00:00

abstract：:Accumulating evidence has demonstrated that the Rho/Rho-associated protein kinase (Rho/ROCK) and nuclear factor κB (NF-κB) signaling pathways are involved in the pathogenesis of diabetic vascular injury. In this study, we investigated the beneficial effects of fasudil, a ROCK inhibitor, on vascular endothelial injury ...

journal_title：Experimental and therapeutic medicine

authors： Lu Y,Li H,Jian W,Zhuang J,Wang K,Peng W,Xu Y

更新日期：2013-08-01 00:00:00

abstract：:Chrysin is a major active ingredient of flavonoids, known to exhibit protective effects against various types of cancer. However, the anticancer role of chrysin against hepatocellular carcinoma (HCC) and the underlying molecular mechanisms remain unclear. In order to evaluate the effects of chrysin on cell viability a...

journal_title：Experimental and therapeutic medicine

authors： Zhang Q,Ma S,Liu B,Liu J,Zhu R,Li M

更新日期：2016-07-01 00:00:00

abstract：:This study was designed to investigate the correlation of vitamin D receptor (VDR) gene polymorphism with bronchial asthma in children. Seventy patients admitted to Daqing Longnan Hospital and diagnosed as bronchial asthma for the first time from April 2015 to May 2017 were selected as observation group. Patients rece...

journal_title：Experimental and therapeutic medicine

authors： Hou C,Zhu X,Chang X

更新日期：2018-03-01 00:00:00

abstract：:The aim of the present study was to evaluate the diagnostic value of ultrasound (US) elastography in differentiating between benign and malignant peripheral lung lesions (PLLs). This retrospective study included 91 consecutive patients with 91 PLLs. Conventional US, strain elastography (SE), acoustic radiation force i...

journal_title：Experimental and therapeutic medicine

authors： Wei H,Lu Y,Ji Q,Zhou H,Zhou X

更新日期：2018-08-01 00:00:00

abstract：:Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant tumor that accounts for 3% of all tumors of the nasal cavity. The incidence of ENB is 0.4 cases per million in the general population, and the most common symptoms are nasal obstruction and epistaxis. Previous studies have indicate...

journal_title：Experimental and therapeutic medicine

authors： Sabongi JG,Gonçalves MC,Alves CD,Alves J,Scapulatempo-Neto C,Moriguchi SM

更新日期：2016-11-01 00:00:00

abstract：:The value of Sonoclot detection technology to guide the clinical medication of the perioperative anticoagulation and antiplatelet therapy in patients with acute myocardial infarction (AMI) undergoing emergent percutaneous coronary intervention (PCI) was estimated. One hundred and twenty-eight patients were randomly di...

journal_title：Experimental and therapeutic medicine

authors： Yang WX,Lai CL,Chen FH,Wang JR,Ji YR,Wang DX

更新日期：2017-06-01 00:00:00

abstract：:Atherosclerosis is the leading cause of death from vascular diseases worldwide, and endothelial cell (EC) dysfunction is the key cause of atherosclerosis. miR-155 was found to induce endothelial injury and to trigger atherosclerosis. In addition, brain and muscle ARNT-like protein-1 (Bmal1) has been found to be closel...

journal_title：Experimental and therapeutic medicine

authors： Liang S,Hu J,Zhang A,Li F,Li X

更新日期：2020-12-01 00:00:00

abstract：:The aim of the present study was to investigate the function of microRNA-146b on myocardial infarction and the mechanism. An MTT assay, Annexin V/propidium iodide (PI) apoptosis assay, ELISA kits, western blot analysis and a caspase-3/8 activity assay were used to measure cell growth, vascular apoptosis inflammatory f...

journal_title：Experimental and therapeutic medicine

authors： Zhao L,Yang XR,Han X

更新日期：2019-02-01 00:00:00

abstract：:The treatment of lymphatic malformations (LMs) represents a great clinical challenge. The present study reported on the treatment of 68 infants with cervical macrocystic LMs using surgical resection. The cases were retrospectively analyzed. All patients underwent pre-operative ultrasonography, computed tomography (CT)...

journal_title：Experimental and therapeutic medicine

authors： Ma J,Biao R,Lou F,Lin K,Gao YQ,Wang ML,Yang YL,Zhang TS

更新日期：2017-08-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is one of the most common cancer types worldwide. Previous studies have indicated that TOR signaling pathway regulator (TIPRL) is involved in the progression of NSCLC. However, the underlying mechanisms of the role of TIPRL in regulating NSCLC metastasis have remained largely elusive...

journal_title：Experimental and therapeutic medicine

authors： Xu X,Zhu H,Yang M,Zheng E,Zhou Y,Ni J,Li R,Yang Z,He T,Zhao G

更新日期：2020-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the expression of targeted genes in a post-transcriptional manner. Increasing evidence indicates that miRNAs play important roles in cancer pathogenesis, including apoptosis, proliferation and differentiation, as oncogenes or tumor suppressors. Previo...

journal_title：Experimental and therapeutic medicine

authors： Shen ZY,Zhang ZZ,Liu H,Zhao EH,Cao H

更新日期：2014-06-01 00:00:00

abstract：:Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting were investigated. Eighty patients undergoing systemic anesthesia with extracorporeal coronary artery bypass grafting in The People's Hospital of Guangxi Zhuang Autonomous Region from January 2015 to A...

journal_title：Experimental and therapeutic medicine

authors： Gong Z,Li J,Zhong Y,Guan X,Huang A,Ma L

更新日期：2018-12-01 00:00:00

abstract：:The diagnostic value of detection of serum β-human chorionic gonadotropin (β-HCG) and Chlamydia trachomatis immunoglobulin G (CT-IgG) combined with transvaginal ultrasonography in early tubal pregnancy was investigated. A total of 55 patients with early tubal pregnancy were selected as the tubal pregnancy group, while...

journal_title：Experimental and therapeutic medicine

authors： Xin H,Liu W,Li P

更新日期：2018-07-01 00:00:00

abstract：:The aim of the present study was to investigate the expression levels and clinical significance of Toll-like receptor (TLR) 3 and 4 in peripheral blood mononuclear cells (PBMCs) collected from children with Henoch-Schönlein purpura (HSP) nephritis. The randomized controlled trial was conducted between August 2011 and ...

journal_title：Experimental and therapeutic medicine

authors： Chang H,Yu DS,Liu XQ,Zhang QY,Cheng N,Zhang SQ,Qu ZH

更新日期：2014-06-01 00:00:00

abstract：:We investigated the clinical value of fractional flow reserve (FFR) for the prognostic evaluation of patients with percutaneous coronary intervention. We enrolled 120 patients who were admitted to the hospital to undergo percutaneous coronary intervention for acute coronary syndromes between May 2014 and June 2015. Th...

journal_title：Experimental and therapeutic medicine

authors： Zhao Q,Ji Z,Li X,Di Y,An H,Wei B,Yang L,Chen W

更新日期：2018-01-01 00:00:00

abstract：:The present study aimed to apply the best single-energy (SE) scanning in energy spectrum computed tomography (CT) to evaluate the usefulness of lower extremity arterial angiography imaging in patients with lower extremity arterial occlusive disease. A total of 64 patients diagnosed with lower extremity arterial occlus...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Zhao D,Ling Z,Wang H,Yu S,Zhang J

更新日期：2019-08-01 00:00:00

abstract：:Human serum albumin (HSA) is a transporting protein that has multiple functions. The binding interaction between HSA and small molecules affects its function and efficacy of small molecules. The present study reports that kaempferol-7-O-α-L-rhamnopyranoside (KR) interacts with HSA as indicated by multiple fluorescence...

journal_title：Experimental and therapeutic medicine

authors： Zhang W,Chen C,Zhang C,Duan J,Yao H,Li Y,Meng A,Shi J

更新日期：2017-06-01 00:00:00

abstract：:The aim of the present study was to investigate the expression levels of estrogen receptor (ER) α and β and human epidermal growth factor receptor-2 (Her-2), as well as the distribution of breast cancer molecular subtypes in Uygur and Han breast cancer patients. Cancer tissues were collected and analyzed from 709 brea...

journal_title：Experimental and therapeutic medicine

authors： Guo L,Hou X,Dilimina Y,Wang B

更新日期：2014-05-01 00:00:00

abstract：:Currently available antiepileptic drugs are effective; however, frequently associated with adverse effects that limit their therapeutic value. Compounds that target the molecular events underlying epilepsy, with minor or no adverse effects, would be of clinical value. Matrix metalloproteinase-9 (MMP-9) and the brain-d...

journal_title：Experimental and therapeutic medicine

authors： Sun ZQ,Meng FH,Tu LX,Sun L

更新日期：2019-04-01 00:00:00

abstract：:One of the critical factors for predicting the success of percutaneous catheter drainage (PCD) is the mean CT density of collection. A higher CT density suggests more necrotic solid tissue within the collection. In the present study, a novel technique for PCD of the necrotic pancreatic collection with a higher mean CT...

journal_title：Experimental and therapeutic medicine

authors： Gupta P,Koshi S,Samanta J,Mandavdhare H,Sharma V,K Sinha S,Dutta U,Kochhar R

更新日期：2020-09-01 00:00:00

abstract：:Cardiovascular ischemic disease refers to a large class of conditions that are harmful to human health. A number of previous studies have demonstrated that microRNAs (miRs) have notable roles in regulating cardiac injury. miR-144 is influential in the differentiation, growth, and metastatic processes of cells; however...

journal_title：Experimental and therapeutic medicine

authors： E L,Jiang H,Lu Z

更新日期：2019-03-01 00:00:00

abstract：:Doxorubicin (DOX), a potent and widely used anticancer agent, can give rise to severe cardiotoxicity that limits its clinical use by inducing oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the central regulator of cellular responses to electrophilic/oxidative stress, which serves a critical ro...

journal_title：Experimental and therapeutic medicine

authors： Guo Z,Yan M,Chen L,Fang P,Li Z,Wan Z,Cao S,Hou Z,Wei S,Li W,Zhang B

更新日期：2018-10-01 00:00:00

abstract：:The aim of this study was to investigate the effects of heat stress on the expression of the coxsackievirus and adenovirus receptor (CAR) in mouse skin keratinocytes. Twenty BALB/c mice were randomly divided into two groups: the sham heat (control) and scald groups. Skin specimens were obtained 6 h after the treatment...

journal_title：Experimental and therapeutic medicine

authors： Deng X,Jia C,Chen F,Liu J,Zhou Z

更新日期：2013-10-01 00:00:00

abstract：:Chitosan, a naturally derived polymer, has been shown to possess antimicrobial and anti-inflammatory properties; however, little is known about the effect of chitosan on the immune responses and glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) and lactate dehydrogenase (LDH) activities in n...

journal_title：Experimental and therapeutic medicine

authors： Yeh MY,Shih YL,Chung HY,Chou J,Lu HF,Liu CH,Liu JY,Huang WW,Peng SF,Wu LY,Chung JG

更新日期：2016-04-01 00:00:00