Abstract:
:The aim of the present study was to investigate the expression levels of estrogen receptor (ER) α and β and human epidermal growth factor receptor-2 (Her-2), as well as the distribution of breast cancer molecular subtypes in Uygur and Han breast cancer patients. Cancer tissues were collected and analyzed from 709 breast cancer patients enrolled between January 2000 and December 2010. The expression levels of ERα, ERβ and Her-2 were determined by immunohistochemistry. The differences in expression and molecular subtype distribution between Uygur and Han patients with breast cancer were analyzed using a Pearson's χ2 test. Statistically significant differences were observed in the expression levels of ERβ, ERα and Her-2 between the Uygur and Han patients with breast cancer (P<0.05). The expression levels of ERβ (++), ERβ (+++) and Her-2 (+++) in Uygur patients were significantly higher, while the expression levels of ERα (+++) in Uygur patients were significantly lower when compared with Han patients. The percentage of luminal A type breast cancer in Uygur patients was significantly lower when compared with the Han patients, whereas the percentages of basal-like and Her-2 overexpression types were significantly higher than those in Han patients (P<0.05). Therefore, expression levels of ERβ, ERα and Her-2, and molecular subtypes of breast cancer were significantly different between the Uygur and Han populations.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Guo L,Hou X,Dilimina Y,Wang Bdoi
10.3892/etm.2014.1596subject
Has Abstractpub_date
2014-05-01 00:00:00pages
1077-1082issue
5eissn
1792-0981issn
1792-1015pii
etm-07-05-1077journal_volume
7pub_type
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abstract::[This corrects the article DOI: 10.3892/etm.2018.6297.]. ...
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journal_title:Experimental and therapeutic medicine
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