Early clinical characteristics of bacterial endophthalmitis in retinopathy of prematurity after intravitreal bevacizumab injection: A case report.

abstract：:MiR-216a-5p has been acknowledged as an oncogene and is known to be involved in the progression and metastasis of numerous cancer subtypes. However, the potential role of miR-216a-5p in renal cell carcinoma (RCC) remains to be elucidated. In the present study, reverse transcription-quantitative polymerase chain reacti...

journal_title：Experimental and therapeutic medicine

authors： Chen P,Quan J,Jin L,Lin C,Xu W,Xu J,Guan X,Chen Z,Ni L,Yang S,Chen Y,Lai Y

更新日期：2018-04-01 00:00:00

abstract：:The aim of the present study was to investigate the roles of matrix metalloproteinase 14 (MMP-14) in corneal inflammatory lymphangiogenesis. The expression of MMP-14 in vivo was detected by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot assays, under vario...

journal_title：Experimental and therapeutic medicine

authors： Du HT,Liu P

更新日期：2016-10-01 00:00:00

abstract：:To study the significance of dynamic evolution of serum tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) and intestinal fatty acid-binding protein (I-FABP) levels in neonatal necrotizing enterocolitis (NEC). A total of 45 NEC child patients, 45 non-NEC child patients and 45 healthy newborns were enrolled. After t...

journal_title：Experimental and therapeutic medicine

authors： Li Z,Sheng L

更新日期：2018-02-01 00:00:00

abstract：:The universal endocrine pathological state affecting young individuals and adults is type 2 diabetes mellitus, which has seen a significant increase in the last 30 years, particularly in children. Genetic and evnironmental factors are the causative agents for this pathological state in children. This rapid and wide sp...

journal_title：Experimental and therapeutic medicine

authors： Xue Y,Gao M,Gao Y

更新日期：2016-10-01 00:00:00

abstract：:Natural killer (NK) cells are innate lymphocytes that aid in the protection of the host from infectious diseases and cancer. In vitro studies of NK cells have provided a foundation for developing clinical adoptive NK-cell transferred immunotherapy against human tumors. To elucidate the functions and mechanisms of NK c...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Yu G,Wang D,Guo S,Shan F

更新日期：2017-05-01 00:00:00

abstract：:Psoriasis affects 2-4% of the population worldwide and its treatment is currently far from satisfactory. Calcipotriol and Portulaca oleracea have been reported to exhibit the capacity to inhibit inflammation in psoriatic patients and improve their clinical condition. However, the efficacy of a combination regimen of t...

journal_title：Experimental and therapeutic medicine

authors： Zhao H,Li S,Luo F,Tan Q,Li H,Zhou W

更新日期：2015-02-01 00:00:00

abstract：:Schisandrin B (SchB) is one of the primary active components of Schisandra chinensis (Turcz.) Baill., a traditional Chinese herb that has been used to treat insomnia for hundreds of years. Our previous studies revealed that SchB exerts sedative and hypnotic effects, increasing the content of γ-aminobutyric acid (GABA)...

journal_title：Experimental and therapeutic medicine

authors： Wang M,Li N,Jing S,Wang C,Sun J,Li H,Liu J,Chen J

更新日期：2020-12-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy due to its broad resistance to chemotherapy. Gemcitabine is used as a standard chemotherapeutic drug for PDAC treatment, either alone or in combination with other chemotherapeutics. However, in patients with advanced disease, survival is rarely ...

journal_title：Experimental and therapeutic medicine

authors： Yao M,Hong Y,Liu Y,Chen W,Wang W

更新日期：2017-09-01 00:00:00

abstract：:The present study aimed to investigate the effect of glutathione S-transferase A1 (GSTA1) on lung cancer cell viability, invasion and adhesion in the presence of nicotine in vitro. Furthermore, the effect of GSTA1 on the epithelial-mesenchymal transition (EMT), a process strongly associated with lung cancer metastasis...

journal_title：Experimental and therapeutic medicine

authors： Wang W,Liu F,Wang C,Wang C,Tang Y,Jiang Z

更新日期：2017-08-01 00:00:00

abstract：:Toxoplasmosis is a zoonotic infection caused by the obligate intracellular apicomplexan parasite Toxoplasma gondii (T. gondii). T. gondii infection is a cause of congenital infection worldwide. Primary infection or the reactivation of latent infection during pregnancy may lead to fetal infection and to congenital toxo...

journal_title：Experimental and therapeutic medicine

authors： Motoi S,Navolan DB,Malita D,Ciohat I,Nemescu D,Manciuc C,Gorun F,Vilibic-Cavlek T,Boda D,Craina M,Dobrescu A

更新日期：2020-10-01 00:00:00

abstract：:The objective of this study was to investigate the effect of seven days of feed restriction (between days 42 and 49) on the morphology of the small intestine in experimental rabbit models. Sixty weaned Hyplus rabbits (35 days old) were included in the experiment and split into three groups of 20 rabbits. The first con...

journal_title：Experimental and therapeutic medicine

authors： Makovicky P,Tumova E,Volek Z,Makovicky P,Vodicka P

更新日期：2014-11-01 00:00:00

abstract：:The aim of the present study was to examine the clinical value of continuously monitoring serum CC16 levels in diagnosing pulmonary contusion, estimating its severity degree and predicting disease progression. Thirty-one acute trauma patients with lung contusion diagnosed by chest computed tomography (CT) were include...

journal_title：Experimental and therapeutic medicine

authors： Wen MN,Zhao G,Zhang JY,Zhao YH

更新日期：2017-09-01 00:00:00

abstract：:DNA methylation is known to regulate the expression of numerous genes but its role in the pathogenesis of thoracic aortic dissection (TAD) has remained largely elusive. In the present study, the DNA methylome of patients with TAD was analyzed using a methylation microarray and bisulfite pyrosequencing was used to dete...

journal_title：Experimental and therapeutic medicine

authors： Li N,Lin H,Zhou H,Zheng D,Xu G,Shi H,Zhu X,Gao J,Shao G,Sun L

更新日期：2020-08-01 00:00:00

abstract：:Cardiopulmonary resuscitation (CPR) after cardiac arrest (CA) often leads to neurological deficits in the absence of effective treatment. The aim of the present basic research study was to investigate the effects of human urine-derived stem cells (hUSCs) on the recovery of neurological function in rats after CA/CPR. h...

journal_title：Experimental and therapeutic medicine

authors： Pan C,Zheng X,Wang L,Chen Q,Lin Q

更新日期：2020-11-01 00:00:00

abstract：:To investigate the in vivo and in vitro inhibitory effects of deuterium-depleted water (DDW) on human lung cancer and the possible mechanisms underlying these effects, we cultured and treated human lung carcinoma cell line A549 and human embryonic lung fibroblasts HLF-1 with various concentrations of DDW from 2 to 72 ...

journal_title：Experimental and therapeutic medicine

authors： Cong FS,Zhang YR,Sheng HC,Ao ZH,Zhang SY,Wang JY

更新日期：2010-03-01 00:00:00

abstract：:Therapeutic drug monitoring is an essential tool when managing the therapeutic use of immunosuppressant cyclosporine A (CsA) in cases with solid organ transplantation. In China, the concentration of CsA is primarily measured using immunoassays. However, existing literature recommends mass spectrometry as the current g...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Qin W,Chen W,Liu H,Zhang D,Zhang X,Li P

更新日期：2021-03-01 00:00:00

abstract：:Cyclic adenosine monophosphate (cAMP) is an important secondary messenger that has long been recognized to control the initiation of meiosis through the activation of protein kinase A (PKA) in mammalian oocytes. However, PKA is not the only target for cAMP. Recent studies on cAMP-dependent and PKA-independent pathways...

journal_title：Experimental and therapeutic medicine

authors： Wang JC,Geng Y,Han Y,Luo HN,Zhang YS

更新日期：2018-08-01 00:00:00

abstract：:A long-acting β2-agonist (LABA) combined with an inhaled corticosteroid (ICS) is frequently prescribed as initial therapy in steroid-naïve asthma patients because of its effective control of symptoms and improvement of pulmonary function. However, it is unclear which patients will be responsive to LABAs and whether br...

journal_title：Experimental and therapeutic medicine

authors： Ohwada A,Inami K,Onuma E,Matsumoto-Yamazaki M,Atsuta R,Takahashi K

更新日期：2011-07-01 00:00:00

abstract：:Diabetic keratopathy is an ocular complication that occurs with diabetes. In the present study, the effect of diabetic keratopathy on corneal optical density, central corneal thickness, and corneal endothelial cell count was investigated. One hundred and eighty diabetic patients (360 eyes) were enrolled in the study d...

journal_title：Experimental and therapeutic medicine

authors： Gao F,Lin T,Pan Y

更新日期：2016-09-01 00:00:00

abstract：:The aim of the present study was to summarize the clinical characteristics of nocardiosis caused by Nocardia otitidiscaviarum in order to improve the knowledge of nocardiosis. A case of dissemination nocardiosis caused by N. otitidiscaviarum in an immunocompetent host is reported and the associated literature reviewed...

journal_title：Experimental and therapeutic medicine

authors： Jiang Y,Huang A,Fang Q

更新日期：2016-11-01 00:00:00

abstract：:Long non-coding RNA (lncRNA) maternally expressed 3 (MEG3) has been reported to be a key component in cancer biology. Preliminary microarray data from a previous study indicated that lncRNA MEG3 expression was altered in plasma of patients with sepsis. The present study found that the plasma levels of lncRNA MEG3 were...

journal_title：Experimental and therapeutic medicine

authors： Chen K,Shi X,Jin Y,Wang F,Shen Q,Xu W

更新日期：2019-11-01 00:00:00

abstract：:Expression of TGF-β1 and miR-99a in patients with early spontaneous abortion and correlation with hormone levels during pregnancy were investigated. A total of 70 pregnant women with early spontaneous abortion diagnosed in Jining No. 1 People's Hospital from February 1, 2015 to May 1, 2018 were selected as the study g...

journal_title：Experimental and therapeutic medicine

authors： Xie J,Cao Y

更新日期：2019-06-01 00:00:00

abstract：:This study aimed to investigate the effect of ambroxol on the concentration of cefotaxime in the bronchioalveolar lavage fluid of rats with bleomycin-induced pulmonary fibrosis. A total of 54 Wistar male rats were randomly divided into three groups, namely the normal control group, model group and ambroxol group. On e...

journal_title：Experimental and therapeutic medicine

authors： Chen F,Zhang YX,Zhang CQ

更新日期：2015-02-01 00:00:00

abstract：:The present study analyzed the ultrasonic features of papillary thyroid microcarcinoma (PTMC) and papillary thyroid non-microcarcinoma (non-PTMC) with the aim of improving the diagnostic value of ultrasonography. The ultrasonic features of 328 patients with papillary thyroid carcinoma (PTC), as confirmed by pathology,...

journal_title：Experimental and therapeutic medicine

authors： Zhang XL,Qian LX

更新日期：2014-10-01 00:00:00

abstract：:Alteration of behavior and PSD proteins in cerebral cortex and hippocampal synaptosome in the Alzheimer's disease (AD) mouse model were determined. AD was established by intraperitoneal injection of streptozotocin (STZ) in neonatal mice (intraperitoneal AD group) or intracerebroventricular injection of STZ in adult mi...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Ding R,Wang S,Ren Z,Xu L,Zhang X,Zhao J,Ding Y,Wu Y,Gong Y

更新日期：2018-09-01 00:00:00

abstract：:The aim of the present study was to analyze the mechanism by which nerve growth factor (NGF) promotes callus formation in mice with tibial fracture. NGF transgenic homozygotic mice and NGF wild homozygotic mice were selected to construct non-stabilized fracture model of tibia. The mice were sacrificed on days 7, 14 an...

journal_title：Experimental and therapeutic medicine

authors： Sang XG,Wang ZY,Cheng L,Liu YH,Li YG,Qin T,Di K

更新日期：2017-04-01 00:00:00

abstract：:A 58-year-old female exhibited the onset of symmetrical sensory abnormalities of the face and extremities. The neurological examination revealed normal muscle strength with abated or absent tendon reflexes. The patient experienced symmetrical glove- and stocking-type pinprick sensations in the distal extremities and a...

journal_title：Experimental and therapeutic medicine

authors： Zhang J,Liu N,Zhang ZC,Zheng RZ,Li Q

更新日期：2014-12-01 00:00:00

abstract：:Aldehyde dehydrogenase 2 (aldh2) serves an important role in the development of organ injury. Therefore, the present study investigated the effects of aldh2 on the oxidative stress response in a mouse model of ketamine-induced cystitis (KIC). A total of 60 8-week-old male Institute of Cancer Research wild-type (WT) mi...

journal_title：Experimental and therapeutic medicine

authors： Xi XJ,Chen SH,Mi H

更新日期：2020-11-01 00:00:00

abstract：:Abnormalities in insulin hormone levels leads to a hyperglycemic condition of diabetic mellitus. Hyperglycemia seriously induces organ and system destructions. The excessive accumulation of collagen fiber deposits occurs in inflammatory and reorganization processes of chronic liver diseases in type I insulin-dependent...

journal_title：Experimental and therapeutic medicine

authors： Komolkriengkrai M,Nopparat J,Vongvatcharanon U,Anupunpisit V,Khimmaktong W

更新日期：2019-08-01 00:00:00

abstract：:Visual inspection via laparoscopy is considered the gold standard for the diagnosis of deep infiltrating endometriosis. Laparoscopy is an invasive procedure; therefore, it would be beneficial to patients if accurate non-invasive modalities were available for the diagnosis of deep infiltrating endometriosis. The purpos...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,He T,Shen W

更新日期：2020-10-01 00:00:00