MicroRNA-144 attenuates cardiac ischemia/reperfusion injury by targeting FOXO1.

abstract：:Abnormalities in insulin hormone levels leads to a hyperglycemic condition of diabetic mellitus. Hyperglycemia seriously induces organ and system destructions. The excessive accumulation of collagen fiber deposits occurs in inflammatory and reorganization processes of chronic liver diseases in type I insulin-dependent...

journal_title：Experimental and therapeutic medicine

authors： Komolkriengkrai M,Nopparat J,Vongvatcharanon U,Anupunpisit V,Khimmaktong W

更新日期：2019-08-01 00:00:00

abstract：:To study the effects of multiple cerebral concussion (MCC)-induced chronic traumatic encephalopathy on balance motion behavior learning and memory abilities of rats and its possible mechanism. 4MCC rat models were established by means of striking the head (4MCC group, n=15), while normal Sprague-Dawley (SD) rats were ...

journal_title：Experimental and therapeutic medicine

authors： Zhang H,Zhang Z,Wang Z,Zhen Y,Yu J,Song H

更新日期：2018-09-01 00:00:00

abstract：:Engineered nanoparticles (NPs) have been increasingly used in numerous fields over the last decade. In particular, iron oxide NPs (Fe2O3NPs) and silver NPs (AgNPs) have contributed to the current increase in NP usage. However, the possible side effects of increased NP exposure remain not fully elucidated. The present ...

journal_title：Experimental and therapeutic medicine

authors： Yousef MI,Abuzreda AA,Kamel MA

更新日期：2019-12-01 00:00:00

abstract：:Peptide P7 specifically binds with basic fibroblast growth factor (bFGF) to inhibit the proliferation and invasion of numerous types of cancer cell. However, this effect has remained to be demonstrated in ovarian cancer-derived cell lines. In the present study, the protein P7 was used treat bFGF-stimulated SKOV3 epith...

journal_title：Experimental and therapeutic medicine

authors： Chen Q,Yang Z,Chen X,Shu L,Qu W

更新日期：2019-04-01 00:00:00

abstract：:The present study aimed to determine the diagnostic yield of OMOM capsule endoscopy for small bowel diseases in adults. A total of 89 patients, including 45 cases of obscure abdominal pain, 22 of chronic diarrhea, 18 of obscure gastrointestinal bleeding and 4 of obscure anemia were enrolled in the present study. The t...

journal_title：Experimental and therapeutic medicine

authors： Zhang L,Shen J,Guo L,Cheng F,Fan Q,Ni K,Xia S,Zhou D

更新日期：2018-04-01 00:00:00

abstract：:Rosai-Dorfman disease (RDD), otherwise known as sinus histiocytosis with massive lymphadenopathy, is a rare disease. Cutaneous RDD (CRDD) is an extremely rare form of RDD, which is limited to the skin. The present study examined a case of purely CRDD in a 25-year-old female patient who presented with a two-month histo...

journal_title：Experimental and therapeutic medicine

authors： Fang S,Chen AJ

更新日期：2015-04-01 00:00:00

abstract：:The present study aimed to investigate the effects of levodopa (LEV) on cellular apoptosis in a rabbit model of steroid-associated necrosis of the femoral head (SANFH). A total of 44 healthy adult Chinese rabbits were randomly divided into three groups: Group A (n=15), administered a combination of lipopolysaccharide ...

journal_title：Experimental and therapeutic medicine

authors： Xi H,Tao W,Jian Z,Sun X,Gong X,Huang L,Dong T

更新日期：2017-01-01 00:00:00

abstract：:The value of Sonoclot detection technology to guide the clinical medication of the perioperative anticoagulation and antiplatelet therapy in patients with acute myocardial infarction (AMI) undergoing emergent percutaneous coronary intervention (PCI) was estimated. One hundred and twenty-eight patients were randomly di...

journal_title：Experimental and therapeutic medicine

authors： Yang WX,Lai CL,Chen FH,Wang JR,Ji YR,Wang DX

更新日期：2017-06-01 00:00:00

abstract：:The aim of this study was to determine the metabolic biomarkers for abnormal Savda syndrome in patients with chronic obstructive pulmonary disease (COPD). Based on Traditional Uyghur Medicine (TUM) theory, a total of 103 patients with COPD were classified into abnormal Savda and non-abnormal Savda syndrome groups and ...

journal_title：Experimental and therapeutic medicine

authors： Xu WF,Upur H,Wu YH,Mamtimin B,Yang J,Ga YJ,You L

更新日期：2015-02-01 00:00:00

abstract：:The present study investigated the aptness of assessing the levels of progastrin-releasing peptide (Pro-GRP) in addition to the T lymphocyte subpopulation in lung cancer patients prior to and after therapy for determining immune function. A total of 45 patients with lung cancer were recruited and stratified in to a no...

journal_title：Experimental and therapeutic medicine

authors： He L,Wang J,Chang D,Lv D,Li H,Zhang H

更新日期：2018-02-01 00:00:00

abstract：:In the present study, the risk factors for systemic air embolism as a complication of percutaneous CT-guided lung biopsy were explored. Data from 2,026 percutaneous CT-guided lung biopsy procedures were retrospectively analyzed. All cases were divided into a concurrent air embolism group and a control group, depending...

journal_title：Experimental and therapeutic medicine

authors： Liu SH,Fu Q,Yu HL,Yang Q,Hu YB,Zhang ZX,Zhang BP,Zhang CY

更新日期：2020-01-01 00:00:00

abstract：:Subclinical hypothyroidism (SCH) is becoming a global health problem due to its increasing prevalence and potential adverse effects, including cardiovascular diseases and nonalcoholic fatty liver disease (NAFLD). However, the association between SCH and NAFLD remains controversial. MicroRNAs (miRNAs/miRs) have been re...

journal_title：Experimental and therapeutic medicine

authors： Zhang L,Wu K,Bo T,Zhou L,Gao L,Zhou X,Chen W

更新日期：2020-02-01 00:00:00

abstract：:Previous studies by our group demonstrated that radix Sophorae tonkinensis could induce hepatotoxicity. However, it remains unclear which components of this herb may be responsible for its hepatotoxicity. The present study aimed to investigate the hepatic toxicity of treatment with matrine (MT) and oxymatrine (OMT) al...

journal_title：Experimental and therapeutic medicine

authors： Gu Y,Lu J,Sun W,Jin R,Ohira T,Zhang Z,Tian X

更新日期：2019-04-01 00:00:00

abstract：:The present study aimed to investigate the expression of the forkhead box protein M1 (FOXM1) in the placenta of patients with preeclampsia, and its effect on trophoblasts. A total of 28 patients with preeclampsia and 30 patients without preeclampsia (controls) who underwent cesarean section and were admitted to the Af...

journal_title：Experimental and therapeutic medicine

authors： Cui X,Xu J,Ji Y,Song X,Wang J,Zhang L,Yang S,Ye Y

更新日期：2018-07-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a critical mediator of the phosphoinositide 3-kinase/protein kinase B/mTOR signaling pathway, and mTOR activity is induced following heat shock. Thermotherapy is used to treat hepatocellular carcinoma (HCC). However, the role of mTOR in modulating thermosensitivity in HCC ha...

journal_title：Experimental and therapeutic medicine

authors： Wang QL,Liu BO,Li XJ,Hu KP,Zhao K,Ye XM

更新日期：2016-03-01 00:00:00

abstract：:The aim of the present study was to investigate whether chronic administration of basic fibroblast growth factor (bFGF) following angioplasty in a dog model of atherosclerotic iliac stenosis may restore endothelium function and prevent restenosis (RS). In total, 40 dogs with atherosclerotic stenosis of the right iliac...

journal_title：Experimental and therapeutic medicine

authors： Ran F,Liu C,Liu Z,Shang T,Zhou M,Qiao T

更新日期：2014-05-01 00:00:00

abstract：:Sepsis is a complication of infection caused by disease or trauma. Increasing evidence have shown that long noncoding RNAs (lncRNAs) are involved in the regulation of sepsis. However, the mechanism of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in the regulation of sepsis progression remains to be elucidated...

journal_title：Experimental and therapeutic medicine

authors： Liu L,Liu F,Sun Z,Peng Z,You T,Yu Z

更新日期：2020-10-01 00:00:00

abstract：:In recent years accumulating evidence has indicated that tocotrienol exhibits an oxidation resistance function, decreased cholesterol function, inhibits cancer function and has unique physiological functions, including anti-inflammatory, anti-apoptotic and anti-oxidative properties. The present study investigated the ...

journal_title：Experimental and therapeutic medicine

authors： Xun C,Mamat M,Guo H,Mamati P,Sheng J,Zhang J,Xu T,Liang W,Cao R,Sheng W

更新日期：2017-07-01 00:00:00

abstract：:The initiation and progression of various types of tumors, such as lung neoplasms, are driven by a population of cells with stem cell properties and their microenvironment. Bone marrow mesenchymal stem cells (BM-MSCs) in long-term in vitro culture may exhibit spontaneous changes in stem cell biological properties, inc...

journal_title：Experimental and therapeutic medicine

authors： Zhang YM,Zhang ZM,Guan QL,Liu YQ,Wu ZW,Li JT,Su Y,Yan CL,Luo YL,Qin J,Wang Q,Xie XD

更新日期：2017-10-01 00:00:00

abstract：:This study describes the case of a 41-year-old woman admitted for anterograde memory loss, right facial grimacing and right arm posturing that had begun 1 month previously. Cranial magnetic resonance-diffusion weighted imaging and -fluid-attenuated inversion recovery imaging revealed a hyperintense signal in the left ...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Li M,Li G,Zhou C,Zhang R

更新日期：2016-01-01 00:00:00

abstract：:The pathogenesis of acute liver failure has not been fully elucidated. The present study investigated the effects of the serum from patients with hepatitis E virus (HEV)-related acute liver failure on human liver cell survival and apoptosis, and evaluated the protective effects of anti-lipopolysaccharide(LPS) antibody...

journal_title：Experimental and therapeutic medicine

authors： Wu F,Wang M,Tian D

更新日期：2014-01-01 00:00:00

abstract：:Effects of propofol, midazolam and dexmedetomidine on patients with sepsis in intensive care unit (ICU) and on arterial blood gas (ABG) were studied. In total 429 ICU patients with sepsis, admitted to Renji Hospital, School of Medicine, Shanghai Jiaotong University from May 2015 to January 2019, were selected as resea...

journal_title：Experimental and therapeutic medicine

authors： Ding J,Chen Y,Gao Y

更新日期：2019-12-01 00:00:00

abstract：:Relative changes in B-type natriuretic peptide (BNP) and amino terminal pro-BNP (NT-proBNP) levels may help to assess the risk of congestive heart failure (CHF). However, whether these levels at the time of admission enable the prediction of outcomes with acute exacerbation remains unknown. The current study determine...

journal_title：Experimental and therapeutic medicine

authors： Dai Y,Yang J,Takagi A,Konishi H,Miyazaki T,Masuda H,Shimada K,Miyauchi K,Daida H

更新日期：2017-08-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is a heterogeneous disease, with varying immunological and histopathological features. The CC chemokine ligand 19 (CCL19) can stimulate T cells and antigen-presenting cells into secondary lymphoid node formation, as observed in allergic rhinitis, inflammatory bowel disease and other inflam...

journal_title：Experimental and therapeutic medicine

authors： Zou Y,Wang Y,Wang SB,Kong YG,Xu YU,Tao ZZ,Chen SM

更新日期：2016-01-01 00:00:00

abstract：:Cardiovascular diseases are among the primary causes of decreased quality of life as well as mortality of hemodialysis patients with end-stage renal disease. The aim of the present study was to evaluate the predictive value of the red blood cell distribution width (RDW)-to-platelet ratio (RPR) and neutrophil-to-lympho...

journal_title：Experimental and therapeutic medicine

authors： Zhu X,Li G,Li S,Gong Z,Liu J,Song S

更新日期：2020-08-01 00:00:00

abstract：:In the present study, the changes in the retinal nerve fiber layer (RNFL) thickness associated with Leber's hereditary optic neuropathy (LHON) were examined by Cirrus high definition-optical coherence tomography (OCT), and the correlation between the RNFL thickness and the best corrected visual acuity (BCVA) was evalu...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Huang H,Wei S,Qiu H,Gong Y,Li H,Dai Y,Jiang Z,Liu Z

更新日期：2014-02-01 00:00:00

abstract：:Atherosclerosis is the leading cause of death from vascular diseases worldwide, and endothelial cell (EC) dysfunction is the key cause of atherosclerosis. miR-155 was found to induce endothelial injury and to trigger atherosclerosis. In addition, brain and muscle ARNT-like protein-1 (Bmal1) has been found to be closel...

journal_title：Experimental and therapeutic medicine

authors： Liang S,Hu J,Zhang A,Li F,Li X

更新日期：2020-12-01 00:00:00

abstract：:The aim of the present study was to analyze the mechanism by which nerve growth factor (NGF) promotes callus formation in mice with tibial fracture. NGF transgenic homozygotic mice and NGF wild homozygotic mice were selected to construct non-stabilized fracture model of tibia. The mice were sacrificed on days 7, 14 an...

journal_title：Experimental and therapeutic medicine

authors： Sang XG,Wang ZY,Cheng L,Liu YH,Li YG,Qin T,Di K

更新日期：2017-04-01 00:00:00

abstract：:E-cadherin is a key cell adhesion molecule implicated in tumor suppression that is frequently altered in hepatocellular carcinoma (HCC), particularly in hepatitis B virus-related tumors. Here, we report that the epigenetic drugs 5-azacytidine and trichostatin A up-regulated E-cadherin expression in HCC cells. The depl...

journal_title：Experimental and therapeutic medicine

authors： Qiu X,Qiao F,Su X,Zhao Z,Fan H

更新日期：2010-05-01 00:00:00

abstract：:The aim of the present study was to investigate whether modified Huangqi Chifeng decoction (MHCD) could be an effective treatment against Doxorubicin-induced nephrosis in rats and whether it regulates autophagy via the phosphoinositide-3 kinase/mammalian target of rapamycin (PI3K/mTOR) signaling pathway. A total of 40...

journal_title：Experimental and therapeutic medicine

authors： Yu ZK,Yang B,Zhang Y,Li LS,Zhao JN,Hao W

更新日期：2018-09-01 00:00:00