Tanshinone IIA attenuates estradiol-induced polycystic ovarian syndrome in mice by ameliorating FSHR expression in the ovary.

abstract：:A 58-year-old female exhibited the onset of symmetrical sensory abnormalities of the face and extremities. The neurological examination revealed normal muscle strength with abated or absent tendon reflexes. The patient experienced symmetrical glove- and stocking-type pinprick sensations in the distal extremities and a...

journal_title：Experimental and therapeutic medicine

authors： Zhang J,Liu N,Zhang ZC,Zheng RZ,Li Q

更新日期：2014-12-01 00:00:00

abstract：:Red cell distribution width (RDW) has been found to be a novel prognostic biomarker in patients with coronary artery disease (CAD); however, the association between RDW and the risk of heart events in patients with CAD is yet to be fully elucidated. Thus, the aim of the present study was to determine whether an elevat...

journal_title：Experimental and therapeutic medicine

authors： Li W,Li X,Wang M,Ge X,Li F,Huang B,Peng J,Li G,Lu L,Yu Z,Ma J,Xu L,Jin M,Si H,Wan R

更新日期：2015-04-01 00:00:00

abstract：:The mortality and disability rate of patients with ruptured anterior communicating artery (AComA) aneurysm after bleeding is high. Even with the most advanced treatment methods, the incidence of complications remains high. The purpose of the present study was to determine the efficacy of microsurgery via supraorbital ...

journal_title：Experimental and therapeutic medicine

authors： Bhattarai R,Liang C,Chen C,Wang H,Huang T,Ning X,Guo Y

更新日期：2020-09-01 00:00:00

abstract：:Seven single-nucleotide polymorphism (SNP) sites located in ASAP1 gene have been found associated with tuberculosis (TB) susceptibility by genome-wide association studies in Russia. The case-control study was carried out to test whether these seven SNPs were associated with susceptibility to TB in a Chinese Xinjiang M...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Ma A,Han X,Litifu A,Xue F

更新日期：2018-04-01 00:00:00

abstract：:The present study aimed to compare the clinical outcome of patients with coronary artery disease (CAD) who underwent a revascularization using conventional coronary angiography or a physiologically guided revascularization with Fractional Flow Reserve (FFR). Furthermore, outcomes in FFR guided percutaneous coronary in...

journal_title：Experimental and therapeutic medicine

authors： Baumann S,Mueller KSE,Hetjens S,Eder F,Schaefer AC,Becher T,Borggrefe M,Akin I,Loßnitzer D

更新日期：2019-03-01 00:00:00

abstract：:Granulomatosis with polyangiitis (GPA) is a rheumatic auto-immune disease involved in vasculitis. It is rarely reported that anti-neutrophil cytoplasmic antibodies (ANCAs) associated with GPA would cause main tract stenosis. The current report documents a 54-year-old woman, with a history of severe cough, presented wi...

journal_title：Experimental and therapeutic medicine

authors： Zhou D,Zhang P,Zhang Y,Zhang Y,Zhang X,Li J,Zhou Z,Zhu N

更新日期：2020-05-01 00:00:00

abstract：:Intactable epilepsy (IE) is relatively common in pediatric epilepsy. The resistance mechanism of IE has been previously investigated. Multidrug-resistant associated protein 1 (MRP1) and MRP2 are associated with drug transport. The aim of the present study was to investigate the expression of MRP1 and MRP2 in periphera...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Yue X,Chen S,Chen J,Li R

更新日期：2015-11-01 00:00:00

abstract：:Angioimmunoblastic T cell lymphoma (AITL)-associated hemophagocytic lymphohistiocytosis (HLH) rarely occurs with annular erythema multiforme-like rashes. The present case report describes a patient who was misdiagnosed with erythema multiforme at an early stage of the disease due to annular erythema multiforme-like er...

journal_title：Experimental and therapeutic medicine

authors： Zhang L,Tong C,Tan Y,Peng S,He Y,Wang T

更新日期：2018-09-01 00:00:00

abstract：:The aim of the present study was to clarify the association between lipid metabolism and the atherosclerosis in early-stage chronic renal failure at the molecular level and to explore the efficacy of decorin on chronic renal failure. Sprague Dawley rats receiving 5/6 nephrectomy and Sham surgery were divided into cont...

journal_title：Experimental and therapeutic medicine

authors： Ma HB,Wang R,Yu KZ,Yu C

更新日期：2015-02-01 00:00:00

abstract：:Coronary artery disease (CAD) is a leading cause of death, and microRNAs (miRNAs) are widely involved in physiological and pathological processes of CAD. We chose the targetscore method calculated via the variational Bayesian Gaussian mixture model (VB-GMM) as the prediction method of target genes. By observing the de...

journal_title：Experimental and therapeutic medicine

authors： Ma XL,Yang X,Fan R

更新日期：2019-03-01 00:00:00

abstract：:Caspase-8 (encoded by the CASP-8 gene) is crucial in generating cell death signals and eliminating potentially malignant cells. Genetic variation in CASP8 may affect susceptibility to cancer. The CASP-8 -652 6N ins/del (rs3834129) polymorphism has been previously reported to influence the progression to several cancer...

journal_title：Experimental and therapeutic medicine

authors： Chen D,Ma T,Liu XW,Liu Z

更新日期：2012-10-01 00:00:00

abstract：:The present study aimed to determine whether nimotuzumab enhances the effect of radiochemotherapy in malignant gliomas. Patients (n=41) with malignant gliomas were divided into 20 cases (treatment group) in which nimotuzumab plus radiochemotherapy were offered and 21 cases (control group) in which placebo and radioche...

journal_title：Experimental and therapeutic medicine

authors： Hong J,Peng Y,Liao Y,Jiang W,Wei R,Huo L,Han Z,Duan C,Zhong M

更新日期：2012-07-01 00:00:00

abstract：:Clinical efficacy of microvascular decompression (MVD) combined with percutaneous stereotactic radiofrequency rhizotomy (PSR) in the treatment of primary trigeminal neuralgia was investigated. The medical records of 141 patients with primary trigeminal neuralgia admitted to Shandong Provincial Hospital from May 2011 t...

journal_title：Experimental and therapeutic medicine

authors： Zhao G,Sun X,Zhang Z,Yang H,Zheng X,Feng B

更新日期：2020-08-01 00:00:00

abstract：:Ventilator-associated pneumonia (VAP) is a common nosocomial infection in neonatal intensive care units with high morbidity and mortality. Bacterial biofilm in the endotracheal tube (ET) provides a notable and persistent source of pathogens that may cause VAP, and thus is important for VAP detection. However, during i...

journal_title：Experimental and therapeutic medicine

authors： Pan Y,Du L,Ai Q,Song S,Tang X,Zhu D,Yu J

更新日期：2017-08-01 00:00:00

abstract：:Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) deficiency is a metabolic disorder caused by mutations in the HMGCS2 gene. The present study describes the identification of four cases of HMGCS2 deficiency in Japan. Hepatomegaly and severe metabolic acidosis were observed in all cases. Fatty liver was id...

journal_title：Experimental and therapeutic medicine

authors： Ago Y,Otsuka H,Sasai H,Abdelkreem E,Nakama M,Aoyama Y,Matsumoto H,Fujiki R,Ohara O,Akiyama K,Fukui K,Watanabe Y,Nakajima Y,Ohnishi H,Ito T,Fukao T

更新日期：2020-11-01 00:00:00

abstract：:Previous studies have demonstrated that Hedyotis diffusa Willd (HDW), a traditional Chinese herbal medicine, exhibits potent anticancer activity in models of colorectal cancer (CRC). Aggressive forms of CRC exhibit resistance to widely used chemotherapeutic drugs, including the antimetabolite, 5-fluorouracil (5-FU); h...

journal_title：Experimental and therapeutic medicine

authors： Li Q,Wang X,Shen A,Zhang Y,Chen Y,Sferra TJ,Lin J,Peng J

更新日期：2015-11-01 00:00:00

abstract：:Eugenol is a naturally occurring compound that is present in a variety of plants and has previous been demonstrated to exert a number of bioactivities. However, the potential effects of Eugenol on cellular protection against oxidative stress remain poorly understood. In the present study, HEK-293 cells and the mouse f...

journal_title：Experimental and therapeutic medicine

authors： Ma L,Liu J,Lin Q,Gu Y,Yu W

更新日期：2021-02-01 00:00:00

abstract：:The current study aimed to assess the repeatability and validity of cervical range of motion (CROM) measurements using an optical motion capture system (OMCS), compared with a CROM device. A total of 20 healthy volunteers were selected and enrolled in the current study after informed consent was received. The motion o...

journal_title：Experimental and therapeutic medicine

authors： Feng M,Liang L,Sun W,Liu GW,Yin X,Han T,Wei X,Zhu L

更新日期：2019-12-01 00:00:00

abstract：:Intervertebral disc degeneration (IDD) is considered to be the main cause of many spinal disorders; however, its underlying pathophysiology is not clearly understood. Recent studies indicate that excessive mechanical loading may serve a major role in the initiation of IDD. The aim of the present study was to explore t...

journal_title：Experimental and therapeutic medicine

authors： Bai X,Wang D,Zhou M,Xu C,Li W,Tao H,He Q,Ruan D

更新日期：2017-04-01 00:00:00

abstract：:We previously demonstrated that vitamin B6 suppresses tumorigenesis in the colon of mice and exerts an anti-inflammatory effect through the inhibition of NF-κB activation. As these effects resemble the pharmacological properties of thiazolidinedione (TZD), a synthetic peroxisome proliferator-activated receptor-γ (PPAR...

journal_title：Experimental and therapeutic medicine

authors： Yanaka N,Kanda M,Toya K,Suehiro H,Kato N

更新日期：2011-05-01 00:00:00

abstract：:Hepatocyte injury is a common pathological effect of cisplatin (CDDP) in various solid tumor therapies. Thus, strategies for minimizing CDDP toxicity are of great clinical interest. N-acetylcysteine (NAC), a known antioxidant, is often used as an antidote for acetaminophen overdose in the clinic due to its ability to ...

journal_title：Experimental and therapeutic medicine

authors： Wang F,Liu S,Shen Y,Zhuang R,Xi J,Fang H,Pan X,Sun J,Cai Z

更新日期：2014-12-01 00:00:00

abstract：:This meta-analysis was performed to evaluate the efficacy and safety of parecoxib sodium for acute postoperative pain. PubMed, Cochrane Central Register of Controlled Trials, EBSCO, Springer, Ovid and Chinese National Knowledge Infrastructure (CNKI) databases were searched from January 1999 to January 2013 to comprehe...

journal_title：Experimental and therapeutic medicine

authors： Wei W,Zhao T,Li Y

更新日期：2013-08-01 00:00:00

abstract：:Insulin is used in the treatment of type 2 diabetes, with its usage reaching 30-50% in Western countries. The aim of the present study was to determine the association between insulin dosage (ID)/insulin usage time (IT) and coronary artery lesions in patients of type 2 diabetes with coronary heart disease. Based on th...

journal_title：Experimental and therapeutic medicine

authors： Luo XL,Yan QK,Wang Y,Fang H,Wang HY,Bai Y,Zeng CY,Wang XK

更新日期：2016-05-01 00:00:00

abstract：:The aim of the present study was to investigate the expression and role of transforming growth factor (TGF)-β1/phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3KC3) in the peripheral blood in patients with hypertension. A total of 28 patients with primary hypertension and 20 healthy control subjects were inc...

journal_title：Experimental and therapeutic medicine

authors： Zhang Q,Liu H,Yang J

更新日期：2019-03-01 00:00:00

abstract：:The prognostic and predictive value of pre-treatment serum levels of carcinoembryonic antigen (CEA) and cytokeratin-19 fragments (CYFRA 21-1) were assessed in advanced non-small cell lung cancer (NSCLC) patients treated with gefitinib or erlotinib. Pre-treatment CEA and CYFRA 21-1 levels were measured in 123 advanced ...

journal_title：Experimental and therapeutic medicine

authors： Jung M,Kim SH,Lee YJ,Hong S,Kang YA,Kim SK,Chang J,Rha SY,Kim JH,Kim DJ,Cho BC

更新日期：2011-07-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) accounts for ~80% of all types of lung cancer, which has the highest morbidity and mortality of all types of cancer worldwide. It is important to identify novel biomarkers and the molecular mechanism of NSCLC to improve current treatments of NSCLC. The present study aimed to investig...

journal_title：Experimental and therapeutic medicine

authors： Luo H,Liang C

更新日期：2018-04-01 00:00:00

abstract：:Chlorogenic acid (CGA) is the primary constituent of Caulis Lonicerae, a Chinese herb used for the treatment of rheumatoid arthritis (RA). The present study aimed to investigate whether CGA was able to inhibit the proliferation of the fibroblast-like synoviocyte cell line (RSC-364), stimulated by interleukin (IL)-6, t...

journal_title：Experimental and therapeutic medicine

authors： Lou L,Zhou J,Liu Y,Wei YI,Zhao J,Deng J,Dong B,Zhu L,Wu A,Yang Y,Chai L

更新日期：2016-05-01 00:00:00

abstract：:There are limited data available on the regression of fibrosis in hepatitis C virus (HCV) patients who have achieved sustained virologic response (SVR) after interferon-free treatments. Moreover, a perfect method for assessing liver fibrosis and its dynamics has not been established yet. The main objective of this stu...

journal_title：Experimental and therapeutic medicine

authors： Leuştean A,Popescu C,Nichita L,Tilişcan C,Aramă V

更新日期：2021-01-01 00:00:00

abstract：:The aim of the present study was to examine the clinical value of continuously monitoring serum CC16 levels in diagnosing pulmonary contusion, estimating its severity degree and predicting disease progression. Thirty-one acute trauma patients with lung contusion diagnosed by chest computed tomography (CT) were include...

journal_title：Experimental and therapeutic medicine

authors： Wen MN,Zhao G,Zhang JY,Zhao YH

更新日期：2017-09-01 00:00:00

abstract：:Sustained-release (SR) formulations of metoprolol succinate (MS) may minimize fluctuations in plasma concentration and decrease the resulting adverse events. The aim of the present study was to optimize the loading capacity of microcapsules and the SR of MS. A uniform design method was applied to optimize the formulat...

journal_title：Experimental and therapeutic medicine

authors： Song L,He S,Ping Q

更新日期：2017-05-01 00:00:00