Protective effects of N-acetylcysteine on cisplatin-induced oxidative stress and DNA damage in HepG2 cells.

abstract：:Spinal cord injury (SCI) may lead to a devastating and permanent loss of neurological function, which may place a great economic burden on the family of the patient and society. Methods for reducing the death of neuronal cells, inhibiting immune and inflammatory reactions, and promoting the growth of axons in order to...

journal_title：Experimental and therapeutic medicine

authors： Ji W,Hu S,Zhou J,Wang G,Wang K,Zhang Y

更新日期：2014-03-01 00:00:00

abstract：:Environmental exposure, including a high-fat diet (HFD), contributes to the high prevalence of colorectal cancer by changing the composition of the intestinal microbiota. However, data examining the interaction between dietary habits and intestinal microbiota of the Chinese population is sparse. We assessed dietary ha...

journal_title：Experimental and therapeutic medicine

authors： Qian L,Gao R,Hong L,Pan C,Li H,Huang J,Qin H

更新日期：2018-08-01 00:00:00

abstract：:The aim of this study is to investigate the effect of vitamin D (VD) on the learning and memory ability of fetal growth restriction (FGR) rat and the expression of NMDA receptor in hippocampus. The FGR models of rat were established through passive smoking, and divided into two groups randomly, i.e. the control group ...

journal_title：Experimental and therapeutic medicine

authors： Zong L,Chu P,Huang P,Guo Y,Lv Y

更新日期：2017-07-01 00:00:00

abstract：:The aim of the present study was to determine the ferulic acid (FA) content of Radix Angelicae Sinensis (AS), Danggui-Buxue-Tang (DBT) and Danggui-Sini-Tang (DST) using the same ultra performance liquid chromatography system and method. FA was eluted using an Acquity BEH C18 column (100×2.1 mm inner diameter; 1.7 μm)....

journal_title：Experimental and therapeutic medicine

authors： Yao JM,Yu LJ,Chen Q,Chen ZQ,Wang DS,Qiu XJ,Zhao LL

更新日期：2014-05-01 00:00:00

abstract：:A mutation in the IIb sodium phosphate transporter SLC34A2 gene has recently been described in pulmonary alveolar microlithiasis (PAM) patients. Experiments in this study were aimed at confirming the role of the gene product in PAM by comparing phosphorylated products in extracellular fluid of alveolar epithelial cell...

journal_title：Experimental and therapeutic medicine

authors： Ma T,Qu D,Yan B,Zhang Q,Ren J,Hu Y

更新日期：2018-01-01 00:00:00

abstract：:The underlying mechanisms of arterial remodeling (AR) remain unclear. Studies have indicated that decellularized scaffolds stimulate the differentiation of fibroblasts into myofibroblasts and promote the accumulation of the extracellular matrix (ECM). In the present study, the impact of ECM changes following AR on vas...

journal_title：Experimental and therapeutic medicine

authors： Xin H,Wang Z,Wu S,Wang P,Tao X,Xu C,You L

更新日期：2019-07-01 00:00:00

abstract：:Dysregulation of microRNAs serves a crucial role in the chemosensitivity to cisplatin (DDP) in ovarian cancer (OVC). The abnormal expression of microRNA (miR)-654-3p has been reported in several types of human cancer. However, the association between miR-654-3p and cisplatin resistance in human OVC remains unclear. Th...

journal_title：Experimental and therapeutic medicine

authors： Niu YC,Tong J,Shi XF,Zhang T

更新日期：2020-08-01 00:00:00

abstract：:In vitro differentiation of human embryonic stem cells (hESCs) into endometrium-like cells may provide a useful tool for clinical treatment. The aim of the present study was to investigate the differentiation potential of hESCs into endometrium-like cells using three methods, which included induction by feeder cells, ...

journal_title：Experimental and therapeutic medicine

authors： Yu W,Niu W,Wang S,Chen X,Sun BO,Wang F,Sun Y

更新日期：2015-07-01 00:00:00

abstract：:The aim of the present study was to evaluate the thymuses of non-thymomatous myasthenia gravis (MG) patients by computed tomography (CT) for differentiating lymphoid follicular hyperplasia (LFH) thymus from normal/involuted thymus in order to assist surgeons in determining whether a non-thymomatous MG patient requires...

journal_title：Experimental and therapeutic medicine

authors： Zhang H,Zhang P,Yu TL

更新日期：2019-01-01 00:00:00

abstract：:The aim of the present study was to investigate the anti-tumor effects of a culture filtrate of Paecilomyces farinosus J3. Various anti-tumor assays using B16 melanoma cells were carried out. Paecilomyces farinosus J3 significantly decreased the wound healing capability, invasiveness and angiogenic activity, which was...

journal_title：Experimental and therapeutic medicine

authors： Lee HJ,Park CH,Son HU,Heo JC,Nam SH,Lee KG,Yeo JH,Yoon CS,Kim JM,Shin YK,Kim SO,Lee SH

更新日期：2011-03-01 00:00:00

abstract：:Silk fibroin (SF), chitosan (CS) and nano-hydroxyapatite (nHA) possess excellent biocompatibility, thus, these were used to construct a SF/CS/nHA composite scaffold. Previously published results identified that this material exhibited satisfactory physical and chemical properties, and therefore qualified as a repair m...

journal_title：Experimental and therapeutic medicine

authors： Ye P,Yu B,Deng J,She RF,Huang WL

更新日期：2017-12-01 00:00:00

abstract：:The aim of the study was to investigate the effects of high-volume continuous renal replacement therapy (HV-CRRT) on procalcitonin (PCT), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), IL-6, IL-8 and IL-10 in acute pancreatitis complicated by acute renal failure. Eighty-six patients with acute pancreatitis com...

journal_title：Experimental and therapeutic medicine

authors： Liu C,Li M,Cao S,Wang J,Huang X,Zhong W

更新日期：2017-10-01 00:00:00

abstract：:The present study was designed to observe the initiation of mitophagy in tumor cells after ultrasound treatment in the presence of curcumin under transmission electron microscopy. Nasopharyngeal carcinoma CNE2 cells were incubated with 10 μM curcumin and then exposed to ultrasound for 8 sec at an intensity of 0.46 W/c...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Leung AW,Luo J,Xu C

更新日期：2012-01-01 00:00:00

abstract：:Gardenia fruit has been used in traditional Chinese medicine for thousands of years. A previous study by the present authors indicated that the ethanol extract of gardenia fruits (EEG) primarily contains eight constituents. In the present study, the potential effects of EEG on unilateral ureteral obstruction (UUO)-ind...

journal_title：Experimental and therapeutic medicine

authors： Li X,Ma M,Zhang X,Deng L,Wang Y,Bian Z,Cai S,Peng B,Yang J,Chen Y

更新日期：2017-08-01 00:00:00

abstract：:The aim of this study was to determine the metabolic biomarkers for abnormal Savda syndrome in patients with chronic obstructive pulmonary disease (COPD). Based on Traditional Uyghur Medicine (TUM) theory, a total of 103 patients with COPD were classified into abnormal Savda and non-abnormal Savda syndrome groups and ...

journal_title：Experimental and therapeutic medicine

authors： Xu WF,Upur H,Wu YH,Mamtimin B,Yang J,Ga YJ,You L

更新日期：2015-02-01 00:00:00

abstract：:Compared to other diseases, early or atypical spinal tuberculosis (TB) is prone to being misdiagnosed due to the lack of specific clinical manifestations and misleading negative results of various laboratory analyses and imaging examinations. Various methods for diagnosing spinal TB have become research hotspots. Rece...

journal_title：Experimental and therapeutic medicine

authors： Pu F,Feng J,Yang L,Zhang L,Xia P

更新日期：2019-11-01 00:00:00

abstract：:The aim of this study was to characterize histo-chemical patterns and Das-1 and Ki67 protein expression in gastric cardia adenocarcinoma (GCA) and intestinal metaplasia (IM) lesions adjacent to GCA. Histochemical techniques, including Alcian blue/periodic acid-Schiff (AB/PAS), high iron diamine/Alcian blue (HID/AB) an...

journal_title：Experimental and therapeutic medicine

authors： Feng XS,Wang YF,Hao SG,Ru Y,Gao SG,Wang LD

更新日期：2013-06-01 00:00:00

abstract：:Cardiac inhibition due to burn injury and anesthetics have been documented previously. However, little is known about their combined effects on cardiac function. The aim of the present study was to observe the effects of a ketamine/xylazine (K/X) combination on the cardiac function of rats with severe scalds and compa...

journal_title：Experimental and therapeutic medicine

authors： Feng Y,Chai J,Chu W,Ma L,Zhang P,Duan H

更新日期：2013-09-01 00:00:00

abstract：:MicroRNA (miR)-199b-5p has been reported to have a critical role in various types of malignancy. However, the exact function miR-199b-5p in renal cancer remains to be fully elucidated. The present study aimed to detect the expression levels of miR-199b-5p in renal cell carcinoma (RCC) tissues and RCC cell lines, and i...

journal_title：Experimental and therapeutic medicine

authors： Lai Y,Quan J,Lin C,Li H,Hu J,Chen P,Xu J,Guan X,Xu W,Lai Y,Ni L

更新日期：2018-07-01 00:00:00

abstract：:The aim of the present study was to identify a natural product with the ability to inhibit nuclear factor of activated T cells c1 (NFATc1) translocation from the cytoplasm to the nucleus by high-throughput screening, and to investigate the effect of the natural product upon osteoclast differentiation and its underlyin...

journal_title：Experimental and therapeutic medicine

authors： Geng X,Yang L,Zhang C,Qin H,Liang Q

更新日期：2015-09-01 00:00:00

abstract：:Hyperlipidemia is a risk factor of kidney damage that can lead to chronic kidney disease. Studies have shown that exercise reduces kidney damage; however, the specific mechanisms underlying the protective effects of exercise remain unclear. For 12 weeks, 8-week-old male apolipoprotein E-deficient (ApoE-/-) mice were r...

journal_title：Experimental and therapeutic medicine

authors： Qian C,Yang Q,Guo L,Zhu H,You X,Liu H,Sun Y

更新日期：2021-02-01 00:00:00

abstract：:Exercise training is an integral component of the pulmonary rehabilitation program for patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to systematically search the published literature and analyze the evidence on the efficacy of supplemental oxygen in improving outcomes during exe...

journal_title：Experimental and therapeutic medicine

authors： Liu Y,Gong F

更新日期：2019-11-01 00:00:00

abstract：:The aim of this study was to compare the results of immunohistochemistry (IHC) assays evaluated by human examiners with the results evaluated by computerized image analysis, and to compare the computerized image analysis results among three automated IHC assays, namely the BioGenex, Dako and Ventana assays. All slides...

journal_title：Experimental and therapeutic medicine

authors： Arihiro K,Oda M,Ogawa K,Tominaga K,Kaneko Y,Shimizu T,Ohnishi S,Oda M,Kurita Y,Taira Y,Fujii M,Tanaka M

更新日期：2010-11-01 00:00:00

abstract：:Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is closely associated with organ injury. The aim of the present study was to investigate the change of ALDH2 expression in a rat model of sepsis-induced acute renal injury, and to observe the effect of ALDH2 inhibition on the kidney. A model of sepsis syndrome was establi...

journal_title：Experimental and therapeutic medicine

authors： Hu JF,Wang HX,Li HH,Hu J,Yu Y,Gao Q

更新日期：2017-09-01 00:00:00

abstract：:Human osteoarthritis (OA) has been reclassified as a systemic musculoskeletal disorder involving activation of the innate and adaptive immune systems. Elevated pro-inflammatory cytokines may serve a key function in the development of the disease. 1,25-Dihydroxyvitamin D3 and dexamethasone (vitD3/Dex) may inhibit infla...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Zhang J,Fang Y,Cao W,Xu B,Chen X

更新日期：2019-01-01 00:00:00

abstract：:Hyponatremia is a risk factor associated with poor prognosis in patients with heart failure (HF) with reduced ejection fraction. However, whether hyponatremia has a similar role in patients with HF with preserved ejection fraction (HFpEF) has remained controversial. Therefore, the present study aimed to investigate th...

journal_title：Experimental and therapeutic medicine

authors： Su Y,Ma M,Zhang H,Pan X,Zhang X,Zhang F,Lv Y,Yan C

更新日期：2020-11-01 00:00:00

abstract：:In the present study, the risk factors for systemic air embolism as a complication of percutaneous CT-guided lung biopsy were explored. Data from 2,026 percutaneous CT-guided lung biopsy procedures were retrospectively analyzed. All cases were divided into a concurrent air embolism group and a control group, depending...

journal_title：Experimental and therapeutic medicine

authors： Liu SH,Fu Q,Yu HL,Yang Q,Hu YB,Zhang ZX,Zhang BP,Zhang CY

更新日期：2020-01-01 00:00:00

abstract：:The aim of the present study was to investigate the effects and mechanisms of the Klotho gene in oxidative stress injury after myocardial infarction. Sprague-Dawley rats were divided into five groups (sham, model, pDC316, LY294002, and pDC316-Klotho). Subsequently, the superoxide dismutase (SOD), glutathione (GSH), an...

journal_title：Experimental and therapeutic medicine

authors： Xu Z,Zheng S,Feng X,Cai C,Ye X,Liu P

更新日期：2021-01-01 00:00:00

abstract：:The aim of this study was to explore the chronergy of intravenous recombinant streptokinase (r-SK) in patients with acute myocardial infarction (AMI). A total of 114 patients were divided into two groups according to the time of AMI onset: the morning onset (6:01-12:00, n=53) and non-morning onset (12:01-06:00, n=61) ...

journal_title：Experimental and therapeutic medicine

authors： Wang ZM,Liu YB,Jin QC,Wang XQ,Dai M,Shao H,Zhao WP,Dong QL,Wang SP,Zhang HT,Kong LC,Liu SY,Wang DY

更新日期：2013-05-01 00:00:00

abstract：:Efficient apoptosis requires Bcl-2 family-mediated mitochondrial outer membrane permeabilization (MOMP), which releases pro-apoptotic proteins to the cytosol, activating apoptosis and inhibiting X-linked inhibitor of apoptosis protein (XIAP). XIAP is a member of the inhibitors of apoptosis protein family whose express...

journal_title：Experimental and therapeutic medicine

authors： Chen C,Liu TS,Zhao SC,Yang WZ,Chen ZP,Yan Y

更新日期：2018-05-01 00:00:00