GATA4 is upregulated in nasopharyngeal cancer and facilitates epithelial-mesenchymal transition and metastasis through regulation of SLUG.

abstract：:Acute cerebral ischemia/reperfusion injury (ACIR) rat model was used to investigate the effect of spermine on oxidative stress and apoptosis. Sixty healthy and clean male Sprague-Dawley rats were randomly divided into 3 groups: The sham-operated group (n=12), the model group (n=12) and the experiment group (n=36). The...

journal_title：Experimental and therapeutic medicine

authors： Du H,Ming X,Zhou S

更新日期：2017-07-01 00:00:00

abstract：:Obstructive sleep apnoea (OSA) is a very common sleep and breathing disorder that occurs in worldwide. It is important to develop a more effective treatment for OSA to overcome lung cell apoptosis during intermittent hypoxia (IH). A mitochondrial separation protein inhibitor (Mdivi-1) has been demonstrated to be a pow...

journal_title：Experimental and therapeutic medicine

authors： Zhao D,Yin CY,Ye XW,Wan ZF,Zhao DG,Zhang XY

更新日期：2019-03-01 00:00:00

abstract：:It is well established that altered expression of microRNAs (miRs) is critical in numerous human cancer types. Nevertheless, the molecular mechanisms of many miRs are yet to be elucidated. In the present study, reverse transcription-quantitative polymerase chain reaction and western blot analyses, and cell migration a...

journal_title：Experimental and therapeutic medicine

authors： Bai X,Yang M,Xu Y

更新日期：2018-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-coding RNAs that are key regulators of gene expression by directly binding to the 3'-untranslated region of their target mRNAs, resulting in translational repression or degradation of mRNA. It has been demonstrated that miRNAs have key roles in a variety of human malignancies, includi...

journal_title：Experimental and therapeutic medicine

authors： He Y,Yu B

更新日期：2017-05-01 00:00:00

abstract：:Thymic carcinoma is a rare thymic epithelial tumor in which chemotherapy for advanced disease has not yet been established. Thymidylate synthase (TS) and orotate phosphoribosyltransferase (OPRT) protein expression levels in thymic carcinoma were evaluated as possible indicators of the anticancer activity of 5-fluorour...

journal_title：Experimental and therapeutic medicine

authors： Yokota K,Sasaki H,Okuda K,Shitara M,Hikosaka Y,Moriyama S,Yano M,Fujii Y

更新日期：2012-10-01 00:00:00

abstract：:To investigate the pharmacological mechanism of Guizhi Fuling Wan (GFW) in the treatment of uterine fibroids, a network pharmacology approach was used. Information on GFW compounds was collected from traditional Chinese medicine (TCM) databases, and input into PharmMapper to identify the compound targets. Genes associ...

journal_title：Experimental and therapeutic medicine

authors： Zeng L,Yang K,Liu H,Zhang G

更新日期：2017-11-01 00:00:00

abstract：:Vascular calcification, characterized by the active deposition of calcium phosphate in the vascular walls, is commonly observed in aging, diabetes mellitus and chronic kidney disease. This process is mediated by different cell types, including vascular stem/progenitor cells. The anti-aging protein klotho may act as an...

journal_title：Experimental and therapeutic medicine

authors： Yu L,Li M

更新日期：2020-12-01 00:00:00

abstract：:The aim of the present study was to determine how Endostar inhibits tumor angiogenesis and increases radiation sensitivity when combined with radiotherapy. In vitro studies were conducted to analyze the expression levels of transforming growth factor-β1 (TGF-β1), hypoxia-inducible factor 1 (HIF-1α) and basic fibroblas...

journal_title：Experimental and therapeutic medicine

authors： Wu Y,Zheng Y,Shen Z,Ge W,Xie Y,Li C

更新日期：2014-04-01 00:00:00

abstract：:The aim of this study was to investigate whether resolvin E1 (RvE1) protects against hepatic fibrosis in a murine model of liver fibrosis induced by Schistosoma japonicum infection. A total of 30 pathogen-free Kunming mice were randomly and equally divided into three groups: Control (uninfected, untreated), model (inf...

journal_title：Experimental and therapeutic medicine

authors： Qiu W,Guo K,Yi L,Gong Y,Huang L,Zhong W

更新日期：2014-06-01 00:00:00

abstract：:Cervical cancer is one of the most common gynecological cancers worldwide. Aberrant expression of E3 ubiquitin ligase isolated by differential display (EDD) has been detected in various types of tumor and has been demonstrated to have an important role in carcinogenesis, tumor growth and drug resistance. However, the ...

journal_title：Experimental and therapeutic medicine

authors： Li J,Wang X,Zhang Y,Zhang Y

更新日期：2016-08-01 00:00:00

abstract：:Giant aneurysm of the posterior circulation is associated with a higher risk of rupture compared with that of the anterior circulation. Furthermore, surgical clipping and interventional embolization for giant aneurysm of the posterior circulation are more difficult and complex to perform. The present study reported on...

journal_title：Experimental and therapeutic medicine

authors： Zhang CL,Shi ZH,Yan ZZ,Ding CL,Cao JM,Wang YH,Zhang P

更新日期：2021-01-01 00:00:00

abstract：:Activation of telomerase is involved in carcinogenesis in most types of cancers. However, the prognostic value of telomerase activity (TA) in patients with gastric carcinoma (GC) remains controversial. We conducted a meta-analysis to assess the relationship between TA and the clinical outcome of GC. A meta-analysis of...

journal_title：Experimental and therapeutic medicine

authors： Lü MH,Deng JQ,Cao YL,Fang DC,Zhang Y,Yang SM

更新日期：2012-04-01 00:00:00

abstract：:Obesity and β-cell dysfunction due to oxidative stress impact the pathogenesis of type 2 diabetes mellitus. We co-cultured 3T3L1 adipocytes and islet cells in the presence or absence of the antioxidant α-lipoic acid (LA) and assayed the effects of the adipocytes and LA on the secretion of insulin by the islet cells an...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Dong W,Ding X,Wang F,Wang Y,Chen X,Yu L,Li X,Zhang A,Peng Y

更新日期：2012-09-01 00:00:00

abstract：:The radiofrequency ablation (RFA) lesion size is posited to be disproportionate to the total delivered energy, and temperature-time integration (TTI) may have a more critical effect on lesion size. The present study aimed to evaluate this hypothesis by determining the temperature threshold and temperature distribution...

journal_title：Experimental and therapeutic medicine

authors： Tseng H,Lin SE,Chang YL,Chen MH,Hung SH

更新日期：2016-03-01 00:00:00

abstract：:The aim of the present study was to investigate the association between polymorphism in the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) in the promoter region of the 5-HTT gene and the pathogenesis of postpartum depression (PPD). Blood samples were collected from 120 female patients with PP...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Wang L,Huang F,Li J,Xiong L,Xue H,Zhang Y

更新日期：2015-01-01 00:00:00

abstract：:Guillain-Barré syndrome is a type of acute inflammatory neuropathy that causes ataxia and is associated with the IgG anti-GM1 antibody. However, the pathogenic role of the IgG anti-GM1 antibody and calcium channels in neuromuscular junctions (NMJs) remains unclear. Thus, the aim of the present study was to investigate...

journal_title：Experimental and therapeutic medicine

authors： Hotta S,Nakatani Y,Kambe T,Abe K,Masuda Y,Utsumomiya I,Taguchi K

更新日期：2015-08-01 00:00:00

abstract：:The present study aimed to investigate the clinical characteristics of von Hippel-Lindau (VHL) disease and the clinical significance of VHL gene detection. The clinical materials of patients with VHL disease were collected from 3 different families between May 1985 and October 2017. A systematic pedigree study and VHL...

journal_title：Experimental and therapeutic medicine

authors： Lin G,Zhao Y,Zhang Z,Zhang H

更新日期：2020-08-01 00:00:00

abstract：:The present study aimed to investigate the effects of glycerol on the physical properties and release of an insulin-loaded polyvinyl alcohol (PVA) hydrogel film. The insulin-loaded hydrogel composite film was produced using the freeze-thawing method, after which the in vitro swelling ratio, transmittance and insulin r...

journal_title：Experimental and therapeutic medicine

authors： Cai Y,Che J,Yuan M,Shi X,Chen W,Yuan WE

更新日期：2016-10-01 00:00:00

abstract：:The aim of the present study was to investigate the susceptibility of two coronary artery disease (CAD)-associated single nucleotide polymorphisms on 9p21 (rs1333049 and rs10757278) to myocardial infarction (MI) in a primary (stratification of high risk group for MI) and secondary prevention setting. The prospective o...

journal_title：Experimental and therapeutic medicine

authors： Nikulina S,Artyukhov I,Shesternya P,Gavrilyuk O,Maksimov V,Voyevoda M,Brusentsov D

更新日期：2019-10-01 00:00:00

abstract：:Jiawei Shenqi-wan (JSQW), which comprises Shenqi-wan and two additional medicinal herbs, has been widely used for the treatment of various growth impairments, including cerebral palsy. In the present study, JSQW was administered to hypoxic-ischemic Sprague-Dawley rats that underwent treadmill training from 4-7 weeks o...

journal_title：Experimental and therapeutic medicine

authors： Kim HN,Pak ME,Shin MJ,Kim SY,Shin YB,Yun YJ,Shin HK,Choi BT

更新日期：2017-05-01 00:00:00

abstract：:The pain-depression dyad is becoming widespread in the clinic and is attracting increasing attention. A previous study by our group found that 100-Hz electro-acupuncture (EA), but not 2-, 50- and 2/100-Hz EA, was effective against the reserpine-induced pain-depression dyad. This finding is in contrast to the fact that...

journal_title：Experimental and therapeutic medicine

authors： Wu YY,Jiang YL,He XF,Zhao XY,Shao XM,Sun J,Shen Z,Shou SY,Wei JJ,Ye JY,Yan SS,Fang JQ

更新日期：2017-07-01 00:00:00

abstract：:The Global Registry of Acute Coronary Events (GRACE) risk score and the mean platelet volume to lymphocyte count ratio (MPVLR) can be used independently to predict adverse outcomes in patients with acute coronary syndromes. However, the level of MPVLR in relation to the GRACE score, and whether a combination of these ...

journal_title：Experimental and therapeutic medicine

authors： Chen X,Shao M,Zhang T,Zhang W,Meng Y,Zhang H,Hai H,Li G

更新日期：2020-06-01 00:00:00

abstract：:Atrial remodeling is considered to be any persistent change in atrial structure or function, and is responsible for the development and perpetuation of atrial fibrillation (AF). Oxidative stress and intracellular pH regulation may also be linked to AF; however it remains unclear whether eicosapentaenoic acid (EPA) or ...

journal_title：Experimental and therapeutic medicine

authors： Tong M,Wang J,Ji Y,Chen X,Wang J,Wang S,Ruan L,Cui H,Zhou Y,Zhang Q,Watanabe E

更新日期：2017-09-01 00:00:00

abstract：:The aim of the present study was to investigate the expression profiles of cyclooxygenase (COX)-2 and microRNA (miRNA)-143 in the tumor tissue and blood samples of patients with osteosarcoma, and their involvement in the disease pathogenesis. Tumor tissue and blood samples were obtained from 46 patients with osteosarc...

journal_title：Experimental and therapeutic medicine

authors： Fang Y,Zhang Z,Wang Q,Zhao J

更新日期：2015-06-01 00:00:00

abstract：:The aim of the present study was to evaluate the diagnostic value of interferon-γ release assays for the detection of active tuberculosis (ATB) in patients previously vaccinated with Bacillus Calmette-Guérin (BCG). In total, 540 patients underwent the T-SPOT.TB test, including 295 patients with active pulmonary TB (PT...

journal_title：Experimental and therapeutic medicine

authors： Yan L,Xiao H,Han M,Zhang Q

更新日期：2015-07-01 00:00:00

abstract：:The T790M mutational basis of treatment failure, following treatment via alteration of the epidermal growth factor receptor (EGFR) pathway, is a well-known anomaly in patients with non-small cell lung cancer (NSCLC). The T790M mutation activates the kinase domain, causing tyrosine kinase inhibitors, such as gefitinib,...

journal_title：Experimental and therapeutic medicine

authors： Zang SZ,Yang YR,Zhao SS,Li YX,Gao XY,Zhong CL

更新日期：2017-05-01 00:00:00

abstract：:The US Food and Drug Administration approved thalidomide and its analogues for the treatment of erythema nodosum leprosum, in spite of the notoriety of reports of severe birth defects in the middle of the last century. As immunomodulatory drugs, thalidomide and its analogues have been used to effectively treat various...

journal_title：Experimental and therapeutic medicine

authors： Liu T,Guo F,Zhu X,He X,Xie L

更新日期：2017-12-01 00:00:00

abstract：:The present study aimed to investigate whether c-mesenchymal epithelial transition factor (C-MET) overexpression combined with RAS (including KRAS, NRAS and HRAS) or BRAF mutations were associated with late distant metastases and the prognosis of patients with colorectal cancer (CRC). A total of 374 patients with stag...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Zeng W,Huang C,Wang J,Xu L,Ma D

更新日期：2018-05-01 00:00:00

abstract：:The present study aimed to analyze the imaging, clinical and pathological features of fungal infection involvement in primary biliary cirrhosis (PBC) by retrospectively analyzing and reviewing the features of two patients with fungal infection involvement in PBC. Both patients were female. One patient had a confirmed ...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Zhao Z,Lu H,Zhang J,Huang F

更新日期：2017-02-01 00:00:00

abstract：:Chinese herbal extracts are being used increasingly to treat osteoarthritis (OA) in recent years. Baicalin (BA) is an active component of Scutellaria baicalensis Georgi extracts and protects chondrocytes against damage. The aim of the present study was to examine the mechanism of action of BA on chondrocytes from mous...

journal_title：Experimental and therapeutic medicine

authors： Wang P,Zhu P,Liu R,Meng Q,Li S

更新日期：2020-12-01 00:00:00