Abstract:
:Vascular calcification, characterized by the active deposition of calcium phosphate in the vascular walls, is commonly observed in aging, diabetes mellitus and chronic kidney disease. This process is mediated by different cell types, including vascular stem/progenitor cells. The anti-aging protein klotho may act as an inhibitor of vascular calcification through direct effects on vascular stem/progenitor cells with osteogenic differentiation potential. A better understanding of the possible effects of klotho on vascular stem/progenitor cells may provide novel insight into the cellular and molecular mechanisms of klotho deficiency-related vascular calcification and disease. The klotho protein may be considered as a promising therapeutic agent for treating vascular calcification and disease and calcification-related vascular diseases.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Yu L,Li Mdoi
10.3892/etm.2020.9252subject
Has Abstractpub_date
2020-12-01 00:00:00pages
124issue
6eissn
1792-0981issn
1792-1015pii
ETM-0-0-09252journal_volume
20pub_type
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