Abstract:
:The aim of the present study was to investigate the anti-tumor effects of a culture filtrate of Paecilomyces farinosus J3. Various anti-tumor assays using B16 melanoma cells were carried out. Paecilomyces farinosus J3 significantly decreased the wound healing capability, invasiveness and angiogenic activity, which was confirmed by wound healing, human umbilical vein endothelial cell and invasion assays. Paecilomyces farinosus J3 strongly inhibited cell migration, tube formation and the angiogenic process in a concentration-dependent manner. Zymographic analysis also indicated a reduced expression of matrix metalloproteinase-9 (MMP-9), a 92-kDa gelatinase. Taken together, the results indicate that the anti-tumor activities of Paecilomyces farinosus J3 originate from the reduction of MMP-9 expression in B16F10 cells.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Lee HJ,Park CH,Son HU,Heo JC,Nam SH,Lee KG,Yeo JH,Yoon CS,Kim JM,Shin YK,Kim SO,Lee SHdoi
10.3892/etm.2011.214subject
Has Abstractpub_date
2011-03-01 00:00:00pages
357-362issue
2eissn
1792-0981issn
1792-1015pii
etm-02-02-0357journal_volume
2pub_type
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journal_title:Experimental and therapeutic medicine
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journal_title:Experimental and therapeutic medicine
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