Giant aneurysm of the bilateral vertebrobasilar junction treated by pipeline and coils: A case report and literature review.

abstract：:Atherosclerosis is caused by various factors, and Glabridin may have protective effects on the cardiovascular system. The purpose of the present study was to evaluate the effects of Glabridin on atherosclerosis and evaluate whether Glabridin attenuates arteriosclerosis and endothelial permeability by suppressing the m...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Sun G,Wang Y,Yu P,Wang X,Zhou B,Zhu H

更新日期：2019-01-01 00:00:00

abstract：:This study investigated the effects of high-dose long-term antioxidant free radicals on the mortality rate, creatinine (Cr) value, partial pressure of oxygen (PaO2), alanine aminotransferase (ALT), as well as the incidence rates of lung fibrosis and dysfunction in the treatment of patients with severe paraquat (PQ) po...

journal_title：Experimental and therapeutic medicine

authors： Hu S,Qiao C,Yuan Z,Li M,Ye J,Ma H,Wang J,Xin S,Zhang J

更新日期：2018-12-01 00:00:00

abstract：:Several molecules have been proven to be associated with responsiveness to chemotherapy. A clinical study on the expression of excision repair cross-complementing (ERCC)-1 and class III β-tubulin was conducted in advanced stage non-small cell lung cancer (NSCLC) patients. We investigated 34 resected stage III NSCLC pa...

journal_title：Experimental and therapeutic medicine

authors： Huang CL,Kadota K,Liu D,Ueno M,Nakasima N,Ishikawa S,Gotoh M,Misaki N,Chang SS,Yokomise H

更新日期：2010-05-01 00:00:00

abstract：:Systemic therapy in patients with concurrent psoriasis and chronic hepatitis B is a challenging task for both dermatologists and gastroenterologists since there is a high risk for hepatitis B virus (HBV) reactivation and hepatic toxicity under biological therapy. The therapeutic management of a patient with psoriasis ...

journal_title：Experimental and therapeutic medicine

authors： Raducan A,Bucur S,Caruntu C,Constantin T,Nita IE,Manolache N,Constantin MM

更新日期：2019-08-01 00:00:00

abstract：:Sepsis is a highly complex and often fatal syndrome which varies widely in its clinical manifestations, and therapies that target the underlying uncontrolled immune status in sepsis are needed. The failure of preclinical approaches to provide significant sepsis survival benefit in the clinic is often attributed to ina...

journal_title：Experimental and therapeutic medicine

authors： Stevens NE,Nash CH,Fraser CK,Kuchel TR,Maiden MJ,Chapman MJ,Diener KR,Hayball JD

更新日期：2019-11-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a rare but highly aggressive type of malignancy. MicroRNA (miR)-25 has been demonstrated to be involved in the genesis of numerous cancer types. The aim of the present study was to investigate the prognostic value and functional role of miR-25 in CCA. The expression of miR-25 was determined...

journal_title：Experimental and therapeutic medicine

authors： Liu H,Ma L,Wang J

更新日期：2019-10-01 00:00:00

abstract：:Nitrogen mustards are chemical agents that are similar to sulfur mustards, with similar toxicities. The present study describes a case of nitrogen mustard-induced acute respiratory failure and myelosuppression in a 33-year-old man. The patient, who was accidentally exposed to nitrogen mustard hydrochloride in a pharma...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Zhang Z,Chen S,Zhao D,Zhang F,Hu Z,Xiao F,Ma X

更新日期：2015-10-01 00:00:00

abstract：:We previously reported that cyclin E (CCNE1) amplification is strongly associated with resistance to treatment in serous ovarian cancer by high-resolution oligonucleotide copy number analysis. Dysregulation of cell cycle control has been implicated as the key event in human oncogenesis, and aberrant expression of G1-S...

journal_title：Experimental and therapeutic medicine

authors： Hashimoto T,Yanaihara N,Okamoto A,Nikaido T,Saito M,Takakura S,Yasuda M,Sasaki H,Ochiai K,Tanaka T

更新日期：2011-03-01 00:00:00

abstract：:Resveratrol (3, 4', 5-trihydroxy-trans-stilbene) is a natural, non-flavonoid polyphenol that exerts protective properties against atherosclerosis-associated endothelial dysfunction and senescence. The present study aimed to assess the influence of resveratrol on vascular contractility and molecular factors including s...

journal_title：Experimental and therapeutic medicine

authors： Wiciński M,Malinowski B,Węclewicz MM,Grześk E,Grześk G

更新日期：2017-05-01 00:00:00

abstract：:Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs. Oxaliplatin, a platinum-based drug, is used for the chemotherapy of colorectal cancer (CRC). However, oxaliplatin resistance is a major challenge in the treatm...

journal_title：Experimental and therapeutic medicine

authors： Cong X,Liu X,Dong X,Fang S,Sun Z,Fan J

更新日期：2021-02-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a critical mediator of the phosphoinositide 3-kinase/protein kinase B/mTOR signaling pathway, and mTOR activity is induced following heat shock. Thermotherapy is used to treat hepatocellular carcinoma (HCC). However, the role of mTOR in modulating thermosensitivity in HCC ha...

journal_title：Experimental and therapeutic medicine

authors： Wang QL,Liu BO,Li XJ,Hu KP,Zhao K,Ye XM

更新日期：2016-03-01 00:00:00

abstract：:The present study aimed to apply the best single-energy (SE) scanning in energy spectrum computed tomography (CT) to evaluate the usefulness of lower extremity arterial angiography imaging in patients with lower extremity arterial occlusive disease. A total of 64 patients diagnosed with lower extremity arterial occlus...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Zhao D,Ling Z,Wang H,Yu S,Zhang J

更新日期：2019-08-01 00:00:00

abstract：:The current study aimed to investigate the effect of sepsis on rat serotonin (5-HT) responses and cardiac action potentials. A total of 20 rats were randomly divided into a sepsis and control group (each, n=10). Rat hearts were harvested and perfused using the Langendorff method 18-h after the induction of sepsis, whi...

journal_title：Experimental and therapeutic medicine

authors： Liu ZJ,Liu H,Wu C,Xue K

更新日期：2019-09-01 00:00:00

abstract：:The aim of this study was to evaluate the therapeutic value of pathological indicators to predict the efficacy of endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS) with nasal polyps. A total of 53 patients with CRS with nasal polyps, who had undergone endoscopic surgery at least one year bef...

journal_title：Experimental and therapeutic medicine

authors： Tang J,Liu S,Zhang L,Chen W,Shi S,Yu Q,Tang C,Wang Y

更新日期：2013-07-01 00:00:00

abstract：:Previous clinical trials have investigated the effect of glucocorticoid therapy in acute respiratory distress syndrome (ARDS), with controversial results, particularly with regard to the early administration of low dose glucocorticoid. The present meta-analysis aimed to assess whether the application of glucocorticoid...

journal_title：Experimental and therapeutic medicine

authors： Yang ZG,Lei XL,Li XL

更新日期：2017-04-01 00:00:00

abstract：:High-mobility group box 1 (HMGB1) is released after focal cerebral ischemia/reperfusion (I/R), and aggravates brain tissue damage. Ginsenoside Rb1 (Rb1), isolated from Panax ginseng, has been reported to inhibit I/R-induced cell death in the brain. The present study aimed to investigate the protective ability of GRb1 ...

journal_title：Experimental and therapeutic medicine

authors： Liu A,Zhu W,Sun L,Han G,Liu H,Chen Z,Zhuang L,Jiang W,Xue X

更新日期：2018-10-01 00:00:00

abstract：:Resveratrol, a naturally occurring polyphenolic phytoalexin antioxidant compound present in grapes and red wine, has been reported to induce various biochemical responses. It has been shown to possess anti-aging, anti-inflammatory and anti-proliferative activities in several cell types. However, the effects of resvera...

journal_title：Experimental and therapeutic medicine

authors： Eo SH,Cho HS,Kim SJ

更新日期：2014-03-01 00:00:00

abstract：:The proliferation and migration of Schwann cells (SCs) are key events in the process of peripheral nerve repair. This is required to promote the growth of SCs and is a challenge during the treatment of peripheral nerve injury. Baicalin is a natural herb-derived flavonoid compound, which has been reported to possess ne...

journal_title：Experimental and therapeutic medicine

authors： Zuo W,Wu H,Zhang K,Lv P,Xu F,Jiang W,Zheng L,Zhao J

更新日期：2017-07-01 00:00:00

abstract：:The aim of the present study was to provide reliable experimental evidence for the application of autologous skin fibroblasts (asFbs) in the repair of depressed scars. In the experiments, depressed trauma was induced in male Wistar rats, and fibroblasts were separated from the removed skin tissues to culture in medium...

journal_title：Experimental and therapeutic medicine

authors： Zhao J,Liu YC,Shi YH,Xie YQ,Cui HP,Li Y,Li XJ,Ren LQ

更新日期：2016-08-01 00:00:00

abstract：:Pediatric or childhood obesity is the most prevalent nutritional disorder among children and adolescents worldwide. Approximately 43 million individuals are obese, 21-24% children and adolescents are overweight, and 16-18% of individuals have abdominal obesity. The prevalence of obesity is highest among specific ethni...

journal_title：Experimental and therapeutic medicine

authors： Xu S,Xue Y

更新日期：2016-01-01 00:00:00

abstract：:Osteoarthritis (OA) is one of the most prevalent causes of joint disease. However, the pathological mechanisms of OA have remained to be completely elucidated, and further investigation into the underlying mechanisms of OA development and the identification of novel therapeutic targets are urgently required. In the pr...

journal_title：Experimental and therapeutic medicine

authors： Gao X,Sun Y,Li X

更新日期：2019-10-01 00:00:00

abstract：:The current study mainly evaluated the plasma level of microRNA (miR)-136 in knee osteoarthritis (KOA) patients and determined if miR-136 could be used as a potential biomarker to screen KOA patients from healthy controls. It was demonstrated that plasma miR-136 was significantly decreased in the plasma of KOA patient...

journal_title：Experimental and therapeutic medicine

authors： Wan L,Zhao Q,Niu G,Xiang T,Ding C,Wang S

更新日期：2018-10-01 00:00:00

abstract：:The present study aimed to investigate the expression of complement component 1, q subcomponent-binding protein (C1QBP) in colon cancer cells, and identify proteins that interact with C1QBP. Total proteins were extracted from both the tumor and normal tissues of 22 patients with colon cancer and analyzed using liquid ...

journal_title：Experimental and therapeutic medicine

authors： Kim K,Kim MJ,Kim KH,Ahn SA,Kim JH,Cho JY,Yeo SG

更新日期：2017-05-01 00:00:00

abstract：:The anticancer properties of epigallocatechin-3-gallate (EGCG) are documented in the treatment of several types of cancer; however, there is no relevant evidence for its efficacy in the treatment of renal cell carcinoma (RCC). In the present study, the therapeutic effects of EGCG in vitro were investigated, with parti...

journal_title：Experimental and therapeutic medicine

authors： Chen SJ,Yao XD,Peng BO,Xu YF,Wang GC,Huang J,Liu M,Zheng JH

更新日期：2016-04-01 00:00:00

abstract：:MicroRNA (miR) are short non-coding RNA that bind to the 3'-untranslational region of their target genes, inhibiting translation and causing mRNA degradation. miR deregulation has been implicated in human cancer; however, the detailed regulatory mechanism of miR-137 in osteosarcoma (OS) remains largely unknown. In the...

journal_title：Experimental and therapeutic medicine

authors： Feng Q,Wu Q,Liu X,Xiong Y,Li H

更新日期：2017-06-01 00:00:00

abstract：:Effects of curcumin on artery blood gas index of rats with pulmonary fibrosis caused by paraquat poisoning and the expression of Mothers against decapentaplegic homolog 4 (Smad4), Smad ubiquitination regulatory factor 2 (Smurf2), interleukin-4 (IL-4) and interferon-γ (IFN-γ) were explored. A total of 54 Wistar rats we...

journal_title：Experimental and therapeutic medicine

authors： Chen H,Yang R,Tang Y,Fu X

更新日期：2019-05-01 00:00:00

abstract：:Alzheimer's disease (AD) brains demonstrate decreased levels of brain-derived neurotrophic factor (BDNF) and increased levels of β-amyloid peptide (Aβ), which is neurotoxic. The present study assessed the impact of BDNF on the toxic effects of Aβ25-35-induced apoptosis and the effects on BDNF-mediated signaling using ...

journal_title：Experimental and therapeutic medicine

authors： Kim JH

更新日期：2014-12-01 00:00:00

abstract：:The aim of this study is to determine the accuracy rate of bronchopulmonary dysplasia (BPD) diagnosis and risk factors of short-term poor prognosis for premature infants. This study analyzed the clinical data of 81 premature infants (<32 weeks gestational age) with BPD, who were on oxygen therapy >28 days, and survive...

journal_title：Experimental and therapeutic medicine

authors： Du Z,Kong X,Ren Y,Feng Z,Huang J,Chen J,Wang R

更新日期：2017-10-01 00:00:00

abstract：:Jiawei Shenqi-wan (JSQW), which comprises Shenqi-wan and two additional medicinal herbs, has been widely used for the treatment of various growth impairments, including cerebral palsy. In the present study, JSQW was administered to hypoxic-ischemic Sprague-Dawley rats that underwent treadmill training from 4-7 weeks o...

journal_title：Experimental and therapeutic medicine

authors： Kim HN,Pak ME,Shin MJ,Kim SY,Shin YB,Yun YJ,Shin HK,Choi BT

更新日期：2017-05-01 00:00:00

abstract：:The aim of the present study was to determine the optimal intensity of anticoagulation therapy in elderly patients with paroxysmal atrial fibrillation (PAF), using aspirin and varied concentrations of warfarin. Elderly patients with PAF (n=1,162) who met the inclusion criteria of the study and were at middle or high-r...

journal_title：Experimental and therapeutic medicine

authors： Chen X,Wan R,Jiang W,Zhang H,Zhen R,Ying Q,Li W,Qian H,Wei F,Xu Z,Tang J,Lei H,Zhou Y

更新日期：2013-08-01 00:00:00