Epigallocatechin-3-gallate inhibits migration and invasion of human renal carcinoma cells by downregulating matrix metalloproteinase-2 and matrix metalloproteinase-9.

abstract：:Mutations in keratin 5 (KRT5) or KRT14 genes are responsible for the most severe form of epidermolysis bullosa simplex (EBS), which is EBS generalized severe (EBS-gen sev). To date, only four pathogenic mutations (p.Arg165Ser and p.Lys199Asn in KRT5; p.Arg125Cys and p.Arg125His in KRT14) have been reported to be respo...

journal_title：Experimental and therapeutic medicine

authors： Zhang J,Yan M,Liang J,Li M,Yao Z

更新日期：2016-11-01 00:00:00

abstract：:Breast cancer remains a worldwide public-health issue. Novel drugs that increase the sensitivity and reduce the toxic side effects of chemotherapeutic agents are urgently required. The present study investigated the effect and mechanism of the short-term intermittent administration of an anticancer bioactive peptide (...

journal_title：Experimental and therapeutic medicine

authors： Li X,Gao B,Su X

更新日期：2020-09-01 00:00:00

abstract：:Phosphocitrate (PC) and its analogue, PC-β ethyl ester, inhibit articular cartilage degeneration in Hartley guinea pigs. However, the underlying molecular mechanisms remain unclear. The present study aimed to investigate the hypothesis that PC exerted its disease-modifying effect on osteoarthritis (OA), in part, by in...

journal_title：Experimental and therapeutic medicine

authors： Sun Y,Kiraly AJ,Cox M,Mauerhan DR,Hanley EN Jr

更新日期：2018-04-01 00:00:00

abstract：:Gamboge, the dried resin secreted by Garcinia maingayii (gambogic tree), was previously demonstrated to exert anti-inflammatory effects. The present study examined the effects of gambogic acid, the major active constituent of gamboge, on myocardial infarction (MI) and inflammation in a rat model and explored the possi...

journal_title：Experimental and therapeutic medicine

authors： Na D,Aijie H,Bo L,Zhilin M,Long Y

更新日期：2018-02-01 00:00:00

abstract：:Impaired insulin secretion and insulin resistance are the primary characteristics of type 2 diabetes (T2D). However, the mechanisms underlying insulin secretion failure have yet to be elucidated. The present study demonstrated that sirtuin 5 (SIRT5) is upregulated in patients with T2D and in pancreatic β-cell lines. I...

journal_title：Experimental and therapeutic medicine

authors： Ma Y,Fei X

更新日期：2018-08-01 00:00:00

abstract：:To investigate the pharmacological mechanism of Guizhi Fuling Wan (GFW) in the treatment of uterine fibroids, a network pharmacology approach was used. Information on GFW compounds was collected from traditional Chinese medicine (TCM) databases, and input into PharmMapper to identify the compound targets. Genes associ...

journal_title：Experimental and therapeutic medicine

authors： Zeng L,Yang K,Liu H,Zhang G

更新日期：2017-11-01 00:00:00

abstract：:The present study aimed to investigate the expression of complement component 1, q subcomponent-binding protein (C1QBP) in colon cancer cells, and identify proteins that interact with C1QBP. Total proteins were extracted from both the tumor and normal tissues of 22 patients with colon cancer and analyzed using liquid ...

journal_title：Experimental and therapeutic medicine

authors： Kim K,Kim MJ,Kim KH,Ahn SA,Kim JH,Cho JY,Yeo SG

更新日期：2017-05-01 00:00:00

abstract：:The present investigation explored the in vitro culture, isolation and characterization of hair follicle cell differentiation from umbilical cord blood mesenchymal stem cells (MSCs). Flow cytometry was used to obtain MSCs from the isolation and purification of human umbilical cord blood MSCs. Culture suspension of hai...

journal_title：Experimental and therapeutic medicine

authors： Bu ZY,Wu LM,Yu XH,Zhong JB,Yang P,Chen J

更新日期：2017-07-01 00:00:00

abstract：:An increasing number of cancer patients receive outpatient chemotherapy as an alternative to inpatient chemotherapy. The aim of this study was to investigate whether quality of life (QOL) during outpatient chemotherapy was better than QOL prior to hospital discharge, and to explore possible related factors prior to ho...

journal_title：Experimental and therapeutic medicine

authors： Matsuda A,Kobayashi M,Sakakibara Y,Tamaoka M,Furuiye M,Inase N,Matsushima E

更新日期：2011-03-01 00:00:00

abstract：:Diffuse ganglioneuromatosis (DG) of the gastrointestinal tract is a rare condition that is closely associated with neurofibromatosis type 1 and multiple endocrine neoplasia type 2B. The occurrence of DG with multiple schwannomas, which, of the GI tract, usually affect the stomach, is considerably more rare. The presen...

journal_title：Experimental and therapeutic medicine

authors： Lu C,Qiu Y,Lu X,Li G,Bu H

更新日期：2015-03-01 00:00:00

abstract：:Epilepsy is one of the few neurologic disorders that requires a constant treatment during pregnancy. Epilepsy affects 0.3-0.8% of pregnant women. Prescription of antiepileptic drugs (AEDs) to pregnant women with epilepsy requires monitoring and maintaining a balance between limiting seizures and decreasing fetal expos...

journal_title：Experimental and therapeutic medicine

authors： Nie Q,Su B,Wei J

更新日期：2016-10-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is one of the most common cancer types worldwide. Previous studies have indicated that TOR signaling pathway regulator (TIPRL) is involved in the progression of NSCLC. However, the underlying mechanisms of the role of TIPRL in regulating NSCLC metastasis have remained largely elusive...

journal_title：Experimental and therapeutic medicine

authors： Xu X,Zhu H,Yang M,Zheng E,Zhou Y,Ni J,Li R,Yang Z,He T,Zhao G

更新日期：2020-03-01 00:00:00

abstract：:Atherosclerosis is the leading cause of death from vascular diseases worldwide, and endothelial cell (EC) dysfunction is the key cause of atherosclerosis. miR-155 was found to induce endothelial injury and to trigger atherosclerosis. In addition, brain and muscle ARNT-like protein-1 (Bmal1) has been found to be closel...

journal_title：Experimental and therapeutic medicine

authors： Liang S,Hu J,Zhang A,Li F,Li X

更新日期：2020-12-01 00:00:00

abstract：:This study investigated optimal pathways for preeclampsia (PE) utilizing the network-based guilt by association (GBA) algorithm. The inference method consisted of four steps: preparing differentially expressed genes (DEGs) between PE patients and normal controls from gene expression data; constructing co-expression ne...

journal_title：Experimental and therapeutic medicine

authors： Ruan Y,Li Y,Liu Y,Zhou J,Wang X,Zhang W

更新日期：2019-05-01 00:00:00

abstract：:Vitiligo is an acquired pigmentary disorder characterized by the loss of skin color and functional melanocytes. The pathogenesis of vitiligo remains unclear, which means that effective clinical treatment is difficult. However, if melanocyte linkage-specific genes are identified in vitiligo lesions, the appropriate tre...

journal_title：Experimental and therapeutic medicine

authors： Xu W,Wang X

更新日期：2019-06-01 00:00:00

abstract：:Valvular heart disease (VHD) is caused by either damage or defect in one of the four heart valves, aortic, mitral, tricuspid or pulmonary. Defects in these valves can be congenital or acquired. Age, gender, tobacco use, hypercholesterolemia, hypertension, and type II diabetes contribute to the risk of disease. VHD is ...

journal_title：Experimental and therapeutic medicine

authors： Zeng YI,Sun R,Li X,Liu M,Chen S,Zhang P

更新日期：2016-04-01 00:00:00

abstract：:Schwannomas may arise from any peripheral nerve containing Schwann cells. However, sural nerve schwannoma is extremely rare. In this study, a case of solitary schwannoma originating from the sural nerve in a 42-year-old male is presented. Physical examination revealed a 3-cm, elastic-hard, mobile, non-tender mass, whi...

journal_title：Experimental and therapeutic medicine

authors： Yamamoto K,Nishio J,Yano S,Naito M

更新日期：2014-01-01 00:00:00

abstract：:Uterine carcinosarcoma (UCS) is a rare but very aggressive cancer of the female reproductive tract with an extremely poor prognosis. With the goal of understanding the role of microRNA (miRNA) dysregulation in these tumors, we profiled the expression of 667 human miRNAs in a panel of eight UCS patients and five benign...

journal_title：Experimental and therapeutic medicine

authors： Devor EJ,DE Mik JN,Ramachandran S,Goodheart MJ,Leslie KK

更新日期：2012-04-01 00:00:00

abstract：:Lung cancer is among the most common causes of cancer-related mortality. It has a high mortality rate and resistance to chemotherapy due to its high metastatic potential. Naringenin, a bioactive compound identified in several fruits, displays anti-inflammatory and antitumor effects. Furthermore, naringenin mitigates t...

journal_title：Experimental and therapeutic medicine

authors： Chang HL,Chang YM,Lai SC,Chen KM,Wang KC,Chiu TT,Chang FH,Hsu LS

更新日期：2017-02-01 00:00:00

abstract：:The present study aimed to evaluate the clinical efficacy of hyperbaric oxygen (HBO) treatment for depression in the convalescent stage following cerebral hemorrhage. A total of 60 cases of patients with depression in the convalescent stage following cerebral hemorrhage (2-6 months) were randomly divided into the trea...

journal_title：Experimental and therapeutic medicine

authors： Cao H,Ju K,Zhong L,Meng T

更新日期：2013-06-01 00:00:00

abstract：:Osteosarcoma is among the most frequently occurring bone tumors in infants and teenagers. However, despite its widespread prevalence, no effective diagnostic and prognostic biomarkers for osteosarcoma are known. Macrophage inhibitory cytokine 1 (MIC-1) has been considered a promising biological marker of various tumor...

journal_title：Experimental and therapeutic medicine

authors： Song X,Tian L,Quan Y,Sun D,Zhang L

更新日期：2018-12-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is a common malignant tumor with poor prognosis and an increasing number of cases. MicroRNA (miR)-4728 is related with the progression of various types of cancer, and is dysregulated in NSCLC, which indicates that miR-4728 may serve as a biomarker for NSCLC. The present study aimed t...

journal_title：Experimental and therapeutic medicine

authors： Hu Y,Zhang X,Gong C,Li J

更新日期：2020-11-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial proliferation and inflammation. Intra-articular corticosteroid injections are commonly used for the treatment of arthritis affecting one or two joints. Although corticosteroid injections are fast-acting, repeated usage can result in se...

journal_title：Experimental and therapeutic medicine

authors： Cho HK,Park GY,Sung WJ,Kawk SG,Jung WB

更新日期：2020-11-01 00:00:00

abstract：:Obstructive salivary gland diseases are common conditions that arise following the disruption of the secretary ductal system and usually results in the swelling and pain of the affected gland(s). There has been an increase in the use of sialendoscopy for the treatment and diagnosis of obstructive salivary gland infect...

journal_title：Experimental and therapeutic medicine

authors： Ding YF,Tseng H,Su CH,Tai CC,Wu YY,Haung CJ,Lee CS,Hung SH

更新日期：2019-04-01 00:00:00

abstract：:The present study aimed to investigate the role and mechanism of microRNA-539 (miR-539) in rheumatoid arthritis (RA). A total of 68 RA patients and 46 osteoarthritis patients were enrolled into the current study. Peripheral blood and joint fluid were collected prior to treatment. Reverse transcription-quantitative pol...

journal_title：Experimental and therapeutic medicine

authors： Liu Y,Qian K,Li C,Ma Y,Chen X

更新日期：2018-03-01 00:00:00

abstract：:Clinical efficacy of octreotide acetate combined with thrombin in the treatment of liver cirrhosis complicated with gastrointestinal hemorrhage was investigated. A retrospective analysis of 157 patients with liver cirrhosis and gastrointestinal hemorrhage admitted to Weifang People's Hospital from March 2012 to Septem...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Liu Y,Zhao J,Zhang J

更新日期：2019-05-01 00:00:00

abstract：:Eosinophilia has been implicated in the pathophysiology of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the role of eosinophil activation in the development of AECOPD remains unclear. In the present study, the reliability of plasma levels of eosinophil activation markers, including eo...

journal_title：Experimental and therapeutic medicine

authors： Yang QF,Lu TT,Shu CM,Feng LF,Chang HT,Ji QY

更新日期：2017-10-01 00:00:00

abstract：:Ocimum sanctum L. (OS) leaves have been shown to exert diverse potential benefits in a variety of stress conditions. The present study was conducted to elucidate the effects of the fixed oil extracted from OS leaves on the blood glucose levels and serum lipid profile of streptozotocin-induced diabetic rats. In additio...

journal_title：Experimental and therapeutic medicine

authors： Suanarunsawat T,Anantasomboon G,Piewbang C

更新日期：2016-03-01 00:00:00

abstract：:The aim of this study was to establish and to optimize the preparation technology of whole blood internal quality control (IQC) products for blood transfusion compatibility testing. Several B-type RhD-negative blood samples collected from healthy donors were mixed. Two groups of whole blood IQC products, namely, the p...

journal_title：Experimental and therapeutic medicine

authors： Yu Y,Ma C,Feng Q,Chen X,Guan X,Zhang X,Chen L,Lin Z,Pan J,Zhang T,Luo Q,Wang D

更新日期：2013-05-01 00:00:00

abstract：:The present study aimed to assess the tumoricidal effect of metastasis-associated protein 1 (MTA1) induced by pterostilbene (PTER) in hepatocellular carcinoma (HCC). The SMMC-7721 hepatoma cell line was treated with PTER. Following treatment, the mRNA transcript abundance of MTA1 was measured using quantitative polyme...

journal_title：Experimental and therapeutic medicine

authors： Qian YY,Liu ZS,Pan DY,Li K

更新日期：2017-10-01 00:00:00