Evaluation of the promoter region polymorphism (5-HTTLPR) in the serotonin transporter gene in females with postpartum depression.

Abstract:

:The aim of the present study was to investigate the association between polymorphism in the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) in the promoter region of the 5-HTT gene and the pathogenesis of postpartum depression (PPD). Blood samples were collected from 120 female patients with PPD and 140 age-matched normal controls. Polymerase chain reaction analysis was performed to detect the 5-HTTLPR polymorphism in these subjects, and the genotype and allele frequencies were compared between the two groups. The disease severity was evaluated using the Hamilton Depression Rating Scale (HAMD) score. The results showed that the frequency of the homozygous long/long (L/L) genotype was significantly lower in the PPD group than that in the control group; by contrast, the frequencies of the heterozygous long/short (L/S) and homozygous S/S genotypes were similar for the two groups, without significant differences. No significant differences were observed in the L and S allele frequencies between the two groups. Furthermore, compared with the L/S heterozygous and S/S homozygous genotypes, patients with PPD with the L/L homozygous genotype had a significantly lower HAMD score. The present results suggest that female patients with PPD carrying the homozygous L/L genotype may be less susceptible to depressive symptoms and that the L/L genotype may be associated with the reduced occurrence of PPD. These findings provide a theoretical basis for the clinical diagnosis and treatment of PPD.

journal_name

Exp Ther Med

authors

Zhang X,Wang L,Huang F,Li J,Xiong L,Xue H,Zhang Y

doi

10.3892/etm.2014.2043

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

245-249

issue

1

eissn

1792-0981

issn

1792-1015

pii

etm-09-01-0245

journal_volume

9

pub_type

杂志文章
  • Potential role of probiotics in the management of gastric ulcer.

    abstract::Gastric ulcer is one of the most common chronic gastrointestinal diseases characterized by a significant defect in the mucosal barrier. Helicobacter pylori (H. pylori) infection and the frequent long-term use of non-steroidal anti-inflammatory drugs are major factors involved in gastric ulcer development. Acid inhibit...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3293

    authors: Khoder G,Al-Menhali AA,Al-Yassir F,Karam SM

    更新日期:2016-07-01 00:00:00

  • Combined treatment with FK506 and nerve growth factor for spinal cord injury in rats.

    abstract::Following spinal cord injury in rats, FK506 is able to protect local nerve tissue, promote neural regeneration, reduce neuronal apoptosis and accelerate the recovery of spinal cord functions. Nerve growth factor (NGF) is important in the regulation of central and peripheral nerve cell regeneration, growth differentiat...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2013.1254

    authors: Chen G,Zhang Z,Wang S,Lv D

    更新日期:2013-10-01 00:00:00

  • Human MLH1 status can potentially predict cisplatin sensitivity but not microsatellite instability in head and neck squamous cell carcinoma cells.

    abstract::Resistance to platinum-based chemotherapy frequently poses a serious problem in the treatment of head and neck squamous cell carcinoma. In this study, we isolated cisplatin-resistant cells from a head and neck squamous cell carcinoma cell line. The mismatch repair (MMR) system is known as one of the cisplatin-resistan...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm_00000017

    authors: Adachi M,Ijichi K,Hasegawa Y,Nakamura H,Ogawa T,Kanematsu N

    更新日期:2010-01-01 00:00:00

  • Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome.

    abstract::The status of the three retinoic acid receptors (RARs) α, β and γ in human colorectal cancer (CRC) has not as yet been examined. RARs are in part responsible for the actions of the retinoids (vitamin A and its derivatives), which are essential for human health and survival due to their extensive involvement in numerou...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2011.242

    authors: Perraud A,Nouaille M,Akil H,Petit D,Labrousse F,Jauberteau MO,Mathonnet M

    更新日期:2011-05-01 00:00:00

  • Childhood type 2 diabetes: Risks and complications.

    abstract::The universal endocrine pathological state affecting young individuals and adults is type 2 diabetes mellitus, which has seen a significant increase in the last 30 years, particularly in children. Genetic and evnironmental factors are the causative agents for this pathological state in children. This rapid and wide sp...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3654

    authors: Xue Y,Gao M,Gao Y

    更新日期:2016-10-01 00:00:00

  • Angelicin inhibits the malignant behaviours of human cervical cancer potentially via inhibiting autophagy.

    abstract::Angelicin is an active compound isolated from the Chinese herb Angelica archangelica, which has been reported to exert antitumor effects by inhibiting malignant behaviors in several types of tumor, including proliferation, colony formation, migration and invasion. However, the effects of angelicin on human cervical ca...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7985

    authors: Wang Y,Chen Y,Chen X,Liang Y,Yang D,Dong J,Yang N,Liang Z

    更新日期:2019-11-01 00:00:00

  • Adoptive cell therapy with autologous tumor-infiltrating lymphocytes and high-dose interleukin-2 for metastatic melanoma: The surgeon's perspective.

    abstract::Tumor-infiltrating lymphocytes (TILs) are produced by resecting tumor tissue and growing and expanding ex vivo large quantities of autologous T cells. Once the TILs are ready for infusion, the patient undergoes a non-myeloablative lympho-depleting course of chemotherapy and subsequent TIL infusion with high-dose bolus...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2012.498

    authors: Zippel DB,Besser M,Shapira R,Ben-Nun A,Goitein D,Davidson T,Treves AJ,Markel G,Schachter J,Papa MZ

    更新日期:2012-05-01 00:00:00

  • Mitochondrial factor and cell cytokines associate with TCM syndrome scale in vascular dementia patients.

    abstract::Mitochondrial factor and cell cytokines play important roles in the incidence of vascular dementia (VD), but their correlations with inflammatory and mitochondrial factors and the role of both in the kidney essence deficiency pattern and phlegm turbidity blocking orifice pattern are not clear. This study was aimed at ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.5387

    authors: Sun L

    更新日期:2018-01-01 00:00:00

  • T-regulatory cells from patients with rheumatoid arthritis retain suppressor functions in vitro.

    abstract::Rheumatoid arthritis (RA) is a chronic disease of connective tissue caused by intolerance to self-antigens. Regulatory T cells (Tregs) are key players in maintaining autotolerance through a variety of suppressor mechanisms. RA is generally believed to develop due to disorders in Tregs; however, there is no consensus o...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2021.9641

    authors: Shevyrev D,Tereshchenko V,Kozlov V,Sizikov A,Chumasova O,Koksharova V

    更新日期:2021-03-01 00:00:00

  • Clinical analysis and prognostic significance of hepatitis B virus infections for diffuse large B-cell lymphoma with or without rituximab therapy.

    abstract::The aim of this study was to analyze the clinical features of hepatitis B surface antigen (HBsAg)-positive and negative diffuse large B-cell lymphomas (DLBCLs) and to compare the outcomes and serum hepatitis B virus (HBV)-DNA loads of patients treated with cyclophosphamide, doxorubicin, vincristine and prednisone (CHO...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2013.1079

    authors: Xie W,Zhou D,Hu K,Xiao X,Huang W,He J,Shi J,Luo Y,Zhang J,Lin M,Cai Z,Huang H,Ye X

    更新日期:2013-07-01 00:00:00

  • Oral administration of Urtica macrorrhiza Hand.-Mazz. polysaccharides to protect against cyclophosphamide-induced intestinal immunosuppression.

    abstract::As a strategy to prevent the well-known immunosuppressant effects of cyclophosphamide (CY), the immunomodulatory activity of the polysaccharide isolated from Urtica macrorrhiza Hand.-Mazz. (UMHMPS) was investigated in the present study. The chemical properties of UMHMPS, including total carbohydrates, uronic acid, pro...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7792

    authors: Wang Z,Li Y,Wang C,Xia H,Liang Y,Li Z

    更新日期:2019-09-01 00:00:00

  • Expression of Foxp3 in renal tissue of patients with HBV-associated glomerulonephritis and their clinical and pathological characteristics.

    abstract::Our study retrospectively investigated the expression of forkhead/winged helix transcription factor (Foxp3) in renal tissue and clinical features of patients with hepatitis B virus (HBV)-associated glomerulonephritis (HBV-GN). A total of 58 patients with HBV-GN were assigned to group A; 45 serum and renal tissue HBsAg...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.5111

    authors: Zhao W,Ma Y,Wang M,Shi C,Sun J,Chu K,Liu C

    更新日期:2017-11-01 00:00:00

  • Vascular regeneration by pinpoint delivery of growth factors using a microcatheter reservoir system in a rabbit hind-limb ischemia model.

    abstract::The purpose of this study was to compare the results of delivering low doses of growth factor iteratively (20 μg x5) via a reservoir system with results obtained following a single administration of 100 μg of growth factor. The delivery systems using gelatin microspheres (GMS) facilitate the controlled release of drug...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2012.574

    authors: Nitta N,Nitta-Seko A,Sonoda A,Watanabe S,Tsuchiya K,Murata K,Tabata Y

    更新日期:2012-08-01 00:00:00

  • Allicin activates autophagic cell death to alleviate the malignant development of thyroid cancer.

    abstract::Allicin has been reported to inhibit cancer cell proliferation, induce cell apoptosis and enhance the accumulation of reactive oxygen species. However, it has remained elusive whether allicin improves multidrug resistance in thyroid cancer cells through modulating autophagy. The present study demonstrated that combine...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.5828

    authors: Xiang Y,Zhao J,Zhao M,Wang K

    更新日期:2018-04-01 00:00:00

  • Level of serum undercarboxylated osteocalcin correlates with bone quality assessed by calcaneal quantitative ultrasound sonometry in young Japanese females.

    abstract::The diagnostic criteria of osteoporosis were established based on bone mineral density (BMD). Therefore, BMD measured by dual energy X-ray absorptiometry has been recognized as the gold standard to diagnose osteoporosis. However, discrepancies between fracture risk and BMD have been recognized. Bone is composed of col...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4206

    authors: Suzuki Y,Maruyama-Nagao A,Sakuraba K,Kawai S

    更新日期:2017-05-01 00:00:00

  • Single-incision laparoscopically assisted vaginal hysterectomy: Operative outcomes and its learning curve.

    abstract::We previously reported on single-incision laparoscopic surgery applied to laparoscopically assisted vaginal hysterectomy (LAVH) cases. We accumulated single-incision LAVH cases to evaluate this operation, including its learning curve. Since July 2009, we planned to perform single-incision LAVH in 50 cases. Operative t...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2011.282

    authors: Koyanagi T,Motomura S

    更新日期:2011-09-01 00:00:00

  • Reduced expression of TRF1 is associated with tumor progression and poor prognosis in oral squamous cell carcinoma.

    abstract::The functions of telomeric repeat-binding factor 1 (TRF1) and 2 (TRF2) in oral carcinogenesis are largely unexplored. This study examined the relationship between the expression of TRF1 and TRF2 and clinicopathological variables and survival in oral cavity squamous cell carcinoma (OCSCC). Western blotting and immunohi...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2010.168

    authors: Chuang HC,Chen CH,Huang CC,Fang FM,Tsai HT,Chien CY

    更新日期:2011-01-01 00:00:00

  • Serum from patients with hepatitis E virus-related acute liver failure induces human liver cell apoptosis.

    abstract::The pathogenesis of acute liver failure has not been fully elucidated. The present study investigated the effects of the serum from patients with hepatitis E virus (HEV)-related acute liver failure on human liver cell survival and apoptosis, and evaluated the protective effects of anti-lipopolysaccharide(LPS) antibody...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2013.1398

    authors: Wu F,Wang M,Tian D

    更新日期:2014-01-01 00:00:00

  • Bronchopulmonary dysplasia: Pathogenesis and treatment.

    abstract::Bronchopulmonary dysplasia (BPD) is a form of chronic lung disease of infancy, which mostly affects premature infants with significant morbidity and mortality. Premature infants who require to be treated for conditions including respiratory distress syndrome have a higher risk of developing BPD. In spite of the improv...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章,评审

    doi:10.3892/etm.2018.6780

    authors: Pasha AB,Chen XQ,Zhou GP

    更新日期:2018-12-01 00:00:00

  • Denitrase activity of Debaryomyces hansenii reduces the oxidized compound 3-nitrotyrosine in mice liver with colitis.

    abstract::The oxidation of tyrosine to 3-nitrotyrosine is irreversible, and due to this characteristic, 3-nitrotyrosine is used as a marker for oxidative stress in a range of diverse chronic and degenerative diseases. It has been established that the yeast Debaryomyces hansenii (D. hansenii) can assimilate free 3-nitrotyrosine ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7395

    authors: Calderón-Torres CM,Sarabia-Curz L,Ledesma-Soto Y,Murguía-Romero M,Terrazas LI

    更新日期:2019-05-01 00:00:00

  • miR-199b-5p serves as a tumor suppressor in renal cell carcinoma.

    abstract::MicroRNA (miR)-199b-5p has been reported to have a critical role in various types of malignancy. However, the exact function miR-199b-5p in renal cancer remains to be fully elucidated. The present study aimed to detect the expression levels of miR-199b-5p in renal cell carcinoma (RCC) tissues and RCC cell lines, and i...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6151

    authors: Lai Y,Quan J,Lin C,Li H,Hu J,Chen P,Xu J,Guan X,Xu W,Lai Y,Ni L

    更新日期:2018-07-01 00:00:00

  • Platelet volume indices have low diagnostic efficiency for predicting bone marrow failure in thrombocytopenic patients.

    abstract::The aim of the present study was to evaluate the predictive efficiency of mean platelet volume (MPV) and platelet size deviation width (PDW) for bone marrow failure (BMF) in thrombocytopenic patients. Platelet count, MPV and PDW data were retrieved from the records of 574 unselected thrombocytopenic patients from betw...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2012.799

    authors: Xu RL,Zheng ZJ,Ma YJ,Hu YP,Zhuang SH

    更新日期:2013-01-01 00:00:00

  • Validation of a novel UPLC-HRMS method for human whole-blood cyclosporine and comparison with a CMIA immunoassay.

    abstract::Therapeutic drug monitoring is an essential tool when managing the therapeutic use of immunosuppressant cyclosporine A (CsA) in cases with solid organ transplantation. In China, the concentration of CsA is primarily measured using immunoassays. However, existing literature recommends mass spectrometry as the current g...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2021.9623

    authors: Wang X,Qin W,Chen W,Liu H,Zhang D,Zhang X,Li P

    更新日期:2021-03-01 00:00:00

  • Clinical efficacy of montelukast sodium combined with budesonide or combined with loratadine in treating children with cough variant asthma and influence on inflammatory factors in the serum.

    abstract::Clinical efficacy of montelukast sodium combined with budesonide or combined with loratadine in children with cough variant asthma was investigated. A retrospective analysis of the medical records of 72 children with cough variant asthma who were treated in Xuzhou Children's Hospital, Xuzhou Medical University from Ap...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7574

    authors: Wei H,Li W,Jiang Z,Xi X,Qi G

    更新日期:2019-07-01 00:00:00

  • 2D-STI combined with gated 99Tcm-MIBI MPI for the diagnosis of myocardial ischemia in hypercholesterolemia patients.

    abstract::This study aimed to investigate the reliability of ultrasound two-dimensional speckle tracking imaging (2D-STI) for the evaluation of myocardial ischemia in familial hypercholesterolemia (FH) patients. We recruited 28 patients clinically diagnosed with homozygous familial hypercholesterolemia (HoFH) and subjected them...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章,收录出版

    doi:10.3892/etm.2017.4602

    authors: Song Y,Zhang RF,Liu Y

    更新日期:2017-08-01 00:00:00

  • Efficacy and safety of parecoxib sodium for acute postoperative pain: A meta-analysis.

    abstract::This meta-analysis was performed to evaluate the efficacy and safety of parecoxib sodium for acute postoperative pain. PubMed, Cochrane Central Register of Controlled Trials, EBSCO, Springer, Ovid and Chinese National Knowledge Infrastructure (CNKI) databases were searched from January 1999 to January 2013 to comprehe...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2013.1172

    authors: Wei W,Zhao T,Li Y

    更新日期:2013-08-01 00:00:00

  • Efficacy and tolerability of oxycodone in moderate-severe cancer-related pain: A meta-analysis of randomized controlled trials.

    abstract::In order to evaluate the efficacy and tolerability of oxycodone in moderate-severe cancer-related pain, we conducted a systematic review of randomized controlled trials (RCTs). Publications addressing the efficacy and tolerability of oxycodone in moderate-severe cancer-related pain were selected from the Cochrane libr...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2012.571

    authors: Wang YM,Liu ZW,Liu JL,Zhang L

    更新日期:2012-08-01 00:00:00

  • Transfer of multiple loci of donor's genes to induce recipient tolerance in organ transplantation.

    abstract::Donor organ rejection remains a significant problem. The present study aimed to assess whether transferring a donor's major histocompatibility complex (MHC) genes to the recipient could mitigate rejection in organ transplantation. Seven loci of MHC genes from donor mice were amplified and ligated into vectors; the vec...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6058

    authors: Li T,Zhang W,Xu Q,Li S,Tong X,Ding J,Li H,Hou S,Xu Z,Jablons DM,You L

    更新日期:2018-06-01 00:00:00

  • Co-culture with lung cancer A549 cells promotes the proliferation and migration of mesenchymal stem cells derived from bone marrow.

    abstract::The initiation and progression of various types of tumors, such as lung neoplasms, are driven by a population of cells with stem cell properties and their microenvironment. Bone marrow mesenchymal stem cells (BM-MSCs) in long-term in vitro culture may exhibit spontaneous changes in stem cell biological properties, inc...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4909

    authors: Zhang YM,Zhang ZM,Guan QL,Liu YQ,Wu ZW,Li JT,Su Y,Yan CL,Luo YL,Qin J,Wang Q,Xie XD

    更新日期:2017-10-01 00:00:00

  • Evaluation of acute skin irritation and phototoxicity by aqueous and ethanol fractions of Angelica keiskei.

    abstract::In this study, to assess whether aqueous and ethanol fractions of Angelica keiskei induce acute skin irritation and phototoxicity, acute skin irritancy and phototoxicity tests were performed. The skin of rabbits or guinea pigs was treated with these fractions (100 mg/dose) and whether the animals sustained significant...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2012.782

    authors: Lee SH

    更新日期:2013-01-01 00:00:00