Abstract:
:The aim of the present study was to investigate the association between serum vascular endothelial growth factor (VEGF) and insulin-like growth factor 1 (IGF-1) levels and the prognosis of patients with uterine fibroids following uterine artery embolization (UAE) treatment. A total of 70 patients with uterine fibroids and 20 healthy controls were enrolled in this study between 2012 and 2014. The serum levels of IGF-1 and VEGF were measured using ELISA. Multiple-factor analysis was performed to assess the association between serum levels of IGF-1/VEGF and certain clinical characteristics, including size, location, number of uterine fibroids and adenomyosis. Progression-free survival curves were analyzed using the Kaplan-Meier method. The serum levels of IGF-1 and VEGF in patients with uterine fibroids prior to UAE treatment were significantly higher than those in controls (P<0.05). At 1 week after UAE treatment, the serum levels of IGF-1 and VEGF were significantly lower compared with those prior to UAE treatment. The serum levels of IGF-1 and VEGF at 1 or 3 months after UAE treatment were significantly higher than those at 1 week after UAE treatment. The serum levels of IGF-1 and VEGF were significantly correlated with the clinical characteristics of uterine fibroids (P<0.05). Lower levels of IGF-1 and VEGF in the serum following UAE treatment were associated with an enhanced progression-free survival of patients. In conclusion, the levels of IGF-1 and VEGF in the serum following UAE treatment can be used as indicators of prognosis in patients with uterine fibroids.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Mu Y,He J,Yan R,Hu X,Liu H,Hao Zdoi
10.3892/etm.2015.2924subject
Has Abstractpub_date
2016-02-01 00:00:00pages
645-649issue
2eissn
1792-0981issn
1792-1015pii
ETM-0-0-2924journal_volume
11pub_type
杂志文章abstract::Patients with spontaneous isolated superior mesenteric artery (SMA) dissection (SISMAD) usually present with acute or chronic abdominal pain and are admitted to the emergency or digestive diseases department to undergo auxiliary examinations, typically abdominal plain CT or contrast-enhanced CT (CECT). Plain CT is the...
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更新日期:2021-01-01 00:00:00
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更新日期:2014-07-01 00:00:00
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journal_title:Experimental and therapeutic medicine
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更新日期:2017-10-01 00:00:00
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journal_title:Experimental and therapeutic medicine
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更新日期:2018-12-01 00:00:00
abstract::The C-X-C Motif Chemokine Receptor 4/C-X-C Motif Chemokine Ligand 12 (CXCR4/CXCL12) axis has been implicated in the pathogenesis of pulmonary fibrosis. However, the mechanisms governing this remain to be determined. The current study demonstrated that human lung fibroblasts (HLFs) exhibit high CXCL12 expression and al...
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doi:10.3892/etm.2020.8433
更新日期:2020-03-01 00:00:00
abstract::Cell-based tissue engineering has the potential to restore cartilage defects. Induced pluripotent stem cells (iPSCs) are regarded as an alternative cell source in regenerative medicine. The purpose of the present study was to evaluate the use of mesenchymal stem cells (MSCs) derived from human iPSCs (hiPSCs) for the r...
journal_title:Experimental and therapeutic medicine
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abstract::Relative changes in B-type natriuretic peptide (BNP) and amino terminal pro-BNP (NT-proBNP) levels may help to assess the risk of congestive heart failure (CHF). However, whether these levels at the time of admission enable the prediction of outcomes with acute exacerbation remains unknown. The current study determine...
journal_title:Experimental and therapeutic medicine
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journal_title:Experimental and therapeutic medicine
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doi:10.3892/etm.2016.3298
更新日期:2016-07-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
doi:10.3892/etm.2013.1057
更新日期:2013-06-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
doi:10.3892/etm.2017.4350
更新日期:2017-06-01 00:00:00
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journal_title:Experimental and therapeutic medicine
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更新日期:2015-09-01 00:00:00
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journal_title:Experimental and therapeutic medicine
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doi:10.3892/etm.2010.157
更新日期:2010-11-01 00:00:00
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journal_title:Experimental and therapeutic medicine
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更新日期:2020-11-01 00:00:00
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journal_title:Experimental and therapeutic medicine
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更新日期:2019-01-01 00:00:00
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journal_title:Experimental and therapeutic medicine
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更新日期:2016-05-01 00:00:00
abstract::Previous studies by our group demonstrated that radix Sophorae tonkinensis could induce hepatotoxicity. However, it remains unclear which components of this herb may be responsible for its hepatotoxicity. The present study aimed to investigate the hepatic toxicity of treatment with matrine (MT) and oxymatrine (OMT) al...
journal_title:Experimental and therapeutic medicine
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更新日期:2019-04-01 00:00:00
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journal_title:Experimental and therapeutic medicine
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abstract::This study describes the case of a 41-year-old woman admitted for anterograde memory loss, right facial grimacing and right arm posturing that had begun 1 month previously. Cranial magnetic resonance-diffusion weighted imaging and -fluid-attenuated inversion recovery imaging revealed a hyperintense signal in the left ...
journal_title:Experimental and therapeutic medicine
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更新日期:2016-01-01 00:00:00
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journal_title:Experimental and therapeutic medicine
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更新日期:2017-07-01 00:00:00
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journal_title:Experimental and therapeutic medicine
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更新日期:2018-10-01 00:00:00
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journal_title:Experimental and therapeutic medicine
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更新日期:2015-07-01 00:00:00