Abstract:
:Environmental exposure, including a high-fat diet (HFD), contributes to the high prevalence of colorectal cancer by changing the composition of the intestinal microbiota. However, data examining the interaction between dietary habits and intestinal microbiota of the Chinese population is sparse. We assessed dietary habits using a food frequency questionnaire (FFQ) in native Chinese community volunteers. Based on the dietary fat content determined using the FFQ, the volunteers were divided into HFD group (≥40% of dietary calories came from fat) or low-fat diet (LFD) group (<40%). Fecal and colonic mucosal microbiota composition was determined using 16S rDNA based methods. In stool matter of HFD group, Prevotella and Abiotrophia showed significantly higher abundance, whereas unclassified genus of S24-7 (family level) of Bacteroidetes, Gemmiger, Akkermansia and Rothia were less abundant. On colonic mucosal tissue testing, unclassified genus of S24-7 showed significantly higher abundance while Bacteroides, Coprobacter, Abiotrophia, and Asteroleplasma were less abundant in HFD group. A high fat and low fiber diet in a native Chinese community may partially contribute to changes of intestinal microbiota composition that may potentially favor the onset and progression of gastrointestinal disorders including inflammatory, hyperplastic and neoplastic diseases.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Qian L,Gao R,Hong L,Pan C,Li H,Huang J,Qin Hdoi
10.3892/etm.2018.6249subject
Has Abstractpub_date
2018-08-01 00:00:00pages
856-866issue
2eissn
1792-0981issn
1792-1015pii
ETM-0-0-6249journal_volume
16pub_type
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abstract::[This corrects the article DOI: 10.3892/etm.2016.3317.]. ...
journal_title:Experimental and therapeutic medicine
pub_type: 已发布勘误
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