Abstract：
:The current published data on p53 expression and its predictive value in the risk of malignant gastrointestinal stromal tumors (GIST) has are inconclusive. To derive a more precise estimation of the correlation between p53 and the biological behavior of GIST, a meta-analysis was performed. Studies were identified by searching PubMed and Embase. Inclusion criteria were GIST patients, and the evaluation of p53 expression and risk of malignancy. The odds ratio (OR) for a positive rate of p53 in the benign group vs. that in the malignant group and the ORs for the positive rate of p53 in the National Institutes of Health (NIH) very low risk + low risk group (VL+L) vs. the NIH intermediate risk + high risk (I+H) group were calculated with a 95% confidence interval (CI) for each study as an estimation of the predictive value of p53. A total of 19 studies including 1163 patients were involved in this meta-analysis. The overall OR for the positive rate of p53 in the malignant group vs. the benign group revealed that significantly elevated risks of positive p53 in the malignant group were achieved (OR 0.14, 95% CI: 0.06-0.31, P<0.00001, P(heterogeneity)=0.86). Moreover, significantly elevated risks of correlation between p53 expression and the NIH I+H group were achieved in the comparison of the NIH VL+L group vs. the NIH I+H group (OR, 0.25; 95% CI, 0.17-0.38; P<0.00001, P(heterogeneity)=0.04). The results indicate that p53 expression correlates with poor prognosis in GIST and has a close relationship within the NIH I+H group.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Zong L,Chen P,Jiang J,Wang L,Li QGdoi
10.3892/etm.2011.369subject
Has Abstractpub_date
2012-01-01 00:00:00pages
87-92issue
1eissn
1792-0981issn
1792-1015pii
etm-03-01-0087journal_volume
3pub_type
杂志文章abstract：:Aged garlic extract (AGE) produced by the aging process has various beneficial pharmacological effects. In this study, the effects of AGE on fatty liver, insulin resistance and intestinal microbiota were compared between ddY-H mice, an insulin resistance mouse, and ddY-L mice, normal mice. Mice were fed an AGE-supplem...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2019.7636
更新日期：2019-07-01 00:00:00
abstract：:In this review, we explored the progress of the pathogenesis of Kümmell's disease intravertebral vacuum. Using different expressions of the same disease including 'Kümmell's disease', 'avascular necrosis after vertebral compression fracture (VCF)', 'post-traumatic vertebral osteonecrosis', 'vertebral pseudarthrosis', ...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2016.3369
更新日期：2016-08-01 00:00:00
abstract：:The present study aimed to characterize the function and hemorheology of red blood cells (RBCs) recovered during liver transplantation surgery in patients with hepatitis B and decompensation. A total of 15 hepatitis B patients with decompensation who underwent liver transplantation surgery were included in the present...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2017.4587
更新日期：2017-08-01 00:00:00
abstract：:The aim of the present study was to investigate the functional status of dendritic cells (DCs) in nasal polyps (NP) and their interactions with T lymphocytes. The interactions between DC and T lymphocytes in the pathogenesis of NP was also studied. The expression of cluster of differentiation (CD)1a and CD83 in NP was...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2018.6128
更新日期：2018-06-01 00:00:00
abstract：:Osteoarthritis (OA) is the most common motor system disease in the elderly, with a high incidence and a huge social and economic burden. Therefore, it is urgent to study its potential pathogenesis to improve the therapeutic effect of the disease. In this study, we constructed a number of regulator-mediated OA dysfunct...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
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abstract：:The aim of this study was to determine the metabolic biomarkers for abnormal Savda syndrome in patients with chronic obstructive pulmonary disease (COPD). Based on Traditional Uyghur Medicine (TUM) theory, a total of 103 patients with COPD were classified into abnormal Savda and non-abnormal Savda syndrome groups and ...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2014.2085
更新日期：2015-02-01 00:00:00
abstract：:The present study aimed to systematically evaluate the effectiveness of single-incision laparoscopic surgery (SILS), conventional laparoscopic appendectomy (CLA) and open appendectomy (OA) for the treatment of acute appendicitis. PubMed and Embase databases were systematically searched to identify relevant studies com...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2017.5343
更新日期：2017-12-01 00:00:00
abstract：:Lung cancer is an aggressive type of cancer that is associated with a high mortality rate. Lung cancer-initiating cells are populations of self-renewing cancer cells with pluripotent differentiation ability. Cancers typically originate from multiple phenotypically distinct cancer-initiating cells. CD133 and CD44 are s...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2019.8220
更新日期：2020-01-01 00:00:00
abstract：:The pathogenesis underlying alcoholic liver disease (ALD), which is often a result of alcohol abuse, currently remains unclear. Previous studies have reported that enteric dysbiosis serves an important role in the pathogenesis of ALD. The present study aimed to investigate the effects of glutamine and probiotics on a ...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2019.8123
更新日期：2019-12-01 00:00:00
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journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2017.5476
更新日期：2018-01-01 00:00:00
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journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
abstract：:Lung adenocarcinoma (LACA) is the leading cause of cancer-associated death worldwide. The present study intended to identify DNA methylation patterns that may serve as diagnostic and prognostic biomarkers for LACA. Data on DNA methylation and the survival data of the patients of LACA were obtained from The Cancer Geno...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2019.8200
更新日期：2020-01-01 00:00:00
abstract：:β-elemene is a novel, plant-derived anticancer drug, which has been used to target multiple solid tumor types. Hyperthermia is an adjuvant therapeutic modality to treat cancer. However, the underlying mechanisms associated with the efficacy of these two treatments are largely unknown. The aim of the present study was ...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2017.4350
更新日期：2017-06-01 00:00:00
abstract：:The herbal medicine Yin Huang Mixture (YHHJ; patent no. 200910031240.7) is an aqueous extract composed from various herbs, including Artemisia capillaries Thunb, Hypericum japonicum Thunb, Eucommia ulmoides Oliver, Rheum officinale Baill, Gardenia jasminoides Ellis, Poria cocos Wolf and Dictamnus dasycarpus Turcz. Pre...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2018.5891
更新日期：2018-04-01 00:00:00
abstract：:The aim of this study was to evaluate the diagnostic value of 64-multislice spiral computed tomography (64-MSCT) for coronary stenosis compared with selective X-ray coronary angiography (SCA). Patients with chest pain, chest tightness or coronary stenosis received SCA and they acted as the controls. The sensitivity an...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2013.905
更新日期：2013-03-01 00:00:00
abstract：:Kawasaki disease (KD) is the leading cause of acquired heart disease in pediatric patients in developed countries. Coronary artery aneurysms and myocardial infarction may occur if the disease remains untreated. An estimated 10-20% of KD patients do not respond to intravenous gamma globulin (IVIG), and thus, alternativ...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2019.7396
更新日期：2019-05-01 00:00:00
abstract：:The aim of this study was to compare the results of immunohistochemistry (IHC) assays evaluated by human examiners with the results evaluated by computerized image analysis, and to compare the computerized image analysis results among three automated IHC assays, namely the BioGenex, Dako and Ventana assays. All slides...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2010.142
更新日期：2010-11-01 00:00:00
abstract：:Aldehyde dehydrogenase 2 (aldh2) serves an important role in the development of organ injury. Therefore, the present study investigated the effects of aldh2 on the oxidative stress response in a mouse model of ketamine-induced cystitis (KIC). A total of 60 8-week-old male Institute of Cancer Research wild-type (WT) mi...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2020.9239
更新日期：2020-11-01 00:00:00
abstract：:The aim of the present study was to characterize the effects of early growth response factor-1 DNA enzyme (EDRz) in a rat abdominal aortic aneurysm (AAA) model to determine the mechanism by which EDRz inhibits AAA and affects the formation of AAA by regulating the activity of matrix metalloproteinase (MMP)-2 and MMP-9...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2018.6139
更新日期：2018-07-01 00:00:00
abstract：:Cardiovascular ischemic disease refers to a large class of conditions that are harmful to human health. A number of previous studies have demonstrated that microRNAs (miRs) have notable roles in regulating cardiac injury. miR-144 is influential in the differentiation, growth, and metastatic processes of cells; however...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2019.7161
更新日期：2019-03-01 00:00:00
abstract：:There is currently no available cure or universally effective treatment for dry eye (DE). The aim of the present study was to investigate the clinical efficacy of transcutaneous electrical stimulation (TES) combined with artificial tears in treating DE. Patients diagnosed with DE were referred for therapy with TES com...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2020.9305
更新日期：2020-12-01 00:00:00
abstract：:The present study aimed to evaluate the safety and efficiency of ciliary sulcus implantation of intraocular lens (IOL) in patients that had undergone manual small incision cataract surgery (MSICS) complicated by large posterior capsule rupture (LPCR). A total of 11 eyes taken from 11 patients in Brazzaville, Republic ...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
abstract：:Seven single-nucleotide polymorphism (SNP) sites located in ASAP1 gene have been found associated with tuberculosis (TB) susceptibility by genome-wide association studies in Russia. The case-control study was carried out to test whether these seven SNPs were associated with susceptibility to TB in a Chinese Xinjiang M...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2018.5800
更新日期：2018-04-01 00:00:00
abstract：:Infantile neuroaxonal dystrophy (INAD) is a rare neurodegenerative disorder. Phospholipase A2 group VI (PLA2G6) gene mutations have been identified in the majority of individuals with INAD. The present case report is on a Chinese female pediatric patient (age, 18 months) diagnosed with INAD with deafness. To date, onl...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2018.6347
更新日期：2018-08-01 00:00:00
abstract：:The present study aimed to analyze the imaging, clinical and pathological features of fungal infection involvement in primary biliary cirrhosis (PBC) by retrospectively analyzing and reviewing the features of two patients with fungal infection involvement in PBC. Both patients were female. One patient had a confirmed ...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2016.3977
更新日期：2017-02-01 00:00:00
abstract：:MicroRNA-155 (miR-155) is overexpressed in numerous human cancer types and has an oncogenic role. Previous study has revealed that miR-155 serves an important role in the progression of clear-cell renal cell carcinoma (ccRCC); however, the underlying mechanism was not completely clarified. The present study aimed to i...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2017.4263
更新日期：2017-05-01 00:00:00
abstract：:The aim of this study was to investigate the association between metabolic syndrome (MS) and vascular endothelial cell dysfunction (ECD) in adolescents. Sixty obese pediatric inpatients at the General Hospital of Tianjin Medical University from February 2011 to February 2012 were included. Among these, 30 patients wer...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2013.1055
更新日期：2013-06-01 00:00:00
abstract：:Different tacrolimus (TAC) population pharmacokinetic (PPK) models have been established in various pediatric disease populations. However, a TAC PPK model for pediatric refractory nephrotic syndrome (PRNS) has not been well characterized. The current study aimed to establish a TAC PPK model in Chinese PRNS and provid...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2019.7446
更新日期：2019-05-01 00:00:00
abstract：:The aim of the present study was to investigate the effects of target-controlled infusion (TCI) of propofol and remifentanil combined with dexmedetomidine on functional endoscopic sinus surgery (FESS) bleeding and surgical field. 62 patients scheduled to undergo FESS were randomly divided into experimental group (intr...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2017.5075
更新日期：2017-11-01 00:00:00
abstract：:The aim of the present study was to investigate the possible mechanism of Janus kinase (JAK)-signal transduction and activator of transcription (STAT)/PSMβ3 signaling in the occurrence of asthenozoospermia. We examined seminal fluid samples from 30 cases of asthenozoospermia and 30 healthy controls. Sperm was collecte...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2016.3959
更新日期：2017-01-01 00:00:00
