Extramedullary hematopoiesis: A report of two cases.

abstract：:Fluvoxamine, a common antidepressant agent, is designed to exert its pharmacological effect by inhibiting synaptic serotonin reuptake. However, increasing evidence has demonstrated that σ1 receptors are likely to be involved in the mechanism of action of fluvoxamine. The present study aimed to observe the effects of f...

journal_title：Experimental and therapeutic medicine

authors： Su DA,Jiang RY,Liu N,Ding LC,Wang DM,Yu HY,Yan ES,Zhu MH,Zhu B

更新日期：2014-02-01 00:00:00

abstract：:The aim of this study was to investigate and analyze the effects of human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) on the recovery of neurological function and telomerase reverse transcriptase (TERT) expression in brain tissue of rats with cerebral ischemia-reperfusion injury. A total of 100 healthy adu...

journal_title：Experimental and therapeutic medicine

authors： Huang X,Zhang S,Li F,Zhou Y,Wang X,Fu G,Ma X

更新日期：2017-12-01 00:00:00

abstract：:The programmed death-1 (PD-1)/PD-ligand 1 (PD-L1) signaling pathway is a negative regulatory mechanism that inhibits T cell proliferation and cytokine production. Soluble PD-1 (sPD-1) and soluble PD-L1 (sPD-L1), are also involved in regulation of the PD-1/PD-L1 signaling pathway. In the present study, the expression l...

journal_title：Experimental and therapeutic medicine

authors： Li Y,Xiao Y,Su M,Zhang R,Ding J,Hao X,Ma Y

更新日期：2016-01-01 00:00:00

abstract：:Jiawei Shenqi-wan (JSQW), which comprises Shenqi-wan and two additional medicinal herbs, has been widely used for the treatment of various growth impairments, including cerebral palsy. In the present study, JSQW was administered to hypoxic-ischemic Sprague-Dawley rats that underwent treadmill training from 4-7 weeks o...

journal_title：Experimental and therapeutic medicine

authors： Kim HN,Pak ME,Shin MJ,Kim SY,Shin YB,Yun YJ,Shin HK,Choi BT

更新日期：2017-05-01 00:00:00

abstract：:The aim of this study was to investigate the effect of ouabain (EO) on myocardial remodeling. Twenty-two adult male Sprague-Dawley rats were randomly divided into two groups: the rats in the EO group (n=12) were intraperitoneally injected with EO daily and those in the control group (n=10) were injected with physiolog...

journal_title：Experimental and therapeutic medicine

authors： Ren Y,Zhang M,Zhang T,Huang R

更新日期：2013-07-01 00:00:00

abstract：:Progesterone (PROG) has been shown to exhibit a protective function against hypoxic-ischemic brain damage. The aim of the present study was to study the effects of PROG in a neonatal rat model of hypoxic-ischemic brain injury. A total of 30 Wistar rats, aged 7 days, were randomly divided into three groups: Sham, model...

journal_title：Experimental and therapeutic medicine

authors： Li X,Zhang J,Zhu X,Hou R,Li X,Dong X,Wang X,Lu C

更新日期：2014-05-01 00:00:00

abstract：:The aim of the present study was to identify a natural product with the ability to inhibit nuclear factor of activated T cells c1 (NFATc1) translocation from the cytoplasm to the nucleus by high-throughput screening, and to investigate the effect of the natural product upon osteoclast differentiation and its underlyin...

journal_title：Experimental and therapeutic medicine

authors： Geng X,Yang L,Zhang C,Qin H,Liang Q

更新日期：2015-09-01 00:00:00

abstract：:In this review, we explored the progress of the pathogenesis of Kümmell's disease intravertebral vacuum. Using different expressions of the same disease including 'Kümmell's disease', 'avascular necrosis after vertebral compression fracture (VCF)', 'post-traumatic vertebral osteonecrosis', 'vertebral pseudarthrosis', ...

journal_title：Experimental and therapeutic medicine

authors： He D,Yu W,Chen Z,Li L,Zhu K,Fan S

更新日期：2016-08-01 00:00:00

abstract：:The diaphragm is an important respiratory organ. The aim of this study was to quantitatively evaluate the longitudinal deformation of the right hemidiaphragm in normal subjects using two-dimensional strain ultrasound speckle tracking. Twenty-one healthy subjects were enrolled in this study. GE Healthcare Vivid E9 equi...

journal_title：Experimental and therapeutic medicine

authors： Ye X,Xiao H,Bai W,Liang Y,Chen M,Zhang S

更新日期：2013-08-01 00:00:00

abstract：:Cardiac inhibition due to burn injury and anesthetics have been documented previously. However, little is known about their combined effects on cardiac function. The aim of the present study was to observe the effects of a ketamine/xylazine (K/X) combination on the cardiac function of rats with severe scalds and compa...

journal_title：Experimental and therapeutic medicine

authors： Feng Y,Chai J,Chu W,Ma L,Zhang P,Duan H

更新日期：2013-09-01 00:00:00

abstract：:The present study aimed to investigate the expression of complement component 1, q subcomponent-binding protein (C1QBP) in colon cancer cells, and identify proteins that interact with C1QBP. Total proteins were extracted from both the tumor and normal tissues of 22 patients with colon cancer and analyzed using liquid ...

journal_title：Experimental and therapeutic medicine

authors： Kim K,Kim MJ,Kim KH,Ahn SA,Kim JH,Cho JY,Yeo SG

更新日期：2017-05-01 00:00:00

abstract：:Schisandrin B (SchB) is one of the primary active components of Schisandra chinensis (Turcz.) Baill., a traditional Chinese herb that has been used to treat insomnia for hundreds of years. Our previous studies revealed that SchB exerts sedative and hypnotic effects, increasing the content of γ-aminobutyric acid (GABA)...

journal_title：Experimental and therapeutic medicine

authors： Wang M,Li N,Jing S,Wang C,Sun J,Li H,Liu J,Chen J

更新日期：2020-12-01 00:00:00

abstract：:The chest X-ray is routinely requested by pediatricians for children with suspected pneumonia, but has been demonstrated to be an insensitive method with relatively low accuracy. Computed tomography (CT) allows for the characterization of the consolidation in pneumonia but has a high risk of radiation exposure in chil...

journal_title：Experimental and therapeutic medicine

authors： Yan C,Hui R,Lijuan Z,Zhou Y

更新日期：2020-02-01 00:00:00

abstract：:Numerous studies have demonstrated that microRNAs (miRNAs) are dysregulated in esophageal squamous cell carcinoma (ESCC). Changes in miRNA expression may be associated with ESCC formation and progression. Therefore, the identification of ESCC-associated miRNAs may facilitate the development of effective therapeutic ap...

journal_title：Experimental and therapeutic medicine

authors： Zhen C,Huang J,Lu J

更新日期：2019-12-01 00:00:00

abstract：:Coronary artery disease (CAD) is a leading cause of death, and microRNAs (miRNAs) are widely involved in physiological and pathological processes of CAD. We chose the targetscore method calculated via the variational Bayesian Gaussian mixture model (VB-GMM) as the prediction method of target genes. By observing the de...

journal_title：Experimental and therapeutic medicine

authors： Ma XL,Yang X,Fan R

更新日期：2019-03-01 00:00:00

abstract：:Matrine is an active component of Leguminosae plants and is thought to exhibit anti-tumor effects. However, the effects of matrine on drug-resistant cancer have not been fully elucidated. The present study aimed to investigate the effects of matrine on vincristine (VCR)-resistant retinoblastoma (RB) cells and to asses...

journal_title：Experimental and therapeutic medicine

authors： Zhao B,Li B,Liu Q,Gao F,Zhang Z,Bai H,Wang Y

更新日期：2020-09-01 00:00:00

abstract：:As an atherosclerotic disease, the process of peripheral arterial disease (PAD) is complicated and includes the abnormal proliferation of vascular smooth muscle. The current study aimed to determine the role of microRNA-15b (miR-15b) in the development of PAD and its associated mechanisms. Human vascular smooth muscle...

journal_title：Experimental and therapeutic medicine

authors： Sun Y,Gao Y,Song T,Yu C,Nie Z,Wang X

更新日期：2019-07-01 00:00:00

abstract：:Diagnostic value between IL-17 combined with IL-18 and CT angiography in carotid atherosclerosis was evaluated. A total of 158 patients with suspected carotid artery stenosis in People's Hospital of Dongying from March 2014 to April 2017 were selected as the subjects. One hundred and two patients with carotid atherosc...

journal_title：Experimental and therapeutic medicine

authors： Suo F,Jiang F,Fang X,Ma A,Ma L

更新日期：2019-02-01 00:00:00

abstract：:The novel orally available inhibitor of the molecular chaperone heat shock protein 90 (Hsp90), BIIB021, induces the apoptosis of various types of tumor cell in vitro and in vivo. However, the effects and mechanisms of this agent on myelodysplastic syndrome (MDS) cell lines remain unknown. The aim of this study was to ...

journal_title：Experimental and therapeutic medicine

authors： Lin S,Li J,Zhou W,Qian W,Wang B,Chen Z

更新日期：2014-06-01 00:00:00

abstract：:Therapeutic drug monitoring is an essential tool when managing the therapeutic use of immunosuppressant cyclosporine A (CsA) in cases with solid organ transplantation. In China, the concentration of CsA is primarily measured using immunoassays. However, existing literature recommends mass spectrometry as the current g...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Qin W,Chen W,Liu H,Zhang D,Zhang X,Li P

更新日期：2021-03-01 00:00:00

abstract：:Interstitial cells of Cajal (ICCs) function as pacemaker cells in the gastrointestinal (GI) tract and therefore, serve an important role in regulating GI motility. The effects of a species of plum (Prunus mume Siebold & Zucc.) on cultured ICC cluster-induced pacemaker potentials in the mouse small intestine were inves...

journal_title：Experimental and therapeutic medicine

authors： Lee SW,Kim SJ,Kim H,Yang D,Kim HJ,Kim BJ

更新日期：2017-01-01 00:00:00

abstract：:In a previous study by our group, Ajuga decumbens extract (ADE) was demonstrated to decrease the number of osteoclasts in subchondral bone and to have a synergistic effect with glucosamine in improving cartilaginous injuries in a rabbit model of osteoarthritis. In the present study, a concentrate of the useful fractio...

journal_title：Experimental and therapeutic medicine

authors： Sawada Y,Sugimoto A,Osaki T,Okamoto Y

更新日期：2018-05-01 00:00:00

abstract：:Vascular calcification (VC) caused by chronic kidney disease (CKD)-mineral and bone disorder is a common complication of CKD. Recent studies have demonstrated that menaquinone-4 (MK-4) is negativly associated with VC in patients with CKD. Furthermore, we have previously shown that runt-related transcription factor 2 (...

journal_title：Experimental and therapeutic medicine

authors： Cui L,Xu J,Zhang J,Zhang M,Zhang S,Bai Y

更新日期：2018-10-01 00:00:00

abstract：:Sjogren's syndrome type B (SSB)/La antibody is an autoantibody generally observed in connective tissue diseases whereas double-stranded deoxyribonucleic acid (dsDNA) antibodies are the most characteristic autoantibodies found in systemic lupus erythematosus (SLE) patients. The relationship of these autoantibodies rema...

journal_title：Experimental and therapeutic medicine

authors： Ding M,Zhang J

更新日期：2016-07-01 00:00:00

abstract：:Granulomatosis with polyangiitis (GPA) is a systemic form of vasculitis that involves small to medium sized vessels and is associated with high morbidity and mortality. GPA presents a continuous and difficult clinical diagnostic concern, due to the rarity of the disease and the diversity of the manifestations. This ca...

journal_title：Experimental and therapeutic medicine

authors： Lu CW,Liu XF,Luan Y,Lu CB,Zhou DD,Guo LM,Sun YB,Chen SN,Wu YL,Hao JL

更新日期：2017-06-01 00:00:00

abstract：:The aim of the present study was to evaluate the thymuses of non-thymomatous myasthenia gravis (MG) patients by computed tomography (CT) for differentiating lymphoid follicular hyperplasia (LFH) thymus from normal/involuted thymus in order to assist surgeons in determining whether a non-thymomatous MG patient requires...

journal_title：Experimental and therapeutic medicine

authors： Zhang H,Zhang P,Yu TL

更新日期：2019-01-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is an inflammatory condition caused by hepatic lipid accumulation that is associated with insulin resistance, diabetes and metabolic syndrome. Although statins should be used with caution in liver diseases, they are increasingly investigated as a possible treatment for NAFLD. ...

journal_title：Experimental and therapeutic medicine

authors： Alkhatatbeh MJ,Lincz LF,Thorne RF

更新日期：2016-04-01 00:00:00

abstract：:Radiation pneumonitis is a clinical problem with a high incidence. Once the onset of radiation pneumonitis has occurred, the administration of antioxidants and anti-inflammatory agents is the most commonly used method of clinical treatment. Quercetin (Que) is a common flavonoid, with potent anti-inflammatory and anti-...

journal_title：Experimental and therapeutic medicine

authors： Qin M,Chen W,Cui J,Li W,Liu D,Zhang W

更新日期：2017-12-01 00:00:00

abstract：:Paeoniflorin serves important cellular roles, exerting anti-cancer, anti-inflammatory and anti-pulmonary fibrosis effects and possesses immune-modulatory properties. However, the exact role of paeoniflorin in the pathogenesis of osteoarthritis (OA) remains unclear. The aim of the present study was to investigate the e...

journal_title：Experimental and therapeutic medicine

authors： Hu PF,Sun FF,Jiang LF,Bao JP,Wu LD

更新日期：2018-08-01 00:00:00

abstract：:This prospective study explored the link between values of C-reactive protein (CRP) in patients with SpA (ankylosing spondylitis, psoriatic arthritis, reactive arthritis, or arthritis-related inflammatory bowel disease) and functional disability in order to derive an algorithm that may predict functional disability ba...

journal_title：Experimental and therapeutic medicine

authors： Catan L,Boariu M,Amaricai E,Popa D,Puenea G,Drăgoi M,Stratul Ș,Drăgoi RG

更新日期：2021-01-01 00:00:00