Expression and clinical significance of the DNA repair enzyme MYH in esophageal squamous cell carcinoma.

abstract：:The use of intravenous dexmedetomidine during surgery has been shown to suppress inflammatory cytokines peri-operatively. It has also been demonstrated that dexmedetomidine may benefit cognitive function in elderly patients following surgery; however, it is not clear whether dexmedetomidine reduces postoperative cogni...

journal_title：Experimental and therapeutic medicine

authors： Li Y,He R,Chen S,Qu Y

更新日期：2015-11-01 00:00:00

abstract：:The initiation and progression of various types of tumors, such as lung neoplasms, are driven by a population of cells with stem cell properties and their microenvironment. Bone marrow mesenchymal stem cells (BM-MSCs) in long-term in vitro culture may exhibit spontaneous changes in stem cell biological properties, inc...

journal_title：Experimental and therapeutic medicine

authors： Zhang YM,Zhang ZM,Guan QL,Liu YQ,Wu ZW,Li JT,Su Y,Yan CL,Luo YL,Qin J,Wang Q,Xie XD

更新日期：2017-10-01 00:00:00

abstract：:Lung adenocarcinoma (LACA) is the leading cause of cancer-associated death worldwide. The present study intended to identify DNA methylation patterns that may serve as diagnostic and prognostic biomarkers for LACA. Data on DNA methylation and the survival data of the patients of LACA were obtained from The Cancer Geno...

journal_title：Experimental and therapeutic medicine

authors： Zheng R,Xu H,Mao W,Du Z,Wang M,Hu M,Gu X

更新日期：2020-01-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are a novel class of transcripts, which are pervasively transcribed in the genome and a have greatly unknown biological function. Previous studies have identified that lncRNAs serve an important role in embryonic development. However, the function and mechanism of lncRNAs in the developm...

journal_title：Experimental and therapeutic medicine

authors： Gao L,Yin J,Wu W

更新日期：2016-06-01 00:00:00

abstract：:Although studies using animal models have demonstrated that nonhemodynamic factors, including inflammatory cells and cytokines, contribute to left ventricular hypertrophy (LVH), there is little clinical data to confirm this association. Therefore in the present study, levels of circulating specific types of leukocyte ...

journal_title：Experimental and therapeutic medicine

authors： Shi H,Chu H,Lv Z,Qi G,Guo J,Fu W,Wang X,Guo X,Ge J,Yin C

更新日期：2017-04-01 00:00:00

abstract：:Effects of minimally invasive plate-screw internal fixation and sacroiliac joint screw fixation in the treatment of posterior pelvic ring fracture were compared. Continuous selection of 20 cases of unstable pelvic posterior ring fractures, according to indications of operation, were divided into a group of 13 cases of...

journal_title：Experimental and therapeutic medicine

authors： Li S,Meng X,Li W,Sun Z,Wang X,Qi H,Wei S,Zhou D

更新日期：2018-11-01 00:00:00

abstract：:Peptide P7 specifically binds with basic fibroblast growth factor (bFGF) to inhibit the proliferation and invasion of numerous types of cancer cell. However, this effect has remained to be demonstrated in ovarian cancer-derived cell lines. In the present study, the protein P7 was used treat bFGF-stimulated SKOV3 epith...

journal_title：Experimental and therapeutic medicine

authors： Chen Q,Yang Z,Chen X,Shu L,Qu W

更新日期：2019-04-01 00:00:00

abstract：:Cervical cancer is one of the most common gynecological cancers worldwide. Aberrant expression of E3 ubiquitin ligase isolated by differential display (EDD) has been detected in various types of tumor and has been demonstrated to have an important role in carcinogenesis, tumor growth and drug resistance. However, the ...

journal_title：Experimental and therapeutic medicine

authors： Li J,Wang X,Zhang Y,Zhang Y

更新日期：2016-08-01 00:00:00

abstract：:The diagnostic criteria of osteoporosis were established based on bone mineral density (BMD). Therefore, BMD measured by dual energy X-ray absorptiometry has been recognized as the gold standard to diagnose osteoporosis. However, discrepancies between fracture risk and BMD have been recognized. Bone is composed of col...

journal_title：Experimental and therapeutic medicine

authors： Suzuki Y,Maruyama-Nagao A,Sakuraba K,Kawai S

更新日期：2017-05-01 00:00:00

abstract：:Lysyl oxidase proteins (LOXs) are amine oxidases, which are mainly located in smooth muscle cells and fibroblasts and serve an important role in the formation of the extracellular matrix (ECM) in a copper-dependent manner. Owing to the ability of LOX proteins to modulate crosslinking between collagens and to promote t...

journal_title：Experimental and therapeutic medicine

authors： Wei S,Gao L,Wu C,Qin F,Yuan J

更新日期：2020-07-01 00:00:00

abstract：:The present study retrospectively analyzed 19 patients diagnosed with paraquat (PQ) poisoning with the aim to investigate the effect of activated charcoal hemoperfusion on renal function and PQ elimination. The results indicated that 7 patients died and 12 survived. Non-oliguric renal failure occurred in all of the 7 ...

journal_title：Experimental and therapeutic medicine

authors： Sun L,Yan PB,Zhang Y,Wei LQ,Li GQ

更新日期：2018-03-01 00:00:00

abstract：:The aim of this study was to investigate the role of the Rho/Rho associated coiled coil-forming protein kinase (Rock) signaling pathway in the pathogenesis of ischemic myocardial fibrosis (MF) in rats. The MF rat model was established using isoprenaline hydrochloride (ISO, 15 mg/kg). Rats were randomly divided into te...

journal_title：Experimental and therapeutic medicine

authors： Gao HC,Zhao H,Zhang WQ,Li YQ,Ren LQ

更新日期：2013-04-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of Forkhead family transcription factor P3 (Foxp3) knockdown on the function of cluster of differentiation (CD)4+CD25+ regulatory T cell (Tregs) and the tumor growth of a hepatocellular carcinoma (HCC) mouse model. CD4+CD25+ Tregs and CD4+CD25- T cells were so...

journal_title：Experimental and therapeutic medicine

authors： Shi C,Zhang Y,Yang H,Dong T,Chen Y,Xu Y,Yang X,Liu P

更新日期：2018-01-01 00:00:00

abstract：:The present study reports the case of a 33-year-old male who presented with Terson syndrome with no cerebral hemorrhage secondary to traumatic brain injury (TBI). A computed tomography scan of the patient, who had sustained an impact injury to the right occipital region, showed no cerebral lesion. Ophthalmoscopy clear...

journal_title：Experimental and therapeutic medicine

authors： Jing XB,Sun LQ

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to evaluate the clincal value of multi-slice spiral computed tomography (MSCT) in the diagnosis of double aortic arch (DAA) and analyze the associated angiography and 3D reconstruction imaging to increase the accuracy of DAA diagnosis. Clinical and imaging data from 15 patients diagnosed with...

journal_title：Experimental and therapeutic medicine

authors： Chen X,Qu Y,Peng ZY,Lu J,Ma X,Hu W

更新日期：2014-08-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial proliferation and inflammation. Intra-articular corticosteroid injections are commonly used for the treatment of arthritis affecting one or two joints. Although corticosteroid injections are fast-acting, repeated usage can result in se...

journal_title：Experimental and therapeutic medicine

authors： Cho HK,Park GY,Sung WJ,Kawk SG,Jung WB

更新日期：2020-11-01 00:00:00

abstract：:There is little information regarding the recent trend of synchronous and metachronous pulmonary metastases in patients with primary colorectal cancer. We investigated patients with sporadic colorectal cancer who underwent surgery in our department between 1990 and 2009. Clinicopathological parameters of primary cance...

journal_title：Experimental and therapeutic medicine

authors： Nozawa H,Sunami E,Nakajima J,Nagawa H,Kitayama J

更新日期：2012-03-01 00:00:00

abstract：:Many studies have focused on the identification of therapeutic targets for the treatment of certain types of cancer. Wogonin is a natural flavonoid compound that exhibits a potent anti-cancer effect. The underlying mechanism of wogonin may therefore reveal an effective way to identify novel therapeutic targets. In the...

journal_title：Experimental and therapeutic medicine

authors： Wang SJ,Zhao JK,Ren S,Sun WW,Zhang WJ,Zhang JN

更新日期：2019-01-01 00:00:00

abstract：:The activation of monocytes and macrophages is associated with steroid-resistant (SR) asthma. Interleukin-35 (IL-35) is an important anti-inflammatory cytokine, but its regulatory effects on monocytes in patients with SR asthma is not fully understood. Based on clinical response to oral prednisolone, 34 patients with ...

journal_title：Experimental and therapeutic medicine

authors： Qian L,Xu D,Xue F,Li M,Wang X,Liu G

更新日期：2020-05-01 00:00:00

abstract：:Therapy using acellular spinal cord (ASC) scaffolds seeded with bone marrow stromal cells (BMSCs) has previously been shown to restore function of the damaged spinal cord and improve functional recovery in a rat model of acute hemisected spinal cord injury (SCI). The aim of the present study was to determine whether B...

journal_title：Experimental and therapeutic medicine

authors： Wang YH,Chen J,Zhou J,Nong F,Lv JH,Liu J

更新日期：2017-01-01 00:00:00

abstract：:The aim of the study was to detect the expression of interleukin-1β (IL-1β) in serum of patients with perimenopausal non-organic sleep disorder (PNSD) and to study the relationship between IL-1β and the severity of insomnia and liver depression, so as to benefit the prevention of PNSD. A total of 268 cases of perimeno...

journal_title：Experimental and therapeutic medicine

authors： Li H,Chen Y,Wu H,Huang J,Ma K,Zheng J,Lv S

更新日期：2019-01-01 00:00:00

abstract：:Effects of curcumin on artery blood gas index of rats with pulmonary fibrosis caused by paraquat poisoning and the expression of Mothers against decapentaplegic homolog 4 (Smad4), Smad ubiquitination regulatory factor 2 (Smurf2), interleukin-4 (IL-4) and interferon-γ (IFN-γ) were explored. A total of 54 Wistar rats we...

journal_title：Experimental and therapeutic medicine

authors： Chen H,Yang R,Tang Y,Fu X

更新日期：2019-05-01 00:00:00

abstract：:Electroacupuncture (EA) may stimulate neurogenesis in animal models of ischemic stroke; however, the associated mechanisms are not clear. The present study aimed to evaluate the neurogenesis efficacy of EA on ischemic stroke and the underlying associated mechanisms. A model of middle cerebral artery occlusion (MCAO) w...

journal_title：Experimental and therapeutic medicine

authors： Tan F,Wang J,Liu JX,Wang C,Li M,Gu Y

更新日期：2018-12-01 00:00:00

abstract：:Various microRNAs (miRs) have been demonstrated to serve important roles in gastric cancer (GC). miR-153 in particular has been reported to serve a suppressive role in GC; however, the underlying mechanism remains unclear. In the present study Reverse transcription-quantitative polymerase chain reaction and western bl...

journal_title：Experimental and therapeutic medicine

authors： Ouyang Y,Yuan W,Qiu S

更新日期：2018-08-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) has become a significant public health risk. Long non-coding RNAs (lncRNAs) have been identified as important factors involved in the proliferation, apoptosis and inflammatory cytokine expression of lung cells. Peripheral blood samples from 66 subjects (18 non-smokers, 24 s...

journal_title：Experimental and therapeutic medicine

authors： Lei Z,Guo H,Zou S,Jiang J,Kui Y,Song J

更新日期：2021-01-01 00:00:00

abstract：:Previous clinical trials have investigated the effect of glucocorticoid therapy in acute respiratory distress syndrome (ARDS), with controversial results, particularly with regard to the early administration of low dose glucocorticoid. The present meta-analysis aimed to assess whether the application of glucocorticoid...

journal_title：Experimental and therapeutic medicine

authors： Yang ZG,Lei XL,Li XL

更新日期：2017-04-01 00:00:00

abstract：:The effect of hepatitis B immune globulin (HBIG) combined with hepatitis B vaccine on blocking hepatitis B virus (HBV) transmission between mother and infant and its effect on immune cells were studied. Ninety newborn infants confirmed to be HBV surface antigen (HBsAg)-positive were divided equally into three groups. ...

journal_title：Experimental and therapeutic medicine

authors： Gong J,Liu X

更新日期：2018-01-01 00:00:00

abstract：:Fluvoxamine, a common antidepressant agent, is designed to exert its pharmacological effect by inhibiting synaptic serotonin reuptake. However, increasing evidence has demonstrated that σ1 receptors are likely to be involved in the mechanism of action of fluvoxamine. The present study aimed to observe the effects of f...

journal_title：Experimental and therapeutic medicine

authors： Su DA,Jiang RY,Liu N,Ding LC,Wang DM,Yu HY,Yan ES,Zhu MH,Zhu B

更新日期：2014-02-01 00:00:00

abstract：:FRMD7 mutations are associated with X-linked idiopathic congenital nystagmus (ICN); however, the underlying mechanisms whereby mutations of FRMD7 lead to ICN remain unclear. In a previous study, the first FRMD7 splice variant (FRMD7-S) was cloned and identified, and FRMD7-S was hypothesized to play a significant role ...

journal_title：Experimental and therapeutic medicine

authors： Li Y,Pu J,Zhang B

更新日期：2014-10-01 00:00:00

abstract：:Endometriosis is a common reproductive disorder in women, with a global prevalence of 10-15%. Long noncoding RNAs (lncRNAs) are critical to gene transcription, cell cycle modulation and immune response. The lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) reportedly mediates autophagy of endometr...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Zhang P,Li Y,Zhao N,Han H

更新日期：2021-01-01 00:00:00