Icariin treatment reduces blood glucose levels in type 2 diabetic rats and protects pancreatic function.

abstract：:Effects of curcumin on artery blood gas index of rats with pulmonary fibrosis caused by paraquat poisoning and the expression of Mothers against decapentaplegic homolog 4 (Smad4), Smad ubiquitination regulatory factor 2 (Smurf2), interleukin-4 (IL-4) and interferon-γ (IFN-γ) were explored. A total of 54 Wistar rats we...

journal_title：Experimental and therapeutic medicine

authors： Chen H,Yang R,Tang Y,Fu X

更新日期：2019-05-01 00:00:00

abstract：:Schisandrin B (SchB) is one of the primary active components of Schisandra chinensis (Turcz.) Baill., a traditional Chinese herb that has been used to treat insomnia for hundreds of years. Our previous studies revealed that SchB exerts sedative and hypnotic effects, increasing the content of γ-aminobutyric acid (GABA)...

journal_title：Experimental and therapeutic medicine

authors： Wang M,Li N,Jing S,Wang C,Sun J,Li H,Liu J,Chen J

更新日期：2020-12-01 00:00:00

abstract：:To investigate the pharmacological mechanism of Guizhi Fuling Wan (GFW) in the treatment of uterine fibroids, a network pharmacology approach was used. Information on GFW compounds was collected from traditional Chinese medicine (TCM) databases, and input into PharmMapper to identify the compound targets. Genes associ...

journal_title：Experimental and therapeutic medicine

authors： Zeng L,Yang K,Liu H,Zhang G

更新日期：2017-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the expression of targeted genes in a post-transcriptional manner. Increasing evidence indicates that miRNAs play important roles in cancer pathogenesis, including apoptosis, proliferation and differentiation, as oncogenes or tumor suppressors. Previo...

journal_title：Experimental and therapeutic medicine

authors： Shen ZY,Zhang ZZ,Liu H,Zhao EH,Cao H

更新日期：2014-06-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of S-adenosyl methionine (SAMe) on infectious premature inflammatory factors and uterine contraction, and to further explore its mechanism of action via the transient receptor protein 3 (TRPC3)/protein kinase Cβ (PKCβ)/C-kinase-activated protein phosphatase-1...

journal_title：Experimental and therapeutic medicine

authors： Ge J,Han T,Li X,Shan L,Zhang J,Hong Y,Xia Y,Wang J,Hou M

更新日期：2018-07-01 00:00:00

abstract：:The aim of this study was to investigate the anticarcinogenic effects of silymarin in diethylnitrosamine (DEN)-induced hepatocarcinogenic rat models. Severe and mild models of hepatocellular carcinoma (HCC) were generated by the intraperitoneal administration of 40 mg/kg DEN once a week for 18 weeks and 100 mg/kg DEN ...

journal_title：Experimental and therapeutic medicine

authors： Imamoto R,Okano JI,Sawada S,Fujise Y,Abe R,Murawaki Y

更新日期：2014-01-01 00:00:00

abstract：:The aim of the present study was to investigate the mucus secretion status of mature goblet cells following the application of mitomycin-C (MMC) in ileal neobladder rat models. Bladder substitution models were established in Sprague Dawley rats, which had been divided into five groups, namely the control (sham), norma...

journal_title：Experimental and therapeutic medicine

authors： Fan W,Yu Y,Shu J,Ming H,Li W,Fan Z

更新日期：2015-08-01 00:00:00

abstract：:The present study aimed to examine the effects of rivastigmine hydrogen tartrate and donepezil hydrochloride on the cognitive function and mental behavior of patients with Alzheimer's disease (AD). For this purpose, a total of 126 patients with AD admitted to Luoyang Central Hospital from January, 2018 to December, 20...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Yu R,Wang H,Zheng R

更新日期：2020-08-01 00:00:00

abstract：:Extramedullary T-lymphoblastic blast crisis of chronic myelogenous leukemia (CML) is uncommon and the prognosis is poor. It was usually misdiagnosed as the co-existence of T-lymphoblastic lymphoma (T-LBL) and CML. In the present study, we report a patient with CML, who developed extramedullary T-lymphoblastic blast cr...

journal_title：Experimental and therapeutic medicine

authors： Zeng DF,Chang C,Li JP,Kong PY,Zhang X,Gao L

更新日期：2015-03-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has a high prevalence in type 2 diabetes mellitus (T2DM) patients, being one of the disorders with a relevant global burden. Cross-sectional studies have shown that patients with T2DM and NAFLD have a higher prevalence of liver fibrosis, compared with the general population. P...

journal_title：Experimental and therapeutic medicine

authors： Bica C,Sandu C,Suceveanu AI,Sarbu E,Stoica RA,Gherghiceanu F,Bohiltea RE,Stefan SD,Stoian AP

更新日期：2020-09-01 00:00:00

abstract：:Traumatic brain injury (TBI) is among the leading causes of irreversible neurological damage and death worldwide. The aim of the present study was to investigate whether edaravone (EDA) had a neuroprotective effect on TBI as well as to identify the potential mechanism. Results demonstrated that EDA suppressed inflamma...

journal_title：Experimental and therapeutic medicine

authors： Zhang M,Teng CH,Wu FF,Ge LY,Xiao J,Zhang HY,Chen DQ

更新日期：2019-07-01 00:00:00

abstract：:Curcumin is a natural polyphenol with powerful antioxidant and anti-inflammatory properties. The present study evaluated the protective effect of curcumin on myocardial injury in rats as well as the mechanisms underlying these effects, and examined the expression of nuclear factor-κB (NF-κB), peroxisome proliferator-a...

journal_title：Experimental and therapeutic medicine

authors： Lv FH,Yin HL,He YQ,Wu HM,Kong J,Chai XY,Zhang SR

更新日期：2016-12-01 00:00:00

abstract：:The transient receptor potential melastatin 2 (TRPM2) channel, a Ca2+ permeable channel activated by cAMP, is expressed on pancreatic β-cells and is responsible for the regulation of insulin secretion. It is known that glucose-stimulated insulin secretion (GSIS) can be potentiated by glucagon like peptide-1 (GLP-1), a...

journal_title：Experimental and therapeutic medicine

authors： Pang B,Kim S,Li D,Ma Z,Sun B,Zhang X,Wu Z,Chen L

更新日期：2017-11-01 00:00:00

abstract：:The present study evaluated the effects of calcitonin gene-related peptide (CGRP) on bone marrow mesenchymal stem cells (BMMSCs) in vitro and in a rat model of mandibular distraction osteogenesis (MDO). Rat BMMSCs were isolated then treated with CGRP or CGRP antagonist (CGRP8-37). The proliferation and migration abili...

journal_title：Experimental and therapeutic medicine

authors： Jia S,Zhang SJ,Wang XD,Yang ZH,Sun YN,Gupta A,Hou R,Lei DL,Hu KJ,Ye WM,Wang L

更新日期：2019-08-01 00:00:00

abstract：:Resveratrol (3, 4', 5-trihydroxy-trans-stilbene) is a natural, non-flavonoid polyphenol that exerts protective properties against atherosclerosis-associated endothelial dysfunction and senescence. The present study aimed to assess the influence of resveratrol on vascular contractility and molecular factors including s...

journal_title：Experimental and therapeutic medicine

authors： Wiciński M,Malinowski B,Węclewicz MM,Grześk E,Grześk G

更新日期：2017-05-01 00:00:00

abstract：:Effect of total glucosides of paeony on the changes of IL-4 and ICAM-1 levels in eczema mouse model serum was investigated. A total of 38 KM mice of SPF grade were divided into 3 groups: the control group (n=10), the model group (n=15) and the treatment group (n=13). The pathological model of chronic eczema in mouse r...

journal_title：Experimental and therapeutic medicine

authors： Zhou M,Sui H

更新日期：2019-03-01 00:00:00

abstract：:The inactivation of the cyclin-dependent kinase inhibitor p16(INK4A) gene by hypermethylation is observed in numerous types of cancer. New findings indicate that DNA and histone methylation act in concert in gene silencing. In this study, we investigated the methylation status of the p16(INK4A) gene promoter and the h...

journal_title：Experimental and therapeutic medicine

authors： Yoruker EE,Mert U,Bugra D,Yamaner S,Dalay N

更新日期：2012-11-01 00:00:00

abstract：:Chemotherapeutic drug resistance is an obstacle for the successful therapy of prostate cancer. The aim of the present study was to identify the effects of proto-oncogene serine/threonine-protein kinase pim-1 (pim-1) in the proliferation of chemotherapeutic drug-resistant prostate cancer cells. Androgen-independent hum...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Sun Y,Wang P,Yang C,Li S

更新日期：2019-10-01 00:00:00

abstract：:The intermingling of two malignant neoplasms within the same cutaneous tumor is rare. No consensus has been reached for a clear definition and categorization. In the current study, we describe a cutaneous neoplasm; a squamomelanocytic tumor (SMT) with histological features combining those of a squamous cell carcinoma ...

journal_title：Experimental and therapeutic medicine

authors： Wang HY,Zhang XB,Su RJ,Wang CB,Liu X

更新日期：2013-03-01 00:00:00

abstract：:This study aimed to analyze the correlation between single nucleotide polymorphisms (SNPs) of the actin, aortic smooth muscle (ACTA2) gene and coronary artery stenosis in patients with type 2 diabetes mellitus (T2DM). Eight SNPs from the promoter region of the ACTA2 gene were screened. Patients with T2DM (n=251) were ...

journal_title：Experimental and therapeutic medicine

authors： Fang H,Luo X,Wang Y,Liu N,Fu C,Wang H,Fang Y,Shi W,Zhang Y,Zeng C,Wang X

更新日期：2014-04-01 00:00:00

abstract：:In this study, to assess whether aqueous and ethanol fractions of Angelica keiskei induce acute skin irritation and phototoxicity, acute skin irritancy and phototoxicity tests were performed. The skin of rabbits or guinea pigs was treated with these fractions (100 mg/dose) and whether the animals sustained significant...

journal_title：Experimental and therapeutic medicine

authors： Lee SH

更新日期：2013-01-01 00:00:00

abstract：:Hepatitis B virus (HBV) can establish a lifelong chronic infection in humans, leading to liver cirrhosis, liver failure and hepatocellular carcinoma. Patients with chronic hepatitis B (CHB) exhibit a weak virus-specific immune response. Regulatory T cells (Tregs) play a key role in regulating the immune response in pa...

journal_title：Experimental and therapeutic medicine

authors： Tang R,Lei Z,Wang X,Qi Q,He J,Liu D,Wang X,Chen X,Zhu J,Li Y,Zhou S,Su C

更新日期：2020-10-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is a common malignant tumor with poor prognosis and an increasing number of cases. MicroRNA (miR)-4728 is related with the progression of various types of cancer, and is dysregulated in NSCLC, which indicates that miR-4728 may serve as a biomarker for NSCLC. The present study aimed t...

journal_title：Experimental and therapeutic medicine

authors： Hu Y,Zhang X,Gong C,Li J

更新日期：2020-11-01 00:00:00

abstract：:The effectiveness of therapy combining dihydroartemisinin (DHA) and small interfering RNA targeting Notch1 (siNotch1) in T-cell lymphoma remains unknown. The present study explored the potential and possible mechanisms of combined dihydroarteminin, and siNotch1 therapy for T-cell lymphoma. It was demonstrated that the...

journal_title：Experimental and therapeutic medicine

authors： Huo L,Wei W,Wu S,Zhao X,Zhao C,Zhao H,Sun L

更新日期：2018-03-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2015.2860.]. ...

journal_title：Experimental and therapeutic medicine

authors： Liu Y,Xiao J,Shi X,Hao G,Chen Q,Zhou J,Wei X

更新日期：2019-04-01 00:00:00

abstract：:The present report describes the clinical course and treatment of a Mooren-like ulcer associated with abuse of topical anesthetics and dexamethasone. A 38-year-old male physician treated himself with lidocaine, tetracaine and dexamethasone (DEX) eye drops for severe pain and decline of vision in both eyes. After six m...

journal_title：Experimental and therapeutic medicine

authors： Wu H,Hu Y,Shi XR,Xu F,Jiang CY,Huang R,Jia H

更新日期：2016-07-01 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TILs) are produced by resecting tumor tissue and growing and expanding ex vivo large quantities of autologous T cells. Once the TILs are ready for infusion, the patient undergoes a non-myeloablative lympho-depleting course of chemotherapy and subsequent TIL infusion with high-dose bolus...

journal_title：Experimental and therapeutic medicine

authors： Zippel DB,Besser M,Shapira R,Ben-Nun A,Goitein D,Davidson T,Treves AJ,Markel G,Schachter J,Papa MZ

更新日期：2012-05-01 00:00:00

abstract：:This study describes the case of a 41-year-old woman admitted for anterograde memory loss, right facial grimacing and right arm posturing that had begun 1 month previously. Cranial magnetic resonance-diffusion weighted imaging and -fluid-attenuated inversion recovery imaging revealed a hyperintense signal in the left ...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Li M,Li G,Zhou C,Zhang R

更新日期：2016-01-01 00:00:00

abstract：:Clobetasol propionate (Clo) is a potent topical glucocorticoid and a potential remyelinating agent that has been approved by the U.S. Food and Drug Administration. However, the effect of Clo on neural stem cells (NSCs) remains largely unknown. The aim of the present study was to investigate the effect of Clo on the di...

journal_title：Experimental and therapeutic medicine

authors： Shi W,Bi S,Dai Y,Yang K,Zhao Y,Zhang Z

更新日期：2019-08-01 00:00:00

abstract：:The aim of the present study was to investigate the functional status of dendritic cells (DCs) in nasal polyps (NP) and their interactions with T lymphocytes. The interactions between DC and T lymphocytes in the pathogenesis of NP was also studied. The expression of cluster of differentiation (CD)1a and CD83 in NP was...

journal_title：Experimental and therapeutic medicine

authors： Lin X,Zhuang X,Li C,Wang X

更新日期：2018-06-01 00:00:00