Promoter and histone methylation and p16(INK4A) gene expression in colon cancer.

abstract：:In the present study, we investigated the effects of hydroxyethyl starch (HES) 130/0.4 on serum pro-inflammatory variables, immunologic variables, fluid balance (FB)-negative(-) rate and renal function in severe acute pancreatitis (SAP) patients. From October, 2007 to November, 2008, a total of 120 SAP patients were e...

journal_title：Experimental and therapeutic medicine

authors： Chen QJ,Yang ZY,Wang CY,Dong LM,Zhang YS,Xie C,Chen CZ,Zhu SK,Yang HJ,Wu HS,Yang C

更新日期：2016-11-01 00:00:00

abstract：:Lung cancer is among the most common causes of cancer-related mortality. It has a high mortality rate and resistance to chemotherapy due to its high metastatic potential. Naringenin, a bioactive compound identified in several fruits, displays anti-inflammatory and antitumor effects. Furthermore, naringenin mitigates t...

journal_title：Experimental and therapeutic medicine

authors： Chang HL,Chang YM,Lai SC,Chen KM,Wang KC,Chiu TT,Chang FH,Hsu LS

更新日期：2017-02-01 00:00:00

abstract：:Conjunctivitis associated systemic lupus erythematosus (caSLE) is a connective tissue autoimmune disease with a large spectrum of clinical manifestations. The disease may lead to ocular complications and in severe cases may be sight-threatening. This study investigated the expression of vascular adhesion protein-1 (VA...

journal_title：Experimental and therapeutic medicine

authors： Liu H,Zhang J,Zhou P,Sun H,Katsarou M,Drakoulis N

更新日期：2019-12-01 00:00:00

abstract：:The aim of the present study was to investigate the application of 3D printing (3DP) rapid prototyping (RP) technique-assisted percutaneous fixation in the treatment of femoral intertrochanteric fracture (ITF) using proximal femoral nail anti-rotation (PFNA). A total of 39 patients with unstable ITF were included in t...

journal_title：Experimental and therapeutic medicine

authors： Zheng SN,Yao QQ,Mao FY,Zheng PF,Tian SC,Li JY,Yu YF,Liu S,Zhou J,Hu J,Xu Y,Tang K,Lou Y,Wang LM

更新日期：2017-10-01 00:00:00

abstract：:MicroRNA (miR)-199b-5p has been reported to have a critical role in various types of malignancy. However, the exact function miR-199b-5p in renal cancer remains to be fully elucidated. The present study aimed to detect the expression levels of miR-199b-5p in renal cell carcinoma (RCC) tissues and RCC cell lines, and i...

journal_title：Experimental and therapeutic medicine

authors： Lai Y,Quan J,Lin C,Li H,Hu J,Chen P,Xu J,Guan X,Xu W,Lai Y,Ni L

更新日期：2018-07-01 00:00:00

abstract：:The clinical efficacy of minimally invasive lumbar interbody fusion via the intervertebral foramen combined with ozone (O3) therapy for the treatment of L3-L4 central-type lumbar disc herniation was explored. We recruited patients with sciatica who attended our hospital between July 2013 and October 2015 and underwent...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Sun H,Qin S

更新日期：2017-02-01 00:00:00

abstract：:Resistance to platinum-based chemotherapy frequently poses a serious problem in the treatment of head and neck squamous cell carcinoma. In this study, we isolated cisplatin-resistant cells from a head and neck squamous cell carcinoma cell line. The mismatch repair (MMR) system is known as one of the cisplatin-resistan...

journal_title：Experimental and therapeutic medicine

authors： Adachi M,Ijichi K,Hasegawa Y,Nakamura H,Ogawa T,Kanematsu N

更新日期：2010-01-01 00:00:00

abstract：:The aim of this study was to evaluate the therapeutic value of pathological indicators to predict the efficacy of endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS) with nasal polyps. A total of 53 patients with CRS with nasal polyps, who had undergone endoscopic surgery at least one year bef...

journal_title：Experimental and therapeutic medicine

authors： Tang J,Liu S,Zhang L,Chen W,Shi S,Yu Q,Tang C,Wang Y

更新日期：2013-07-01 00:00:00

abstract：:Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) deficiency is a metabolic disorder caused by mutations in the HMGCS2 gene. The present study describes the identification of four cases of HMGCS2 deficiency in Japan. Hepatomegaly and severe metabolic acidosis were observed in all cases. Fatty liver was id...

journal_title：Experimental and therapeutic medicine

authors： Ago Y,Otsuka H,Sasai H,Abdelkreem E,Nakama M,Aoyama Y,Matsumoto H,Fujiki R,Ohara O,Akiyama K,Fukui K,Watanabe Y,Nakajima Y,Ohnishi H,Ito T,Fukao T

更新日期：2020-11-01 00:00:00

abstract：:Peripheral nerve predegeneration has been used as a tool to improve the in vitro cultivation of Schwann cells. The process of predegeneration may be accomplished either in vivo or in vitro. In previously published studies, various predegeneration periods were used, ranging from a few days until up to 5 weeks. The pres...

journal_title：Experimental and therapeutic medicine

authors： Tomko P,Slovinská L,Vanický I

更新日期：2019-01-01 00:00:00

abstract：:This study investigated the effects of high-dose long-term antioxidant free radicals on the mortality rate, creatinine (Cr) value, partial pressure of oxygen (PaO2), alanine aminotransferase (ALT), as well as the incidence rates of lung fibrosis and dysfunction in the treatment of patients with severe paraquat (PQ) po...

journal_title：Experimental and therapeutic medicine

authors： Hu S,Qiao C,Yuan Z,Li M,Ye J,Ma H,Wang J,Xin S,Zhang J

更新日期：2018-12-01 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) possess good proliferative and differentiative abilities, making then a promising candidate for the treatment of cartilage defects. However, local ischemia often causes apoptosis in ADSCs. Transforming growth factor-β3 (TGF-β3) is often used as a chondrogenic differentiation cytokine...

journal_title：Experimental and therapeutic medicine

authors： Wu F,Ye H,Lin J,Xu Y,Zhang Z,Xiong H,Laing M,Zhen Y,Chen S

更新日期：2018-05-01 00:00:00

abstract：:MicroRNAs (miRs), a class of small non-coding RNAs, function as key regulators in gene expression through binding to the 3'-untranslated region (UTR) of their target mRNA, which further leads to translational repression or mRNA degradation. Recently, miR-138 has been found to have a tumor suppressive role in a variety...

journal_title：Experimental and therapeutic medicine

authors： Yuan Z,Mo H,Mo L,He J,Wu Z,Lin X

更新日期：2017-06-01 00:00:00

abstract：:Effects of laryngoscope-assisted and cotton ball wiping methods on the prevention of oral and pulmonary infection in patients receiving mechanical ventilation were compared to explore the influence of the two methods on high-sensitivity C-reactive protein (hs-CRP) and procalcitonin (PCT). In total, 152 patients who un...

journal_title：Experimental and therapeutic medicine

authors： Zhang P,Xia G,Dai L,Cheng Y,Wang Z

更新日期：2019-07-01 00:00:00

abstract：:Diabetes mellitus is becoming a major health burden worldwide. Pancreatic β-cell death is a characteristic of type 2 diabetes (T2D), but the underlying mechanisms of pancreatic β-cell death remain unknown. Therefore, the aim of the present study was to identify potential targets in the pancreatic islet of T2D. The GSE...

journal_title：Experimental and therapeutic medicine

authors： Zhou DY,Mou X,Liu K,Liu WH,Xu YQ,Zhou D

更新日期：2020-11-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are involved in bone formation in the embryo, bone repair and remodeling. The differentiation of these cells is a complex multistep pathway that involves discrete cellular transitions and is similar to that which occurs during hematopoiesis. MSCs have self-renewal capacity without differe...

journal_title：Experimental and therapeutic medicine

authors： Shima WN,Ali AM,Subramani T,Mohamed Alitheen NB,Hamid M,Samsudin AR,Yeap SK

更新日期：2015-06-01 00:00:00

abstract：:Tools to define the active ingredients and flavors of Traditional Chinese Medicines (TCMs) are limited by long analysis times, complex sample preparation and a lack of multiplexed analysis. The aim of the present study was to optimize and validate an electronic tongue (E-tongue) methodology to analyze the bitterness o...

journal_title：Experimental and therapeutic medicine

authors： Li X,Gao X,Liu R,Wang J,Wu Z,Zhang L,Li H,Gui X,Kang B,Shi J

更新日期：2016-11-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression and specific role of microRNA (miR)-142-5p in the progression of intrahepatic cholangiocarcinoma (ICC). Reverse transcription-quantitative polymerase chain reaction was performed to evaluate miR-142-5p expression in patients with ICC and healthy control subje...

journal_title：Experimental and therapeutic medicine

authors： Wei G,Yuan Y,He X,Jin L,Jin D

更新日期：2019-05-01 00:00:00

abstract：:The present study aimed to investigate the expression of the forkhead box protein M1 (FOXM1) in the placenta of patients with preeclampsia, and its effect on trophoblasts. A total of 28 patients with preeclampsia and 30 patients without preeclampsia (controls) who underwent cesarean section and were admitted to the Af...

journal_title：Experimental and therapeutic medicine

authors： Cui X,Xu J,Ji Y,Song X,Wang J,Zhang L,Yang S,Ye Y

更新日期：2018-07-01 00:00:00

abstract：:The aim of the present study was to explore the association between the M235T polymorphism of the angiotensinogen (AGT) gene and cytokines in patients with essential hypertension (EH). A total of 300 patients with EH and an age-matched control group of 150 individuals without EH, secondary hypertension, myocardial inf...

journal_title：Experimental and therapeutic medicine

authors： Cheng JL,Wang AL,Wan J

更新日期：2012-03-01 00:00:00

abstract：:Postprandial hypertriglyceridemia impairs endothelial function and plays an important role in the development of atherosclerosis. The aim of the present study was to examine the postprandial effects of the dipeptidyl peptidase-4 inhibitor vildagliptin and the α-glucosidase inhibitor voglibose on endothelial dysfunctio...

journal_title：Experimental and therapeutic medicine

authors： Noguchi K,Hirota M,Miyoshi T,Tani Y,Noda Y,Ito H,Nanba S

更新日期：2015-01-01 00:00:00

abstract：:Certain microRNAs (miRs) regulate the progression and metastasis of various cancer types. In the present study, the role of miR-370 in the progression and proliferation of human astrocytoma and glioblastoma cells was assessed and the underlying molecular mechanism was investigated. miR-370 levels in clinical specimens...

journal_title：Experimental and therapeutic medicine

authors： Lu M,Wang Y,Zhou S,Xu J,Li J,Tao R,Zhu Y

更新日期：2018-01-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) may lead to physical and pathological damage and has been a focus of research for decades. Evaluating tensile damage caused by deformation in ICH is an important component of damage assessment for correct diagnosis and treatment. Traditional research on ICH paid little attention to quant...

journal_title：Experimental and therapeutic medicine

authors： Ren P,Wang BC,Wang YZ,Hao SL,Guo TW,Li XF

更新日期：2018-12-01 00:00:00

abstract：:In the development of anti-blood cancer drugs, the chronic myelocytic leukemia (KU812), acute myelocytic leukemia (KG-1) and lymphoma (U937) cell lines are commonly used in preclinical pharmacology studies as human cancer xenograft models in mice. In the present study, mRNA expression levels of typical human ATP-bindi...

journal_title：Experimental and therapeutic medicine

authors： Takeuchi K,Shibata M,Kashiyama E,Umehara K

更新日期：2012-09-01 00:00:00

abstract：:Cardiovascular ischemic disease refers to a large class of conditions that are harmful to human health. A number of previous studies have demonstrated that microRNAs (miRs) have notable roles in regulating cardiac injury. miR-144 is influential in the differentiation, growth, and metastatic processes of cells; however...

journal_title：Experimental and therapeutic medicine

authors： E L,Jiang H,Lu Z

更新日期：2019-03-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a critical mediator of the phosphoinositide 3-kinase/protein kinase B/mTOR signaling pathway, and mTOR activity is induced following heat shock. Thermotherapy is used to treat hepatocellular carcinoma (HCC). However, the role of mTOR in modulating thermosensitivity in HCC ha...

journal_title：Experimental and therapeutic medicine

authors： Wang QL,Liu BO,Li XJ,Hu KP,Zhao K,Ye XM

更新日期：2016-03-01 00:00:00

abstract：:Inflammation has been implicated in the pathogenesis of myocardial ischemia/reperfusion (I/R) injury (MIRI). Previous studies have confirmed that deleted in esophageal cancer 1 (DEC1) is an important transcription factor in inflammation. However, the role of DEC1 in MIRI remains unclear. The present study aimed to det...

journal_title：Experimental and therapeutic medicine

authors： Xu W,Zhang K,Zhang Y,Ma S,Jin D

更新日期：2020-07-01 00:00:00

abstract：:Diagnostic value between IL-17 combined with IL-18 and CT angiography in carotid atherosclerosis was evaluated. A total of 158 patients with suspected carotid artery stenosis in People's Hospital of Dongying from March 2014 to April 2017 were selected as the subjects. One hundred and two patients with carotid atherosc...

journal_title：Experimental and therapeutic medicine

authors： Suo F,Jiang F,Fang X,Ma A,Ma L

更新日期：2019-02-01 00:00:00

abstract：:The activation of monocytes and macrophages is associated with steroid-resistant (SR) asthma. Interleukin-35 (IL-35) is an important anti-inflammatory cytokine, but its regulatory effects on monocytes in patients with SR asthma is not fully understood. Based on clinical response to oral prednisolone, 34 patients with ...

journal_title：Experimental and therapeutic medicine

authors： Qian L,Xu D,Xue F,Li M,Wang X,Liu G

更新日期：2020-05-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) accumulation and hypertrophy are common in vascular disorders, and inflammation has a crucial role in the development of these diseases. To investigate the effect of inflammation on the neurotransmission of VSMC, bioinformatic analysis was performed, following next generation sequenc...

journal_title：Experimental and therapeutic medicine

authors： Gan S,Qiu S,Feng Y,Zhang Y,Qian Q,Wan Z,Tang J

更新日期：2017-04-01 00:00:00