Thrombocytopenia induces multiple intracranial hemorrhages in patients with severe burns: A review of 16 cases.

Abstract:

:The aim of this study was to explore the etiology and diagnosis of multiple intracranial hemorrhages (ICHs) following severe burns, with a retrospective review of 16 cases of severe burns further complicated by multiple ICHs. Using cranial CT scans of the brains, we identified that all patients presented with low platelet counts and coagulation abnormalities prior to intracranial hemorrhaging. Following conventional treatment and various supporting treatments, five cases succumbed following a progressive reduction in blood platelet levels and the ICHs were cured in 11 cases following the restoration of normal platelet levels. We conclude that low platelet counts and coagulation abnormalities may cause multiple ICHs following severe burns and early diagnosis and treatment is the key to successful treatment.

journal_name

Exp Ther Med

authors

Zhou J,Liu J,Luo C,Hu F,Liu R,Chen Z,Chen Y,Xiong W,Xie J,He Q,Yin C,Wang S,Zhang Y,Zeng S

doi

10.3892/etm.2013.1081

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

223-227

issue

1

eissn

1792-0981

issn

1792-1015

pii

etm-06-01-0223

journal_volume

6

pub_type

杂志文章
  • Main tract stenosis complicated by granulomatous with polyangiitis: A case report.

    abstract::Granulomatosis with polyangiitis (GPA) is a rheumatic auto-immune disease involved in vasculitis. It is rarely reported that anti-neutrophil cytoplasmic antibodies (ANCAs) associated with GPA would cause main tract stenosis. The current report documents a 54-year-old woman, with a history of severe cough, presented wi...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.8603

    authors: Zhou D,Zhang P,Zhang Y,Zhang Y,Zhang X,Li J,Zhou Z,Zhu N

    更新日期:2020-05-01 00:00:00

  • Protective effects of N-acetylcysteine on cisplatin-induced oxidative stress and DNA damage in HepG2 cells.

    abstract::Hepatocyte injury is a common pathological effect of cisplatin (CDDP) in various solid tumor therapies. Thus, strategies for minimizing CDDP toxicity are of great clinical interest. N-acetylcysteine (NAC), a known antioxidant, is often used as an antidote for acetaminophen overdose in the clinic due to its ability to ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.2019

    authors: Wang F,Liu S,Shen Y,Zhuang R,Xi J,Fang H,Pan X,Sun J,Cai Z

    更新日期:2014-12-01 00:00:00

  • Contrast of diagnostic value between IL-17 combined with IL-18 and CT angiography in carotid atherosclerosis.

    abstract::Diagnostic value between IL-17 combined with IL-18 and CT angiography in carotid atherosclerosis was evaluated. A total of 158 patients with suspected carotid artery stenosis in People's Hospital of Dongying from March 2014 to April 2017 were selected as the subjects. One hundred and two patients with carotid atherosc...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.7088

    authors: Suo F,Jiang F,Fang X,Ma A,Ma L

    更新日期:2019-02-01 00:00:00

  • Comparison of clinical efficacy of metoprolol combined with irbesartan and hydrochlorothiazide and non-invasive ventilator in the emergency treatment of patients with severe heart failure.

    abstract::Clinical efficacy of metoprolol combined with irbesartan and hydrochlorothiazide and non-invasive ventilator in the emergency treatment of patients with severe heart failure (HF) was investigated. A retrospective analysis of the medical records of 124 patients with severe HF admitted to Binzhou Medical University Hosp...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6828

    authors: Zhang F,Zhou G,Guo L,Lu F,Zhou G

    更新日期:2018-12-01 00:00:00

  • Chrysin induces cell apoptosis via activation of the p53/Bcl-2/caspase-9 pathway in hepatocellular carcinoma cells.

    abstract::Chrysin is a major active ingredient of flavonoids, known to exhibit protective effects against various types of cancer. However, the anticancer role of chrysin against hepatocellular carcinoma (HCC) and the underlying molecular mechanisms remain unclear. In order to evaluate the effects of chrysin on cell viability a...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3282

    authors: Zhang Q,Ma S,Liu B,Liu J,Zhu R,Li M

    更新日期:2016-07-01 00:00:00

  • Effects of nitric oxide on the biological behavior of HepG2 human hepatocellular carcinoma cells.

    abstract::Many studies have found the function of nitric oxide (NO) in cancer as a pro-neoplastic vs. an anti-neoplastic effector, but the role of NO in hepatocellular carcinoma (HCC) remains unclear. The present study aimed to investigate the effects of nitric oxide (NO) on the biological behavior of the human hepatocellular c...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3128

    authors: Zhou L,Zhang H,Wu J

    更新日期:2016-05-01 00:00:00

  • Co-culture with endometrial stromal cells enhances the differentiation of human embryonic stem cells into endometrium-like cells.

    abstract::In vitro differentiation of human embryonic stem cells (hESCs) into endometrium-like cells may provide a useful tool for clinical treatment. The aim of the present study was to investigate the differentiation potential of hESCs into endometrium-like cells using three methods, which included induction by feeder cells, ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2490

    authors: Yu W,Niu W,Wang S,Chen X,Sun BO,Wang F,Sun Y

    更新日期:2015-07-01 00:00:00

  • Weikangning therapy in functional dyspepsia and the protective role of Nrf2.

    abstract::Functional dyspepsia (FD) is a non-organic gastrointestinal disorder that has a marked negative impact on quality of life. Compared with conventional pharmacological therapies, the traditional Chinese medicine weikangning (WKN) is a safe and effective treatment for FD. The present study aimed to determine the molecula...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4892

    authors: Chang Y,Wei W,Tong L,Liu Y,Zhou A,Chen J,Wei R,Zhang P,Su X

    更新日期:2017-10-01 00:00:00

  • Synchronous diffuse ganglioneuromatosis and multiple schwannomas of the colon: A case report and literature review.

    abstract::Diffuse ganglioneuromatosis (DG) of the gastrointestinal tract is a rare condition that is closely associated with neurofibromatosis type 1 and multiple endocrine neoplasia type 2B. The occurrence of DG with multiple schwannomas, which, of the GI tract, usually affect the stomach, is considerably more rare. The presen...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2212

    authors: Lu C,Qiu Y,Lu X,Li G,Bu H

    更新日期:2015-03-01 00:00:00

  • Correlation between single nucleotide polymorphisms of the ACTA2 gene and coronary artery stenosis in patients with type 2 diabetes mellitus.

    abstract::This study aimed to analyze the correlation between single nucleotide polymorphisms (SNPs) of the actin, aortic smooth muscle (ACTA2) gene and coronary artery stenosis in patients with type 2 diabetes mellitus (T2DM). Eight SNPs from the promoter region of the ACTA2 gene were screened. Patients with T2DM (n=251) were ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.1510

    authors: Fang H,Luo X,Wang Y,Liu N,Fu C,Wang H,Fang Y,Shi W,Zhang Y,Zeng C,Wang X

    更新日期:2014-04-01 00:00:00

  • Methylation-regulated ZNF545 inhibits growth of the p53-mutant KYSE150 cell line by inducing p21 and Bax.

    abstract::The Krüppel-associated box zinc-finger protein 545 (ZNF545) was recently identified as a tumor suppressor in esophageal squamous cell carcinoma (ESCC). However, the role of ZNF545 in the tumorigenesis of esophageal cancer cells expressing loss-of-function mutant p53 has not been elucidated. In the present study, the r...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7737

    authors: Fan Y,Wang Y,Fu S,Liu D,Lin S

    更新日期:2019-09-01 00:00:00

  • Promoter and histone methylation and p16(INK4A) gene expression in colon cancer.

    abstract::The inactivation of the cyclin-dependent kinase inhibitor p16(INK4A) gene by hypermethylation is observed in numerous types of cancer. New findings indicate that DNA and histone methylation act in concert in gene silencing. In this study, we investigated the methylation status of the p16(INK4A) gene promoter and the h...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2012.683

    authors: Yoruker EE,Mert U,Bugra D,Yamaner S,Dalay N

    更新日期:2012-11-01 00:00:00

  • Effects of recombinant adeno-associated virus-mediated CD151 gene transfer on the expression of rat vascular endothelial growth factor in ischemic myocardium.

    abstract::The aim of this study was to observe the effects of cluster of differentiation (CD) 151 on the expression of vascular endothelial growth factor (VEGF) in ischemic myocardium by the injection of a recombinant adeno-associated virus (rAAV) vector carrying the human CD151 gene. A rat acute myocardial infarction model was...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.2079

    authors: Fu H,Tan J,Yin Q

    更新日期:2015-01-01 00:00:00

  • Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study.

    abstract::In the present study, we investigated the effects of hydroxyethyl starch (HES) 130/0.4 on serum pro-inflammatory variables, immunologic variables, fluid balance (FB)-negative(-) rate and renal function in severe acute pancreatitis (SAP) patients. From October, 2007 to November, 2008, a total of 120 SAP patients were e...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3744

    authors: Chen QJ,Yang ZY,Wang CY,Dong LM,Zhang YS,Xie C,Chen CZ,Zhu SK,Yang HJ,Wu HS,Yang C

    更新日期:2016-11-01 00:00:00

  • Neurological teratogenic effects of antiepileptic drugs during pregnancy.

    abstract::Epilepsy is one of the few neurologic disorders that requires a constant treatment during pregnancy. Epilepsy affects 0.3-0.8% of pregnant women. Prescription of antiepileptic drugs (AEDs) to pregnant women with epilepsy requires monitoring and maintaining a balance between limiting seizures and decreasing fetal expos...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3628

    authors: Nie Q,Su B,Wei J

    更新日期:2016-10-01 00:00:00

  • Regulation of TGF-β1 on PI3KC3 and its role in hypertension-induced vascular injuries.

    abstract::The aim of the present study was to investigate the expression and role of transforming growth factor (TGF)-β1/phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3KC3) in the peripheral blood in patients with hypertension. A total of 28 patients with primary hypertension and 20 healthy control subjects were inc...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.7128

    authors: Zhang Q,Liu H,Yang J

    更新日期:2019-03-01 00:00:00

  • A case of crusted scabies combined with bullous scabies.

    abstract::Scabies is a contagious skin disease that causes extremely itching. It is a parasitic disease caused by the mite Sarcoptes scabiei and characterized by polymorphous lesions. Vesicular and bullous lesions in cases of scabies are rather rare. Bullous scabies has a pemphigoid presentation. Crusted scabies, also known as ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2668

    authors: Su WJ,Fang S,Chen AJ,Shan K

    更新日期:2015-10-01 00:00:00

  • The 4-hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions.

    abstract::Lipid peroxidation is associated with several metabolic diseases. Lipid peroxidation causes cellular damage through reactive aldehyde species such as 4-hydroxyonenal (4-HNE). The exact mechanism(s) by which 4-HNE causes damage in the intravascular compartment is not yet exactly understood. Using an in vitro system, th...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6419

    authors: Mustafa AG,Alfaqih MA,Al-Shboul O

    更新日期:2018-09-01 00:00:00

  • Cyanidin ameliorates cisplatin-induced cardiotoxicity via inhibition of ROS-mediated apoptosis.

    abstract::Oxidative stress and apoptosis serve an essential role in cisplatin-induced cardiotoxicity, which limits its clinical use, and increases the risk of cardiovascular disease. As a natural drug, the antioxidant and antitumor effects of cyanidin have been recognized, but its protective effect on cisplatin-induced cardiomy...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.5617

    authors: Qian P,Yan LJ,Li YQ,Yang HT,Duan HY,Wu JT,Fan XW,Wang SL

    更新日期:2018-02-01 00:00:00

  • MicroRNA-652 inhibits the biological characteristics of esophageal squamous cell carcinoma by directly targeting fibroblast growth factor receptor 1.

    abstract::Numerous studies have demonstrated that microRNAs (miRNAs) are dysregulated in esophageal squamous cell carcinoma (ESCC). Changes in miRNA expression may be associated with ESCC formation and progression. Therefore, the identification of ESCC-associated miRNAs may facilitate the development of effective therapeutic ap...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.8072

    authors: Zhen C,Huang J,Lu J

    更新日期:2019-12-01 00:00:00

  • Multimodal therapy for category III chronic prostatitis/chronic pelvic pain syndrome in UPOINTS phenotyped patients.

    abstract::The complex network of etiological factors, signals and tissue responses involved in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) cannot be successfully targeted by a single therapeutic agent. Multimodal approaches to the therapy of CP/CPPS have been and are currently being tested, as in the frame of com...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.2152

    authors: Magri V,Marras E,Restelli A,Wagenlehner FM,Perletti G

    更新日期:2015-03-01 00:00:00

  • Comparison of the clinical efficacy of AcrySof® IQ and TECNIS® toric intraocular lenses: A real-world study.

    abstract::Corneal astigmatism significantly compromises uncorrected visual acuity (UCVA) after phacoemulsification with implantation of traditional spherical or non-spherical monofocal intraocular lens (IOL). Toric IOL provides an effective way to gain favorable postoperative UCVA for the patients with cataracts with corneal as...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.9153

    authors: Yang JJ,Qin YZ,Qin L,Li JM

    更新日期:2020-11-01 00:00:00

  • Study of genes associated with the 'anger-in' and 'anger-out' emotions of humans using a rat model.

    abstract::The aim of the present study was to investigate the genes associated with 'anger-in' (tendency to suppress anger) and 'anger-out' (tendency to express anger through verbal or physical means) emotions in humans. Wistar rats were divided into five groups (n=10/group), based on the type of model and the Chinese medicinal...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2246

    authors: Guo Y,Zhang H,Gao J,Wei S,Song C,Sun P,Qiao M

    更新日期:2015-04-01 00:00:00

  • Expression of ERβ, ERα and Her-2 and distribution of molecular subtypes in Uygur and Han patients with breast cancer.

    abstract::The aim of the present study was to investigate the expression levels of estrogen receptor (ER) α and β and human epidermal growth factor receptor-2 (Her-2), as well as the distribution of breast cancer molecular subtypes in Uygur and Han breast cancer patients. Cancer tissues were collected and analyzed from 709 brea...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.1596

    authors: Guo L,Hou X,Dilimina Y,Wang B

    更新日期:2014-05-01 00:00:00

  • The urotensin II receptor antagonist, urantide, protects against atherosclerosis in rats.

    abstract::The aim of this study was to explore the use of urantide as an antagonist of the urotensin II (UII) receptor, G protein-coupled receptor 14 (GPR14), to protect against atherosclerosis (AS) in rats. The AS rat model was induced by an intraperitoneal injection of vitamin D3 (VD3) into rats fed with a high-fat diet for f...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2013.1052

    authors: Zhao J,Yu QX,Kong W,Gao HC,Sun B,Xie YQ,Ren LQ

    更新日期:2013-06-01 00:00:00

  • Surgical treatment of incarcerated calculi via laparoscopic bile duct exploration using laparotomy biliary lithotomy forceps.

    abstract::The present study aimed to investigate the practicability and clinical value of applying laparotomy biliary lithotomy forceps to laparoscopic bile duct exploration (LCBDE) for the surgical treatment of incarcerated calculi. A total of 63 patients were diagnosed with cholecystolithiasis and choledocholithiasis. The pre...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3618

    authors: Jiang H,Wang SY,Jin XL,Jin JC,Gu HB,Zhang FM

    更新日期:2016-10-01 00:00:00

  • A compound heterozygous mutation of the alkaline phosphatase ALPL gene causes hypophosphatasia in a Han Chinese family.

    abstract::Hypophosphatasia (HPP) is a rare hereditary systemic disease that is characterized by defective bone and/or dental mineralization, and is caused by mutations in the alkaline phosphatase gene (ALPL). The present study investigated the ALPL mutation in a Chinese Han family with HPP and studied the pathogenesis of the mu...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.9281

    authors: Huang H,Wang J,Liang Y,Wei X,Guo D,Sun H,Zhang X,Xu X,Xiong F

    更新日期:2020-12-01 00:00:00

  • Adoptive cell therapy with autologous tumor-infiltrating lymphocytes and high-dose interleukin-2 for metastatic melanoma: The surgeon's perspective.

    abstract::Tumor-infiltrating lymphocytes (TILs) are produced by resecting tumor tissue and growing and expanding ex vivo large quantities of autologous T cells. Once the TILs are ready for infusion, the patient undergoes a non-myeloablative lympho-depleting course of chemotherapy and subsequent TIL infusion with high-dose bolus...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2012.498

    authors: Zippel DB,Besser M,Shapira R,Ben-Nun A,Goitein D,Davidson T,Treves AJ,Markel G,Schachter J,Papa MZ

    更新日期:2012-05-01 00:00:00

  • Treadmill exercise reduces spinal cord injury-induced apoptosis by activating the PI3K/Akt pathway in rats.

    abstract::Apoptosis occurring secondary to spinal cord injury (SCI) causes further neural damage and functional loss. In this study, a rat model was used to investigate the effect of treadmill exercise on SCI-induced apoptosis and expression of neurotrophic factors. To produce SCI, a contusion injury (10 g × 25 mm) was applied ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2013.1451

    authors: Jung SY,Kim DY,Yune TY,Shin DH,Baek SB,Kim CJ

    更新日期:2014-03-01 00:00:00

  • Vascular endothelial growth factor +936C/T polymorphism and gastric cancer risk: A meta-analysis.

    abstract::The aim of this study was to determine whether the vascular endothelial growth factor (VEGF) +936C/T polymorphism confers susceptibility to gastric cancer (GC) by conducting a meta-analysis. Publications addressing the association between the VEGF +936C/T polymorphism and GC risk were selected from the Pubmed, Embase ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2011.278

    authors: Zhou LP,Luan H,Dong XH,Jin GJ,Man DL,Shang H

    更新日期:2011-09-01 00:00:00