Abstract:
:The aim of this study was to evaluate the efficacy and safety of polyethylene glycol 4000 (PEG 4000) for the treatment of constipation in children over 8 years of age. A total of 216 children from 7 hospitals were enrolled. A total of 105 patients received oral PEG 4000 (20 g/day) and 111 patients received oral lactulose (15 ml/day) for 2 weeks. The stool frequency, stool consistency and abdominal pain of the patients were monitored. In the PEG group, following one week and two weeks of treatment, the median weekly stool frequency improved from 2 times prior to treatment to 6 and 7 times, respectively, following treatment. The clinical remission rates of the PEG and lactulose groups following one week of treatment were 70.48 and 39.64%, respectively, and following two weeks of treatment were 72.38 and 41.44%, respectively. Abdominal pain disappeared in 74.6% of patients following two weeks of PEG 4000 treatment. No significant clinical adverse effects or abnormalities in the laboratory tests were observed in the two treatment groups. In conclusion, PEG 4000 is a safe and more effective drug compared to lactulose for the treatment of constipation in children.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Wang Y,Wang B,Jiang X,Jiang M,Xu C,Shao C,Jia L,Huang Z,Xu X,Liu H,Shang Ldoi
10.3892/etm.2012.491subject
Has Abstractpub_date
2012-05-01 00:00:00pages
853-856issue
5eissn
1792-0981issn
1792-1015pii
etm-03-05-0853journal_volume
3pub_type
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