Bronchopulmonary dysplasia: Pathogenesis and treatment.

abstract：:CGA-N46 is a novel antifungal peptide derived from the N-terminus of human Chromogranin A, corresponding to the 31st to 76th amino acids. Further research on its activities and characteristics may be helpful for the application of CGA-N46 in medical or other situations. In the present study, the antifungal spectrum an...

journal_title：Experimental and therapeutic medicine

authors： Li RF,Lu YL,Lu YB,Zhang HR,Huang L,Yin Y,Zhang L,Liu S,Lu Z,Sun Y

更新日期：2015-12-01 00:00:00

abstract：:Osteosarcoma is among the most frequently occurring bone tumors in infants and teenagers. However, despite its widespread prevalence, no effective diagnostic and prognostic biomarkers for osteosarcoma are known. Macrophage inhibitory cytokine 1 (MIC-1) has been considered a promising biological marker of various tumor...

journal_title：Experimental and therapeutic medicine

authors： Song X,Tian L,Quan Y,Sun D,Zhang L

更新日期：2018-12-01 00:00:00

abstract：:The primarily metabolic abnormality in type 2 diabetes mellitus (T2DM) is the defect in gluconeogenesis and glucose uptake. Itraconazole (ITCZ) is a traditional azole drug with anti-fungal and anticancer properties. However, limited attention has been directed towards the contribution of ITCZ to hepatic gluconeogenesi...

journal_title：Experimental and therapeutic medicine

authors： Na RS,Ma C,Liu QR,Wu LM,Zheng XL,Liu ZW

更新日期：2018-02-01 00:00:00

abstract：:The present study aimed to evaluate whether thymosin α1 (Tα1) increases survival rates through the improvement of immunofunction and inhibition of hepatocyte apoptosis in rats with acute liver failure (ALF). A total of 25 rats were randomly divided into the control group (CG), the model group (MG) and the treatment gr...

journal_title：Experimental and therapeutic medicine

authors： Yang X,Chen Y,Zhang J,Tang T,Kong Y,Ye F,Zhang X,Liu X,Lin S

更新日期：2018-04-01 00:00:00

abstract：:The aim of this study was to investigate the anticarcinogenic effects of silymarin in diethylnitrosamine (DEN)-induced hepatocarcinogenic rat models. Severe and mild models of hepatocellular carcinoma (HCC) were generated by the intraperitoneal administration of 40 mg/kg DEN once a week for 18 weeks and 100 mg/kg DEN ...

journal_title：Experimental and therapeutic medicine

authors： Imamoto R,Okano JI,Sawada S,Fujise Y,Abe R,Murawaki Y

更新日期：2014-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2017.4943.]. ...

journal_title：Experimental and therapeutic medicine

authors： Li S,Xu G,Gao F,Bi J,Huo R

更新日期：2018-10-01 00:00:00

abstract：:Eyelid conditioning, including delay eyelid conditioning and trace eyelid conditioning, has been used extensively to study neural structures and mechanisms of learning and memory as a form of associative learning. In the present study, microcurrent electrical stimulation was used to stimulate the medial prefrontal cor...

journal_title：Experimental and therapeutic medicine

authors： Zheng YJ,Dong YC,Zhu C,Zhao MS

更新日期：2016-03-01 00:00:00

abstract：:Gamboge, the dried resin secreted by Garcinia maingayii (gambogic tree), was previously demonstrated to exert anti-inflammatory effects. The present study examined the effects of gambogic acid, the major active constituent of gamboge, on myocardial infarction (MI) and inflammation in a rat model and explored the possi...

journal_title：Experimental and therapeutic medicine

authors： Na D,Aijie H,Bo L,Zhilin M,Long Y

更新日期：2018-02-01 00:00:00

abstract：:In the central nervous system (CNS), ischemic injury induced by inflammation associated with astrocytes serves an important role in physiological and pathological processes. Neuroinflammation leads to the release of pro-inflammatory cytokines, including tumor necrosis factor-α and interleukin-1β. The aim of the presen...

journal_title：Experimental and therapeutic medicine

authors： Xiang Y,Du P,Zhang X,Biswas S,Jiao G,Liu H

更新日期：2018-09-01 00:00:00

abstract：:The aim of the present study was to determine the ferulic acid (FA) content of Radix Angelicae Sinensis (AS), Danggui-Buxue-Tang (DBT) and Danggui-Sini-Tang (DST) using the same ultra performance liquid chromatography system and method. FA was eluted using an Acquity BEH C18 column (100×2.1 mm inner diameter; 1.7 μm)....

journal_title：Experimental and therapeutic medicine

authors： Yao JM,Yu LJ,Chen Q,Chen ZQ,Wang DS,Qiu XJ,Zhao LL

更新日期：2014-05-01 00:00:00

abstract：:Serum thymidine kinase 1 (STK1) is a reliable proliferation marker in most solid tumors, including gastric cancer. The aim of this study was to evaluate whether STK1 levels are related to the tumor response to chemotherapy and survival in advanced gastric cancer. The results showed that the average STK1 level in patie...

journal_title：Experimental and therapeutic medicine

authors： Liu Y,Ling Y,Qi Q,Tang Y,Xu J,Tong Z,Sheng G,Yang Q,Pan Y

更新日期：2011-11-01 00:00:00

abstract：:The aim of the present study was to evaluate the diagnostic value of ultrasound (US) elastography in differentiating between benign and malignant peripheral lung lesions (PLLs). This retrospective study included 91 consecutive patients with 91 PLLs. Conventional US, strain elastography (SE), acoustic radiation force i...

journal_title：Experimental and therapeutic medicine

authors： Wei H,Lu Y,Ji Q,Zhou H,Zhou X

更新日期：2018-08-01 00:00:00

abstract：:Compared with traditional imaging techniques, multimodal imaging obtains more accurate images that may increase disease detection rates. The present study prepared stromal cell-derived factor 1 (SDF-1)-loaded, targeted nanoparticles coated with iron (II,III) oxide and perfluorohexane (PFH) to be used as polymer-shelle...

journal_title：Experimental and therapeutic medicine

authors： Wang F,Wang Z,Pang L,Wan S,Qiu L

更新日期：2020-09-01 00:00:00

abstract：:Metastatic breast cancer is one of the most common metastatic tumors. Although studies have validated the role of β-inducible gene-h3 (βig-h3) in human biology and disease, the detailed mechanisms mediated by βig-h3 in breast carcinoma metastasis remain unclear. Thus, the present study investigated the role and potent...

journal_title：Experimental and therapeutic medicine

authors： Zhang J,Li Z

更新日期：2018-03-01 00:00:00

abstract：:Enamel matrix derivative (EMD) is a commercially available protein extract, mainly comprising amelogenins. A number of other polypeptides have been identified in EMD, mostly growth factors, which promote cementogenesis and osteogenesis during the regeneration processes through the regulation of cell proliferation, dif...

journal_title：Experimental and therapeutic medicine

authors： Wyganowska-Świątkowska M,Urbaniak P,Nohawica MM,Kotwicka M,Jankun J

更新日期：2015-06-01 00:00:00

abstract：:Herpes Zoster (HZ) is reported as the most prevalent viral infection in patients with systemic lupus erythematosus (SLE). The aim of the present study was to investigate the clinical features, complications, and potential risk factors of HZ in patients with SLE from Southern China. A retrospective study was performed ...

journal_title：Experimental and therapeutic medicine

authors： Chen D,Li H,Xie J,Zhan Z,Liang L,Yang X

更新日期：2017-12-01 00:00:00

abstract：:The aim of the present study was to investigate the feasibility of using composite scaffolds of poly(lactic-co-glycolic acid) (PLGA) and bioactive glass (BG) to repair bone defects. PLGA/BG composite scaffolds were prepared by thermally-induced phase separation. Scanning electron microscopy (SEM) was used to study the...

journal_title：Experimental and therapeutic medicine

authors： Yang L,Liu S,Fang W,Chen J,Chen Y

更新日期：2019-12-01 00:00:00

abstract：:The novel orally available inhibitor of the molecular chaperone heat shock protein 90 (Hsp90), BIIB021, induces the apoptosis of various types of tumor cell in vitro and in vivo. However, the effects and mechanisms of this agent on myelodysplastic syndrome (MDS) cell lines remain unknown. The aim of this study was to ...

journal_title：Experimental and therapeutic medicine

authors： Lin S,Li J,Zhou W,Qian W,Wang B,Chen Z

更新日期：2014-06-01 00:00:00

abstract：:Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is an acute event characterized by the worsening of a patient's respiratory symptoms. To the best of our knowledge, few studies have investigated the computed tomography (CT) manifestation of AECOPD. Thus, the aim of the present study was to examine ...

journal_title：Experimental and therapeutic medicine

authors： Cheng T,Wan H,Cheng Q,Guo YI,Qian Y,Fan L,Feng Y,Song Y,Zhou M,Li Q,Shi G,Huang S

更新日期：2016-02-01 00:00:00

abstract：:Giant aneurysm of the posterior circulation is associated with a higher risk of rupture compared with that of the anterior circulation. Furthermore, surgical clipping and interventional embolization for giant aneurysm of the posterior circulation are more difficult and complex to perform. The present study reported on...

journal_title：Experimental and therapeutic medicine

authors： Zhang CL,Shi ZH,Yan ZZ,Ding CL,Cao JM,Wang YH,Zhang P

更新日期：2021-01-01 00:00:00

abstract：:Saw palmetto extract can induce the apoptosis of prostate cancer cells. The aim of the present study was to investigate the effect of saw palmetto extract on the phosphatidylinositol 3-kinase (PI3K)/Akt signaling transduction pathway in human glioma U87 and U251 cell lines. Suspensions of U87 and U251 cells in a logar...

journal_title：Experimental and therapeutic medicine

authors： Yang Y,Hui L,Yuqin C,Jie L,Shuai H,Tiezhu Z,Wei W

更新日期：2014-08-01 00:00:00

abstract：:The aim of our study was to analyze the role of toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signal pathway on Hepcidin regulation in non-alcoholic fatty liver disease (NAFLD). A total of 60 male Sprague-Dawley rats were randomly divided into the control, NAFLD and intervention groups. Rats in the control group ...

journal_title：Experimental and therapeutic medicine

authors： Chen W,Wang X,Huang LI,Liu BO

更新日期：2016-01-01 00:00:00

abstract：:The aim of this study was to isolate and purify Rhizoma Pinelliae trypsin inhibitor (RPTI), determine its N-terminal amino acid sequence and evaluate its inhibitory effect on the proliferation of poorly differentiated BGC-823 human gastric adenocarcinoma cells. RPTI was separated and purified from a 40% (NH4)2SO4 prec...

journal_title：Experimental and therapeutic medicine

authors： Zu G,Wang H,Wang J,Dou Y,Zhao W,Sun Y

更新日期：2014-07-01 00:00:00

abstract：:Osteoarthritis (OA) is the most common motor system disease in the elderly, with a high incidence and a huge social and economic burden. Therefore, it is urgent to study its potential pathogenesis to improve the therapeutic effect of the disease. In this study, we constructed a number of regulator-mediated OA dysfunct...

journal_title：Experimental and therapeutic medicine

authors： Wang F,Guo Z,Yuan Y

更新日期：2020-01-01 00:00:00

abstract：:The present study aimed to determine the expression of microRNA (miRNA or miR)-145 in hypertrophic scars at the tissue and cellular levels, and to investigate its biological functions and mechanism of action. A total of 36 patients who were diagnosed with hypertrophic scar were included in the present study. Reverse t...

journal_title：Experimental and therapeutic medicine

authors： Wang S,Li C,Yu Y,Qiao J

更新日期：2019-11-01 00:00:00

abstract：:Previous studies have indicated pro-tumor functions of macrophages in tumor progression in different types of malignant tumors. The detailed mechanisms of cell-cell interaction between macrophages and tumor cells have been investigated by means of in vitro co-culture experiments. The present study developed magnetite ...

journal_title：Experimental and therapeutic medicine

authors： Komohara Y,Kawauchi R,Makiyama E,Mikami K,Horlad H,Fujiwara Y,Kida T,Takeya M,Niidome T

更新日期：2017-08-01 00:00:00

abstract：:An early and accurate diagnosis of pulmonary thromboembolism (PTE) remains challenging. The present study aimed to evaluate the diagnostic value of platelet-derived microparticles in PTE based on a population study. A total of 102 patients with PTE, 102 healthy controls and 40 patients suspected with PTE were enrolled...

journal_title：Experimental and therapeutic medicine

authors： Wang M,Fu Y,Xu L,Xiao L,Yue Y,Liu S,Huang Q,Li S,Li Y

更新日期：2018-10-01 00:00:00

abstract：:Multi infarct dementia (MID) is a form of dementia that is preventable and treatable. However, at present, the drugs used in MID treatment were developed for Alzheimer's disease. While only a limited range of drugs is available, the incidence of MID is increasing year on year. The present study aimed to investigate th...

journal_title：Experimental and therapeutic medicine

authors： Fu Y,Wei J,Li B,Gao L,Xia P,Wen Y,Xu S

更新日期：2020-11-01 00:00:00

abstract：:Chemotherapy-induced anorexia (CIA), which may lead to severe nutrition-associated problems, is a common complication associated with anti-cancer therapies. In the present study, the anti-anorexigenic effect of electroacupuncture (EA) was explored through assessing a change in appetite-associated peptides and c-Fos ex...

journal_title：Experimental and therapeutic medicine

authors： Kang KS,Huh W,Bang Y,Choi HJ,Baek JY,Song JH,Kang JW,Kim TH

更新日期：2019-04-01 00:00:00

abstract：:The aim of this study was to investigate the effects of advanced glycation end-products (AGEs) on podocyte adhesion and the underlying mechanisms. Immortalized mouse podocytes were exposed to various conditions and podocyte adhesion was evaluated using a hexosaminidase assay. The expression levels of integrin-linked k...

journal_title：Experimental and therapeutic medicine

authors： Cheng C,Zheng Z,Shi C,Liu X,Ye Z,Lou T

更新日期：2013-12-01 00:00:00