Abstract:
:Increasing evidence connects gallstone disease (GD) to cardio-cerebrovascular disease (CVD). The aim of the present systematic review and meta-analysis was to determine whether and to what extent an association between GD and CVD existed. PubMed, EMBASE and the Cochrane Library were systemically searched up to March 3rd, 2018. A total of 10 studies (1,272,177 participants; 13,833 records; 5 prospective cohorts and 5 retrospective cohorts) were included. It was demonstrated that GD was associated with an increased risk of incidence [hazard ratio=1.24, 95% (CI) confidence interval: 1.17-1.31] and prevalence (unadjusted odds ratio=1.23, 95% CI: 1.21-1.25) of CVD. In conclusion, the presence of GD was associated with an increased risk of CVD incidence and prevalence. The association may be influenced by age and sex. These findings suggest that individuals identified with cardio-cerebrovascular disease should be evaluated for GD.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Zhao SF,Wang AM,Yu XJ,Wang LL,Xu XN,Shi GJdoi
10.3892/etm.2019.7291subject
Has Abstractpub_date
2019-04-01 00:00:00pages
3092-3100issue
4eissn
1792-0981issn
1792-1015pii
ETM-0-0-7291journal_volume
17pub_type
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