MMP-9 and TIMP-1 in placenta of hypertensive disorder complicating pregnancy.

abstract：:Diffuse ganglioneuromatosis (DG) of the gastrointestinal tract is a rare condition that is closely associated with neurofibromatosis type 1 and multiple endocrine neoplasia type 2B. The occurrence of DG with multiple schwannomas, which, of the GI tract, usually affect the stomach, is considerably more rare. The presen...

journal_title：Experimental and therapeutic medicine

authors： Lu C,Qiu Y,Lu X,Li G,Bu H

更新日期：2015-03-01 00:00:00

abstract：:Acute myocardial infarction (AMI) evokes a temporally coordinated immune response, in which monocytes are critically involved in the clearance of cell debris; however, excessive inflammation induced by the classical sub-population of monocytes frequently limits the endogenous reparative process. In the present study, ...

journal_title：Experimental and therapeutic medicine

authors： Zhu H,Ding Y,Zhang Y,Ding X,Zhao J,Ouyang W,Gong J,Zou Y,Liu X,Wu W

更新日期：2020-03-01 00:00:00

abstract：:To investigate the in vivo and in vitro inhibitory effects of deuterium-depleted water (DDW) on human lung cancer and the possible mechanisms underlying these effects, we cultured and treated human lung carcinoma cell line A549 and human embryonic lung fibroblasts HLF-1 with various concentrations of DDW from 2 to 72 ...

journal_title：Experimental and therapeutic medicine

authors： Cong FS,Zhang YR,Sheng HC,Ao ZH,Zhang SY,Wang JY

更新日期：2010-03-01 00:00:00

abstract：:Sodium 4-phenylbutyrate (PBA) exerts therapeutic effects in a wide range of pathologies. A previous study by the present authors revealed that intraperitoneal administration of PBA suppresses the onset of dextran sulfate sodium (DSS)-induced colitis in mice. In the present study, the effects of orally administered PBA...

journal_title：Experimental and therapeutic medicine

authors： Ono K,Nimura S,Hideshima Y,Nabeshima K,Nakashima M

更新日期：2017-12-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are a novel class of transcripts, which are pervasively transcribed in the genome and a have greatly unknown biological function. Previous studies have identified that lncRNAs serve an important role in embryonic development. However, the function and mechanism of lncRNAs in the developm...

journal_title：Experimental and therapeutic medicine

authors： Gao L,Yin J,Wu W

更新日期：2016-06-01 00:00:00

abstract：:Cardiovascular disease is the main cause of morbidity and mortality in end-stage renal disease (ESRD) patients. Recent population based epidemiological studies demonstrated a correlation between reduced renal function and risk for all causes and cardiovascular mortality, 50% of patients dying before the commencement o...

journal_title：Experimental and therapeutic medicine

authors： Timofte D,Dragoș D,Balcangiu-Stroescu AE,Tănăsescu MD,Gabriela Bălan D,Răducu L,Tulin A,Stiru O,Ionescu D

更新日期：2020-07-01 00:00:00

abstract：:A long-acting β2-agonist (LABA) combined with an inhaled corticosteroid (ICS) is frequently prescribed as initial therapy in steroid-naïve asthma patients because of its effective control of symptoms and improvement of pulmonary function. However, it is unclear which patients will be responsive to LABAs and whether br...

journal_title：Experimental and therapeutic medicine

authors： Ohwada A,Inami K,Onuma E,Matsumoto-Yamazaki M,Atsuta R,Takahashi K

更新日期：2011-07-01 00:00:00

abstract：:Abnormalities in insulin hormone levels leads to a hyperglycemic condition of diabetic mellitus. Hyperglycemia seriously induces organ and system destructions. The excessive accumulation of collagen fiber deposits occurs in inflammatory and reorganization processes of chronic liver diseases in type I insulin-dependent...

journal_title：Experimental and therapeutic medicine

authors： Komolkriengkrai M,Nopparat J,Vongvatcharanon U,Anupunpisit V,Khimmaktong W

更新日期：2019-08-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of microRNA (miR)-92a on cystatin C expression in patients with type II diabetes and lower limb ischemia. A total of 199 patients diagnosed with type II diabetes were included in the study and divided into three experimental groups: Simple type II diabetes mel...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Guan Q,Jin X

更新日期：2015-06-01 00:00:00

abstract：:Oxidative stress and apoptosis serve an essential role in cisplatin-induced cardiotoxicity, which limits its clinical use, and increases the risk of cardiovascular disease. As a natural drug, the antioxidant and antitumor effects of cyanidin have been recognized, but its protective effect on cisplatin-induced cardiomy...

journal_title：Experimental and therapeutic medicine

authors： Qian P,Yan LJ,Li YQ,Yang HT,Duan HY,Wu JT,Fan XW,Wang SL

更新日期：2018-02-01 00:00:00

abstract：:Different neoadjuvant therapy regimens are available for rectal cancer, but the relative effects are controversial. The aim of the present network meta-analysis (NMA) was to estimate the relative efficacy and safety of neoadjuvant therapies for resectable rectal cancer. MEDLINE, EMBASE and Cochrane Central Registry of...

journal_title：Experimental and therapeutic medicine

authors： Zhong W,Xue X,Dai L,Li R,Nie K,Zhou S

更新日期：2020-04-01 00:00:00

abstract：:The present study reported a case of portopulmonary hypertension (POPH) that was secondary to underlying liver cirrhosis in a 58-year-old woman, who was successfully treated with low-dose tolvaptan. The patient had suffered from refractory peripheral edema and electrolyte abnormalities, including severe hypokalemia, u...

journal_title：Experimental and therapeutic medicine

authors： Ogihara Y,Yamada N,Dohi K,Matsuda A,Ota S,Ishikura K,Nakamura M,Ito M

更新日期：2017-01-01 00:00:00

abstract：:Phthalates are confirmed to have toxic effects on the reproductive system and are likely to have further damaging actions in humans. The present study explored the molecular mechanisms of the toxic effect of mono-(2-ethylhexyl) phthalate (MEHP) on mouse Sertoli cells. Cell apoptosis and proliferation assays were used ...

journal_title：Experimental and therapeutic medicine

authors： Wang L,Dou T,Li S,Liu Y

更新日期：2019-04-01 00:00:00

abstract：:Rhynchophylline (Rhy) is a major active component of Uncaria rhynchophylla and exhibits the potential to inhibit the proliferation of airway smooth muscle cells (ASMCs). In the current study, it was hypothesized that Rhy serves a key role in the anti-asthma effect of Uncaria rhynchophylla by inhibiting transforming gr...

journal_title：Experimental and therapeutic medicine

authors： Wang M,Li H,Zhao Y,Lv C,Zhou G

更新日期：2019-01-01 00:00:00

abstract：:Arteriovenous fistula (AVF) thrombosis is a common complication in patients undergoing hemodialysis, and early intervention is required. Urokinase has been used as a thrombolytic agent for declotting the thrombosed access. However, the optimal route for infusing urokinase remains to be determined. In the present retro...

journal_title：Experimental and therapeutic medicine

authors： Wan Z,Xiang R,Wang H,Zhong Q,Tu B

更新日期：2019-05-01 00:00:00

abstract：:Single-port laparoscopic technology is effective in minimally invasive surgery. However, this technology requires expensive instrumentation. In the present study, an alternative minimally invasive technique, periumbilical laparoscopic surgery through triple channels using common instrumentation, is introduced. Increas...

journal_title：Experimental and therapeutic medicine

authors： Ge JY,Wang L,Zou H,Zhang XW

更新日期：2013-04-01 00:00:00

abstract：:In order to provide a scientific basis for rational use of antibiotics, we studied and compared the therapeutic effects of step-down and step-up antibiotic treatment schemes in children with lobar pneumonia. Eighty cases of children with lobar pneumonia were enrolled in this study and were randomly divided into two gr...

journal_title：Experimental and therapeutic medicine

authors： Li Y,Han F,Yang Y,Chu J

更新日期：2017-06-01 00:00:00

abstract：:Atrial remodeling is considered to be any persistent change in atrial structure or function, and is responsible for the development and perpetuation of atrial fibrillation (AF). Oxidative stress and intracellular pH regulation may also be linked to AF; however it remains unclear whether eicosapentaenoic acid (EPA) or ...

journal_title：Experimental and therapeutic medicine

authors： Tong M,Wang J,Ji Y,Chen X,Wang J,Wang S,Ruan L,Cui H,Zhou Y,Zhang Q,Watanabe E

更新日期：2017-09-01 00:00:00

abstract：:Posterior communicating artery (PCoA) in patients with posterior circulation ischemia (PCI) was quantitatively studied using phase contrast magnetic resonance angiography (PC-MRA). Fifty-one cases who received PC-MRA were included in the study, and divided into the research and control groups. The mean flow volume, me...

journal_title：Experimental and therapeutic medicine

authors： Zhou W,Lu M,Li J,Chen F,Hu Q,Yang S

更新日期：2019-01-01 00:00:00

abstract：:Cardiovascular ischemic disease refers to a large class of conditions that are harmful to human health. A number of previous studies have demonstrated that microRNAs (miRs) have notable roles in regulating cardiac injury. miR-144 is influential in the differentiation, growth, and metastatic processes of cells; however...

journal_title：Experimental and therapeutic medicine

authors： E L,Jiang H,Lu Z

更新日期：2019-03-01 00:00:00

abstract：:The aim of the study was to detect the expression of interleukin-1β (IL-1β) in serum of patients with perimenopausal non-organic sleep disorder (PNSD) and to study the relationship between IL-1β and the severity of insomnia and liver depression, so as to benefit the prevention of PNSD. A total of 268 cases of perimeno...

journal_title：Experimental and therapeutic medicine

authors： Li H,Chen Y,Wu H,Huang J,Ma K,Zheng J,Lv S

更新日期：2019-01-01 00:00:00

abstract：:The interaction between TEM-1 β-lactamase and antibiotics is very important in the hydrolysis of antibiotics. In the present study, the recognition and binding of TEM-1 β-lactamase with three β-lactam antibiotics, including penicillin G, cefalexin and cefoxitin, was investigated by fluorescence and ultraviolet-visible...

journal_title：Experimental and therapeutic medicine

authors： Yang J,Li Q,Bian L

更新日期：2017-10-01 00:00:00

abstract：:MicroRNA-155 (miR-155) is overexpressed in numerous human cancer types and has an oncogenic role. Previous study has revealed that miR-155 serves an important role in the progression of clear-cell renal cell carcinoma (ccRCC); however, the underlying mechanism was not completely clarified. The present study aimed to i...

journal_title：Experimental and therapeutic medicine

authors： Ji H,Tian D,Zhang B,Zhang Y,Yan D,Wu S

更新日期：2017-05-01 00:00:00

abstract：:Previous studies have demonstrated that aripiprazole (APZ), a third-generation atypical antipsychotic drug, exhibits anti-depressant and neuroprotective effects by promoting dopaminergic neuronal cell recovery in stroke. To investigate the neuroprotective effects of APZ, behavioral and histopathological experiments we...

journal_title：Experimental and therapeutic medicine

authors： Gil CH,Kim YR,Lee HJ,Jung DH,Shin HK,Choi BT

更新日期：2018-01-01 00:00:00

abstract：:Schisandrin B (SchB) is one of the primary active components of Schisandra chinensis (Turcz.) Baill., a traditional Chinese herb that has been used to treat insomnia for hundreds of years. Our previous studies revealed that SchB exerts sedative and hypnotic effects, increasing the content of γ-aminobutyric acid (GABA)...

journal_title：Experimental and therapeutic medicine

authors： Wang M,Li N,Jing S,Wang C,Sun J,Li H,Liu J,Chen J

更新日期：2020-12-01 00:00:00

abstract：:Chronic antibody-mediated rejection (ABMR) is a major cause of the transplant renal interstitial fibrosis and transplanted kidney epithelial cell transdifferentiation is one of the main mechanisms. The transforming growth factor (TGF)-β1/integrin-linked kinase (ILK) signaling pathway has a significant role in the epit...

journal_title：Experimental and therapeutic medicine

authors： Yan Q,Luo H,Wang B,Sui W,Zou G,Chen H,Zou H

更新日期：2017-05-01 00:00:00

abstract：:The present study aimed to apply the best single-energy (SE) scanning in energy spectrum computed tomography (CT) to evaluate the usefulness of lower extremity arterial angiography imaging in patients with lower extremity arterial occlusive disease. A total of 64 patients diagnosed with lower extremity arterial occlus...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Zhao D,Ling Z,Wang H,Yu S,Zhang J

更新日期：2019-08-01 00:00:00

abstract：:Vascular calcification (VC) caused by chronic kidney disease (CKD)-mineral and bone disorder is a common complication of CKD. Recent studies have demonstrated that menaquinone-4 (MK-4) is negativly associated with VC in patients with CKD. Furthermore, we have previously shown that runt-related transcription factor 2 (...

journal_title：Experimental and therapeutic medicine

authors： Cui L,Xu J,Zhang J,Zhang M,Zhang S,Bai Y

更新日期：2018-10-01 00:00:00

abstract：:Dysregulation of microRNAs serves a crucial role in the chemosensitivity to cisplatin (DDP) in ovarian cancer (OVC). The abnormal expression of microRNA (miR)-654-3p has been reported in several types of human cancer. However, the association between miR-654-3p and cisplatin resistance in human OVC remains unclear. Th...

journal_title：Experimental and therapeutic medicine

authors： Niu YC,Tong J,Shi XF,Zhang T

更新日期：2020-08-01 00:00:00

abstract：:The aim of the present study was to investigate the mechanism underlying the effects of different doses of agmatine in rats with chronic epilepsy. To generate chronic epilepsy models, rats pretreated with different doses of agmatine (20, 40 and 80 mg/kg) were intraperitoneally injected with pentylenetetrazole (35 mg/k...

journal_title：Experimental and therapeutic medicine

authors： Xu H,Ou F,Wang P,Naren M,Tu D,Zheng R

更新日期：2014-07-01 00:00:00