当前位置： SCI文献检索 > Experimental and Therapeutic Medicine期刊下所有文献 > Principles of antibiotic application in children with lobar pneumonia: Step-up or step-down.

Principles of antibiotic application in children with lobar pneumonia: Step-up or step-down.

Abstract：

:In order to provide a scientific basis for rational use of antibiotics, we studied and compared the therapeutic effects of step-down and step-up antibiotic treatment schemes in children with lobar pneumonia. Eighty cases of children with lobar pneumonia were enrolled in this study and were randomly divided into two groups: The observation group and the control group, with 40 cases in each group. In the observation group, there were 23 cases with mild and 17 cases with severe lobar pneumonia, and in the control group, 25 were mild and 15 were severe cases. Patients in the control group were treated with antibiotics using step-up therapy method, while patients in the observation group were treated using step-down antibiotic therapy. Our results showed no significant differences in white blood cell (WBC) reduction rate, the course of antibiotic treatment, disappearance time of pulmonary rales and total efficiency in children with mild lobar pneumonia in the observation group after 72 h of treatment. The level of high-sensitivity C-reactive protein (hs-CRP) and procalcitonin (PCT) in the observation group were significantly lower. After 72 h of treatment of children with severe lobar pneumonia in the observation group, the rate of WBC reduction accelerated significantly. Compared to the patients in the control group, the course of antibiotic treatment and disappearance time of pulmonary rales were shortened significantly, while the total efficiency of treatment was improved considerably in the observation group. Also in the observation group, hs-CRP and PCT levels were significantly lower than that in the control group. In severe cases, step-down therapy showed a better result in relieving the inflammatory reactions. The disappearance time of pulmonary rales and the effective rate of treatment was significantly higher than those of step-up therapy. It was obvious that for children with severe lobar pneumonia, step-down therapy produced better results in relieving the inflammatory reaction.

journal_name

Exp Ther Med

journal_title

Experimental and therapeutic medicine

authors

Li Y,Han F,Yang Y,Chu J

doi

10.3892/etm.2017.4319

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

2681-2684

issue

eissn

1792-0981

issn

1792-1015

pii

ETM-0-0-4319

journal_volume

pub_type

杂志文章

在线工具

Principles of antibiotic application in children with lobar pneumonia: Step-up or step-down.