Effects of recombinant human growth hormone in the treatment of dwarfism and relationship between IGF-1, IGFBP-3 and thyroid hormone.

abstract：:MicroRNAs (miRs) are a class of endogenous small non-coding RNAs that have been revealed to negatively mediate the expression of their target genes at the post-transcriptional level. Recently, particular miRs have demonstrated an involvement in the pathogenesis of Alzheimer's disease (AD). However, the specific role o...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Xing H,Guo S,Zheng Z,Wang H,Xu D

更新日期：2016-08-01 00:00:00

abstract：:Endometriosis (EM) is associated with oxidative stress. Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress, which serve an important role as an inflammatory mediator in various chronic diseases. In order to examine the role of AOPPs in infertile women with EM, the present study analyzed ...

journal_title：Experimental and therapeutic medicine

authors： Song Y,Liu J,Qiu Z,Chen D,Luo C,Liu X,Hua R,Zhu X,Lin Y,Li L,Liu W,Quan S

更新日期：2018-01-01 00:00:00

abstract：:Diabetic keratopathy is an ocular complication that occurs with diabetes. In the present study, the effect of diabetic keratopathy on corneal optical density, central corneal thickness, and corneal endothelial cell count was investigated. One hundred and eighty diabetic patients (360 eyes) were enrolled in the study d...

journal_title：Experimental and therapeutic medicine

authors： Gao F,Lin T,Pan Y

更新日期：2016-09-01 00:00:00

abstract：:The aim of the present study was to summarize the clinical characteristics of nocardiosis caused by Nocardia otitidiscaviarum in order to improve the knowledge of nocardiosis. A case of dissemination nocardiosis caused by N. otitidiscaviarum in an immunocompetent host is reported and the associated literature reviewed...

journal_title：Experimental and therapeutic medicine

authors： Jiang Y,Huang A,Fang Q

更新日期：2016-11-01 00:00:00

abstract：:The aim of the present study was to investigate the correlation between the protein expression of A-kinase anchor protein 95 (AKAP95), cyclin D3 and AKT with pathological indicators in lung cancer tissues. Immunohistochemistry was used to detect the protein expression levels of the proteins in 51 lung cancer tissue sa...

journal_title：Experimental and therapeutic medicine

authors： Yu X,Yuan Y,Zhi X,Teng B,Chen X,Huang Q,Chen Y,Guan Z,Zhang Y

更新日期：2015-09-01 00:00:00

abstract：:The efficacy of DNA vaccines may be improved by small interfering (si)RNA adjuvants targeting pro-apoptotic genes. The aim of the present study was to investigate the capacity of siRNAs targeting B-cell lymphoma 2 homologous antagonist killer (BAK) and B-cell lymphoma 2-associated X protein (BAX) to improve the effica...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Feng K,Zhao L,Luo H,Zhu Y

更新日期：2017-06-01 00:00:00

abstract：:The aim of the present study was to investigate the association between polymorphism in the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) in the promoter region of the 5-HTT gene and the pathogenesis of postpartum depression (PPD). Blood samples were collected from 120 female patients with PP...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Wang L,Huang F,Li J,Xiong L,Xue H,Zhang Y

更新日期：2015-01-01 00:00:00

abstract：:Aberrant methylation of gene promoter regions is one of the mechanisms for inactivation of tumor suppressor genes in human malignancies. In this study, the methylation pattern of 24 tumor suppressor genes was analyzed in 75 samples of ovarian cancer using the methylation-specific multiplex ligation-dependent probe amp...

journal_title：Experimental and therapeutic medicine

authors： Ozdemir F,Altinisik J,Karateke A,Coksuer H,Buyru N

更新日期：2012-12-01 00:00:00

abstract：:Chronic hepatitis B virus (CHB) infection is a burden on global healthcare and is associated with a higher risk of serious sequelae, including cirrhosis and hepatocellular carcinoma. The clinical application of entecavir as a treatment for CHB has produced positive outcomes, and so is an attractive form of pharmacolog...

journal_title：Experimental and therapeutic medicine

authors： Gai XD,Wu WF

更新日期：2017-10-01 00:00:00

abstract：:Women with endometrial cancer often undergo hysteroscopy during their diagnostic work-up. Whether or not the duration of hysteroscopy affects the rate of positive peritoneal cells and the duration of recurrence-free survival is unknown. In a retrospective multi-centre study, the records of 552 patients with endometria...

journal_title：Experimental and therapeutic medicine

authors： Tempfer C,Froese G,Buerkle B,Polterauer S,Grimm C,Concin N,Hofstetter G,Weigert M,Oehler MK

更新日期：2011-09-01 00:00:00

abstract：:Tanshinone IIA (TSIIA) is a major component of Salvia miltiorrhiza, a Chinese herb that exhibits a therapeutic effect on polycystic ovary syndrome (PCOS). The present study replicated PCOS via the neonatal treatment of estradiol in mice. Estrous cycles, body and ovarian weight, serum levels of testosterone and estradi...

journal_title：Experimental and therapeutic medicine

authors： Jin J,Hu QY,Xu WW,Zhu WJ,Liu B,Liu J,Wang W,Zhou HF

更新日期：2019-05-01 00:00:00

abstract：:To evaluate how metformin plus rosiglitazone affect serum adiponectin levels in people suffering from type 2 diabetes mellitus (T2DM), 240 patients having T2DM were selected in this cohort study. Included subjects were randomly and equally separated into three subsets: i) Group A (rosiglitazone group); ii) group B (me...

journal_title：Experimental and therapeutic medicine

authors： Nie JM,Li HF

更新日期：2017-09-01 00:00:00

abstract：:Many studies have found the function of nitric oxide (NO) in cancer as a pro-neoplastic vs. an anti-neoplastic effector, but the role of NO in hepatocellular carcinoma (HCC) remains unclear. The present study aimed to investigate the effects of nitric oxide (NO) on the biological behavior of the human hepatocellular c...

journal_title：Experimental and therapeutic medicine

authors： Zhou L,Zhang H,Wu J

更新日期：2016-05-01 00:00:00

abstract：:Late spontaneous recanalization (SR) of an occluded internal carotid artery (ICA) has been rarely reported and the prognosis of affected patients remains elusive. In the present study, the incidence of late SR of atherosclerotic occlusion of the ICA and associated outcomes were assessed in a single center. A total of ...

journal_title：Experimental and therapeutic medicine

authors： Wu H,Liu Y,Li B,Zhang H,Liu C

更新日期：2018-11-01 00:00:00

abstract：:This study aimed to investigate the reliability of ultrasound two-dimensional speckle tracking imaging (2D-STI) for the evaluation of myocardial ischemia in familial hypercholesterolemia (FH) patients. We recruited 28 patients clinically diagnosed with homozygous familial hypercholesterolemia (HoFH) and subjected them...

journal_title：Experimental and therapeutic medicine

authors： Song Y,Zhang RF,Liu Y

更新日期：2017-08-01 00:00:00

abstract：:The present study aimed to explore the treatment effects of Taohongsiwu decoction on the liver fibrosis in a rat model, as few prior studies have investigated the anti-fibrotic effects of Taohongsiwu decoction. High-performance liquid chromatography was used to measure the concentration of ferulic acid and hydrosafflo...

journal_title：Experimental and therapeutic medicine

authors： Wang T,Wu D,Li P,Zhang K,Tao S,Li Z,Li J

更新日期：2017-08-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is common in elderly patients. Senegenin, an active component of extracts from Polygala tenuifolia root, a traditional Chinese medicine, has neuroprotective and neuroregenerative effects. However, the mechanism underlying the effects of senegenin against postoperative cogniti...

journal_title：Experimental and therapeutic medicine

authors： Yu L,Sun L,Chen S

更新日期：2014-04-01 00:00:00

abstract：:Apoptosis occurring secondary to spinal cord injury (SCI) causes further neural damage and functional loss. In this study, a rat model was used to investigate the effect of treadmill exercise on SCI-induced apoptosis and expression of neurotrophic factors. To produce SCI, a contusion injury (10 g × 25 mm) was applied ...

journal_title：Experimental and therapeutic medicine

authors： Jung SY,Kim DY,Yune TY,Shin DH,Baek SB,Kim CJ

更新日期：2014-03-01 00:00:00

abstract：:Expression of TGF-β1 and miR-99a in patients with early spontaneous abortion and correlation with hormone levels during pregnancy were investigated. A total of 70 pregnant women with early spontaneous abortion diagnosed in Jining No. 1 People's Hospital from February 1, 2015 to May 1, 2018 were selected as the study g...

journal_title：Experimental and therapeutic medicine

authors： Xie J,Cao Y

更新日期：2019-06-01 00:00:00

abstract：:The aim of this study was to investigate the pathogenesis of autophagy and apoptosis mediated by Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signal pathway after the onset of acute spinal cord injury (ASCI). A total of 45 Sprague-Dawley adult rats of either sex were selected for this...

journal_title：Experimental and therapeutic medicine

authors： Xia Y,Xia H,Chen D,Liao Z,Yan Y

更新日期：2017-08-01 00:00:00

abstract：:Effects of curcumin on artery blood gas index of rats with pulmonary fibrosis caused by paraquat poisoning and the expression of Mothers against decapentaplegic homolog 4 (Smad4), Smad ubiquitination regulatory factor 2 (Smurf2), interleukin-4 (IL-4) and interferon-γ (IFN-γ) were explored. A total of 54 Wistar rats we...

journal_title：Experimental and therapeutic medicine

authors： Chen H,Yang R,Tang Y,Fu X

更新日期：2019-05-01 00:00:00

abstract：:High mobility group box chromosomal protein 1 (HMGB1) is an important proinflammatory molecule in a number of inflammatory disorders, but little is known about its role in acute-on-chronic liver failure (ACLF). To elucidate the role of HMGB1 in ACLF, the expression of HMGB1 in liver specimens from patients with ACLF w...

journal_title：Experimental and therapeutic medicine

authors： Xu H,Li H,Qu Y,Zheng J,Lu J

更新日期：2014-10-01 00:00:00

abstract：:The aim of this study was to analyze the clinical features of hepatitis B surface antigen (HBsAg)-positive and negative diffuse large B-cell lymphomas (DLBCLs) and to compare the outcomes and serum hepatitis B virus (HBV)-DNA loads of patients treated with cyclophosphamide, doxorubicin, vincristine and prednisone (CHO...

journal_title：Experimental and therapeutic medicine

authors： Xie W,Zhou D,Hu K,Xiao X,Huang W,He J,Shi J,Luo Y,Zhang J,Lin M,Cai Z,Huang H,Ye X

更新日期：2013-07-01 00:00:00

abstract：:Evaluation of multi-slice CT angiography (MSCTA) and digital subtraction angiography (DSA) was made through the comparison of the two methods in detecting the blood supply of meningiomas, providing further clues for the improved application of MSCTA and DSA in the blood supply of meningiomas. In this study, 20 patient...

journal_title：Experimental and therapeutic medicine

authors： Han X,Zhan Y,Chen J

更新日期：2012-01-01 00:00:00

abstract：:The aim of the present study was to explore the association between the M235T polymorphism of the angiotensinogen (AGT) gene and cytokines in patients with essential hypertension (EH). A total of 300 patients with EH and an age-matched control group of 150 individuals without EH, secondary hypertension, myocardial inf...

journal_title：Experimental and therapeutic medicine

authors： Cheng JL,Wang AL,Wan J

更新日期：2012-03-01 00:00:00

abstract：:The CC chemokine receptor 9 (CCR9) and its natural secreted ligand CC motif chemokine ligand 25 (CCL25) have been implicated in cancer metastasis. However, their metastatic potential in non-small cell lung cancer (NSCLC) remains unclear. In the present study, immunohistochemistry was used to detect the expression and ...

journal_title：Experimental and therapeutic medicine

authors： Niu Y,Tang D,Fan L,Gao W,Lin H

更新日期：2020-06-01 00:00:00

abstract：:The aim of the study was to investigate the possibility of human umbilical cord mesenchymal stem cells (UC-MSCs) surviving and differentiating into hepatocyte-like cells in partially hepatectomized model rats. MSCs were isolated from human umbilical cord and cultured with collagenase digestion. Cell surface markers we...

journal_title：Experimental and therapeutic medicine

authors： Chen Z,Kuang Q,Lao XJ,Yang J,Huang W,Zhou D

更新日期：2016-09-01 00:00:00

abstract：:Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have previously been associated with a predisposition to pituitary adenomas. However, to the best of our knowledge, mutations in AIP that relate specifically to sporadic non-functioning pituitary adenomas (NFPAs) have yet to be reported. Therefo...

journal_title：Experimental and therapeutic medicine

authors： Hu Y,Yang J,Chang Y,Ma S,Qi J

更新日期：2016-03-01 00:00:00

abstract：:We previously reported that cyclin E (CCNE1) amplification is strongly associated with resistance to treatment in serous ovarian cancer by high-resolution oligonucleotide copy number analysis. Dysregulation of cell cycle control has been implicated as the key event in human oncogenesis, and aberrant expression of G1-S...

journal_title：Experimental and therapeutic medicine

authors： Hashimoto T,Yanaihara N,Okamoto A,Nikaido T,Saito M,Takakura S,Yasuda M,Sasaki H,Ochiai K,Tanaka T

更新日期：2011-03-01 00:00:00

abstract：:The aim of the present study was to investigate the functional status of dendritic cells (DCs) in nasal polyps (NP) and their interactions with T lymphocytes. The interactions between DC and T lymphocytes in the pathogenesis of NP was also studied. The expression of cluster of differentiation (CD)1a and CD83 in NP was...

journal_title：Experimental and therapeutic medicine

authors： Lin X,Zhuang X,Li C,Wang X

更新日期：2018-06-01 00:00:00