Abstract：
:The present study was an open-label, prospective, uncontrolled and multicenter clinical trial to investigate the safety and effectiveness of bevacizumab (Lumiere®) administered by the intravitreal route for the treatment of neovascular age-related macular degeneration (nAMD). A total of 22 patients without previous treatment with anti-vascular endothelial growth factor were recruited. Monthly therapy with 1.25 mg intravitreal bevacizumab was applied. Adverse events (AE), visual acuity (VA) and central retinal thickness (CRT) were assessed at baseline, day 1 and day 28 after each injection. A total of 87 AEs were reported; most of them were not serious (96.6%), expected (65.5%) and occurred after the third injection (56.3%). The most frequent AE was 'conjunctival hemorrhage' (29.9% of AEs), attributed to the injection procedure. Treatment was not suspended due to safety reasons in any case. After six months, a statistically significant gain of +8.2 (SD±8.8) letters and a CRT reduction of -75.50 µm (SD±120.3) were achieved with unilateral therapy. VA improvement and CRT reduction were also achieved with bilateral therapy, although to a lesser extent. The results of the present study suggested that therapy with a minimum of 3 doses of bevacizumab over a 6-month period was well tolerated and resulted in a sustained response regarding VA improvement and CRT reduction from the beginning of therapy compared with the baseline value. The study protocol was registered at clinicaltrials.gov (ref. no. NCT03668054).
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Benisek DA,Manzitti J,Scorsetti D,Rousselot Ascarza AM,Ascarza AA,Gomez Rancaño D,Quercia R,Ramirez Gismondi M,Carpio Total MA,Scorsetti ML,Spitzer E,Lombas C,Deprati M,Penna MI,Fernández F,Tinelli MAdoi
10.3892/etm.2020.9291subject
Has Abstractpub_date
2020-12-01 00:00:00pages
162issue
6eissn
1792-0981issn
1792-1015pii
ETM-0-0-09291journal_volume
20pub_type
杂志文章abstract：:[This corrects the article DOI: 10.3892/etm.2017.4943.]. ...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章,已发布勘误
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abstract：:Pulmonary arterial hypertension (PAH) is a progressive disease with a high mortality rate. Previous studies have revealed the important function of the β3 adrenergic receptor (β3-AR) in cardiovascular diseases, and the potential beneficial effects of numerous β3-AR agonists on pulmonary vasodilation. Conversely, a num...
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abstract：:Driving under the influence of alcohol and/or psychoactive substances increases the risk of severe, even fatal motor vehicle accidents. The aim of this descriptive study was to present the impact of alcohol and/or psychoactive substances on fatal road traffic accidents (RTAs) during the period 2011-2017. For this purp...
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journal_title：Experimental and therapeutic medicine
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doi：10.3892/etm.2016.3634
更新日期：2016-10-01 00:00:00
abstract：:The aim of this study was to evaluate the application of acoustic radiation force impulse (ARFI) ultrasound imaging and its potential value in the characterization of cervical cancer. ARFI ultrasound imaging of the uterine cervix was performed in 58 patients with cervical cancer prior to surgery. The diagnosis of cerv...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
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更新日期：2013-06-01 00:00:00
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journal_title：Experimental and therapeutic medicine
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pub_type： 杂志文章
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更新日期：2021-01-01 00:00:00
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journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2017.5494
更新日期：2018-01-01 00:00:00
abstract：:Non-small cell lung cancer (NSCLC) accounts for ~80% of all types of lung cancer, which has the highest morbidity and mortality of all types of cancer worldwide. It is important to identify novel biomarkers and the molecular mechanism of NSCLC to improve current treatments of NSCLC. The present study aimed to investig...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：Experimental and therapeutic medicine
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journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
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更新日期：2015-05-01 00:00:00
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journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
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更新日期：2015-03-01 00:00:00
abstract：:This study was designed to investigate the clinical efficacy of intravenous anesthesia on breast segmental surgery and the effects on hemodynamics of patients. A total of 267 patients were collected as research subjects. These patients underwent breast segmental surgery in Chun'an First People's Hospital from March 20...
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abstract：:The aim of this study was to observe the effects of cluster of differentiation (CD) 151 on the expression of vascular endothelial growth factor (VEGF) in ischemic myocardium by the injection of a recombinant adeno-associated virus (rAAV) vector carrying the human CD151 gene. A rat acute myocardial infarction model was...
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journal_title：Experimental and therapeutic medicine
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journal_title：Experimental and therapeutic medicine
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journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
abstract：:The present study aimed to investigate the role and mechanism of microRNA-539 (miR-539) in rheumatoid arthritis (RA). A total of 68 RA patients and 46 osteoarthritis patients were enrolled into the current study. Peripheral blood and joint fluid were collected prior to treatment. Reverse transcription-quantitative pol...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
abstract：:[This corrects the article DOI: 10.3892/etm.2016.3317.]. ...
journal_title：Experimental and therapeutic medicine
pub_type： 已发布勘误
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journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
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journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
abstract：:Obstructive salivary gland diseases are common conditions that arise following the disruption of the secretary ductal system and usually results in the swelling and pain of the affected gland(s). There has been an increase in the use of sialendoscopy for the treatment and diagnosis of obstructive salivary gland infect...
journal_title：Experimental and therapeutic medicine
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abstract：:The present study examined the effectiveness of the method of inversing the distal clavicle anatomic locking plate to treat medial-end clavicle fractures. This involved retrospectively analyzing six cases of medial-end clavicle fractures treated using the method of inversing the distal clavicle anatomic locking plate ...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
abstract：:Capillary density on nailfold capillaroscopy (NFC) is considered a promising instrument for assessing disease characteristics in patients with systemic sclerosis (SSc), however, there is no agreement yet over how to analyze and interpret the results. The objective of this study was to investigate the possible associat...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
abstract：:Effect of total glucosides of paeony on the changes of IL-4 and ICAM-1 levels in eczema mouse model serum was investigated. A total of 38 KM mice of SPF grade were divided into 3 groups: the control group (n=10), the model group (n=15) and the treatment group (n=13). The pathological model of chronic eczema in mouse r...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章
doi：10.3892/etm.2018.7122
更新日期：2019-03-01 00:00:00
