Comparison of laparoscopy-assisted surgery and laparotomy for treating locally advanced distal gastric antral cancer.

abstract：:The aim of the present study was to investigate the effect of microRNA (miR)-92a on cystatin C expression in patients with type II diabetes and lower limb ischemia. A total of 199 patients diagnosed with type II diabetes were included in the study and divided into three experimental groups: Simple type II diabetes mel...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Guan Q,Jin X

更新日期：2015-06-01 00:00:00

abstract：:Fluvoxamine, a common antidepressant agent, is designed to exert its pharmacological effect by inhibiting synaptic serotonin reuptake. However, increasing evidence has demonstrated that σ1 receptors are likely to be involved in the mechanism of action of fluvoxamine. The present study aimed to observe the effects of f...

journal_title：Experimental and therapeutic medicine

authors： Su DA,Jiang RY,Liu N,Ding LC,Wang DM,Yu HY,Yan ES,Zhu MH,Zhu B

更新日期：2014-02-01 00:00:00

abstract：:The objective of this study was to investigate the protective effects of scopolamine and penehyclidine hydrochloride on acute cerebral ischemia-reperfusion injury after cardiopulmonary resuscitation, and the effect on cytokine levels. Eighty patients with cardiac arrest admitted to our hospital from June 2011 to Decem...

journal_title：Experimental and therapeutic medicine

authors： Wang D,Jiang Q,Du X

更新日期：2018-02-01 00:00:00

abstract：:In the development of anti-blood cancer drugs, the chronic myelocytic leukemia (KU812), acute myelocytic leukemia (KG-1) and lymphoma (U937) cell lines are commonly used in preclinical pharmacology studies as human cancer xenograft models in mice. In the present study, mRNA expression levels of typical human ATP-bindi...

journal_title：Experimental and therapeutic medicine

authors： Takeuchi K,Shibata M,Kashiyama E,Umehara K

更新日期：2012-09-01 00:00:00

abstract：:B-cell lymphoma 6 (BCL6), a proto-oncogene, is an evolutionarily conserved zinc finger protein that functions as a transcriptional repressor. BCL6 is the master regulator of B-lymphocyte development, and it has been reported that BCL6 may serve an important role in breast cancer progression. The aim of the present stu...

journal_title：Experimental and therapeutic medicine

authors： Ang L,Zheng L,Wang J,Huang J,Hu HG,Zou Q,Zhao Y,Liu QM,Zhao M,Wu ZS

更新日期：2017-11-01 00:00:00

abstract：:Angelicin is an active compound isolated from the Chinese herb Angelica archangelica, which has been reported to exert antitumor effects by inhibiting malignant behaviors in several types of tumor, including proliferation, colony formation, migration and invasion. However, the effects of angelicin on human cervical ca...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Chen Y,Chen X,Liang Y,Yang D,Dong J,Yang N,Liang Z

更新日期：2019-11-01 00:00:00

abstract：:The aim of this study was to characterize the clinical and genetic features of a 4-year-old female with merosin-deficient congenital muscular dystrophy type 1A (MDC1A). MDC1A is the most common form of congenital muscular dystrophy. MDC1A is caused by mutation of the laminin α-2 gene (LAMA2), localized to chromosome 6...

journal_title：Experimental and therapeutic medicine

authors： He Z,Luo X,Liang L,Li P,Li D,Zhe M

更新日期：2013-11-01 00:00:00

abstract：:Human serum albumin (HSA) is a transporting protein that has multiple functions. The binding interaction between HSA and small molecules affects its function and efficacy of small molecules. The present study reports that kaempferol-7-O-α-L-rhamnopyranoside (KR) interacts with HSA as indicated by multiple fluorescence...

journal_title：Experimental and therapeutic medicine

authors： Zhang W,Chen C,Zhang C,Duan J,Yao H,Li Y,Meng A,Shi J

更新日期：2017-06-01 00:00:00

abstract：:GATA4, a member of the GATA family, serves a key function in several types of cancer, including hepatoblastoma, gastric cancer and breast cancer. However, the function of GATA4 in nasopharyngeal cancer (NPC) is largely unknown. The present study revealed that GATA4 was upregulated in NPC tissue samples and the NPC cel...

journal_title：Experimental and therapeutic medicine

authors： Zhou Y,Chang H,Yang B

更新日期：2018-12-01 00:00:00

abstract：:Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer with increasing incidence. In recent years, several microRNAs (miRs) have been demonstrated to serve an oncogenic or tumor suppressive role in CSCC. However, the exact role of miR-34a in CSCC and the underlying regulatory mechanism ...

journal_title：Experimental and therapeutic medicine

authors： Li S,Luo C,Zhou J,Zhang Y

更新日期：2017-12-01 00:00:00

abstract：:Alzheimer's disease (AD) brains demonstrate decreased levels of brain-derived neurotrophic factor (BDNF) and increased levels of β-amyloid peptide (Aβ), which is neurotoxic. The present study assessed the impact of BDNF on the toxic effects of Aβ25-35-induced apoptosis and the effects on BDNF-mediated signaling using ...

journal_title：Experimental and therapeutic medicine

authors： Kim JH

更新日期：2014-12-01 00:00:00

abstract：:Caspase-8 (encoded by the CASP-8 gene) is crucial in generating cell death signals and eliminating potentially malignant cells. Genetic variation in CASP8 may affect susceptibility to cancer. The CASP-8 -652 6N ins/del (rs3834129) polymorphism has been previously reported to influence the progression to several cancer...

journal_title：Experimental and therapeutic medicine

authors： Chen D,Ma T,Liu XW,Liu Z

更新日期：2012-10-01 00:00:00

abstract：:Mitochondrial factor and cell cytokines play important roles in the incidence of vascular dementia (VD), but their correlations with inflammatory and mitochondrial factors and the role of both in the kidney essence deficiency pattern and phlegm turbidity blocking orifice pattern are not clear. This study was aimed at ...

journal_title：Experimental and therapeutic medicine

authors： Sun L

更新日期：2018-01-01 00:00:00

abstract：:Resistance to platinum-based chemotherapy frequently poses a serious problem in the treatment of head and neck squamous cell carcinoma. In this study, we isolated cisplatin-resistant cells from a head and neck squamous cell carcinoma cell line. The mismatch repair (MMR) system is known as one of the cisplatin-resistan...

journal_title：Experimental and therapeutic medicine

authors： Adachi M,Ijichi K,Hasegawa Y,Nakamura H,Ogawa T,Kanematsu N

更新日期：2010-01-01 00:00:00

abstract：:In this study, to assess whether aqueous and ethanol fractions of Angelica keiskei induce acute skin irritation and phototoxicity, acute skin irritancy and phototoxicity tests were performed. The skin of rabbits or guinea pigs was treated with these fractions (100 mg/dose) and whether the animals sustained significant...

journal_title：Experimental and therapeutic medicine

authors： Lee SH

更新日期：2013-01-01 00:00:00

abstract：:The pathogenesis underlying alcoholic liver disease (ALD), which is often a result of alcohol abuse, currently remains unclear. Previous studies have reported that enteric dysbiosis serves an important role in the pathogenesis of ALD. The present study aimed to investigate the effects of glutamine and probiotics on a ...

journal_title：Experimental and therapeutic medicine

authors： Huang H,Lin Z,Zeng Y,Lin X,Zhang Y

更新日期：2019-12-01 00:00:00

abstract：:DNA methylation is known to regulate the expression of numerous genes but its role in the pathogenesis of thoracic aortic dissection (TAD) has remained largely elusive. In the present study, the DNA methylome of patients with TAD was analyzed using a methylation microarray and bisulfite pyrosequencing was used to dete...

journal_title：Experimental and therapeutic medicine

authors： Li N,Lin H,Zhou H,Zheng D,Xu G,Shi H,Zhu X,Gao J,Shao G,Sun L

更新日期：2020-08-01 00:00:00

abstract：:Mutations of the β-catenin gene are common in various cancer types. MicroRNA (miR)-24 suppresses gene expression during the cell cycle. However, the effects of miR-24 on the cell viability and autophagy of glioma cells, and how these biological processes are regulated by β-catenin are largely unclear. The current stud...

journal_title：Experimental and therapeutic medicine

authors： Chen H,Lu Q,Chen C,Di Y,Li Y,Min W,Yu Z,Dai D

更新日期：2019-08-01 00:00:00

abstract：:Although there has been progress moving from a 'one-size-fits-all' cytotoxic approach to personalized molecular medicine, the majority of patients with cancer receive chemotherapy using cytotoxic anticancer drugs. The sequencing analysis of 409 genes associated with cancer was conducted in the present study using 59 D...

journal_title：Experimental and therapeutic medicine

authors： Udagawa C,Sasaki Y,Suemizu H,Ohnishi Y,Ohnishi H,Tokino T,Zembutsu H

更新日期：2018-02-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of target-controlled infusion (TCI) of propofol and remifentanil combined with dexmedetomidine on functional endoscopic sinus surgery (FESS) bleeding and surgical field. 62 patients scheduled to undergo FESS were randomly divided into experimental group (intr...

journal_title：Experimental and therapeutic medicine

authors： Ding DF,Wu LF,Wang P,Jiang YX,Luo YW,Dai ZL,Zhang XP,Li YL

更新日期：2017-11-01 00:00:00

abstract：:The present study was an open-label, prospective, uncontrolled and multicenter clinical trial to investigate the safety and effectiveness of bevacizumab (Lumiere®) administered by the intravitreal route for the treatment of neovascular age-related macular degeneration (nAMD). A total of 22 patients without previous tr...

journal_title：Experimental and therapeutic medicine

authors： Benisek DA,Manzitti J,Scorsetti D,Rousselot Ascarza AM,Ascarza AA,Gomez Rancaño D,Quercia R,Ramirez Gismondi M,Carpio Total MA,Scorsetti ML,Spitzer E,Lombas C,Deprati M,Penna MI,Fernández F,Tinelli MA

更新日期：2020-12-01 00:00:00

abstract：:Active P-glycoprotein (P-gp) molecules have been shown to transport steroids out of peripheral lymphocytes, resulting in poor responses to systemic steroid therapy in patients with systemic lupus erythematosus (SLE). This study was carried out to investigate the correlation between the expression or activity of P-gp i...

journal_title：Experimental and therapeutic medicine

authors： Zhang B,Shi Y,Lei TC

更新日期：2012-10-01 00:00:00

abstract：:Action potential (AP) contours vary considerably between the fibers of normal adult and aged left atria. The underlying ionic and molecular mechanisms that mediate these differences remain unknown. The aim of the present study was to investigate whether the L-type calcium current (ICa.L) and the L-type Ca2+ channel of...

journal_title：Experimental and therapeutic medicine

authors： Gan TY,Qiao W,Xu GJ,Zhou XH,Tang BP,Song JG,Li YD,Zhang J,Li FP,Mao T,Jiang T

更新日期：2013-10-01 00:00:00

abstract：:Chrysin is a major active ingredient of flavonoids, known to exhibit protective effects against various types of cancer. However, the anticancer role of chrysin against hepatocellular carcinoma (HCC) and the underlying molecular mechanisms remain unclear. In order to evaluate the effects of chrysin on cell viability a...

journal_title：Experimental and therapeutic medicine

authors： Zhang Q,Ma S,Liu B,Liu J,Zhu R,Li M

更新日期：2016-07-01 00:00:00

abstract：:Primary lung enteric adenocarcinoma is a rare type of invasive lung carcinoma. Its morphology and immunohistochemistry are those of colorectal carcinoma, but there is no associated primary colorectal carcinoma. The present study describes the case of a 53-year-old female who presented with an irritating cough and a ma...

journal_title：Experimental and therapeutic medicine

authors： Lin LI,Xu CW,Zhang BO,Liu RR,Ge FJ,Zhao CH,Jia RU,Qin QH,Stojsic J,Wang Y,Xu JM

更新日期：2016-01-01 00:00:00

abstract：:To investigate the effects of propofol on myocardial ischemia reperfusion in rats with type 2 diabetes, male adult rats were divided into five groups: Sham-operation (CC), ischemia-reperfusion (CI), low-dose propofol (LP), moderate-dose propofol (MP) and high-dose propofol (HP). The LP, MP and HP groups were administe...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Zhang K,Qi X,Yang G,Wang H,Zhang Z,Yang B

更新日期：2020-04-01 00:00:00

abstract：:The aim of this study was to evaluate the efficacy and safety of polyethylene glycol 4000 (PEG 4000) for the treatment of constipation in children over 8 years of age. A total of 216 children from 7 hospitals were enrolled. A total of 105 patients received oral PEG 4000 (20 g/day) and 111 patients received oral lactul...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Wang B,Jiang X,Jiang M,Xu C,Shao C,Jia L,Huang Z,Xu X,Liu H,Shang L

更新日期：2012-05-01 00:00:00

abstract：:The global incidence of melanoma is increasing. Mortality from melanoma is influenced primarily by metastasis in advanced stages of the disease. Current treatments are largely ineffective; thus, novel gene delivery approaches that target tumor-specific markers may be useful for the treatment of melanoma. Systemic admi...

journal_title：Experimental and therapeutic medicine

authors： Saavedra-Alonso S,Zapata-Benavides P,Chavez-Escamilla AK,Manilla-Muñoz E,Zamora-Avila DE,Franco-Molina MA,Rodriguez-Padilla C

更新日期：2016-12-01 00:00:00

abstract：:Uncommon causes of nail failures and surgical reinterventions were determined. The study included 23 osteoporotic patients, 13 of whom followed a fast recovery program with early walking (FWB group). The other 10 patients were not allowed full weight bearing until 6 weeks (NFWB group). The T-score was determined befor...

journal_title：Experimental and therapeutic medicine

authors： Dragosloveanu Ş,Dragosloveanu CDM,Stanca HT,Cotor DC,Dragosloveanu CI,Stoica CI

更新日期：2020-12-01 00:00:00

abstract：:Scabies is a contagious skin disease that causes extremely itching. It is a parasitic disease caused by the mite Sarcoptes scabiei and characterized by polymorphous lesions. Vesicular and bullous lesions in cases of scabies are rather rare. Bullous scabies has a pemphigoid presentation. Crusted scabies, also known as ...

journal_title：Experimental and therapeutic medicine

authors： Su WJ,Fang S,Chen AJ,Shan K

更新日期：2015-10-01 00:00:00