Abstract:
:Coronaviruses may exert severely negative effects on the mortality and morbidity of birds and mammals including humans and domestic animals. Most recently CoVID-19 has killed about half million people (27th of June, 2020). Susceptibility to this disease appears to differ markedly across different societies but the factors underlying this variability are not known. Given that prevalence of toxoplasmosis in human societies may serve as a proxy for hygiene, and it also exerts both direct and immune-mediated antiviral effects, we hypothesize a negative covariation between toxoplasmosis and measures of the CoVID-19 pandemic across countries. We obtained aged-adjusted toxoplasmosis prevalence of pregnant women from the literature. Since the differences in the CoVID-19 morbidity and mortality may depend on the different timing of the epidemics in each country, we applied the date of first documented CoVID-19 in each country as a proxy of susceptibility, with a statistical control for population size effects. Using these two indices, we show a highly significant negative co-variation between the two pandemics across 86 countries. Then, considering that the wealth of nations often co-varies with the prevalence of diseases, we introduced GDP per capita into our model. The prevalence of toxoplasmosis co-varies negatively, while the date of first CoVID-19 co-varies positively with GDP per capita across countries. Further, to control for the strong spatial autocorrelation among countries, we carried out a Spatial Structure Analyses of the relationships between the date of first CoVID-19, prevalence of toxoplasmosis, and GDP per capita. Results of this analysis did not confirm a direct causal relationship between toxoplasmosis and susceptibility to the CoVID-19 pandemics. As far as an analysis of observational data let us to suggest, it appears that the interaction between CoVID-19 and toxoplasmosis is mediated by GDP per capita and spatial effects. This prompts the question whether the formerly known covariations of CoVID-19 and BCG vaccination or air pollution might have also emerged as spurious indirect effects.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jankowiak Ł,Rozsa L,Tryjanowski P,Møller APdoi
10.1038/s41598-020-69351-xsubject
Has Abstractpub_date
2020-07-27 00:00:00pages
12512issue
1issn
2045-2322pii
10.1038/s41598-020-69351-xjournal_volume
10pub_type
杂志文章abstract::Scattered and indirect evidence suggests that sea ice occurred as far south as the Iceland Sea during the Early Pliocene, when the global climate was warmer than present. However, conclusive evidence as well as potential mechanisms governing sea ice occurrence outside the Arctic Ocean during a time with elevated green...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37047-y
更新日期:2019-01-30 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-42491-5
更新日期:2019-05-03 00:00:00
abstract::The secreted Ly-6/uPAR Related Protein-1 (SLURP1) is an immunomodulatory protein that promotes corneal immune- and angiogenic-privilege. Here, we have examined the influence of SLURP1 on neutrophil-vascular endothelial cell interactions using human umbilical vein endothelial cells (HUVEC) and differentiated neutrophil...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42437-x
更新日期:2019-04-11 00:00:00
abstract::The current study aims at characterizing the mechanisms that allow humans to entrain the mind and body to incoming rhythmic sensory inputs in real time. We addressed this unresolved issue by examining the relationship between covert neural processes and overt behavior in the context of musical rhythm. We measured temp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20612
更新日期:2016-02-05 00:00:00
abstract::We analyze a transition from single peaked to bimodal velocity distribution in a relativistic fluid under increasing temperature, in contrast with a non-relativistic gas, where only a monotonic broadening of the bell-shaped distribution is observed. Such transition results from the interplay between the raise in therm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00611
更新日期:2012-01-01 00:00:00
abstract::Bacterial infections are a major threat to the health of patients in healthcare facilities including hospitals. One of the major causes of patient morbidity is infection with Staphylococcus aureus. One of the the most dominant nosocomial bacteria, Methicillin Resistant Staphylococcus aureus (MRSA) have been reported t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24770
更新日期:2016-04-21 00:00:00
abstract::The present research relates to a fusion protein comprising a chromogenic blue ultramarine protein (UM) bound to a keratin-based peptide (KP). The KP-UM fusion protein explores UM chromogenic nature together with KP affinity towards hair. For the first time a fusion protein with a chromogenic nature is explored as a h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50283-0
更新日期:2019-10-01 00:00:00
abstract::Structural polymeric materials incorporating a microencapsulated liquid healing agent demonstrate the ability to autonomously heal cracks. Understanding how an advancing crack interacts with the microcapsules is critical to optimizing performance through tailoring the size, distribution and density of these capsules. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54242-7
更新日期:2019-11-28 00:00:00
abstract::Cytochrome P450 (CYP) 3A accounts for nearly 30% of the total CYP enzymes in the human liver and participates in the metabolism of over 50% of clinical drugs. Moreover, CYP3A plays an important role in chemical metabolism, toxicity, and carcinogenicity. New animal models are needed to investigate CYP3A functions, espe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42922
更新日期:2017-02-20 00:00:00
abstract::The accurate diagnosis of malignant cervical lymphadenopathy remains challenging. In this study, we determined the value of quantitative parameters derived from dual-energy computed tomography (DECT) for differentiating malignant cervical lymphadenopathy caused by thyroid carcinoma (TC), salivary gland carcinoma (SC),...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31020
更新日期:2016-08-08 00:00:00
abstract::This study aimed to evaluate the effects of ischemia-reperfusion injury (IRI) on the risk of hepatocellular carcinoma (HCC) recurrence after liver transplantation. Data of 195 patients were retrospectively analysed. Post-reperfusion aspartate (AST), alanine transaminase, and lactate dehydrogenase (LDH) levels were the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27319-y
更新日期:2018-06-12 00:00:00
abstract::In mature erythrocytes, glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) yield NADPH, a crucial cofactor of the enzyme glutathione reductase (GR) converting glutathione disulfide (GSSG) into its reduced state (GSH). GSH is essential for detoxification processes in and survival of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28754
更新日期:2016-06-29 00:00:00
abstract::Diminished microRNA-29b levels have recently been revealed to provoke increased expression and accumulation of extracellular matrix molecules, such as collagens in fibrotic remodeling. Subsequently, the aim of this study was to find out whether microRNA-29b might also regulate human xylosyltransferase (XT)-I expressio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36217-2
更新日期:2018-12-12 00:00:00
abstract::Oxidative stress is one of the strongest toxic factors in nature: it can harm or even kill cells. Cellular means of subverting the toxicity of oxidative stress are important for the success of infectious diseases. Many types of bacterium inhabit the intestine, where they can encounter pathogens. During oxidative stres...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27086-w
更新日期:2018-06-13 00:00:00
abstract::Calcium-activated potassium ion channel-3.1 (KCa3.1) plays a pivotal role in the potassium-calcium exchange involved in atopy. This study aimed to explore the impact of lentiviral-mediated shRNA silencing KCa3.1 on allergic response in a murine allergic rhinitis (AR) model. The BALB/c mice were divided into four group...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13127
更新日期:2015-08-14 00:00:00
abstract::There is strong in vitro cell survival evidence that the relative biological effectiveness (RBE) of protons is variable, with dependence on factors such as linear energy transfer (LET) and dose. This is coupled with the growing in vivo evidence, from post-treatment image change analysis, of a variable RBE. Despite thi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56258-5
更新日期:2019-12-27 00:00:00
abstract::Due to their unique properties, Weyl semimetals (WSMs) are promising materials for the future electronics. Currently, the two types (I and II) of WSMs are discovered experimentally. These types of WSMs differ from each other in their topological properties. In this paper we showed that a coexistence of types I and II ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32104-y
更新日期:2018-09-12 00:00:00
abstract::Imaging the distribution of sphingomyelin (SM) in membranes is an important issue in lipid-raft research. Recently we developed novel fluorescent SM analogs that exhibit partition and dynamic behaviors similar to native SM, and succeeded in visualizing lateral domain-segregation between SM-rich liquid-ordered (Lo) and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16361-x
更新日期:2017-12-01 00:00:00
abstract::The ecosystem of the Source Region of Yangtze River (SRYR) is highly susceptible to climate change. In this study, the spatial-temporal variation of NPP from 2000 to 2014 was analyzed, using outputs of Carnegie-Ames-Stanford Approach model. Then the correlation characteristics of NPP and climatic factors were evaluate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80494-9
更新日期:2021-01-14 00:00:00
abstract::Local communities are assembled from larger-scale species pools via dispersal, environmental filtering, biotic interactions, and local stochastic demographic processes. The relative importance, scaling and interplay of these assembly processes can be elucidated by comparing local communities to variously circumscribed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09337
更新日期:2015-03-23 00:00:00
abstract::We investigated if fermentation with probiotic cultures could improve the production of health-promoting biological compounds in Astragalus membranaceus. We tested the probiotics Enterococcus faecium, Lactobacillus plantarum and Enterococcus faecium + Lactobacillus plantarum and applied PacBio single molecule, real-ti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30288-x
更新日期:2018-08-08 00:00:00
abstract::C4.4A is a modular glycolipid-anchored Ly6/uPAR/α-neurotoxin multidomain protein that exhibits a prominent membrane-associated expression in stratified squamous epithelia. C4.4A is also expressed in various solid cancer lesions, where high expression levels often are correlated to poor prognosis. Circumstantial eviden...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25833
更新日期:2016-05-12 00:00:00
abstract::There have been no large nationwide birth cohort studies examining for the effects of maternal alcohol use during pregnancy on placental abnormality. This study searched for associations between alcohol consumption and the placental abnormalities of placenta previa, placental abruption, and placenta accreta using the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46760-1
更新日期:2019-07-16 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-57947-2
更新日期:2020-01-30 00:00:00
abstract::The photo-reduction of metal ions in solution induced by femtosecond laser is an important and novel method for fabricating three-dimensional metal microstructures. However, the nonlinear absorption cross section of metal ions remains unknown because its measurement is difficult. In the present study, a method based o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17712
更新日期:2015-12-11 00:00:00
abstract::A new and facile approach to selectively functionalize the internal and external surfaces of porous silicon (pSi) for drug delivery applications is reported. To provide a surface that is suitable for sustained drug release of the hydrophobic cancer chemotherapy drug camptothecin (CPT), the internal surfaces of pSi fil...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37750-w
更新日期:2019-02-04 00:00:00
abstract::Grapevine is an important and extensively grown fruit crop, which is severely hampered by drought worldwide. So, comprehending the impact of drought on grapevine genetic resources is necessary. In the present study, RNA-sequencing was executed using cDNA libraries constructed from both drought-stress and control plant...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13464-3
更新日期:2017-10-13 00:00:00
abstract::The mechanism underlying tissue fusion mediated by laser irradiation remains unclear. We clarify the mechanisms underlying laser-mediated tissue fusion using a novel model. Microscopic examinations of morphological changes within the adventitia of a bovine carotid artery and a collagen sheet prepared from bovine dermi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45486-4
更新日期:2019-06-28 00:00:00
abstract::Cell-free enzymatic reaction cascades combine the advantages of well-established in vitro biocatalysis with the power of multi-step in vivo pathways. The absence of a regulatory cell environment enables direct process control including methods for facile bottleneck identification and process optimization. Within this ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48151-y
更新日期:2019-08-13 00:00:00
abstract::We demonstrate an experimental methodology for measuring the temporal distribution of pico-second level electron bunch with low energy using radial electric and azimuthal magnetic fields of an accelerating ([Formula: see text] mode) radio frequency (RF) cavity that is used for accelerating electron beams in a linear a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76054-w
更新日期:2020-11-03 00:00:00