The role of genetic polymorphism within PD-L1 gene in cancer. Review.

abstract：:To assess elastin biosynthesis in the aortic wall in response to acute elevation of blood pressure, we studied the aortic gene expression of tropoelastin in a rabbit midthoracic aortic coarctation model. The time points of the study were 1, 3, and 7 days and 2, 4, and 8 weeks after coarctation. Additional animals were...

journal_title：Experimental and molecular pathology

authors： Xu C,Zarins CK,Glagov S

更新日期：2002-04-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra. Recently, microRNAs (miRNAs) were emerging as important mediators in dopaminergic neuron biology. This study determined miR-410 expression in the 6-hydroxydopamine (6-OHDA)-induced in ...

journal_title：Experimental and molecular pathology

authors： Ge H,Yan Z,Zhu H,Zhao H

更新日期：2019-08-01 00:00:00

abstract：:The development of cyclophosphamide-induced pulmonary lesions over a 1-year period was studied in mice. Male BALB/c mice received a single intraperitoneal injection of 100 mg/kg of cyclophosphamide. Within 3 weeks there were scattered foci of intraalveolar foamy macrophages. With time, these foci increased in size and...

journal_title：Experimental and molecular pathology

authors： Morse CC,Sigler C,Lock S,Hakkinen PJ,Haschek WM,Witschi HP

更新日期：1985-04-01 00:00:00

abstract：:Ureaplasma urealyticum is a common inhabitant of mucosal surfaces but is also associated with a higher incidence of pneumonia and bronchopulmonary dysplasia in preterm infants. Culture and polymerase chain reaction demonstrate high isolation rates of ureaplasma in clinical specimens documenting their presence but do n...

journal_title：Experimental and molecular pathology

authors： Benstein BD,Crouse DT,Shanklin DR,Ourth DD

更新日期：2003-10-01 00:00:00

abstract：:Ischemia has elicited a great deal of interest among the scientific community due to its role in life-threatening pathologies such as cancer, stroke, acute renal failure, and myocardial infarction. Oxygen deprivation (hypoxia) associated with ischemia has recently become a subject of intense scrutiny. New investigator...

journal_title：Experimental and molecular pathology

authors： Russ AL,Haberstroh KM,Rundell AE

更新日期：2007-10-01 00:00:00

abstract：:Sprague Dawley male rats (200-220 g) were subjected to a long-term treatment with low doses of catecholamines in an attempt to assess the effect of the adrenergic stimulation on ventricular weights, hemodynamics, and hydroxyproline content in the myocardium. Data are presented indicating that both exogenous catecholam...

journal_title：Experimental and molecular pathology

authors： Genovese A,Chiariello M,Bozzaotre M,Latte S,De Alfieri W,Condorelli M

更新日期：1984-12-01 00:00:00

abstract：:Chronic heart failure (CHF) is a common disease in clinical practice, and its incidence has been increasing in recent years. Understanding the pathogenesis of CHF is the key to its future clinical diagnosis and treatment. Molecular research is a hot topic in modern hospitals, and long non-coding RNA (LncRNA) has been ...

journal_title：Experimental and molecular pathology

authors： Li G,Du P,Qiang X,Jin D,Liu H,Li B,Guo J

更新日期：2020-12-01 00:00:00

abstract：:The glycosaminoglycan (GAG) contents of hypertrophic scars, normal scars, and human skin from cadavers of matched ages were compared. Cellulose acetate electrophoresis, chondroitinase digestions, and reaction product and infrared analyses were used to characterize the component GAGs. DEAE-cellulose chromatography was ...

journal_title：Experimental and molecular pathology

authors： Donoff RB,Swann DA,Schweidt SH

更新日期：1984-02-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is a clinical syndrome that is characterized by diffuse alveolar damage usually secondary to an intense host inflammatory response of the lung to a pulmonary or extrapulmonary infectious or noninfectious insult. In this report we describe a unique animal model in which CBA/J ...

journal_title：Experimental and molecular pathology

authors： London L,Majeski EI,Paintlia MK,Harley RA,London SD

更新日期：2002-02-01 00:00:00

abstract：:Overexpression of c-Yes has been noted to correlation with several human cancers. However, the effects of c-Yes on epithelial ovarian cancer (EOC) development remain unclear. The aim of this study is going to prove the effects of c-Yes and related mechanisms in proliferation, metastasis and invasion of EOC. Immunohist...

journal_title：Experimental and molecular pathology

authors： Jin Y,Huang M,Wang Y,Yi C,Deng Y,Chen Y,Jiang L,Wang J,Shen Q,Liu R,QinghuaXi

更新日期：2016-08-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is highly fatal due to late diagnosis and inefficient treatment. Early disease detection could improve diagnosis and patient survival. Esophageal squamous epithelial cells express SPRR3, a member of the small proline-rich protein family, which is downregulated in ESCC. Therefo...

journal_title：Experimental and molecular pathology

authors： de A Simão T,Souza-Santos PT,de Oliveira DS,Bernardo V,Lima SC,Rapozo DC,Kruel CD,Faria PA,Ribeiro Pinto LF,Albano RM

更新日期：2011-10-01 00:00:00

abstract：:Antigen-specific CD8 suppressor T cells (CD8(+) Ts) are adaptive regulatory T cells that are induced in vivo and in vitro by chronic antigenic stimulation of human T cells. CD8(+) Ts induce the upregulation of the inhibitory receptors ILT3 and ILT4 on monocytes and dendritic cells rendering these antigen presenting ce...

journal_title：Experimental and molecular pathology

authors： Vlad G,Suciu-Foca N

更新日期：2012-12-01 00:00:00

abstract：:The purpose of this work was to determine if mitochondrial dysfunction is involved in the development of non-alcoholic fatty liver disease (NAFLD). Using a model of obesity induced by the neonatal treatment of rats with monosodium L-glutamate (MSG), several parameters of liver mitochondrial function and their impact o...

journal_title：Experimental and molecular pathology

authors： Lazarin Mde O,Ishii-Iwamoto EL,Yamamoto NS,Constantin RP,Garcia RF,da Costa CE,Vitoriano Ade S,de Oliveira MC,Salgueiro-Pagadigorria CL

更新日期：2011-12-01 00:00:00

abstract：OBJECT:Mutations of the gene encoding isocitrate dehydrogenase (IDH) have been shown in a significant proportion of diffuse gliomas. These mutations are specific to gliomas and their utility for diagnosis and prognostication of these tumors is being proclaimed. The present study was conducted with the aim of assessing ...

journal_title：Experimental and molecular pathology

authors： Jha P,Suri V,Sharma V,Singh G,Sharma MC,Pathak P,Chosdol K,Jha P,Suri A,Mahapatra AK,Kale SS,Sarkar C

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVES:Ethanol has been considered as a lifestyle risk factor for cancer in humans. While some studies have indicated that alcohol intake has a preventive effect for renal cell cancer, others have not. The metabolism of alcohol in cancer cells may be in many ways different than in healthy tissue and its disturbance...

journal_title：Experimental and molecular pathology

authors： Orywal K,Jelski W,Werel T,Szmitkowski M

更新日期：2015-06-01 00:00:00

abstract：:Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is closely linked to the occurrence and development of many malignant tumors. Many studies have reported that enhanced expression of LETM1 in several types of human cancers was associated with poor clinical outcomes; however, its clinical significance i...

journal_title：Experimental and molecular pathology

authors： Li H,Piao L,Xu D,Xuan Y

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:Tumor surgery is aimed at complete resection of the lesion while ensuring a sufficient tumor-specific safety distance. Nevertheless, in many cases the most peripheral part - the invasion front - remains in situ. Tumor cells at the tumor margin have been reported to lose their epithelial properties and acquire f...

journal_title：Experimental and molecular pathology

authors： Alkatout I,Hübner F,Wenners A,Hedderich J,Wiedermann M,Sánchez C,Röcken C,Mathiak M,Maass N,Klapper W

更新日期：2017-04-01 00:00:00

abstract：:Subacute (2 week) oral or intravenous administration of DL-alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), caused diarrhea and frequent emesis as early as 4 to 5 days in dogs (dose greater than or equal to 200 mg/kg/day). Diarrhea also occurred in monkeys after 1 week ...

journal_title：Experimental and molecular pathology

authors： Yarrington JT,Sprinkle DJ,Loudy DE,Diekema KA,McCann PP,Gibson JP

更新日期：1983-12-01 00:00:00

abstract：:IL-12Rβ2(-/-) mice, which are unresponsive to IL-12, develop severe experimental autoimmune encephalomyelitis (EAE). The mechanisms for enhanced autoimmunity are incompletely understood. We report that in IL-12Rβ2(-/-) mice, thymocytes undergo markedly accelerated maturation. This occurs at the transition from a doubl...

journal_title：Experimental and molecular pathology

authors： Gran B,Yu S,Zhang GX,Rostami A

更新日期：2010-10-01 00:00:00

abstract：:The testicular effects of daily oral dosing with two glycol ethers--either ethylene glycol monomethyl ether (EGM) or monoethyl ether (EGE) were studied in the prepubertal rat by histological examination of the testes. Over the 11-day dosing period studied, EGM was found to produce testicular damage at dose levels of a...

journal_title：Experimental and molecular pathology

authors： Creasy DM,Foster PM

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:Hypospadias, as a congenital disorder of the urethra, is the second most common birth abnormality of the male reproductive system. This study primarily investigates the effects of microRNA-494 (miR-494) on the transforming growth factor-β1 (TGF-β1)/Smads signaling pathway and on the development of hypospadia...

journal_title：Experimental and molecular pathology

authors： Tian RH,Guo KM,Han GH,Bai Y

更新日期：2020-08-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have recently been recognized as the important regulators in cardiac diseases. This study was aimed to investigate the role and molecular mechanism of lncRNA KCNQ1OT1 in regulating cardiomyocyte apoptosis in heart failure (HF). The mouse model of HF was induced by doxorubicin (ADR). Cell ...

journal_title：Experimental and molecular pathology

authors： Lai L,Xu Y,Kang L,Yang J,Zhu G

更新日期：2020-08-01 00:00:00

abstract：:The CXC chemokine receptor CXCR4 was the first molecule identified as a coreceptor working in conjunction with CD4 to mediate cellular entry for the human immunodeficiency virus (HIV-1). Since that original discovery, 11 other seven-mtransmembrane domain molecules, many of which are chemokine receptors, have been show...

journal_title：Experimental and molecular pathology

authors： van der Meer P,Ulrich AM,Gonźalez-Scarano F,Lavi E

更新日期：2000-12-01 00:00:00

abstract：:SNAIL, a potent repressor of E-cadherin expression, plays a key role in inducing epithelial-to-mesenchymal transition (EMT) in epithelial cells. During EMT, epithelial cells lose cell polarity and adhesion, and undergo drastic morphological changes acquiring highly migratory abilities. Although there is increasing evi...

journal_title：Experimental and molecular pathology

authors： Nishioka R,Itoh S,Gui T,Gai Z,Oikawa K,Kawai M,Tani M,Yamaue H,Muragaki Y

更新日期：2010-10-01 00:00:00

abstract：:A novel intrauterine transplantation (IUT) approach was developed to improve the efficiency of engraftment of hematopoietic stem cells (HSCs). HSCs with a green fluorescent protein (GFP) reporter gene were transplanted in utero on days 12.5, 13.5 and 14.5 post coitum (p.c.). The degree of chimerism of donor cells in r...

journal_title：Experimental and molecular pathology

authors： Chen X,Gong XL,Katsumata M,Zeng YT,Huang SZ,Zeng F

更新日期：2009-12-01 00:00:00

abstract：:This paper is based upon the "Charles Lieber Satellite Symposia" organized by Manuela G. Neuman at the Research Society on Alcoholism (RSA) Annual Meetings, 2013 and 2014. The present review includes pre-clinical, translational and clinical research that characterize alcoholic liver disease (ALD) and non-alcoholic ste...

journal_title：Experimental and molecular pathology

authors： Neuman MG,French SW,French BA,Seitz HK,Cohen LB,Mueller S,Osna NA,Kharbanda KK,Seth D,Bautista A,Thompson KJ,McKillop IH,Kirpich IA,McClain CJ,Bataller R,Nanau RM,Voiculescu M,Opris M,Shen H,Tillman B,Li J,Liu H

更新日期：2014-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common carcinoma worldwide. Despite the progress in screening and treatment, CRC remains a leading cause of cancer-related mortality. Alterations to normal nucleic acid processing may drive neoplastic transformation of colorectal epithelium. DNA repair machinery performs an es...

journal_title：Experimental and molecular pathology

authors： Al-Shaheri FN,Al-Shami KM,Gamal EH,Mahasneh AA,Ayoub NM

更新日期：2020-04-01 00:00:00

abstract：:The molecular alterations involved in the pathogenesis of gallbladder cancer are not yet well defined. Our aim was to determine the microsatellite status of gallbladder carcinomas and its possible correlation with alterations in K-ras and p53 genes as well as the clinicopathological characteristics of these tumors. A ...

journal_title：Experimental and molecular pathology

authors： Saetta AA,Gigelou F,Papanastasiou PI,Koilakou SV,Kalekou-Greca H,Miliaras D,Michalopoulos NV,Patsouris E

更新日期：2006-02-01 00:00:00

abstract：:In this paper, we report on phosphorescence measurements for oxygen dynamics in cells by means of a correlation method, which is an expansion of the fluorescence correlation spectroscopy. The intensity correlation function of the emission excited by a pulsed light source was measured. With changing the pulse timing, b...

journal_title：Experimental and molecular pathology

authors： Nishimura G,Pack CG,Tamura M

更新日期：2007-04-01 00:00:00

abstract：:Genes involved in the control of cell proliferation and survival (those genes most important to cancer pathogenesis) are often specifically regulated at the translational level, through RNA-protein interactions involving the 5'-untranslated region of the mRNA. IGF1R is a proto-oncogene strongly implicated in human bre...

journal_title：Experimental and molecular pathology

authors： Blume SW,Jackson NL,Frost AR,Grizzle WE,Shcherbakov OD,Choi H,Meng Z

更新日期：2010-06-01 00:00:00