Genetic and Functional Analyses of Virulence Potential of an Escherichia coli O157:H7 Strain Isolated From Super-Shedder Cattle.

abstract：:During intestinal invasion, Entamoeba histolytica opens tight junctions (TJs) reflected by transepithelial electrical resistance (TEER) dropping. To explore the molecular mechanisms underlying this, we studied in vitro and in vivo the damage produced by the recombinant E. histolytica cysteine protease (rEhCP112) on TJ...

journal_title：Frontiers in cellular and infection microbiology

authors： Cuellar P,Hernández-Nava E,García-Rivera G,Chávez-Munguía B,Schnoor M,Betanzos A,Orozco E

更新日期：2017-08-16 00:00:00

abstract：:Half of invasive fungal infections lead to death. Amongst pathogenic fungi, the most widespread species belong to the Candida genus and vary in their susceptibility to antifungal drugs. The emergence of antifungal resistance has become a major clinical problem. Therefore, the definition of susceptibility patterns is c...

journal_title：Frontiers in cellular and infection microbiology

authors： Delavy M,Dos Santos AR,Heiman CM,Coste AT

更新日期：2019-02-07 00:00:00

abstract：:Different species inhabit different sensory worlds and thus have evolved diverse means of processing information, learning and memory. In the escalated arms race with host defense, each pathogenic bacterium not only has evolved its individual cellular sensing and behavior, but also collective sensing, interbacterial c...

journal_title：Frontiers in cellular and infection microbiology

authors： Steinert M

更新日期：2014-01-31 00:00:00

abstract：:Enterohemorrhagic E. coli (EHEC) is a food-borne pathogen that causes disease ranging from uncomplicated diarrhea to life-threatening hemolytic uremic syndrome (HUS) and nervous system complications. Shiga toxin 2 (Stx2) is the major virulence factor of EHEC and is critical for development of HUS. The genes encoding S...

journal_title：Frontiers in cellular and infection microbiology

authors： Iversen H,L' Abée-Lund TM,Aspholm M,Arnesen LP,Lindbäck T

更新日期：2015-02-03 00:00:00

abstract：:The intracellular parasite Toxoplasma gondii can cause chronic infections in most warm-blooded animals, including humans. In the USA, strains belonging to four different Toxoplasma clonal lineages (types 1, 2, 3, and 12) are commonly isolated, whereas strains not belonging to these lineages are predominant in other co...

journal_title：Frontiers in cellular and infection microbiology

authors： Arranz-Solís D,Cordeiro C,Young LH,Dardé ML,Commodaro AG,Grigg ME,Saeij JPJ

更新日期：2019-11-29 00:00:00

abstract：:Streptococcus dentisani 7746, isolated from dental plaque of caries-free individuals, has been shown to have several beneficial effects in vitro which could contribute to promote oral health, including an antimicrobial activity against oral pathogens by the production of bacteriocins and a pH buffering capacity throug...

journal_title：Frontiers in cellular and infection microbiology

authors： Ferrer MD,López-López A,Nicolescu T,Perez-Vilaplana S,Boix-Amorós A,Dzidic M,Garcia S,Artacho A,Llena C,Mira A

更新日期：2020-08-31 00:00:00

abstract：:The type VI secretion system (T6SS) secretes numerous toxins for bacteria-bacteria competition. TplE is a newly identified trans-kingdom toxin secreted by the T6SS in Pseudomonas aeruginosa, while TplEi neutralizes the toxic effect of TplE to protect bacteria autointoxication. Blocking the interaction of TplE-TplEi co...

journal_title：Frontiers in cellular and infection microbiology

authors： Gao X,Mu Z,Qin B,Sun Y,Cui S

更新日期：2017-09-20 00:00:00

abstract：:Despite decades of dedicated research, there remains a dire need for new drugs against tuberculosis (TB). Current therapies are generations old and problematic. Resistance to these existing therapies results in an ever-increasing burden of patients with disease that is difficult or impossible to treat. Novel chemical ...

journal_title：Frontiers in cellular and infection microbiology

authors： Butman HS,Kotzé TJ,Dowd CS,Strauss E

更新日期：2020-12-15 00:00:00

abstract：:The development of new effective vaccines strongly depends on adjuvants and formulations able to stimulate not only strong humoral responses against a certain pathogen but also effector as well as memory CD4+ and CD8+ T cells (Dubensky et al., 2013). However, the majority of vaccines licensed for human use or currentl...

journal_title：Frontiers in cellular and infection microbiology

authors： Ebensen T,Delandre S,Prochnow B,Guzmán CA,Schulze K

更新日期：2019-02-19 00:00:00

abstract：:Understanding the systems biology approaches for promoting the development of new therapeutic drugs is attaining importance nowadays. The threat of COVID-19 outbreak needs to be vanished for global welfare, and every section of research is focusing on it. There is an opportunity for finding new, quick, and accurate to...

journal_title：Frontiers in cellular and infection microbiology

authors： Jaiswal S,Kumar M,Mandeep,Sunita,Singh Y,Shukla P

更新日期：2020-10-28 00:00:00

abstract：:Cell death can be critical for host defense against intracellular pathogens because it eliminates a crucial replicative niche, and pro-inflammatory cell death can alert neighboring cells to the presence of pathogenic organisms and enhance downstream immune responses. Pyroptosis is a pro-inflammatory form of cell death...

journal_title：Frontiers in cellular and infection microbiology

authors： Casson CN,Shin S

更新日期：2013-12-27 00:00:00

abstract：:The emerging relapsing fever spirochete Borrelia (B.) miyamotoi is transmitted by ixodid ticks and causes the so-called hard tick-borne relapsing fever or B. miyamotoi disease (BMD). More recently, we identified a surface-exposed molecule, CbiA exhibiting complement binding and inhibitory capacity and rendering spiroc...

journal_title：Frontiers in cellular and infection microbiology

authors： Nguyen NTT,Röttgerding F,Devraj G,Lin YP,Koenigs A,Kraiczy P

更新日期：2018-02-02 00:00:00

abstract：Background:Disseminated histoplasmosis remains a major killer of immunocompromised patients in Latin America. Cytological and histological methods are usually present in most hospitals and may represent a precious diagnostic method. We report 15 years of experience of the department of pathology of the Centre Hospitali...

journal_title：Frontiers in cellular and infection microbiology

authors： Drak Alsibai K,Couppié P,Blanchet D,Adenis A,Epelboin L,Blaizot R,Louvel D,Djossou F,Demar M,Nacher M

更新日期：2020-10-29 00:00:00

abstract：:Genital tract infections with Chlamydia trachomatis (C. trachomatis) are the most frequent sexually transmitted disease worldwide. Severe clinical sequelae such as pelvic inflammatory disease (PID), tubal occlusion, and tubal infertility are linked to inflammatory processes of chronically infected tissues. The oxygen ...

journal_title：Frontiers in cellular and infection microbiology

authors： Jerchel S,Kaufhold I,Schuchardt L,Shima K,Rupp J

更新日期：2014-04-16 00:00:00

abstract：:The cell envelope of pathogenic bacteria is a barrier against host environmental conditions and immunity molecules, as well as the site where many virulence factors are assembled. Extracytoplasmic stress responses (ESRs) have evolved to help maintain its integrity in conditions where it might be compromised. These ESR...

journal_title：Frontiers in cellular and infection microbiology

authors： Flores-Kim J,Darwin AJ

更新日期：2012-10-10 00:00:00

abstract：:HIGHLIGHTS What is already known about this subject?Celiac disease (CD) has a high clinical and histological diversity and the mechanisms underlying this phenomenon remain elusive.H. pylori is a bacterium that chronically infect gastric and duodenal mucosa activating both a Th1/Th17 and T-reg pathways.The role of H. p...

journal_title：Frontiers in cellular and infection microbiology

authors： Lucero Y,Oyarzún A,O'Ryan M,Quera R,Espinosa N,Valenzuela R,Simian D,Alcalde E,Arce C,Farfán MJ,Vergara AF,Gajardo I,Mendez J,Carrasco J,Errázuriz G,Gonzalez M,Ossa JC,Maiza E,Perez-Bravo F,Castro M,Araya M

更新日期：2017-08-23 00:00:00

abstract：:The Toxoplasma gondii parasitophorous vacuole membrane (PVM) offers protection from the host immune system but is also a barrier for uptake of nutrients from the host. Previously, we showed that GRA17 mediates the tachyzoite PVM permeability to small molecules. During the conversion from tachyzoites to encysted bradyz...

journal_title：Frontiers in cellular and infection microbiology

authors： Paredes-Santos T,Wang Y,Waldman B,Lourido S,Saeij JP

更新日期：2019-09-12 00:00:00

abstract：:Cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB, and CdtC. Among these three toxin subunits, CdtB is the toxic moiety of CDT with DNase I activity, resulting in DNA double-strand breaks (DSB) and, consequently, cell cycle arrest at the G2/M stage and apoptosis. Ra...

journal_title：Frontiers in cellular and infection microbiology

authors： Lin HJ,Liu HH,Lin CD,Kao MC,Chen YA,Chiang-Ni C,Jiang ZP,Huang MZ,Lin CJ,Lo UG,Lin LC,Lai CK,Lin H,Hsieh JT,Chiu CH,Lai CH

更新日期：2017-06-08 00:00:00

abstract：:Background: The pathogenesis of inflammatory bowel disease (IBD) is linked to an intricate association of environmental, microbial, and host-related factors. Polysaccharide affects host immunity by regulating the composition and metabolism of gut microbiota is the common mechanism of disease resistance. However, the e...

journal_title：Frontiers in cellular and infection microbiology

authors： Su L,Mao C,Wang X,Li L,Tong H,Mao J,Ji,Lu T,Hao M,Huang Z,Fei C,Zhang K,Yan G

更新日期：2020-10-21 00:00:00

abstract：:Francisella tularensis is the causative agent of tularemia and a Tier I bioterrorism agent. In the 1900s, several vaccines were developed against tularemia including the killed "Foshay" vaccine, subunit vaccines comprising F. tularensis protein(s) or lipoproteins(s) in an adjuvant formulation, and the F. tularensis Li...

journal_title：Frontiers in cellular and infection microbiology

authors： Jia Q,Horwitz MA

更新日期：2018-05-15 00:00:00

abstract：:ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanni, Pseudomonas aeruginosa, and Enterobacter species) pathogens have characteristic multiple-drug resistance and cause an increasing number of nosocomial infections worldwide. Peptide-based therapeutics to treat ESKAPE infe...

journal_title：Frontiers in cellular and infection microbiology

authors： Du H,Puri S,McCall A,Norris HL,Russo T,Edgerton M

更新日期：2017-02-15 00:00:00

abstract：:Postpartum depressive disorder (PPD) is a unique subtype of major depressive disorder and a substantial contributor to maternal morbidity and mortality. However, the pathogenesis of PPD has still remained elusive, and it may associate with genetic and environmental factors. Gut microbiota has already been proved to be...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhou Y,Chen C,Yu H,Yang Z

更新日期：2020-09-29 00:00:00

abstract：:Gut microbiota serves as a critical indicator for gut health during treatment of pathogenic bacterial infection. Both Pulsatilla Decoction (abbreviated to PD, a traditional Chinese medicine compound) and Levofloxacin Hydrochloride (LVX) were known to have therapeutic effects to intestinal infectious disease. However, ...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu X,He S,Li Q,Mu X,Hu G,Dong H

更新日期：2020-06-30 00:00:00

abstract：:Objectives:Citrobacter freundii is a frequent cause of nosocomial infections and a known cause of diarrheal infections, and has increasingly become multidrug resistant (MDR). In this study, we aimed to determine the genetic diversity, the antimicrobial resistance profiles and in vitro virulence properties of C. freund...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu L,Chen D,Liu L,Lan R,Hao S,Jin W,Sun H,Wang Y,Liang Y,Xu J

更新日期：2018-07-10 00:00:00

abstract：:In the last decade it has become clear that, similarly to nucleated cells, enucleated red blood cells (RBCs) are susceptible to programmed apoptotic cell death. Erythrocytic apoptosis seems to play a role in physiological clearance of aged RBCs, but it may also be implicated in anemia of different etiological sources ...

journal_title：Frontiers in cellular and infection microbiology

authors： Totino PR,Daniel-Ribeiro CT,Ferreira-da-Cruz MF

更新日期：2016-12-09 00:00:00

abstract：:The plasma membrane of mammalian cells is susceptible to disruption by mechanical and biochemical damages that frequently occur within tissues. Therefore, efficient and rapid repair of the plasma membrane is essential for maintaining cellular homeostasis and survival. Excessive damage of the plasma membrane and defect...

journal_title：Frontiers in cellular and infection microbiology

authors： Pathak-Sharma S,Zhang X,Lam JGT,Weisleder N,Seveau SM

更新日期：2017-07-14 00:00:00

abstract：:Emerging antibiotic resistance in pathogenic bacteria like Mycobacterium sp., poses a threat to human health and therefore calls for the development of novel antibacterial strategies. We have recently discovered that bacterial membrane peptides, such as KdpF, possess anti-virulence properties when overproduced in path...

journal_title：Frontiers in cellular and infection microbiology

authors： Rosas Olvera M,Vivès E,Molle V,Blanc-Potard AB,Gannoun-Zaki L

更新日期：2017-04-06 00:00:00

abstract：:Background:Staphylococcus aureus biofilms contribute negatively to a number of chronic conditions, including chronic rhinosinusitis (CRS). With the inherent tolerance of biofilm-bound bacteria to antibiotics and the global problem of bacterial antibiotic resistance, the need to develop novel therapeutics is paramount....

journal_title：Frontiers in cellular and infection microbiology

authors： Drilling AJ,Ooi ML,Miljkovic D,James C,Speck P,Vreugde S,Clark J,Wormald PJ

更新日期：2017-02-24 00:00:00

abstract：:Chronic HCV infection is characterized by several immunological alterations, such as the accumulation of suppressor cells and of hyperactivated T lymphocytes. However, it is unclear whether direct-acting antiviral (DAA)-mediated HCV clearance restores immune dysfunctions. We performed a phenotypic characterization by ...

journal_title：Frontiers in cellular and infection microbiology

authors： Telatin V,Nicoli F,Frasson C,Menegotto N,Barbaro F,Castelli E,Erne E,Palù G,Caputo A

更新日期：2019-06-14 00:00:00

abstract：:Sepsis is a severe syndrome that arises when the host response to an insult is exacerbated, leading to organ failure and frequently to death. How a chronic infection that causes a prolonged Th1 expansion affects the course of sepsis is unknown. In this study, we showed that mice chronically infected with Toxoplasma go...

journal_title：Frontiers in cellular and infection microbiology

authors： Souza MC,Fonseca DM,Kanashiro A,Benevides L,Medina TS,Dias MS,Andrade WA,Bonfá G,Silva MAB,Gozzi A,Borges MC,Gazzinelli RT,Alves-Filho JC,Cunha FQ,Silva JS

更新日期：2017-04-07 00:00:00