The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and Qualitative Enhanced Immune Responses Post Immunization.

abstract：:The intracellular parasite Toxoplasma gondii can cause chronic infections in most warm-blooded animals, including humans. In the USA, strains belonging to four different Toxoplasma clonal lineages (types 1, 2, 3, and 12) are commonly isolated, whereas strains not belonging to these lineages are predominant in other co...

journal_title：Frontiers in cellular and infection microbiology

authors： Arranz-Solís D,Cordeiro C,Young LH,Dardé ML,Commodaro AG,Grigg ME,Saeij JPJ

更新日期：2019-11-29 00:00:00

abstract：:Sepsis is a life-threatening health condition caused by infectious pathogens of the respiratory tract, and accounts for 28-50% of annual deaths in the US alone. Current treatment regimen advocates the use of corticosteroids as adjunct treatment with antibiotics, for their broad inhibitory effect on the activity and pr...

journal_title：Frontiers in cellular and infection microbiology

authors： Ngo Ndjom CG,Kantor LV,Jones HP

更新日期：2017-06-22 00:00:00

abstract：:Enterohemorrhagic E. coli (EHEC) is a food-borne pathogen that causes disease ranging from uncomplicated diarrhea to life-threatening hemolytic uremic syndrome (HUS) and nervous system complications. Shiga toxin 2 (Stx2) is the major virulence factor of EHEC and is critical for development of HUS. The genes encoding S...

journal_title：Frontiers in cellular and infection microbiology

authors： Iversen H,L' Abée-Lund TM,Aspholm M,Arnesen LP,Lindbäck T

更新日期：2015-02-03 00:00:00

abstract：:Sepsis is a severe syndrome that arises when the host response to an insult is exacerbated, leading to organ failure and frequently to death. How a chronic infection that causes a prolonged Th1 expansion affects the course of sepsis is unknown. In this study, we showed that mice chronically infected with Toxoplasma go...

journal_title：Frontiers in cellular and infection microbiology

authors： Souza MC,Fonseca DM,Kanashiro A,Benevides L,Medina TS,Dias MS,Andrade WA,Bonfá G,Silva MAB,Gozzi A,Borges MC,Gazzinelli RT,Alves-Filho JC,Cunha FQ,Silva JS

更新日期：2017-04-07 00:00:00

abstract：:Ticks modulate their hosts' defense responses by secreting a biopharmacopiea of hundreds to thousands of proteins and bioactive chemicals into the feeding site (tick-host interface). These molecules and their functions evolved over millions of years as ticks adapted to blood-feeding, tick lineages diverged, and host-s...

journal_title：Frontiers in cellular and infection microbiology

authors： Mans BJ,Featherston J,de Castro MH,Pienaar R

更新日期：2017-09-25 00:00:00

abstract：:Histoplasmosis is one of the most frequent systemic mycosis in HIV patients. In these patients, histoplasmosis has high rates of morbidity/mortality if diagnosis and treatment are delayed. Despite its relevance, there is a paucity of information concerning the interaction between Histoplasma capsulatum and the human h...

journal_title：Frontiers in cellular and infection microbiology

authors： Almeida MA,Almeida-Paes R,Guimarães AJ,Valente RH,Soares CMA,Zancopé-Oliveira RM

更新日期：2020-10-29 00:00:00

abstract：:An important component in host resistance to malaria infection are inherited mutations that give rise to abnormalities and deficiencies in erythrocyte proteins and enzymes. Understanding how such mutations confer protection against the disease may be useful for developing new treatment strategies. A mouse ENU-induced ...

journal_title：Frontiers in cellular and infection microbiology

authors： Schnider CB,Yang H,Starrs L,Ehmann A,Rahimi F,Di Pierro E,Graziadei G,Matthews K,De Koning-Ward T,Bauer DC,Foote SJ,Burgio G,McMorran BJ

更新日期：2020-09-03 00:00:00

abstract：:Streptococcus dentisani 7746, isolated from dental plaque of caries-free individuals, has been shown to have several beneficial effects in vitro which could contribute to promote oral health, including an antimicrobial activity against oral pathogens by the production of bacteriocins and a pH buffering capacity throug...

journal_title：Frontiers in cellular and infection microbiology

authors： Ferrer MD,López-López A,Nicolescu T,Perez-Vilaplana S,Boix-Amorós A,Dzidic M,Garcia S,Artacho A,Llena C,Mira A

更新日期：2020-08-31 00:00:00

abstract：:Group A Streptococcus (GAS), also called Streptococcus pyogenes, is a Gram-positive beta-hemolytic human pathogen which causes a wide range of mostly self-limiting but also several life-threatening diseases. Innate immune responses are fundamental for defense against GAS, yet their activation by pattern recognition re...

journal_title：Frontiers in cellular and infection microbiology

authors： Fieber C,Kovarik P

更新日期：2014-10-02 00:00:00

abstract：:Pertussis is a respiratory infectious disease that has been resurged during the last decades. The change from the traditional multi-antigen whole-cell pertussis (wP) vaccines to acellular pertussis (aP) vaccines that consist of a few antigens formulated with alum, appears to be a key factor in the resurgence of pertus...

journal_title：Frontiers in cellular and infection microbiology

authors： Zurita ME,Wilk MM,Carriquiriborde F,Bartel E,Moreno G,Misiak A,Mills KHG,Hozbor D

更新日期：2019-04-26 00:00:00

abstract：:Non-typeable Haemophilus influenzae (NTHI) is an opportunistic bacterial pathogen of the human respiratory tract and is a leading cause of respiratory infections in children and adults. NTHI is considered to be an extracellular pathogen, but has consistently been observed within and between human respiratory epithelia...

journal_title：Frontiers in cellular and infection microbiology

authors： Clementi CF,Murphy TF

更新日期：2011-11-18 00:00:00

abstract：:Syf1 is a tetratricopeptide repeat (TPR) protein implicated in transcription elongation, spliceosome conformation, mRNA nuclear-cytoplasmic export and transcription-coupled DNA repair. Recently, we identified the spliceosomal components of the human parasite Entamoeba histolytica, among them is EhSyf. Molecular predic...

journal_title：Frontiers in cellular and infection microbiology

authors： Torres-Cifuentes DM,Galindo-Rosales JM,Saucedo-Cárdenas O,Valdés J

更新日期：2018-07-09 00:00:00

abstract：:Due to increased travel, climatic, and environmental changes, the incidence of tick-borne disease in both humans and animals is increasing throughout Europe. Therefore, extended surveillance tools are desirable. To accurately screen tick-borne pathogens (TBPs), a large scale epidemiological study was conducted on 7050...

journal_title：Frontiers in cellular and infection microbiology

authors： Michelet L,Delannoy S,Devillers E,Umhang G,Aspan A,Juremalm M,Chirico J,van der Wal FJ,Sprong H,Boye Pihl TP,Klitgaard K,Bødker R,Fach P,Moutailler S

更新日期：2014-07-29 00:00:00

abstract：:Salmonella is a facultative intracellular Gram-negative bacterium, responsible for a wide range of food- and water-borne diseases ranging from gastroenteritis to typhoid fever depending on hosts and serotypes. Salmonella thus represents a major threat to public health. A key step in Salmonella pathogenesis is the inva...

journal_title：Frontiers in cellular and infection microbiology

authors： Mambu J,Virlogeux-Payant I,Holbert S,Grépinet O,Velge P,Wiedemann A

更新日期：2017-12-08 00:00:00

abstract：:The mechanism by which microRNAs (miRNAs) modulate innate immunity and autophagy has not been fully elucidated in Mycobacterium bovis (M. bovis) infections. In this study, we identified that miR-199a inhibited key innate immune responses and autophagy in murine macrophages infected with M. bovis. Using ex vivo and in ...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang J,Hussain T,Yue R,Liao Y,Li Q,Yao J,Song Y,Sun X,Wang N,Xu L,Sreevatsan S,Zhao D,Zhou X

更新日期：2018-07-10 00:00:00

abstract：:Bacterial persisters are a small proportion of phenotypically heterogeneous variants with the transient capability to survive in high concentrations of antibiotics, causing recurrent infections in both human and aquatic animals. Transfer-messenger RNA (tmRNA), which was encoded by the ssrA gene, was identified as a de...

journal_title：Frontiers in cellular and infection microbiology

authors： Yu W,Li D,Li H,Tang Y,Tang H,Ma X,Liu Z

更新日期：2020-02-28 00:00:00

abstract：:Pneumonia and meningitis continue to present an enormous public health burden and pose a major threat to young children. Among the causative organisms of pneumonia and meningitis, bacteria are the most common causes of serious disease and deaths. It is challenging to accurately and rapidly identify these agents. To so...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhang C,Xiu L,Xiao Y,Xie Z,Ren L,Peng J

更新日期：2018-04-05 00:00:00

abstract：:In the last decade it has become clear that, similarly to nucleated cells, enucleated red blood cells (RBCs) are susceptible to programmed apoptotic cell death. Erythrocytic apoptosis seems to play a role in physiological clearance of aged RBCs, but it may also be implicated in anemia of different etiological sources ...

journal_title：Frontiers in cellular and infection microbiology

authors： Totino PR,Daniel-Ribeiro CT,Ferreira-da-Cruz MF

更新日期：2016-12-09 00:00:00

abstract：:Metagenomic approaches applied to viruses have highlighted their prevalence in almost all microbial ecosystems investigated. In all ecosystems, notably those associated with humans or animals, the viral fraction is dominated by bacteriophages. Whether they contribute to dysbiosis, i.e., the departure from microbiota c...

journal_title：Frontiers in cellular and infection microbiology

authors： De Paepe M,Leclerc M,Tinsley CR,Petit MA

更新日期：2014-03-28 00:00:00

abstract：:Eradication of Helicobacter pylori has been found to be effective for gastric cancer prevention, but uncertainties remain about the possible adverse consequences such as the potential microbial dysbiosis. In our study, we investigated the association between gut microbiota and H. pylori-related gastric lesions in 47 s...

journal_title：Frontiers in cellular and infection microbiology

authors： Gao JJ,Zhang Y,Gerhard M,Mejias-Luque R,Zhang L,Vieth M,Ma JL,Bajbouj M,Suchanek S,Liu WD,Ulm K,Quante M,Li ZX,Zhou T,Schmid R,Classen M,Li WQ,You WC,Pan KF

更新日期：2018-06-19 00:00:00

abstract：:Non-optimal vaginal microbiota, as observed in bacterial vaginosis (BV), is typically characterized by a depletion of beneficial lactobacilli and an abundance of numerous anaerobes. These non-optimal conditions are associated with subclinical cervicovaginal inflammation and an increased risk of HIV infection compared ...

journal_title：Frontiers in cellular and infection microbiology

authors： Delgado-Diaz DJ,Tyssen D,Hayward JA,Gugasyan R,Hearps AC,Tachedjian G

更新日期：2020-01-10 00:00:00

abstract：:Nocardia is one of the causing agents of bovine mastitis and increasing prevalence of nocardial mastitis in shape of serious outbreaks has been reported from many countries. However, the mechanisms by which this pathogen damages the bovine mammary epithelial cells (bMECs) is not yet studied. Therefore, this study was ...

journal_title：Frontiers in cellular and infection microbiology

authors： Chen W,Liu Y,Zhang L,Gu X,Liu G,Shahid M,Gao J,Ali T,Han B

更新日期：2017-05-18 00:00:00

abstract：:Background: Increasing evidence has shown that Helicobacter pylori is associated with coronary heart disease (CHD); however, the underlying mechanism remains unclear. Methods: The expression of miR-25 and mRNAs was measured using qRT-PCR. Protein levels were detected using western blotting and exosomes were assessed w...

journal_title：Frontiers in cellular and infection microbiology

authors： Li N,Liu SF,Dong K,Zhang GC,Huang J,Wang ZH,Wang TJ

更新日期：2019-10-29 00:00:00

abstract：:Solid-state fermentation of feedstuffs by Bacillus subtilis MA139 can reduce insoluble dietary fiber content in vitro and improve growth performance in pigs. This study was conducted to investigate the effects of dietary corn bran (CB) fermented by B. subtilis on growth performance and gut microbiota composition in fi...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu P,Zhao J,Guo P,Lu W,Geng Z,Levesque CL,Johnston LJ,Wang C,Liu L,Zhang J,Ma N,Qiao S,Ma X

更新日期：2017-12-22 00:00:00

abstract：:Due to the importance of a rapid determination of patients infected by multidrug resistant bacteria, we evaluated two rapid diagnostic tests for the detection of third-generation cephalosporins (3GC)-resistant Enterobacterales directly from positive blood cultures within 1 h: BL-REDTM (electrochemical method) and β-LA...

journal_title：Frontiers in cellular and infection microbiology

authors： Durand C,Boudet A,Lavigne JP,Pantel A

更新日期：2020-09-11 00:00:00

abstract：:Clostridium difficile is a toxin-producing bacterium that is a frequent cause of hospital-acquired and antibiotic-associated diarrhea. The incidence, severity, and costs associated with C. difficile associated disease are substantial and increasing, making C. difficile a significant public health concern. The two prim...

journal_title：Frontiers in cellular and infection microbiology

authors： Pruitt RN,Lacy DB

更新日期：2012-03-16 00:00:00

abstract：:To gain insights into differences in the virulence among T. gondii strains at the post-translational level, we conducted a quantitative analysis of the phosphoproteome profile of T. gondii strains belonging to three different genotypes. Phosphopeptides from three strains, type I (RH strain), type II (PRU strain) and T...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang ZX,Zhou CX,Calderón-Mantilla G,Petsalaki E,He JJ,Song HY,Elsheikha HM,Zhu XQ

更新日期：2019-08-23 00:00:00

abstract：:Deposition of Burkholderia pseudomallei within either the lungs or nasal passages of the Balb/c murine model resulted in different infection kinetics. The infection resulting from the inhalation of B. pseudomallei within a 12 μm particle aerosol was prolonged compared to a 1 μm particle aerosol with a mean time-to-dea...

journal_title：Frontiers in cellular and infection microbiology

authors： Thomas RJ,Davies C,Nunez A,Hibbs S,Eastaugh L,Harding S,Jordan J,Barnes K,Oyston P,Eley S

更新日期：2012-07-23 00:00:00

abstract：:Emerging antibiotic resistance in pathogenic bacteria like Mycobacterium sp., poses a threat to human health and therefore calls for the development of novel antibacterial strategies. We have recently discovered that bacterial membrane peptides, such as KdpF, possess anti-virulence properties when overproduced in path...

journal_title：Frontiers in cellular and infection microbiology

authors： Rosas Olvera M,Vivès E,Molle V,Blanc-Potard AB,Gannoun-Zaki L

更新日期：2017-04-06 00:00:00

abstract：:Lung microbiome ecosystem homeostasis in idiopathic pulmonary fibrosis (IPF) remains uncharacterized. The aims of this study were to identify unique microbial signatures of the lung microbiome and analyze microbial gene function in IPF patients. DNA isolated from BALF samples was obtained for high-throughput gene sequ...

journal_title：Frontiers in cellular and infection microbiology

authors： Tong X,Su F,Xu X,Xu H,Yang T,Xu Q,Dai H,Huang K,Zou L,Zhang W,Pei S,Xiao F,Li Y,Wang C

更新日期：2019-05-21 00:00:00