Bacteriophages: an underestimated role in human and animal health?

abstract：:Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocat...

journal_title：Frontiers in cellular and infection microbiology

authors： Salcedo SP,Marchesini MI,Degos C,Terwagne M,Von Bargen K,Lepidi H,Herrmann CK,Santos Lacerda TL,Imbert PR,Pierre P,Alexopoulou L,Letesson JJ,Comerci DJ,Gorvel JP

更新日期：2013-07-08 00:00:00

abstract：:Escherichia coli O157:H7 and other pathogenic E. coli strains are enteric pathogens associated with food safety threats and which remain a significant cause of morbidity and mortality worldwide. In the current study, we investigated whether enterohemorrhagic E. coli (EHEC), Shiga toxin-producing E. coli (STEC), and en...

journal_title：Frontiers in cellular and infection microbiology

authors： Botkin DJ,Galli L,Sankarapani V,Soler M,Rivas M,Torres AG

更新日期：2012-02-14 00:00:00

abstract：:During chronic human immunodeficiency virus type 1 (HIV-1) infection, upregulation of inhibitory molecules contributes to effector cell dysfunction and exhaustion. This, in combination with the ability of HIV-1 to reside dormant in cellular reservoirs and escape immune recognition, makes the pathway to HIV-1 cure part...

journal_title：Frontiers in cellular and infection microbiology

authors： Holder KA,Grant MD

更新日期：2020-05-05 00:00:00

abstract：:Streptococcus pyogenes (Group A Streptococcus or GAS) is a hemolytic human pathogen associated with a wide variety of infections ranging from minor skin and throat infections to life-threatening invasive diseases. The cell wall of GAS consists of peptidoglycan sacculus decorated with a carbohydrate comprising a polyrh...

journal_title：Frontiers in cellular and infection microbiology

authors： Edgar RJ,Chen J,Kant S,Rechkina E,Rush JS,Forsberg LS,Jaehrig B,Azadi P,Tchesnokova V,Sokurenko EV,Zhu H,Korotkov KV,Pancholi V,Korotkova N

更新日期：2016-10-13 00:00:00

abstract：:Eradication of Helicobacter pylori has been found to be effective for gastric cancer prevention, but uncertainties remain about the possible adverse consequences such as the potential microbial dysbiosis. In our study, we investigated the association between gut microbiota and H. pylori-related gastric lesions in 47 s...

journal_title：Frontiers in cellular and infection microbiology

authors： Gao JJ,Zhang Y,Gerhard M,Mejias-Luque R,Zhang L,Vieth M,Ma JL,Bajbouj M,Suchanek S,Liu WD,Ulm K,Quante M,Li ZX,Zhou T,Schmid R,Classen M,Li WQ,You WC,Pan KF

更新日期：2018-06-19 00:00:00

abstract：:Anopheles female mosquitoes can transmit Plasmodium, the malaria parasite. During their aquatic life, wild Anopheles mosquito larvae are exposed to a huge diversity of microbes present in their breeding sites. Later, adult females often take successive blood meals that might also carry different micro-organisms, inclu...

journal_title：Frontiers in cellular and infection microbiology

authors： Dieme C,Rotureau B,Mitri C

更新日期：2017-12-07 00:00:00

abstract：:The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in immune compromised individuals. This pathogen is typically acquired via inhalation, and enters the respiratory tract. Innate immune cells such as macrophages and dendritic cells (DCs) are the first host cells that encounter C. neoform...

journal_title：Frontiers in cellular and infection microbiology

authors： Nelson BN,Hawkins AN,Wozniak KL

更新日期：2020-02-11 00:00:00

abstract：:Protein secretion systems are vital for prokaryotic life, as they enable bacteria to acquire nutrients, communicate with other species, defend against biological and chemical agents, and facilitate disease through the delivery of virulence factors. In this review, we will focus on the recently discovered type IX secre...

journal_title：Frontiers in cellular and infection microbiology

authors： Lasica AM,Ksiazek M,Madej M,Potempa J

更新日期：2017-05-26 00:00:00

abstract：:In 2019, the United States Food and Drug Administration accorded restricted approval to Sanofi Pasteur's Dengvaxia, a live attenuated vaccine (LAV) for dengue fever, a mosquito-borne viral disease, caused by four antigenically distinct dengue virus serotypes (DENV 1-4). The reason for this limited approval is the conc...

journal_title：Frontiers in cellular and infection microbiology

authors： Shukla R,Ramasamy V,Shanmugam RK,Ahuja R,Khanna N

更新日期：2020-10-22 00:00:00

abstract：:Response regulators are a critical part of the two-component system of gene expression regulation in bacteria, transferring a signal from a sensor kinase into DNA binding activity resulting in alteration of gene expression. In this study, we investigated a previously uncharacterized response regulator in Francisella n...

journal_title：Frontiers in cellular and infection microbiology

authors： Dean SN,Milton ME,Cavanagh J,van Hoek ML

更新日期：2020-03-13 00:00:00

abstract：:Microsporidia are a group of intracellular pathogens causing self-limited and severe diseases in immunocompetent and immunocompromised individuals, respectively. A cellular type 1 adaptive response, mediated by IL-12, IFNγ, CD4+, and CD8+ T cells has been shown to be essential for host resistance, and dendritic cells ...

journal_title：Frontiers in cellular and infection microbiology

authors： Bernal CE,Zorro MM,Sierra J,Gilchrist K,Botero JH,Baena A,Ramirez-Pineda JR

更新日期：2016-02-02 00:00:00

abstract：:HIGHLIGHTS What is already known about this subject?Celiac disease (CD) has a high clinical and histological diversity and the mechanisms underlying this phenomenon remain elusive.H. pylori is a bacterium that chronically infect gastric and duodenal mucosa activating both a Th1/Th17 and T-reg pathways.The role of H. p...

journal_title：Frontiers in cellular and infection microbiology

authors： Lucero Y,Oyarzún A,O'Ryan M,Quera R,Espinosa N,Valenzuela R,Simian D,Alcalde E,Arce C,Farfán MJ,Vergara AF,Gajardo I,Mendez J,Carrasco J,Errázuriz G,Gonzalez M,Ossa JC,Maiza E,Perez-Bravo F,Castro M,Araya M

更新日期：2017-08-23 00:00:00

abstract：:Deposition of Burkholderia pseudomallei within either the lungs or nasal passages of the Balb/c murine model resulted in different infection kinetics. The infection resulting from the inhalation of B. pseudomallei within a 12 μm particle aerosol was prolonged compared to a 1 μm particle aerosol with a mean time-to-dea...

journal_title：Frontiers in cellular and infection microbiology

authors： Thomas RJ,Davies C,Nunez A,Hibbs S,Eastaugh L,Harding S,Jordan J,Barnes K,Oyston P,Eley S

更新日期：2012-07-23 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) O157:H7 EspF is an important multifunctional protein that destroys the tight junctions of intestinal epithelial cells and promotes host cell apoptosis. However, its molecular mechanism remains elusive. We knocked out the espF sequence (747 bp, ΔespF), N-terminal sequence (219 ...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang X,Du Y,Hua Y,Fu M,Niu C,Zhang B,Zhao W,Zhang Q,Wan C

更新日期：2017-09-21 00:00:00

abstract：:A cohort study was conducted to evaluate oral microbial diversity among toddlers aged 12-24 months, and to describe the dynamic processes of colonization, development, and stabilization of the oral microflora during tooth eruption using high-throughput sequencing technology. A total of 20 healthy toddlers aged 12 mont...

journal_title：Frontiers in cellular and infection microbiology

authors： Li F,Tao D,Feng X,Wong MCM,Lu H

更新日期：2018-12-04 00:00:00

abstract：:In this study, a next-generation sequencing strategy on 16S ribosomal RNA (16S rRNA) gene was employed to analyze 70 oral samples from 32 patients with throat cancer, nine patients with vocal cord polyp, and 29 healthy individuals (normal controls). Using this strategy, we demonstrated, for the first time, that the sa...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang L,Yin G,Guo Y,Zhao Y,Zhao M,Lai Y,Sui P,Shi T,Guo W,Huang Z

更新日期：2019-07-03 00:00:00

abstract：:The human-specific pathogen Salmonella enterica serovar Typhi causes typhoid, a major public health issue in developing countries. Several aspects of its pathogenesis are still poorly understood. S. Typhi possesses 14 fimbrial gene clusters including 12 chaperone-usher fimbriae (stg, sth, bcf, fim, saf, sef, sta, stb,...

journal_title：Frontiers in cellular and infection microbiology

authors： Dufresne K,Saulnier-Bellemare J,Daigle F

更新日期：2018-02-08 00:00:00

abstract：:Objectives:Pneumocystis jirovecii pneumonia (PCP) is an AIDS-defining illness. In patients with HIV, the benefit of PCP prophylaxis is well-defined when the CD4 T-cell count decreases below 200 cells/μL. In other immunocompromised patients, the value of PCP prophylaxis is not always as well-established. This study aim...

journal_title：Frontiers in cellular and infection microbiology

authors： Dunbar A,Schauwvlieghe A,Algoe S,van Hellemond JJ,Reynders M,Vandecasteele S,Boelens J,Depuydt P,Rijnders B

更新日期：2020-05-15 00:00:00

abstract：:Fusarium is an important genus of plant pathogenic fungi, and is widely distributed in soil and associated with plants worldwide. The diversity of mycoviruses in Fusarium is increasing continuously due to the development and extensive use of state-of-the-art RNA deep sequencing techniques. To date, fully-sequenced myc...

journal_title：Frontiers in cellular and infection microbiology

authors： Li P,Bhattacharjee P,Wang S,Zhang L,Ahmed I,Guo L

更新日期：2019-07-18 00:00:00

abstract：:Chlamydiae are obligate intracellular pathogens of eukaryotes. The bacteria grow in an intracellular vesicle called an inclusion, the membrane of which is heavily modified by chlamydial proteins called Incs (Inclusion membrane proteins). Incs represent 7-10% of the genomes of Chlamydia and, given their localization at...

journal_title：Frontiers in cellular and infection microbiology

authors： Gauliard E,Ouellette SP,Rueden KJ,Ladant D

更新日期：2015-02-11 00:00:00

abstract：:Mycoplasma bovis is an important cause of bovine respiratory disease worldwide. To understand its virulence mechanisms, we sequenced three attenuated M. bovis strains, P115, P150, and P180, which were passaged in vitro 115, 150, and 180 times, respectively, and exhibited progressively decreasing virulence. Comparative...

journal_title：Frontiers in cellular and infection microbiology

authors： Rasheed MA,Qi J,Zhu X,Chenfei H,Menghwar H,Khan FA,Zhao G,Zubair M,Hu C,Chen Y,Chen H,Guo A

更新日期：2017-05-11 00:00:00

abstract：:The phenylacetic acid (PA) degradative pathway is the central pathway by which various aromatic compounds (e.g., styrene) are degraded. Upper pathways for different aromatic compounds converge at common intermediate phenylacetyl-CoA (PA-CoA), which is then metabolized to succinyl-CoA and acetyl-CoA. We previously made...

journal_title：Frontiers in cellular and infection microbiology

authors： Imolorhe IA,Cardona ST

更新日期：2011-12-14 00:00:00

abstract：:Esophageal microbiota plays important roles in esophageal cancer. Esophagectomy, as the most important therapeutic way, contributes to changes of esophageal microbiome. However, there are few studies examining the esophageal microbiome and the metabolic changes before and after esophagectomy. The present study charact...

journal_title：Frontiers in cellular and infection microbiology

authors： Li D,He R,Hou G,Ming W,Fan T,Chen L,Zhang L,Jiang W,Wang W,Lu Z,Feng H,Geng Q

更新日期：2020-06-26 00:00:00

abstract：:Staphylococcus aureus is a major cause of infective endocarditis (IE) and sepsis. Both methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) strains cause these illnesses. Common S. aureus strains include pulsed-field gel electrophoresis (PFGE) types USA200, 300, and 400 types where we hypothesize that secrete...

journal_title：Frontiers in cellular and infection microbiology

authors： Spaulding AR,Satterwhite EA,Lin YC,Chuang-Smith ON,Frank KL,Merriman JA,Schaefers MM,Yarwood JM,Peterson ML,Schlievert PM

更新日期：2012-02-21 00:00:00

abstract：:Half of invasive fungal infections lead to death. Amongst pathogenic fungi, the most widespread species belong to the Candida genus and vary in their susceptibility to antifungal drugs. The emergence of antifungal resistance has become a major clinical problem. Therefore, the definition of susceptibility patterns is c...

journal_title：Frontiers in cellular and infection microbiology

authors： Delavy M,Dos Santos AR,Heiman CM,Coste AT

更新日期：2019-02-07 00:00:00

abstract：:Osteomyelitis is commonly caused by Staphylococcus aureus. Both erythromycin and curcumin can suppress S. aureus growth, but their roles in osteomyelitis are barely studied. We aim to explore the activities of erythromycin and curcumin against chronical osteomyelitis induced by methicillin-resistant S. aureus (MRSA). ...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhou Z,Pan C,Lu Y,Gao Y,Liu W,Yin P,Yu X

更新日期：2017-08-24 00:00:00

abstract：:Despite decades of dedicated research, there remains a dire need for new drugs against tuberculosis (TB). Current therapies are generations old and problematic. Resistance to these existing therapies results in an ever-increasing burden of patients with disease that is difficult or impossible to treat. Novel chemical ...

journal_title：Frontiers in cellular and infection microbiology

authors： Butman HS,Kotzé TJ,Dowd CS,Strauss E

更新日期：2020-12-15 00:00:00

abstract：:Different species inhabit different sensory worlds and thus have evolved diverse means of processing information, learning and memory. In the escalated arms race with host defense, each pathogenic bacterium not only has evolved its individual cellular sensing and behavior, but also collective sensing, interbacterial c...

journal_title：Frontiers in cellular and infection microbiology

authors： Steinert M

更新日期：2014-01-31 00:00:00

abstract：:The oral microbiome can play a role in the instigation and progression of oral diseases that can manifest into other systemic conditions. These associations encourage the exploration of oral dysbiosis leading to the pathogenesis of cancers. In this study, oral rinse was used to characterize the oral microbiome fluctua...

journal_title：Frontiers in cellular and infection microbiology

authors： Lim Y,Fukuma N,Totsika M,Kenny L,Morrison M,Punyadeera C

更新日期：2018-08-03 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) represents the etiological agent for several human malignancies, including Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD), which are mostly seen in immunocompromised patients. In fact, KSHV has developed many strategies ...

journal_title：Frontiers in cellular and infection microbiology

authors： Barrett L,Chen J,Dai L,Plaisance-Bonstaff K,Del Valle L,Qin Z

更新日期：2020-10-30 00:00:00