TIGIT Blockade: A Multipronged Approach to Target the HIV Reservoir.

abstract：:Bacterial persisters are a small proportion of phenotypically heterogeneous variants with the transient capability to survive in high concentrations of antibiotics, causing recurrent infections in both human and aquatic animals. Transfer-messenger RNA (tmRNA), which was encoded by the ssrA gene, was identified as a de...

journal_title：Frontiers in cellular and infection microbiology

authors： Yu W,Li D,Li H,Tang Y,Tang H,Ma X,Liu Z

更新日期：2020-02-28 00:00:00

abstract：:Preservation of health from infectious diseases depends upon both mucosal and systemic immunity via the collaborative effort of innate and adaptive immune responses. The proficiency of host immunity stems from robust defense mechanisms--physical barriers and specialized immune cells--and a failure of these mechanisms ...

journal_title：Frontiers in cellular and infection microbiology

authors： Denny JE,Powell WL,Schmidt NW

更新日期：2016-04-11 00:00:00

abstract：:Shigella is the major cause of bacillary dysentery world-wide. It is divided into four species, named S. flexneri, S. sonnei, S. dysenteriae, and S. boydii, which are distinct genomically and in their ability to cause disease. Shigellosis, the clinical presentation of Shigella infection, is characterized by watery dia...

journal_title：Frontiers in cellular and infection microbiology

authors： Mattock E,Blocker AJ

更新日期：2017-03-24 00:00:00

abstract：:Cell death can be critical for host defense against intracellular pathogens because it eliminates a crucial replicative niche, and pro-inflammatory cell death can alert neighboring cells to the presence of pathogenic organisms and enhance downstream immune responses. Pyroptosis is a pro-inflammatory form of cell death...

journal_title：Frontiers in cellular and infection microbiology

authors： Casson CN,Shin S

更新日期：2013-12-27 00:00:00

abstract：:Herpes simplex virus-1 (HSV-1) is a significant human pathogen. Upon infection, HSV-1 expresses its immediate early (IE) genes, and the IE transcription factor ICP4 (infectious cell protein-4) plays a pivotal role in initiating the downstream gene-expression cascade. Using live-cell time-lapse fluorescence microscopy,...

journal_title：Frontiers in cellular and infection microbiology

authors： Chaturvedi S,Engel R,Weinberger L

更新日期：2020-06-24 00:00:00

abstract：:While microbiome plays key roles in the etiology of multiple sclerosis (MS), its mechanism remains elusive. Here, we conducted a comprehensive metagenome-wide association study (MWAS) of the relapsing-remitting MS gut microbiome (ncase = 26, ncontrol = 77) in the Japanese population, by using whole-genome shotgun sequ...

journal_title：Frontiers in cellular and infection microbiology

authors： Kishikawa T,Ogawa K,Motooka D,Hosokawa A,Kinoshita M,Suzuki K,Yamamoto K,Masuda T,Matsumoto Y,Nii T,Maeda Y,Nakamura S,Inohara H,Mochizuki H,Okuno T,Okada Y

更新日期：2020-12-11 00:00:00

abstract：:Response regulators are a critical part of the two-component system of gene expression regulation in bacteria, transferring a signal from a sensor kinase into DNA binding activity resulting in alteration of gene expression. In this study, we investigated a previously uncharacterized response regulator in Francisella n...

journal_title：Frontiers in cellular and infection microbiology

authors： Dean SN,Milton ME,Cavanagh J,van Hoek ML

更新日期：2020-03-13 00:00:00

abstract：:The intracellular bacterial pathogen Francisella tularensis causes serious infectious disease in humans and animals. Moreover, F. tularensis, a highly infectious pathogen, poses a major concern for the public as a bacterium classified under Category A of bioterrorism agents. Unfortunately, research has so far failed t...

journal_title：Frontiers in cellular and infection microbiology

authors： Krocova Z,Macela A,Kubelkova K

更新日期：2017-10-16 00:00:00

abstract：:Vaccination remains a major tool for prevention and progression of Johne's disease, a chronic enteritis of ruminants worldwide. Currently there is only one licensed vaccine within the United States and two vaccines licensed internationally against Johne's disease. All licensed vaccines reduce fecal shedding of Mycobac...

journal_title：Frontiers in cellular and infection microbiology

authors： Lamont EA,Talaat AM,Coussens PM,Bannantine JP,Grohn YT,Katani R,Li LL,Kapur V,Sreevatsan S

更新日期：2014-06-30 00:00:00

abstract：:For centuries, hydrogen sulfide (H2S) was considered primarily as a poisonous gas and environmental hazard. However, with the discovery of prokaryotic and eukaryotic enzymes for H2S production, breakdown, and utilization, H2S has emerged as an important signaling molecule in a wide range of physiological and pathologi...

journal_title：Frontiers in cellular and infection microbiology

authors： Rahman MA,Glasgow JN,Nadeem S,Reddy VP,Sevalkar RR,Lancaster JR Jr,Steyn AJC

更新日期：2020-11-10 00:00:00

abstract：:Anopheles female mosquitoes can transmit Plasmodium, the malaria parasite. During their aquatic life, wild Anopheles mosquito larvae are exposed to a huge diversity of microbes present in their breeding sites. Later, adult females often take successive blood meals that might also carry different micro-organisms, inclu...

journal_title：Frontiers in cellular and infection microbiology

authors： Dieme C,Rotureau B,Mitri C

更新日期：2017-12-07 00:00:00

abstract：:Background:Pseudomonas aeruginosa causes severe chronic respiratory diseases and is associated with recalcitrant chronic rhinosinusitis (CRS). P. aeruginosa exoproteins contain virulence factors and play important roles in the pathogenicity of P. aeruginosa, however their role in CRS pathophysiology remains unknown. M...

journal_title：Frontiers in cellular and infection microbiology

authors： Li J,Ramezanpour M,Fong SA,Cooksley C,Murphy J,Suzuki M,Psaltis AJ,Wormald PJ,Vreugde S

更新日期：2019-02-27 00:00:00

abstract：:Candida albicans is a common human fungal pathogen capable of causing serious systemic infections that can progress to become lethal. Current therapeutic approaches have limited effectiveness, especially once a systemic infection is established, in part due to the lack of an effective immune response. Boosting the imm...

journal_title：Frontiers in cellular and infection microbiology

authors： Carpino N,Naseem S,Frank DM,Konopka JB

更新日期：2017-11-21 00:00:00

abstract：:Sortases function as cysteine transpeptidases that catalyze the covalent attachment of virulence-associated surface proteins into the cell wall peptidoglycan in Gram-positive bacteria. The substrate proteins targeted by sortase enzymes have a cell wall sorting signal (CWSS) located at the C-terminus. Up to date, it is...

journal_title：Frontiers in cellular and infection microbiology

authors： Yin JC,Fei CH,Lo YC,Hsiao YY,Chang JC,Nix JC,Chang YY,Yang LW,Huang IH,Wang S

更新日期：2016-11-22 00:00:00

abstract：:Lipophilic yeasts of the genus Malassezia are important skin commensals and opportunistic skin pathogens in a variety of animals. The species M. pachydermatis was first isolated from the skin of a captive Indian rhinoceros with an exfoliative dermatitis in 1925, recognized as an important otic pathogen of dogs in the ...

journal_title：Frontiers in cellular and infection microbiology

authors： Guillot J,Bond R

更新日期：2020-02-28 00:00:00

abstract：:Toxoplasma gondii is a prevalent parasite of mammals and birds including up to 30% of humans world-wide. Primary infection of immunocompetent hosts leads to a robust cell-mediated immune response, which controls but does not clear the infection, thus enabling long-term parasite persistence in brain and muscle tissues....

journal_title：Frontiers in cellular and infection microbiology

authors： Ehmen HG,Lüder CGK

更新日期：2019-06-28 00:00:00

abstract：:The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in immune compromised individuals. This pathogen is typically acquired via inhalation, and enters the respiratory tract. Innate immune cells such as macrophages and dendritic cells (DCs) are the first host cells that encounter C. neoform...

journal_title：Frontiers in cellular and infection microbiology

authors： Nelson BN,Hawkins AN,Wozniak KL

更新日期：2020-02-11 00:00:00

abstract：:Owing to the genetic similarities and conserved pathways between a fruit fly and mammals, the use of the Drosophila model as a platform to unveil novel mechanisms of infection and disease progression has been justified and widely instigated. Gaining proper insight into host-pathogen interactions and identifying chief ...

journal_title：Frontiers in cellular and infection microbiology

authors： Younes S,Al-Sulaiti A,Nasser EAA,Najjar H,Kamareddine L

更新日期：2020-06-23 00:00:00

abstract：:The development of new effective vaccines strongly depends on adjuvants and formulations able to stimulate not only strong humoral responses against a certain pathogen but also effector as well as memory CD4+ and CD8+ T cells (Dubensky et al., 2013). However, the majority of vaccines licensed for human use or currentl...

journal_title：Frontiers in cellular and infection microbiology

authors： Ebensen T,Delandre S,Prochnow B,Guzmán CA,Schulze K

更新日期：2019-02-19 00:00:00

abstract：:The emergence of antimicrobial-resistant (AR) Salmonella has a major concern worldwide. This study was designed to determine the AR profiles and serovars distribution of Salmonella enterica isolated from different breeds of breeder chickens in the province of Henan, China. For this, 2,139 dead embryo samples were coll...

journal_title：Frontiers in cellular and infection microbiology

authors： Xu Y,Zhou X,Jiang Z,Qi Y,Ed-Dra A,Yue M

更新日期：2020-09-15 00:00:00

abstract：:Understanding the systems biology approaches for promoting the development of new therapeutic drugs is attaining importance nowadays. The threat of COVID-19 outbreak needs to be vanished for global welfare, and every section of research is focusing on it. There is an opportunity for finding new, quick, and accurate to...

journal_title：Frontiers in cellular and infection microbiology

authors： Jaiswal S,Kumar M,Mandeep,Sunita,Singh Y,Shukla P

更新日期：2020-10-28 00:00:00

abstract：:Cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB, and CdtC. Among these three toxin subunits, CdtB is the toxic moiety of CDT with DNase I activity, resulting in DNA double-strand breaks (DSB) and, consequently, cell cycle arrest at the G2/M stage and apoptosis. Ra...

journal_title：Frontiers in cellular and infection microbiology

authors： Lin HJ,Liu HH,Lin CD,Kao MC,Chen YA,Chiang-Ni C,Jiang ZP,Huang MZ,Lin CJ,Lo UG,Lin LC,Lai CK,Lin H,Hsieh JT,Chiu CH,Lai CH

更新日期：2017-06-08 00:00:00

abstract：:In the present study, we determined the in vitro characteristics and binding interactions of chicken PD-1 (chPD-1) and PD-L1 (chPD-L1) and developed a panel of specific monoclonal antibodies against the two proteins. ChPD-1 and chPD-L1 sequence identities and similarities were lower compared with those of humans and o...

journal_title：Frontiers in cellular and infection microbiology

authors： Reddy VRAP,Mwangi W,Sadigh Y,Nair V

更新日期：2019-12-19 00:00:00

abstract：:Mammalian species contain an internal circadian (i.e., 24-h) clock that is synchronized to the day and night cycles. Large epidemiological studies, which are supported by carefully controlled studies in numerous species, support the idea that chronic disruption of our circadian cycles results in a number of health iss...

journal_title：Frontiers in cellular and infection microbiology

authors： Shivshankar P,Fekry B,Eckel-Mahan K,Wetsel RA

更新日期：2020-08-14 00:00:00

abstract：:Overwhelming cardiac inflammation has been reported to be the pathogenic mechanism of Coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC), while the detailed molecular mechanisms remain unknown. Membrane-bound dipeptidases (MBD, also known as Dpep) have been shown to be involved in inflammatory diseases. However,...

journal_title：Frontiers in cellular and infection microbiology

authors： Yang X,Yue Y,Xiong S

更新日期：2019-03-07 00:00:00

abstract：:Enterococcus faecium is a clinically important pathogen associated with opportunistic infection and multi-drug resistance. E. faecium has been shown to produce membrane vesicles (MVs), but MV production by E. faecium under antibiotic stress conditions and the pathogenic traits thereof have yet to be determined. This s...

journal_title：Frontiers in cellular and infection microbiology

authors： Kim MH,Kim SY,Son JH,Kim SI,Lee H,Kim S,Shin M,Lee JC

更新日期：2019-08-14 00:00:00

abstract：:Interferon (IFN)-sensitive and replication-incompetent influenza viruses are likely to be the alternatives to inactivated and attenuated virus vaccines. Some IFN-sensitive influenza vaccine candidates with modified non-structural protein 1 (NS1) are highly attenuated in IFN-competent hosts but induce robust antiviral ...

journal_title：Frontiers in cellular and infection microbiology

authors： Chen C,Fan W,Li J,Zheng W,Zhang S,Yang L,Liu D,Liu W,Sun L

更新日期：2018-05-01 00:00:00

abstract：:Systemic and endemic mycoses are considered life-threatening respiratory diseases which are caused by a group of dimorphic fungal pathogens belonging to the genera Histoplasma, Coccidioides, Blastomyces, Paracoccidioides, Talaromyces, and the newly described pathogen Emergomyces. T-cell mediated immunity, mainly T hel...

journal_title：Frontiers in cellular and infection microbiology

authors： Puerta-Arias JD,Mejía SP,González Á

更新日期：2020-12-14 00:00:00

abstract：:The emerging relapsing fever spirochete Borrelia (B.) miyamotoi is transmitted by ixodid ticks and causes the so-called hard tick-borne relapsing fever or B. miyamotoi disease (BMD). More recently, we identified a surface-exposed molecule, CbiA exhibiting complement binding and inhibitory capacity and rendering spiroc...

journal_title：Frontiers in cellular and infection microbiology

authors： Nguyen NTT,Röttgerding F,Devraj G,Lin YP,Koenigs A,Kraiczy P

更新日期：2018-02-02 00:00:00

abstract：:Intestinal microbes are an important system in the human body, with significant effects on behavior. An increasing body of research indicates that intestinal microbes affect brain function and neurogenesis, including sensitivity to stress. To investigate the effects of microbial colonization on behavior, we examined b...

journal_title：Frontiers in cellular and infection microbiology

authors： Huo R,Zeng B,Zeng L,Cheng K,Li B,Luo Y,Wang H,Zhou C,Fang L,Li W,Niu R,Wei H,Xie P

更新日期：2017-11-30 00:00:00