iTRAQ-Based Global Phosphoproteomics Reveals Novel Molecular Differences Between Toxoplasma gondii Strains of Different Genotypes.

abstract：:Non-typeable Haemophilus influenzae (NTHI) is an opportunistic bacterial pathogen of the human respiratory tract and is a leading cause of respiratory infections in children and adults. NTHI is considered to be an extracellular pathogen, but has consistently been observed within and between human respiratory epithelia...

journal_title：Frontiers in cellular and infection microbiology

authors： Clementi CF,Murphy TF

更新日期：2011-11-18 00:00:00

abstract：:The spirochete endoflagellum is a unique motility apparatus among bacteria. Despite its critical importance for pathogenesis, the full composition of the flagellum remains to be determined. We have recently reported that FcpA is a novel flagellar protein and a major component of the sheath of the filament of the spiro...

journal_title：Frontiers in cellular and infection microbiology

authors： Wunder EA Jr,Slamti L,Suwondo DN,Gibson KH,Shang Z,Sindelar CV,Trajtenberg F,Buschiazzo A,Ko AI,Picardeau M

更新日期：2018-05-08 00:00:00

abstract：:Shigella is the major cause of bacillary dysentery world-wide. It is divided into four species, named S. flexneri, S. sonnei, S. dysenteriae, and S. boydii, which are distinct genomically and in their ability to cause disease. Shigellosis, the clinical presentation of Shigella infection, is characterized by watery dia...

journal_title：Frontiers in cellular and infection microbiology

authors： Mattock E,Blocker AJ

更新日期：2017-03-24 00:00:00

abstract：:Murid and cricetid rodents were previously believed to be the principal reservoir hosts of hantaviruses. Recently, however, multiple newfound hantaviruses have been discovered in shrews, moles, and bats, suggesting a complex evolutionary history. Little is known about the genetic diversity and geographic distribution ...

journal_title：Frontiers in cellular and infection microbiology

authors： Kikuchi F,Aoki K,Ohdachi SD,Tsuchiya K,Motokawa M,Jogahara T,Sơn NT,Bawm S,Lin KS,Thwe TL,Gamage CD,Ranorosoa MC,Omar H,Maryanto I,Suzuki H,Tanaka-Taya K,Morikawa S,Mizutani T,Suzuki M,Yanagihara R,Arai S

更新日期：2020-08-27 00:00:00

abstract：:Parasitic infections like amebiasis, trichomoniasis, and giardiasis are major health threats in tropical and subtropical regions of the world. Metronidazole (MTZ) is the current drug of choice for amebiasis, giardiasis, and trichomoniasis but it has several adverse effects and potential resistance is a concern. In ord...

journal_title：Frontiers in cellular and infection microbiology

authors： Kumar S,Bains T,Won Kim AS,Tam C,Kim J,Cheng LW,Land KM,Debnath A,Kumar V

更新日期：2018-10-30 00:00:00

abstract：:Background: The pathogenesis of inflammatory bowel disease (IBD) is linked to an intricate association of environmental, microbial, and host-related factors. Polysaccharide affects host immunity by regulating the composition and metabolism of gut microbiota is the common mechanism of disease resistance. However, the e...

journal_title：Frontiers in cellular and infection microbiology

authors： Su L,Mao C,Wang X,Li L,Tong H,Mao J,Ji,Lu T,Hao M,Huang Z,Fei C,Zhang K,Yan G

更新日期：2020-10-21 00:00:00

abstract：:ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanni, Pseudomonas aeruginosa, and Enterobacter species) pathogens have characteristic multiple-drug resistance and cause an increasing number of nosocomial infections worldwide. Peptide-based therapeutics to treat ESKAPE infe...

journal_title：Frontiers in cellular and infection microbiology

authors： Du H,Puri S,McCall A,Norris HL,Russo T,Edgerton M

更新日期：2017-02-15 00:00:00

abstract：:Whole genome sequencing (WGS) methods provide new possibilities in the field of molecular epidemiology. This is particularly true for monomorphic organisms where the discriminatory power of traditional methods (e.g., restriction enzyme length polymorphism typing, multi locus sequence typing etc.) is inadequate to eluc...

journal_title：Frontiers in cellular and infection microbiology

authors： Wittwer M,Altpeter E,Pilo P,Gygli SM,Beuret C,Foucault F,Ackermann-Gäumann R,Karrer U,Jacob D,Grunow R,Schürch N

更新日期：2018-03-22 00:00:00

abstract：:Cryptosporidium spp. and Enterocytozoon bieneusi are two important zoonotic pathogens that can infect humans and a broad range of animal hosts. However, few studies have been conducted to study infection of the two pathogens in domestic geese until now. The aims of the present study were to determine the prevalence of...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhao W,Zhou HH,Ma TM,Cao J,Lu G,Shen YJ

更新日期：2019-12-04 00:00:00

abstract：:Ten bacteriophages were isolated from faeces and their lytic effects assayed on 103 pathogenic and non-pathogenic Enterobacteriaceae. Two phages (DT1 and DT6) were selected based on their host ranges, and their lytic effects on pathogenic E. coli strains inoculated on pieces of beef were determined. We evaluated the r...

journal_title：Frontiers in cellular and infection microbiology

authors： Tomat D,Migliore L,Aquili V,Quiberoni A,Balagué C

更新日期：2013-06-06 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis, a rare disease of biodefense concern with high mortality and extreme difficulty in treatment. No human vaccines are available that protect against B. pseudomallei infection, and with the current limitations of antibiotic treatment, the development of new...

journal_title：Frontiers in cellular and infection microbiology

authors： Van Zandt KE,Tuanyok A,Keim PS,Warren RL,Gelhaus HC

更新日期：2012-09-26 00:00:00

abstract：:Osteomyelitis is commonly caused by Staphylococcus aureus. Both erythromycin and curcumin can suppress S. aureus growth, but their roles in osteomyelitis are barely studied. We aim to explore the activities of erythromycin and curcumin against chronical osteomyelitis induced by methicillin-resistant S. aureus (MRSA). ...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhou Z,Pan C,Lu Y,Gao Y,Liu W,Yin P,Yu X

更新日期：2017-08-24 00:00:00

abstract：:Burkholderia mallei (Bm) is a highly infectious intracellular pathogen classified as a category B biological agent by the Centers for Disease Control and Prevention. After respiratory exposure, Bm establishes itself within host macrophages before spreading into major organ systems, which can lead to chronic infection,...

journal_title：Frontiers in cellular and infection microbiology

authors： Bozue JA,Chaudhury S,Amemiya K,Chua J,Cote CK,Toothman RG,Dankmeyer JL,Klimko CP,Wilhelmsen CL,Raymond JW,Zavaljevski N,Reifman J,Wallqvist A

更新日期：2016-02-26 00:00:00

abstract：:Histoplasmosis is one of the most frequent systemic mycosis in HIV patients. In these patients, histoplasmosis has high rates of morbidity/mortality if diagnosis and treatment are delayed. Despite its relevance, there is a paucity of information concerning the interaction between Histoplasma capsulatum and the human h...

journal_title：Frontiers in cellular and infection microbiology

authors： Almeida MA,Almeida-Paes R,Guimarães AJ,Valente RH,Soares CMA,Zancopé-Oliveira RM

更新日期：2020-10-29 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fcimb.2018.00102.]. ...

journal_title：Frontiers in cellular and infection microbiology

authors： Yin Y,Zhou D

更新日期：2018-07-27 00:00:00

abstract：:Background: Increasing evidence has shown that Helicobacter pylori is associated with coronary heart disease (CHD); however, the underlying mechanism remains unclear. Methods: The expression of miR-25 and mRNAs was measured using qRT-PCR. Protein levels were detected using western blotting and exosomes were assessed w...

journal_title：Frontiers in cellular and infection microbiology

authors： Li N,Liu SF,Dong K,Zhang GC,Huang J,Wang ZH,Wang TJ

更新日期：2019-10-29 00:00:00

abstract：:Chronic HCV infection is characterized by several immunological alterations, such as the accumulation of suppressor cells and of hyperactivated T lymphocytes. However, it is unclear whether direct-acting antiviral (DAA)-mediated HCV clearance restores immune dysfunctions. We performed a phenotypic characterization by ...

journal_title：Frontiers in cellular and infection microbiology

authors： Telatin V,Nicoli F,Frasson C,Menegotto N,Barbaro F,Castelli E,Erne E,Palù G,Caputo A

更新日期：2019-06-14 00:00:00

abstract：:Quorum Sensing (QS) mediated by Acyl Homoserine Lactone (AHL) molecules are probably the most widespread and studied among Gram-negative bacteria. Canonical AHL systems are composed by a synthase (LuxI family) and a regulator element (LuxR family), whose genes are usually adjacent in the genome. However, incomplete AH...

journal_title：Frontiers in cellular and infection microbiology

authors： Martínez P,Huedo P,Martinez-Servat S,Planell R,Ferrer-Navarro M,Daura X,Yero D,Gibert I

更新日期：2015-05-15 00:00:00

abstract：:In 2019, the United States Food and Drug Administration accorded restricted approval to Sanofi Pasteur's Dengvaxia, a live attenuated vaccine (LAV) for dengue fever, a mosquito-borne viral disease, caused by four antigenically distinct dengue virus serotypes (DENV 1-4). The reason for this limited approval is the conc...

journal_title：Frontiers in cellular and infection microbiology

authors： Shukla R,Ramasamy V,Shanmugam RK,Ahuja R,Khanna N

更新日期：2020-10-22 00:00:00

abstract：:Vibrio alginolyticus is a major cause of Vibriosis in farmed marine aquatic animals and has caused large economic losses to the Asian aquaculture industry in recent years. Therefore, it is necessary to control V. alginolyticus effectively. The virulence mechanism of V. alginolyticus, the Type III secretion system (T3S...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhou S,Tu X,Pang H,Hoare R,Monaghan SJ,Luo J,Jian J

更新日期：2020-04-28 00:00:00

abstract：:Escherichia coli carrying prophage with genes that encode for Shiga toxins are categorized as Shiga toxin-producing E. coli (STEC) pathotype. Illnesses caused by STEC in humans, which are often foodborne, range from mild to bloody diarrhea with life-threatening complications of renal failure and hemolytic uremic syndr...

journal_title：Frontiers in cellular and infection microbiology

authors： Ludwig JB,Shi X,Shridhar PB,Roberts EL,DebRoy C,Phebus RK,Bai J,Nagaraja TG

更新日期：2020-07-29 00:00:00

abstract：:The cell surface mucin MUC1 is an important host factor limiting Helicobacter pylori (H. pylori) pathogenesis in both humans and mice by providing a protective barrier and modulating mucosal epithelial and leukocyte responses. The aim of this study was to establish the time-course of molecular events in MUC1-modulated...

journal_title：Frontiers in cellular and infection microbiology

authors： Sheng YH,Ng GZ,Summers KM,Every AL,Price G,Hasnain SZ,Sutton P,McGuckin MA

更新日期：2020-07-24 00:00:00

abstract：:The mechanism by which microRNAs (miRNAs) modulate innate immunity and autophagy has not been fully elucidated in Mycobacterium bovis (M. bovis) infections. In this study, we identified that miR-199a inhibited key innate immune responses and autophagy in murine macrophages infected with M. bovis. Using ex vivo and in ...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang J,Hussain T,Yue R,Liao Y,Li Q,Yao J,Song Y,Sun X,Wang N,Xu L,Sreevatsan S,Zhao D,Zhou X

更新日期：2018-07-10 00:00:00

abstract：:Pathogenic species of Leptospira cause leptospirosis, a bacterial zoonotic disease with a global distribution affecting over one million people annually. Reservoir hosts of leptospirosis, including rodents, dogs, and cattle, exhibit little to no signs of disease but shed large numbers of organisms in their urine. Tran...

journal_title：Frontiers in cellular and infection microbiology

authors： Nally JE,Grassmann AA,Planchon S,Sergeant K,Renaut J,Seshu J,McBride AJ,Caimano MJ

更新日期：2017-08-09 00:00:00

abstract：:Due to the importance of a rapid determination of patients infected by multidrug resistant bacteria, we evaluated two rapid diagnostic tests for the detection of third-generation cephalosporins (3GC)-resistant Enterobacterales directly from positive blood cultures within 1 h: BL-REDTM (electrochemical method) and β-LA...

journal_title：Frontiers in cellular and infection microbiology

authors： Durand C,Boudet A,Lavigne JP,Pantel A

更新日期：2020-09-11 00:00:00

abstract：:Objectives: To evaluate metagenomic next-generation sequencing (mNGS) as a diagnostic tool in detecting pathogens from osteoarticular infection (OAI) samples. Methods: 130 samples of joint fluid, sonicate fluid, and tissue were prospectively collected from 92 patients with OAI. The performance of mNGS and microbiology...

journal_title：Frontiers in cellular and infection microbiology

authors： Huang ZD,Zhang ZJ,Yang B,Li WB,Zhang CJ,Fang XY,Zhang CF,Zhang WM,Lin JH

更新日期：2020-09-17 00:00:00

abstract：:With major advances in experimental techniques to track antigen-specific immune responses many basic questions on the kinetics of virus-specific immunity in humans remain unanswered. To gain insights into kinetics of T and B cell responses in human volunteers we combined mathematical models and experimental data from ...

journal_title：Frontiers in cellular and infection microbiology

authors： Le D,Miller JD,Ganusov VV

更新日期：2015-01-09 00:00:00

abstract：:The emerging relapsing fever spirochete Borrelia (B.) miyamotoi is transmitted by ixodid ticks and causes the so-called hard tick-borne relapsing fever or B. miyamotoi disease (BMD). More recently, we identified a surface-exposed molecule, CbiA exhibiting complement binding and inhibitory capacity and rendering spiroc...

journal_title：Frontiers in cellular and infection microbiology

authors： Nguyen NTT,Röttgerding F,Devraj G,Lin YP,Koenigs A,Kraiczy P

更新日期：2018-02-02 00:00:00

abstract：:Occurrence of non-Candida albicans Candida (NCAC) species that are associated with elevated MIC values and therapeutic failures are increasing. As a result, timely and accurate means of identification to the species level is becoming an essential part of diagnostic practices in clinical settings. In this study, 301 cl...

journal_title：Frontiers in cellular and infection microbiology

authors： Arastehfar A,Daneshnia F,Kord M,Roudbary M,Zarrinfar H,Fang W,Hashemi SJ,Najafzadeh MJ,Khodavaisy S,Pan W,Liao W,Badali H,Rezaie S,Zomorodian K,Hagen F,Boekhout T

更新日期：2019-02-15 00:00:00

abstract：:Leptospira are emerging zoonotic pathogens transmitted from animals to humans typically through contaminated environmental sources of water and soil. Regulatory pathways of pathogenic Leptospira spp. underlying the adaptive response to different hosts and environmental conditions remains elusive. In this study, we pro...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhukova A,Fernandes LG,Hugon P,Pappas CJ,Sismeiro O,Coppée JY,Becavin C,Malabat C,Eshghi A,Zhang JJ,Yang FX,Picardeau M

更新日期：2017-01-19 00:00:00