Non-typeable Haemophilus influenzae invasion and persistence in the human respiratory tract.

abstract：:MicroRNAs (miRNAs), a group of small molecule non-encoding RNAs, are key post-transcriptional regulators of gene expression that are implicated in many biological processes. In the current study, miR-217 from Eriocheir sinensis was selected for studying its roles during host-virus interaction. Overexpression or silenc...

journal_title：Frontiers in cellular and infection microbiology

authors： Huang Y,Han K,Wang W,Ren Q

更新日期：2017-05-04 00:00:00

abstract：:The Mycobacterium fortuitum complex comprises several closely related species, causing pulmonary and extra-pulmonary infections. However, there is very limited knowledge about the disease pathogenesis involved in M. fortuitum infections, particularly due to the lack of suitable animal models. Using the zebrafish model...

journal_title：Frontiers in cellular and infection microbiology

authors： Johansen MD,Kremer L

更新日期：2020-07-17 00:00:00

abstract：:Intracellular bacterial pathogens have evolved distinct lifestyles inside eukaryotic cells. Some pathogens coexist with the infected cell in an obligate intracellular state, whereas others transit between the extracellular and intracellular environment. Adaptation to these intracellular lifestyles is regulated in both...

journal_title：Frontiers in cellular and infection microbiology

authors： Ortega AD,Quereda JJ,Pucciarelli MG,García-del Portillo F

更新日期：2014-11-12 00:00:00

abstract：:Lipids are essential players in parasites pathogenesis. In particular, the highly phagocytic trophozoites of Entamoeba histolytica, the causative agent of amoebiasis, exhibit a dynamic membrane fusion and fission, in which lipids strongly participate; particularly during the overstated motility of the parasite to reac...

journal_title：Frontiers in cellular and infection microbiology

authors： Castellanos-Castro S,Bolaños J,Orozco E

更新日期：2020-03-10 00:00:00

abstract：:Cerebral malaria is characterized by permanent cognitive impairments in Plasmodium-infected children. Antimalarial therapies show little effectiveness to avoid neurological deficits and brain tissue alterations elicited by severe malaria. Melatonin is a well-recognized endogenous hormone involved in the control of bra...

journal_title：Frontiers in cellular and infection microbiology

authors： Ataide BJA,Kauffmann N,Mendes NSF,Torres MLM,Dos Anjos LM,Passos ADCF,de Moraes SAS,Batista EJO,Herculano AM,Oliveira KRHM

更新日期：2020-09-30 00:00:00

abstract：:The ability of the opportunistic pathogen, Staphylococcus aureus, to form biofilms is increasingly being viewed as an important contributor to chronic infections. In vitro methods for analyzing S. aureus biofilm formation have focused on bacterial attachment and accumulation on abiotic surfaces, such as in microtiter ...

journal_title：Frontiers in cellular and infection microbiology

authors： Walker JN,Horswill AR

更新日期：2012-03-27 00:00:00

abstract：:The worldwide increase in antibiotic-resistant pathogens means that identification of alternative antibacterial drug targets and the subsequent development of new treatment strategies are urgently required. One such new target is the quorum sensing (QS) system. Coral microbial consortia harbor an enormous diversity of...

journal_title：Frontiers in cellular and infection microbiology

authors： Ma ZP,Song Y,Cai ZH,Lin ZJ,Lin GH,Wang Y,Zhou J

更新日期：2018-05-08 00:00:00

abstract：:Melioidosis is a neglected tropical disease with high mortality rate. It is caused by the Gram-negative, CDC category B select agent Burkholderia pseudomallei (B. ps) that is intrinsically resistant to first-line antibiotics. An antibody-based vaccine is likely to be the most effective control measure. Previous studie...

journal_title：Frontiers in cellular and infection microbiology

authors： Chaichana P,Kronsteiner B,Rongkard P,Teparrukkul P,Limmathurotsakul D,Chantratita N,Day NPJ,Fletcher HA,Dunachie SJ

更新日期：2020-08-26 00:00:00

abstract：:Dermatophytosis is one of the most common human infections affecting both immunocompetent individuals and immunocompromised patients, in whom the disease is more aggressive and can reach deep tissues. Over the last decades, cases of deep dermatophytosis have increased and the dermatophyte-host interplay remains poorly...

journal_title：Frontiers in cellular and infection microbiology

authors： Almeida DF,Fraga-Silva TF,Santos AR,Finato AC,Marchetti CM,Golim MA,Lara VS,Arruda MS,Venturini J

更新日期：2017-01-20 00:00:00

abstract：:Dengue fever is an Aedes mosquito-borne illness caused by any one of the four different dengue virus (DENV) serotypes (1-4) and manifests in the form of symptoms ranging from mild or asymptomatic to severe disease with vascular leakage, leading to shock, and viral hemorrhagic syndrome. Increased risk of severe disease...

journal_title：Frontiers in cellular and infection microbiology

authors： Narayan R,Tripathi S

更新日期：2020-10-02 00:00:00

abstract：:Sortases function as cysteine transpeptidases that catalyze the covalent attachment of virulence-associated surface proteins into the cell wall peptidoglycan in Gram-positive bacteria. The substrate proteins targeted by sortase enzymes have a cell wall sorting signal (CWSS) located at the C-terminus. Up to date, it is...

journal_title：Frontiers in cellular and infection microbiology

authors： Yin JC,Fei CH,Lo YC,Hsiao YY,Chang JC,Nix JC,Chang YY,Yang LW,Huang IH,Wang S

更新日期：2016-11-22 00:00:00

abstract：:Cytokinesis, or the division of the cytoplasm, following the end of mitosis or meiosis, is accomplished in animal cells, fungi, and amoebae, by the constriction of an actomyosin contractile ring, comprising filamentous actin, myosin II, and associated proteins. However, despite this being the best-studied mode of cyto...

journal_title：Frontiers in cellular and infection microbiology

authors： Hammarton TC

更新日期：2019-11-21 00:00:00

abstract：:The development of new effective vaccines strongly depends on adjuvants and formulations able to stimulate not only strong humoral responses against a certain pathogen but also effector as well as memory CD4+ and CD8+ T cells (Dubensky et al., 2013). However, the majority of vaccines licensed for human use or currentl...

journal_title：Frontiers in cellular and infection microbiology

authors： Ebensen T,Delandre S,Prochnow B,Guzmán CA,Schulze K

更新日期：2019-02-19 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis, a rare disease of biodefense concern with high mortality and extreme difficulty in treatment. No human vaccines are available that protect against B. pseudomallei infection, and with the current limitations of antibiotic treatment, the development of new...

journal_title：Frontiers in cellular and infection microbiology

authors： Van Zandt KE,Tuanyok A,Keim PS,Warren RL,Gelhaus HC

更新日期：2012-09-26 00:00:00

abstract：:Response regulators are a critical part of the two-component system of gene expression regulation in bacteria, transferring a signal from a sensor kinase into DNA binding activity resulting in alteration of gene expression. In this study, we investigated a previously uncharacterized response regulator in Francisella n...

journal_title：Frontiers in cellular and infection microbiology

authors： Dean SN,Milton ME,Cavanagh J,van Hoek ML

更新日期：2020-03-13 00:00:00

abstract：:Increased numbers of peripheral blood mononucleocytes (PBMC) and increased IFN-γ secretion following in vitro challenge of blood samples with soluble Leishmania antigen (SLA), have been proposed as biomarkers of specific cell-mediated immunity, indicating that treatment of visceral leishmaniasis (VL) has been successf...

journal_title：Frontiers in cellular and infection microbiology

authors： Botana L,Matía B,San Martin JV,Romero-Maté A,Castro A,Molina L,Fernandez L,Ibarra-Meneses A,Aguado M,Sánchez C,Horrillo L,Chicharro C,Nieto J,Ortega S,Ruiz-Giardin JM,Carrillo E,Moreno J

更新日期：2018-11-13 00:00:00

abstract：:Sepsis is a severe syndrome that arises when the host response to an insult is exacerbated, leading to organ failure and frequently to death. How a chronic infection that causes a prolonged Th1 expansion affects the course of sepsis is unknown. In this study, we showed that mice chronically infected with Toxoplasma go...

journal_title：Frontiers in cellular and infection microbiology

authors： Souza MC,Fonseca DM,Kanashiro A,Benevides L,Medina TS,Dias MS,Andrade WA,Bonfá G,Silva MAB,Gozzi A,Borges MC,Gazzinelli RT,Alves-Filho JC,Cunha FQ,Silva JS

更新日期：2017-04-07 00:00:00

abstract：:Background:Pseudomonas aeruginosa causes severe chronic respiratory diseases and is associated with recalcitrant chronic rhinosinusitis (CRS). P. aeruginosa exoproteins contain virulence factors and play important roles in the pathogenicity of P. aeruginosa, however their role in CRS pathophysiology remains unknown. M...

journal_title：Frontiers in cellular and infection microbiology

authors： Li J,Ramezanpour M,Fong SA,Cooksley C,Murphy J,Suzuki M,Psaltis AJ,Wormald PJ,Vreugde S

更新日期：2019-02-27 00:00:00

abstract：:Neutrophils are the first cells recruited to the dermal site of Leishmania infection following injection by needle or sand fly bite. The role of neutrophils in either promoting or suppressing host immunity remains controversial. We discuss the events driving neutrophil recruitment, their interaction with the parasite ...

journal_title：Frontiers in cellular and infection microbiology

authors： Ribeiro-Gomes FL,Sacks D

更新日期：2012-05-04 00:00:00

abstract：:The protozoan Trypanosoma cruzi is the etiological agent of Chagas disease. In immunosuppressed individuals, as it occurs in the coinfection with human immunodeficiency virus (HIV), the central nervous system may be affected. In this regard, reactivation of Chagas disease is severe and often lethal, and it accounts fo...

journal_title：Frontiers in cellular and infection microbiology

authors： Urquiza JM,Burgos JM,Ojeda DS,Pascuale CA,Leguizamón MS,Quarleri JF

更新日期：2017-08-02 00:00:00

abstract：:Non-encapsulated Streptococcus pneumoniae often possess two genes, aliB-like ORF 1 and aliB-like ORF 2, in place of capsule genes. AliB-like ORF 1 is thought to encode a substrate binding protein of an ABC transporter which binds peptide SETTFGRDFN, found in 50S ribosomal subunit protein L4 of Enterobacteriaceae. Here...

journal_title：Frontiers in cellular and infection microbiology

authors： Nasher F,Kwun MJ,Croucher NJ,Heller M,Hathaway LJ

更新日期：2019-09-10 00:00:00

abstract：:Due to increased travel, climatic, and environmental changes, the incidence of tick-borne disease in both humans and animals is increasing throughout Europe. Therefore, extended surveillance tools are desirable. To accurately screen tick-borne pathogens (TBPs), a large scale epidemiological study was conducted on 7050...

journal_title：Frontiers in cellular and infection microbiology

authors： Michelet L,Delannoy S,Devillers E,Umhang G,Aspan A,Juremalm M,Chirico J,van der Wal FJ,Sprong H,Boye Pihl TP,Klitgaard K,Bødker R,Fach P,Moutailler S

更新日期：2014-07-29 00:00:00

abstract：:Bacteria of the Salmonella genus cause diseases ranging from gastroenteritis to life-threatening typhoid fever and are among the most successful intracellular pathogens known. After the invasion of the eukaryotic cell, Salmonella exhibits contrasting lifestyles with different replication rates and subcellular location...

journal_title：Frontiers in cellular and infection microbiology

authors： Castanheira S,García-Del Portillo F

更新日期：2017-10-04 00:00:00

abstract：:The hemostatic system comprises platelet aggregation, coagulation and fibrinolysis and is a host defense mechanism that protects the integrity of the vascular system after tissue injury. During bacterial infections, the coagulation system cooperates with the inflammatory system to eliminate the invading pathogens. How...

journal_title：Frontiers in cellular and infection microbiology

authors： Loof TG,Deicke C,Medina E

更新日期：2014-09-11 00:00:00

abstract：:To investigate the parameters associated with post-treatment recurrence of bacterial vaginosis (BV), clinical factors and vaginal microbiota were examined and analyzed for BV patients who received standard metronidazole therapy. The variables associated with BV recurrence included clinical factors of past BV history, ...

journal_title：Frontiers in cellular and infection microbiology

authors： Xiao B,Wu C,Song W,Niu X,Qin N,Liu Z,Xu Q

更新日期：2019-06-11 00:00:00

abstract：:The emerging relapsing fever spirochete Borrelia (B.) miyamotoi is transmitted by ixodid ticks and causes the so-called hard tick-borne relapsing fever or B. miyamotoi disease (BMD). More recently, we identified a surface-exposed molecule, CbiA exhibiting complement binding and inhibitory capacity and rendering spiroc...

journal_title：Frontiers in cellular and infection microbiology

authors： Nguyen NTT,Röttgerding F,Devraj G,Lin YP,Koenigs A,Kraiczy P

更新日期：2018-02-02 00:00:00

abstract：:Despite decades of dedicated research, there remains a dire need for new drugs against tuberculosis (TB). Current therapies are generations old and problematic. Resistance to these existing therapies results in an ever-increasing burden of patients with disease that is difficult or impossible to treat. Novel chemical ...

journal_title：Frontiers in cellular and infection microbiology

authors： Butman HS,Kotzé TJ,Dowd CS,Strauss E

更新日期：2020-12-15 00:00:00

abstract：:Diethylhexylphthalate (DEHP), acting as an endocrine disruptor, disturbed reproductive health. Here, we evaluated the effects of Lactobacillus plantarum TW1-1 (L. plantarum TW1-1) on DEHP-induced testicular damage in adult male mice. Results showed that oral supplementation of L. plantarum TW1-1 significantly increase...

journal_title：Frontiers in cellular and infection microbiology

authors： Tian X,Yu Z,Feng P,Ye Z,Li R,Liu J,Hu J,Kakade A,Liu P,Li X

更新日期：2019-06-26 00:00:00

abstract：Background:Disseminated histoplasmosis remains a major killer of immunocompromised patients in Latin America. Cytological and histological methods are usually present in most hospitals and may represent a precious diagnostic method. We report 15 years of experience of the department of pathology of the Centre Hospitali...

journal_title：Frontiers in cellular and infection microbiology

authors： Drak Alsibai K,Couppié P,Blanchet D,Adenis A,Epelboin L,Blaizot R,Louvel D,Djossou F,Demar M,Nacher M

更新日期：2020-10-29 00:00:00

abstract：:A cohort study was conducted to evaluate oral microbial diversity among toddlers aged 12-24 months, and to describe the dynamic processes of colonization, development, and stabilization of the oral microflora during tooth eruption using high-throughput sequencing technology. A total of 20 healthy toddlers aged 12 mont...

journal_title：Frontiers in cellular and infection microbiology

authors： Li F,Tao D,Feng X,Wong MCM,Lu H

更新日期：2018-12-04 00:00:00