CFTR Depletion Confers Hypersusceptibility to Mycobacterium fortuitum in a Zebrafish Model.

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) represents the etiological agent for several human malignancies, including Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD), which are mostly seen in immunocompromised patients. In fact, KSHV has developed many strategies ...

journal_title：Frontiers in cellular and infection microbiology

authors： Barrett L,Chen J,Dai L,Plaisance-Bonstaff K,Del Valle L,Qin Z

更新日期：2020-10-30 00:00:00

abstract：:The hemostatic system comprises platelet aggregation, coagulation and fibrinolysis and is a host defense mechanism that protects the integrity of the vascular system after tissue injury. During bacterial infections, the coagulation system cooperates with the inflammatory system to eliminate the invading pathogens. How...

journal_title：Frontiers in cellular and infection microbiology

authors： Loof TG,Deicke C,Medina E

更新日期：2014-09-11 00:00:00

abstract：:Over the last few decades, concepts of protein intrinsic disorder have been implicated in different biological processes. Recent studies have suggested that intrinsically disordered proteins (IDPs) provide structural plasticity and functional diversity to viral proteins that are involved in rapid replication and immun...

journal_title：Frontiers in cellular and infection microbiology

authors： Giri R,Kumar D,Sharma N,Uversky VN

更新日期：2016-11-04 00:00:00

abstract：:The hemorrhagic septicemic disease vibriosis caused by Vibrio anguillarum shows noticeable similarities to invasive septicemia in humans, and in this case, the V. anguillarum-host system has the potential to serve as a model for understanding native eukaryotic host-pathogen interactions. Iron acquisition, as a fierce ...

journal_title：Frontiers in cellular and infection microbiology

authors： Li Y,Ma Q

更新日期：2017-07-25 00:00:00

abstract：:Dengue virus (DENV) threatens almost 70% of the world's population, with no therapeutic currently available. The severe, potentially lethal forms of DENV disease (dengue hemorrhagic fever/dengue shock syndrome) are associated with the production of high level of cytokines, elicited as part of the host antiviral respon...

journal_title：Frontiers in cellular and infection microbiology

authors： Giovannoni F,Ladelfa MF,Monte M,Jans DA,Hemmerich P,García C

更新日期：2019-08-13 00:00:00

abstract：:Postpartum depressive disorder (PPD) is a unique subtype of major depressive disorder and a substantial contributor to maternal morbidity and mortality. However, the pathogenesis of PPD has still remained elusive, and it may associate with genetic and environmental factors. Gut microbiota has already been proved to be...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhou Y,Chen C,Yu H,Yang Z

更新日期：2020-09-29 00:00:00

abstract：:The frequent emergence of azole-resistant strains has increasingly led azoles to fail in treating candidiasis. Combination with other drugs is a good option to effectively reduce or retard its incidence of resistance. Natural products are a promising synergist source to assist azoles in treating resistant candidiasis....

journal_title：Frontiers in cellular and infection microbiology

authors： Xu J,Liu R,Sun F,An L,Shang Z,Kong L,Yang M

更新日期：2019-06-20 00:00:00

abstract：:With major advances in experimental techniques to track antigen-specific immune responses many basic questions on the kinetics of virus-specific immunity in humans remain unanswered. To gain insights into kinetics of T and B cell responses in human volunteers we combined mathematical models and experimental data from ...

journal_title：Frontiers in cellular and infection microbiology

authors： Le D,Miller JD,Ganusov VV

更新日期：2015-01-09 00:00:00

abstract：:Nosocomial pathogens that develop multidrug resistance present an increasing problem for healthcare facilities. Due to its rapid rise in antibiotic resistance, Acinetobacter baumannii is one of the most concerning gram-negative species. A. baumannii typically infects immune compromised individuals resulting in a varie...

journal_title：Frontiers in cellular and infection microbiology

authors： Waack U,Johnson TL,Chedid K,Xi C,Simmons LA,Mobley HLT,Sandkvist M

更新日期：2017-08-28 00:00:00

abstract：:The spread of microorganisms in hospitals is an important public health threat, and yet few studies have assessed how human microbial communities (microbiota) evolve in the hospital setting. Studies conducted so far have mainly focused on a limited number of bacterial species, mostly pathogenic ones and primarily duri...

journal_title：Frontiers in cellular and infection microbiology

authors： Lazarevic V,Gaïa N,Emonet S,Girard M,Renzi G,Despres L,Wozniak H,Yugueros Marcos J,Veyrieras JB,Chatellier S,van Belkum A,Pugin J,Schrenzel J

更新日期：2014-05-23 00:00:00

abstract：:MiRNAs are important post-transcriptional regulators of gene expression. MiRNA expression is a crucial part of host responses to bacterial infection, however there is limited knowledge of their impact on the outcome of infections. We investigated the influence of miR-21 on macrophage responses during infection with Li...

journal_title：Frontiers in cellular and infection microbiology

authors： Johnston DGW,Kearney J,Zasłona Z,Williams MA,O'Neill LAJ,Corr SC

更新日期：2017-05-23 00:00:00

abstract：:Visceral leishmaniasis is a neglected tropical disease caused by Leishmania (L.) donovani parasite in the Indian subcontinent. Macrophages (mϕ) are the harboring cells for parasite and their interactions dictate the pathogenesis of this disease. Polyunsaturated fatty acids are an integral part of the mϕ cell membrane ...

journal_title：Frontiers in cellular and infection microbiology

authors： Saini S,Rai AK

更新日期：2020-08-07 00:00:00

abstract：:The intracellular parasite Toxoplasma gondii can cause chronic infections in most warm-blooded animals, including humans. In the USA, strains belonging to four different Toxoplasma clonal lineages (types 1, 2, 3, and 12) are commonly isolated, whereas strains not belonging to these lineages are predominant in other co...

journal_title：Frontiers in cellular and infection microbiology

authors： Arranz-Solís D,Cordeiro C,Young LH,Dardé ML,Commodaro AG,Grigg ME,Saeij JPJ

更新日期：2019-11-29 00:00:00

abstract：:Macrophages being the connecting link between innate and adaptive immune system plays a crucial role in microbial antigen presentation and orchestrates the subsequent clearance of microorganisms. Microbial invasion of macrophages trigger a plethora of signaling cascades, which interact among them to generate a dynamic...

journal_title：Frontiers in cellular and infection microbiology

authors： Saha S,Das P,BoseDasgupta S

更新日期：2020-10-20 00:00:00

abstract：:Proton pump inhibitors (PPIs) are the standard therapy for gastroesophageal reflux disease. In adults, PPI treatment is associated with Clostridium difficile infections (CDI). In contrast to adults the microbiome of infants develops from sterility at birth toward an adult-like profile in the first years of life. The e...

journal_title：Frontiers in cellular and infection microbiology

authors： Castellani C,Singer G,Kashofer K,Huber-Zeyringer A,Flucher C,Kaiser M,Till H

更新日期：2017-10-11 00:00:00

abstract：:The formation of biofilms by Staphylococcus aureus and Staphylococcus epidermidis is an important aspect of many staphylococcal infections, most notably endocarditis, osteomyelitis and infections associated with indwelling medical devices. The major constituents of staphylococcal biofilms are polysaccharides, such as ...

journal_title：Frontiers in cellular and infection microbiology

authors： Cue D,Lei MG,Lee CY

更新日期：2012-03-26 00:00:00

abstract：:Diethylhexylphthalate (DEHP), acting as an endocrine disruptor, disturbed reproductive health. Here, we evaluated the effects of Lactobacillus plantarum TW1-1 (L. plantarum TW1-1) on DEHP-induced testicular damage in adult male mice. Results showed that oral supplementation of L. plantarum TW1-1 significantly increase...

journal_title：Frontiers in cellular and infection microbiology

authors： Tian X,Yu Z,Feng P,Ye Z,Li R,Liu J,Hu J,Kakade A,Liu P,Li X

更新日期：2019-06-26 00:00:00

abstract：:Background:Pseudomonas aeruginosa causes severe chronic respiratory diseases and is associated with recalcitrant chronic rhinosinusitis (CRS). P. aeruginosa exoproteins contain virulence factors and play important roles in the pathogenicity of P. aeruginosa, however their role in CRS pathophysiology remains unknown. M...

journal_title：Frontiers in cellular and infection microbiology

authors： Li J,Ramezanpour M,Fong SA,Cooksley C,Murphy J,Suzuki M,Psaltis AJ,Wormald PJ,Vreugde S

更新日期：2019-02-27 00:00:00

abstract：:Intracellular bacterial pathogens (IBPs) invade and replicate in different cell types including immune cells, in particular of the innate immune system (IIS) during infection in the acute phase. However, immune cells primarily function as essential players in the highly effective and integrated host defense systems co...

journal_title：Frontiers in cellular and infection microbiology

authors： Eisenreich W,Rudel T,Heesemann J,Goebel W

更新日期：2017-07-13 00:00:00

abstract：:The ability of the opportunistic pathogen, Staphylococcus aureus, to form biofilms is increasingly being viewed as an important contributor to chronic infections. In vitro methods for analyzing S. aureus biofilm formation have focused on bacterial attachment and accumulation on abiotic surfaces, such as in microtiter ...

journal_title：Frontiers in cellular and infection microbiology

authors： Walker JN,Horswill AR

更新日期：2012-03-27 00:00:00

abstract：:Pathogenic fungi have developed many strategies to evade the host immune system. Multiple escape mechanisms appear to function together to inhibit attack by the various stages of both the adaptive and the innate immune response. Thus, after entering the host, such pathogens fight to overcome the immune system to allow...

journal_title：Frontiers in cellular and infection microbiology

authors： Marcos CM,de Oliveira HC,de Melo WC,da Silva JF,Assato PA,Scorzoni L,Rossi SA,de Paula E Silva AC,Mendes-Giannini MJ,Fusco-Almeida AM

更新日期：2016-11-15 00:00:00

abstract：:In 2019, the United States Food and Drug Administration accorded restricted approval to Sanofi Pasteur's Dengvaxia, a live attenuated vaccine (LAV) for dengue fever, a mosquito-borne viral disease, caused by four antigenically distinct dengue virus serotypes (DENV 1-4). The reason for this limited approval is the conc...

journal_title：Frontiers in cellular and infection microbiology

authors： Shukla R,Ramasamy V,Shanmugam RK,Ahuja R,Khanna N

更新日期：2020-10-22 00:00:00

abstract：:Extracellular vesicles (EVs) have garnered much interest in the cell biology and biomedical research fields. Many studies have reported the existence of EVs in all types of living cells, including in fifteen different fungal genera. EVs play diverse biological roles, from the regulation of physiological events and res...

journal_title：Frontiers in cellular and infection microbiology

authors： Rizzo J,Rodrigues ML,Janbon G

更新日期：2020-07-15 00:00:00

abstract：:Streptococcus mutans is an oral species closely associated with dental caries. As an early oral colonizer, S. mutans utilizes interspecies coaggregation to promote the colonization of subsequent species and affect polymicrobial pathogenesis. Previous studies have confirmed several adhering partner species of S. mutans...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu T,Liu J,Liu J,Yang R,Lu X,He X,Shi W,Guo L

更新日期：2020-07-07 00:00:00

abstract：:Cross talk occurs between the human gut and the lung through a gut-lung axis involving the gut microbiota. However, the signatures of the human gut microbiota after active Mycobacterium tuberculosis infection have not been fully understood. Here, we investigated changes in the gut microbiota in tuberculosis (TB) patie...

journal_title：Frontiers in cellular and infection microbiology

authors： Hu Y,Feng Y,Wu J,Liu F,Zhang Z,Hao Y,Liang S,Li B,Li J,Lv N,Xu Y,Zhu B,Sun Z

更新日期：2019-04-03 00:00:00

abstract：:Brucella is a facultative intracellular pathogen that causes zoonotic infection known as brucellosis which results in abortion and infertility in natural host. Humans, especially in low income countries, can acquire infection by direct contact with infected animal or by consumption of animal products and show high mor...

journal_title：Frontiers in cellular and infection microbiology

authors： Ahmed W,Zheng K,Liu ZF

更新日期：2016-03-15 00:00:00

abstract：:Thyroxine metabolism is an important topic of pathogenesis research and treatment schedule of subclinical hypothyroidism (SCH). L-Thyroxine replacement therapy (LRT) is usually recommended for severe SCH patients only. Our previous studies reported that disordered serum lipid of mild SCH people could also benefit from...

journal_title：Frontiers in cellular and infection microbiology

authors： Yao Z,Zhao M,Gong Y,Chen W,Wang Q,Fu Y,Guo T,Zhao J,Gao L,Bo T

更新日期：2020-09-18 00:00:00

abstract：:The oral microbiome can play a role in the instigation and progression of oral diseases that can manifest into other systemic conditions. These associations encourage the exploration of oral dysbiosis leading to the pathogenesis of cancers. In this study, oral rinse was used to characterize the oral microbiome fluctua...

journal_title：Frontiers in cellular and infection microbiology

authors： Lim Y,Fukuma N,Totsika M,Kenny L,Morrison M,Punyadeera C

更新日期：2018-08-03 00:00:00

abstract：:The plasma membrane of mammalian cells is susceptible to disruption by mechanical and biochemical damages that frequently occur within tissues. Therefore, efficient and rapid repair of the plasma membrane is essential for maintaining cellular homeostasis and survival. Excessive damage of the plasma membrane and defect...

journal_title：Frontiers in cellular and infection microbiology

authors： Pathak-Sharma S,Zhang X,Lam JGT,Weisleder N,Seveau SM

更新日期：2017-07-14 00:00:00

abstract：:Objective:Streptococcus pneumoniae colonizes the nasopharynx of children, and from nasopharynx it could migrate to the middle ear and causes acute otitis media (AOM). During colonization and AOM, the pneumococcus forms biofilms. In vitro biofilm formation requires a functional LuxS/AI-2 quorum-sensing system. We inves...

journal_title：Frontiers in cellular and infection microbiology

authors： Yadav MK,Vidal JE,Go YY,Kim SH,Chae SW,Song JJ

更新日期：2018-05-04 00:00:00