Establishment of Chronic Infection: Brucella's Stealth Strategy.

abstract：:Mycobacterium bovis (M. bovis) is the pathogen of animals and humans that can replicate in the phagosomes of myeloid cells. Cytosolic detection of bacterial products plays a crucial role in initiating the innate immune response, including autophagy activation and interferon-β (IFN-β) release. Although IFN-β release an...

journal_title：Frontiers in cellular and infection microbiology

authors： Chunfa L,Xin S,Qiang L,Sreevatsan S,Yang L,Zhao D,Zhou X

更新日期：2017-05-05 00:00:00

abstract：:Myocarditis, inflammation of the heart muscle, affects all demographics and is a major cause of sudden and unexpected death in young people. It is most commonly caused by viral infections of the heart, with coxsackievirus B3 (CVB3) being among the most prevalent pathogens. To understand the molecular pathogenesis of C...

journal_title：Frontiers in cellular and infection microbiology

authors： Hanson PJ,Hossain AR,Qiu Y,Zhang HM,Zhao G,Li C,Lin V,Sulaimon S,Vlok M,Fung G,Chen VH,Jan E,McManus BM,Granville DJ,Yang D

更新日期：2019-07-24 00:00:00

abstract：:Thyroxine metabolism is an important topic of pathogenesis research and treatment schedule of subclinical hypothyroidism (SCH). L-Thyroxine replacement therapy (LRT) is usually recommended for severe SCH patients only. Our previous studies reported that disordered serum lipid of mild SCH people could also benefit from...

journal_title：Frontiers in cellular and infection microbiology

authors： Yao Z,Zhao M,Gong Y,Chen W,Wang Q,Fu Y,Guo T,Zhao J,Gao L,Bo T

更新日期：2020-09-18 00:00:00

abstract：:The intracellular parasite Toxoplasma gondii can cause chronic infections in most warm-blooded animals, including humans. In the USA, strains belonging to four different Toxoplasma clonal lineages (types 1, 2, 3, and 12) are commonly isolated, whereas strains not belonging to these lineages are predominant in other co...

journal_title：Frontiers in cellular and infection microbiology

authors： Arranz-Solís D,Cordeiro C,Young LH,Dardé ML,Commodaro AG,Grigg ME,Saeij JPJ

更新日期：2019-11-29 00:00:00

abstract：:Background: Intraocular tuberculosis (IOTB), an extrapulmonary manifestation of tuberculosis of the eye, has unique and varied clinical presentations with poorly understood pathogenesis. As it is a significant cause of inflammation and visual morbidity, particularly in TB endemic countries, it is essential to study th...

journal_title：Frontiers in cellular and infection microbiology

authors： Abhishek S,Saikia UN,Gupta A,Bansal R,Gupta V,Singh N,Laal S,Verma I

更新日期：2018-10-02 00:00:00

abstract：:Schistosomes, a class of parasitic trematode worms, cause schistosomiasis. Accumulating evidence suggests that microRNAs (miRNAs)-small, non-coding RNAs that are known to play critical regulatory roles in many organisms-may be involved in schistosome development and sexual maturation, as well as the pathogenesis of sc...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhu L,Liu J,Cheng G

更新日期：2014-11-11 00:00:00

abstract：:Sortases function as cysteine transpeptidases that catalyze the covalent attachment of virulence-associated surface proteins into the cell wall peptidoglycan in Gram-positive bacteria. The substrate proteins targeted by sortase enzymes have a cell wall sorting signal (CWSS) located at the C-terminus. Up to date, it is...

journal_title：Frontiers in cellular and infection microbiology

authors： Yin JC,Fei CH,Lo YC,Hsiao YY,Chang JC,Nix JC,Chang YY,Yang LW,Huang IH,Wang S

更新日期：2016-11-22 00:00:00

abstract：:Clostridium difficile infections (CDI) are a major cause of antibiotic-associated diarrhea. It is hypothesized that CDI develops due to the antibiotic-induced disruption of the intestinal microbial community structure, which allows C. difficile to flourish. Here, we pre-treated weaned pigs with the antibiotics Clindam...

journal_title：Frontiers in cellular and infection microbiology

authors： Jurburg SD,Cornelissen JJBWJ,de Boer P,Smits MA,Rebel JMJ

更新日期：2019-08-06 00:00:00

abstract：:The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB2 toxin capable of inducing lymphocytes, and other cell types, to undergo cell cycle arrest and apoptosis. Exposure to Cdt results in binding to the cell surface followed by internalization and translocation of the active...

journal_title：Frontiers in cellular and infection microbiology

authors： Boesze-Battaglia K,Walker LP,Dhingra A,Kandror K,Tang HY,Shenker BJ

更新日期：2017-11-14 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) represents the etiological agent for several human malignancies, including Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD), which are mostly seen in immunocompromised patients. In fact, KSHV has developed many strategies ...

journal_title：Frontiers in cellular and infection microbiology

authors： Barrett L,Chen J,Dai L,Plaisance-Bonstaff K,Del Valle L,Qin Z

更新日期：2020-10-30 00:00:00

abstract：:An important component in host resistance to malaria infection are inherited mutations that give rise to abnormalities and deficiencies in erythrocyte proteins and enzymes. Understanding how such mutations confer protection against the disease may be useful for developing new treatment strategies. A mouse ENU-induced ...

journal_title：Frontiers in cellular and infection microbiology

authors： Schnider CB,Yang H,Starrs L,Ehmann A,Rahimi F,Di Pierro E,Graziadei G,Matthews K,De Koning-Ward T,Bauer DC,Foote SJ,Burgio G,McMorran BJ

更新日期：2020-09-03 00:00:00

abstract：:Escherichia coli O157:H7 is a notorious pathogen often contracted by intake of contaminated water or food. Infection with this agent is associated with a broad spectrum of illness ranging from mild diarrhea and hemorrhagic colitis to the potentially fatal hemolytic uremic syndrome (HUS). Treating E. coli O157:H7 infec...

journal_title：Frontiers in cellular and infection microbiology

authors： Rahal EA,Kazzi N,Nassar FJ,Matar GM

更新日期：2012-11-15 00:00:00

abstract：:Syf1 is a tetratricopeptide repeat (TPR) protein implicated in transcription elongation, spliceosome conformation, mRNA nuclear-cytoplasmic export and transcription-coupled DNA repair. Recently, we identified the spliceosomal components of the human parasite Entamoeba histolytica, among them is EhSyf. Molecular predic...

journal_title：Frontiers in cellular and infection microbiology

authors： Torres-Cifuentes DM,Galindo-Rosales JM,Saucedo-Cárdenas O,Valdés J

更新日期：2018-07-09 00:00:00

abstract：:Cold shock-domain family proteins (Csps) are highly conserved nucleic acid binding proteins regulating the expression of various genes including those involved in stress resistance and virulence in bacteria. We show here that Csps are involved in virulence, cell aggregation and flagella-based extracellular motility of...

journal_title：Frontiers in cellular and infection microbiology

authors： Eshwar AK,Guldimann C,Oevermann A,Tasara T

更新日期：2017-10-26 00:00:00

abstract：:The Mycobacterium fortuitum complex comprises several closely related species, causing pulmonary and extra-pulmonary infections. However, there is very limited knowledge about the disease pathogenesis involved in M. fortuitum infections, particularly due to the lack of suitable animal models. Using the zebrafish model...

journal_title：Frontiers in cellular and infection microbiology

authors： Johansen MD,Kremer L

更新日期：2020-07-17 00:00:00

abstract：:Nosocomial pathogens that develop multidrug resistance present an increasing problem for healthcare facilities. Due to its rapid rise in antibiotic resistance, Acinetobacter baumannii is one of the most concerning gram-negative species. A. baumannii typically infects immune compromised individuals resulting in a varie...

journal_title：Frontiers in cellular and infection microbiology

authors： Waack U,Johnson TL,Chedid K,Xi C,Simmons LA,Mobley HLT,Sandkvist M

更新日期：2017-08-28 00:00:00

abstract：:Pneumocystis pneumonia (PCP) remains the most frequent AIDS-defining illness in developed countries. This infection also occurs in non-AIDS immunosuppressed patients, e.g., those who have undergone an organ transplantation. Moreover, mild Pneumocystis jirovecii infections related to low pulmonary fungal burden, freque...

journal_title：Frontiers in cellular and infection microbiology

authors： Bonnet P,Le Gal S,Calderon E,Delhaes L,Quinio D,Robert-Gangneux F,Ramel S,Nevez G

更新日期：2020-09-29 00:00:00

abstract：:Chlamydia trachomatis is the leading cause of preventable blindness and the most common bacterial sexually transmitted infection. Different strains are associated with ocular or urogenital infections, and a proposed mechanism that may explain this tissue tropism is the active tryptophan biosynthesis pathway encoded by...

journal_title：Frontiers in cellular and infection microbiology

authors： O'Neill CE,Skilton RJ,Pearson SA,Filardo S,Andersson P,Clarke IN

更新日期：2018-12-14 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) O157:H7 EspF is an important multifunctional protein that destroys the tight junctions of intestinal epithelial cells and promotes host cell apoptosis. However, its molecular mechanism remains elusive. We knocked out the espF sequence (747 bp, ΔespF), N-terminal sequence (219 ...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang X,Du Y,Hua Y,Fu M,Niu C,Zhang B,Zhao W,Zhang Q,Wan C

更新日期：2017-09-21 00:00:00

abstract：:Background: The pathogenesis of inflammatory bowel disease (IBD) is linked to an intricate association of environmental, microbial, and host-related factors. Polysaccharide affects host immunity by regulating the composition and metabolism of gut microbiota is the common mechanism of disease resistance. However, the e...

journal_title：Frontiers in cellular and infection microbiology

authors： Su L,Mao C,Wang X,Li L,Tong H,Mao J,Ji,Lu T,Hao M,Huang Z,Fei C,Zhang K,Yan G

更新日期：2020-10-21 00:00:00

abstract：:Ticks are vectors of pathogens affecting human and animal health worldwide. Nevertheless, the ecological and evolutionary interactions between ticks, hosts, and pathogens are largely unknown. Here, we integrated a framework to evaluate the associations of the tick Ixodes ricinus with its hosts and environmental niches...

journal_title：Frontiers in cellular and infection microbiology

authors： Estrada-Peña A,de la Fuente J,Cabezas-Cruz A

更新日期：2017-05-31 00:00:00

abstract：:Toxoplasma gondii is a prevalent parasite of mammals and birds including up to 30% of humans world-wide. Primary infection of immunocompetent hosts leads to a robust cell-mediated immune response, which controls but does not clear the infection, thus enabling long-term parasite persistence in brain and muscle tissues....

journal_title：Frontiers in cellular and infection microbiology

authors： Ehmen HG,Lüder CGK

更新日期：2019-06-28 00:00:00

abstract：:Vibrio alginolyticus is a major cause of Vibriosis in farmed marine aquatic animals and has caused large economic losses to the Asian aquaculture industry in recent years. Therefore, it is necessary to control V. alginolyticus effectively. The virulence mechanism of V. alginolyticus, the Type III secretion system (T3S...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhou S,Tu X,Pang H,Hoare R,Monaghan SJ,Luo J,Jian J

更新日期：2020-04-28 00:00:00

abstract：:Interferons (IFNs) were discovered over a half-century ago as antiviral factors. The role of type I IFNs has been studied in the pathogenesis of both acute and chronic microbial infections. Deregulated type I IFN production results in a damaging cascade of cell death, inflammation, and immunological host responses tha...

journal_title：Frontiers in cellular and infection microbiology

authors： Malireddi RK,Kanneganti TD

更新日期：2013-11-12 00:00:00

abstract：:The concept of pathogenesis has evolved considerably over recent years, and the scenario "a microbe + virulence factors = disease" is probably far from reality in a number of cases. Actual pathogens have extremely broad biological diversity and are found in all major groups of microorganisms (viruses, bacteria, fungi,...

journal_title：Frontiers in cellular and infection microbiology

authors： Vayssier-Taussat M,Albina E,Citti C,Cosson JF,Jacques MA,Lebrun MH,Le Loir Y,Ogliastro M,Petit MA,Roumagnac P,Candresse T

更新日期：2014-03-05 00:00:00

abstract：:Fusarium is an important genus of plant pathogenic fungi, and is widely distributed in soil and associated with plants worldwide. The diversity of mycoviruses in Fusarium is increasing continuously due to the development and extensive use of state-of-the-art RNA deep sequencing techniques. To date, fully-sequenced myc...

journal_title：Frontiers in cellular and infection microbiology

authors： Li P,Bhattacharjee P,Wang S,Zhang L,Ahmed I,Guo L

更新日期：2019-07-18 00:00:00

abstract：:Increased numbers of peripheral blood mononucleocytes (PBMC) and increased IFN-γ secretion following in vitro challenge of blood samples with soluble Leishmania antigen (SLA), have been proposed as biomarkers of specific cell-mediated immunity, indicating that treatment of visceral leishmaniasis (VL) has been successf...

journal_title：Frontiers in cellular and infection microbiology

authors： Botana L,Matía B,San Martin JV,Romero-Maté A,Castro A,Molina L,Fernandez L,Ibarra-Meneses A,Aguado M,Sánchez C,Horrillo L,Chicharro C,Nieto J,Ortega S,Ruiz-Giardin JM,Carrillo E,Moreno J

更新日期：2018-11-13 00:00:00

abstract：:The Gram-negative bacterial cell envelope consists of an inner membrane (IM) that surrounds the cytoplasm and an asymmetrical outer-membrane (OM) that forms a protective barrier to the external environment. The OM consists of lipopolysaccahride (LPS), phospholipids, outer membrane proteins (OMPs), and lipoproteins. Ox...

journal_title：Frontiers in cellular and infection microbiology

authors： Piek S,Kahler CM

更新日期：2012-12-20 00:00:00

abstract：:Burkholderia cenocepacia is an opportunistic respiratory pathogen of individuals with cystic fibrosis (CF). Some strains of B. cenocepacia are highly transmissible and resistant to almost all antibiotics. Approximately one-third of B. cenocepacia infected CF patients go on to develop fatal "cepacia syndrome." During t...

journal_title：Frontiers in cellular and infection microbiology

authors： Ganesan S,Sajjan US

更新日期：2012-01-11 00:00:00

abstract：:Chlamydiae are obligate intracellular pathogens of eukaryotes. The bacteria grow in an intracellular vesicle called an inclusion, the membrane of which is heavily modified by chlamydial proteins called Incs (Inclusion membrane proteins). Incs represent 7-10% of the genomes of Chlamydia and, given their localization at...

journal_title：Frontiers in cellular and infection microbiology

authors： Gauliard E,Ouellette SP,Rueden KJ,Ladant D

更新日期：2015-02-11 00:00:00