A comparison of the endotoxin biosynthesis and protein oxidation pathways in the biogenesis of the outer membrane of Escherichia coli and Neisseria meningitidis.

abstract：:Dozens of Gram negative pathogens use one or more type III secretion systems (T3SS) to disarm host defenses or occupy a beneficial niche during infection of a host organism. While the T3SS represents an attractive drug target and dozens of compounds with T3SS inhibitory activity have been identified, few T3SS inhibito...

journal_title：Frontiers in cellular and infection microbiology

authors： Morgan JM,Lam HN,Delgado J,Luu J,Mohammadi S,Isberg RR,Wang H,Auerbuch V

更新日期：2018-11-22 00:00:00

abstract：:Candida albicans is one of the most common fungal pathogens. Our previous study demonstrated that concomitant use of berberine (BBR) and fluconazole (FLC) showed a synergistic action against FLC-resistant C. albicans in vitro and BBR had a major antifungal effect in the synergism, while FLC played a role of increasing...

journal_title：Frontiers in cellular and infection microbiology

authors： Xu Y,Quan H,Wang Y,Zhong H,Sun J,Xu J,Jia N,Jiang Y

更新日期：2017-11-29 00:00:00

abstract：:Staphylococcus aureus is a major cause of infective endocarditis (IE) and sepsis. Both methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) strains cause these illnesses. Common S. aureus strains include pulsed-field gel electrophoresis (PFGE) types USA200, 300, and 400 types where we hypothesize that secrete...

journal_title：Frontiers in cellular and infection microbiology

authors： Spaulding AR,Satterwhite EA,Lin YC,Chuang-Smith ON,Frank KL,Merriman JA,Schaefers MM,Yarwood JM,Peterson ML,Schlievert PM

更新日期：2012-02-21 00:00:00

abstract：:Non-encapsulated Streptococcus pneumoniae often possess two genes, aliB-like ORF 1 and aliB-like ORF 2, in place of capsule genes. AliB-like ORF 1 is thought to encode a substrate binding protein of an ABC transporter which binds peptide SETTFGRDFN, found in 50S ribosomal subunit protein L4 of Enterobacteriaceae. Here...

journal_title：Frontiers in cellular and infection microbiology

authors： Nasher F,Kwun MJ,Croucher NJ,Heller M,Hathaway LJ

更新日期：2019-09-10 00:00:00

abstract：:Eradication of Helicobacter pylori has been found to be effective for gastric cancer prevention, but uncertainties remain about the possible adverse consequences such as the potential microbial dysbiosis. In our study, we investigated the association between gut microbiota and H. pylori-related gastric lesions in 47 s...

journal_title：Frontiers in cellular and infection microbiology

authors： Gao JJ,Zhang Y,Gerhard M,Mejias-Luque R,Zhang L,Vieth M,Ma JL,Bajbouj M,Suchanek S,Liu WD,Ulm K,Quante M,Li ZX,Zhou T,Schmid R,Classen M,Li WQ,You WC,Pan KF

更新日期：2018-06-19 00:00:00

abstract：:Escherichia coli carrying prophage with genes that encode for Shiga toxins are categorized as Shiga toxin-producing E. coli (STEC) pathotype. Illnesses caused by STEC in humans, which are often foodborne, range from mild to bloody diarrhea with life-threatening complications of renal failure and hemolytic uremic syndr...

journal_title：Frontiers in cellular and infection microbiology

authors： Ludwig JB,Shi X,Shridhar PB,Roberts EL,DebRoy C,Phebus RK,Bai J,Nagaraja TG

更新日期：2020-07-29 00:00:00

abstract：:Objectives:Citrobacter freundii is a frequent cause of nosocomial infections and a known cause of diarrheal infections, and has increasingly become multidrug resistant (MDR). In this study, we aimed to determine the genetic diversity, the antimicrobial resistance profiles and in vitro virulence properties of C. freund...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu L,Chen D,Liu L,Lan R,Hao S,Jin W,Sun H,Wang Y,Liang Y,Xu J

更新日期：2018-07-10 00:00:00

abstract：:Interferon (IFN)-sensitive and replication-incompetent influenza viruses are likely to be the alternatives to inactivated and attenuated virus vaccines. Some IFN-sensitive influenza vaccine candidates with modified non-structural protein 1 (NS1) are highly attenuated in IFN-competent hosts but induce robust antiviral ...

journal_title：Frontiers in cellular and infection microbiology

authors： Chen C,Fan W,Li J,Zheng W,Zhang S,Yang L,Liu D,Liu W,Sun L

更新日期：2018-05-01 00:00:00

abstract：:Microsporidia are a group of intracellular pathogens causing self-limited and severe diseases in immunocompetent and immunocompromised individuals, respectively. A cellular type 1 adaptive response, mediated by IL-12, IFNγ, CD4+, and CD8+ T cells has been shown to be essential for host resistance, and dendritic cells ...

journal_title：Frontiers in cellular and infection microbiology

authors： Bernal CE,Zorro MM,Sierra J,Gilchrist K,Botero JH,Baena A,Ramirez-Pineda JR

更新日期：2016-02-02 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), which leads to an estimated 1. 5 million deaths worldwide each year. Although the immune correlates of protection against Mtb infection and TB disease have not been well-defined, natural killer (NK) cells are increasingly recognized as a key...

journal_title：Frontiers in cellular and infection microbiology

authors： Harris LD,Khayumbi J,Ongalo J,Sasser LE,Tonui J,Campbell A,Odhiambo FH,Ouma SG,Alter G,Gandhi NR,Day CL

更新日期：2020-03-24 00:00:00

abstract：:Gram-positive and Gram-negative pathogens exist as planktonic cells only at limited times during their life cycle. In response to environmental signals such as temperature, pH, osmolality, and nutrient availability, pathogenic bacteria can adopt varied cellular fates, which involves the activation of virulence gene pr...

journal_title：Frontiers in cellular and infection microbiology

authors： Desai SK,Kenney LJ

更新日期：2019-12-11 00:00:00

abstract：:Programmed cell death plays crucial roles in organismal development and host defense. Recent studies have highlighted mechanistic overlaps and extensive, multifaceted crosstalk between pyroptosis, apoptosis, and necroptosis, three programmed cell death pathways traditionally considered autonomous. The growing body of ...

journal_title：Frontiers in cellular and infection microbiology

authors： Christgen S,Zheng M,Kesavardhana S,Karki R,Malireddi RKS,Banoth B,Place DE,Briard B,Sharma BR,Tuladhar S,Samir P,Burton A,Kanneganti TD

更新日期：2020-05-29 00:00:00

abstract：:Salmonellae are facultative intracellular pathogens that cause globally distributed diseases with massive morbidity and mortality in humans and animals. In the past decades, numerous studies were focused on host defenses against Salmonella infection. Autophagy has been demonstrated to be an important defense mechanism...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang L,Yan J,Niu H,Huang R,Wu S

更新日期：2018-03-14 00:00:00

abstract：:Proton pump inhibitors (PPIs) are the standard therapy for gastroesophageal reflux disease. In adults, PPI treatment is associated with Clostridium difficile infections (CDI). In contrast to adults the microbiome of infants develops from sterility at birth toward an adult-like profile in the first years of life. The e...

journal_title：Frontiers in cellular and infection microbiology

authors： Castellani C,Singer G,Kashofer K,Huber-Zeyringer A,Flucher C,Kaiser M,Till H

更新日期：2017-10-11 00:00:00

abstract：:Intracellular bacterial pathogens (IBPs) invade and replicate in different cell types including immune cells, in particular of the innate immune system (IIS) during infection in the acute phase. However, immune cells primarily function as essential players in the highly effective and integrated host defense systems co...

journal_title：Frontiers in cellular and infection microbiology

authors： Eisenreich W,Rudel T,Heesemann J,Goebel W

更新日期：2017-07-13 00:00:00

abstract：:Gut microbiota serves as a critical indicator for gut health during treatment of pathogenic bacterial infection. Both Pulsatilla Decoction (abbreviated to PD, a traditional Chinese medicine compound) and Levofloxacin Hydrochloride (LVX) were known to have therapeutic effects to intestinal infectious disease. However, ...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu X,He S,Li Q,Mu X,Hu G,Dong H

更新日期：2020-06-30 00:00:00

abstract：:Chronic HCV infection is characterized by several immunological alterations, such as the accumulation of suppressor cells and of hyperactivated T lymphocytes. However, it is unclear whether direct-acting antiviral (DAA)-mediated HCV clearance restores immune dysfunctions. We performed a phenotypic characterization by ...

journal_title：Frontiers in cellular and infection microbiology

authors： Telatin V,Nicoli F,Frasson C,Menegotto N,Barbaro F,Castelli E,Erne E,Palù G,Caputo A

更新日期：2019-06-14 00:00:00

abstract：:Meningitis, the inflammation of the protective membrane surrounding the brain and spinal cord (known as meninges), is a condition associated with high mortality rates and permanent neurological sequelae in a significant proportion of survivors. The opportunistic pathogen Streptococcus pneumoniae (SPN/pneumococcus) is ...

journal_title：Frontiers in cellular and infection microbiology

authors： Anil A,Banerjee A

更新日期：2020-11-03 00:00:00

abstract：:The Asian tiger mosquito Aedes (Stegomya) albopictus is an invasive species that has spread across the world in the last two decades, showing a great capacity to adapt to contrasting climates and environments. While demonstrated in many insects, the contribution of bacterial symbionts in Aedes ecology is a challenging...

journal_title：Frontiers in cellular and infection microbiology

authors： Minard G,Tran FH,Dubost A,Tran-Van V,Mavingui P,Moro CV

更新日期：2014-05-14 00:00:00

abstract：:The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in immune compromised individuals. This pathogen is typically acquired via inhalation, and enters the respiratory tract. Innate immune cells such as macrophages and dendritic cells (DCs) are the first host cells that encounter C. neoform...

journal_title：Frontiers in cellular and infection microbiology

authors： Nelson BN,Hawkins AN,Wozniak KL

更新日期：2020-02-11 00:00:00

abstract：:Additional research on soft ticks in the family Argasidae is needed to bridge the knowledge gap relative to hard ticks of the family Ixodidae; especially, the molecular mechanisms of Ornithodoros biology. Ornithodoros species are vectors of human and animal pathogens that include tick-borne relapsing fever spirochetes...

journal_title：Frontiers in cellular and infection microbiology

authors： Armstrong BA,Kneubehl AR,Mitchell RD 3rd,Krishnavajhala A,Teel PD,Pérez de León AA,Lopez JE

更新日期：2020-05-05 00:00:00

abstract：:Most strains of Staphylococcus aureus and Staphylococcus epidermidis possess a strong restriction barrier that hinders exchange of DNA. Recently, major advances have been made in identifying and characterizing the restriction-modification (RM) systems involved. In particular a novel type IV restriction enzyme that rec...

journal_title：Frontiers in cellular and infection microbiology

authors： Monk IR,Foster TJ

更新日期：2012-04-12 00:00:00

abstract：:Melioidosis is a neglected tropical disease with high mortality rate. It is caused by the Gram-negative, CDC category B select agent Burkholderia pseudomallei (B. ps) that is intrinsically resistant to first-line antibiotics. An antibody-based vaccine is likely to be the most effective control measure. Previous studie...

journal_title：Frontiers in cellular and infection microbiology

authors： Chaichana P,Kronsteiner B,Rongkard P,Teparrukkul P,Limmathurotsakul D,Chantratita N,Day NPJ,Fletcher HA,Dunachie SJ

更新日期：2020-08-26 00:00:00

abstract：:Non-typeable Haemophilus influenzae (NTHI) is an opportunistic bacterial pathogen of the human respiratory tract and is a leading cause of respiratory infections in children and adults. NTHI is considered to be an extracellular pathogen, but has consistently been observed within and between human respiratory epithelia...

journal_title：Frontiers in cellular and infection microbiology

authors： Clementi CF,Murphy TF

更新日期：2011-11-18 00:00:00

abstract：:Leptospira are emerging zoonotic pathogens transmitted from animals to humans typically through contaminated environmental sources of water and soil. Regulatory pathways of pathogenic Leptospira spp. underlying the adaptive response to different hosts and environmental conditions remains elusive. In this study, we pro...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhukova A,Fernandes LG,Hugon P,Pappas CJ,Sismeiro O,Coppée JY,Becavin C,Malabat C,Eshghi A,Zhang JJ,Yang FX,Picardeau M

更新日期：2017-01-19 00:00:00

abstract：:Owing to the genetic similarities and conserved pathways between a fruit fly and mammals, the use of the Drosophila model as a platform to unveil novel mechanisms of infection and disease progression has been justified and widely instigated. Gaining proper insight into host-pathogen interactions and identifying chief ...

journal_title：Frontiers in cellular and infection microbiology

authors： Younes S,Al-Sulaiti A,Nasser EAA,Najjar H,Kamareddine L

更新日期：2020-06-23 00:00:00

abstract：:Objectives: The emergence of carbapenem-resistant Enterobacteriaceae, especially Klebsiella pneumoniae, has become a major concern in clinic settings. Combination therapy is gaining momentum to counter the secondary resistance and potential suboptimal efficacy of monotherapy. The aim of this study was to evaluate the ...

journal_title：Frontiers in cellular and infection microbiology

authors： Yu W,Zhou K,Guo L,Ji J,Niu T,Xiao T,Shen P,Xiao Y

更新日期：2017-06-16 00:00:00

abstract：:The development of new effective vaccines strongly depends on adjuvants and formulations able to stimulate not only strong humoral responses against a certain pathogen but also effector as well as memory CD4+ and CD8+ T cells (Dubensky et al., 2013). However, the majority of vaccines licensed for human use or currentl...

journal_title：Frontiers in cellular and infection microbiology

authors： Ebensen T,Delandre S,Prochnow B,Guzmán CA,Schulze K

更新日期：2019-02-19 00:00:00

abstract：:Postpartum depressive disorder (PPD) is a unique subtype of major depressive disorder and a substantial contributor to maternal morbidity and mortality. However, the pathogenesis of PPD has still remained elusive, and it may associate with genetic and environmental factors. Gut microbiota has already been proved to be...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhou Y,Chen C,Yu H,Yang Z

更新日期：2020-09-29 00:00:00

abstract：:Vibrio parahaemolyticus, autochthonous to estuarine, marine, and coastal environments throughout the world, is the causative agent of food-borne gastroenteritis. More than 80 serotypes have been described worldwide, based on antigenic properties of the somatic (O) and capsular (K) antigens. Serovar O3:K6 emerged in In...

journal_title：Frontiers in cellular and infection microbiology

authors： Ceccarelli D,Hasan NA,Huq A,Colwell RR

更新日期：2013-12-11 00:00:00