Abstract：
:Vibrio parahaemolyticus, autochthonous to estuarine, marine, and coastal environments throughout the world, is the causative agent of food-borne gastroenteritis. More than 80 serotypes have been described worldwide, based on antigenic properties of the somatic (O) and capsular (K) antigens. Serovar O3:K6 emerged in India in 1996 and subsequently was isolated worldwide, leading to the conclusion that the first V. parahaemolyticus pandemic had taken place. Most strains of V. parahaemolyticus isolated from the environment or seafood, in contrast to clinical strains, do not produce a thermostable direct hemolysin (TDH) and/or a TDH-related hemolysin (TRH). Type 3 secretion systems (T3SSs), needle-like apparatuses able to deliver bacterial effectors into host cytoplasm, were identified as triggering cytotoxicity and enterotoxicity. Type 6 secretion systems (T6SS) predicted to be involved in intracellular trafficking and vesicular transport appear to play a role in V. parahaemolyticus virulence. Recent advances in V. parahaemolyticus genomics identified several pathogenicity islands (VpaIs) located on either chromosome in both epidemic and pandemic strains and comprising additional colonization factors, such as restriction-modification complexes, chemotaxis proteins, classical bacterial surface virulence factors, and putative colicins. Furthermore, studies indicate strains lacking toxins and genomic regions associated with pathogenicity may also be pathogenic, suggesting other important virulence factors remain to be identified. The unique repertoire of virulence factors identified to date, their occurrence and distribution in both epidemic and pandemic strains worldwide are described, with the aim of highlighting the complexity of V. parahaemolyticus pathogenicity as well as its dynamic genome.
journal_name
Front Cell Infect Microbioljournal_title
Frontiers in cellular and infection microbiologyauthors
Ceccarelli D,Hasan NA,Huq A,Colwell RRdoi
10.3389/fcimb.2013.00097subject
Has Abstractpub_date
2013-12-11 00:00:00pages
97issn
2235-2988journal_volume
3pub_type
杂志文章,评审abstract：:The hemorrhagic septicemic disease vibriosis caused by Vibrio anguillarum shows noticeable similarities to invasive septicemia in humans, and in this case, the V. anguillarum-host system has the potential to serve as a model for understanding native eukaryotic host-pathogen interactions. Iron acquisition, as a fierce ...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章,评审
doi：10.3389/fcimb.2017.00342
更新日期：2017-07-25 00:00:00
abstract：:Cold shock-domain family proteins (Csps) are highly conserved nucleic acid binding proteins regulating the expression of various genes including those involved in stress resistance and virulence in bacteria. We show here that Csps are involved in virulence, cell aggregation and flagella-based extracellular motility of...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2017.00453
更新日期：2017-10-26 00:00:00
abstract：:Iron is the most abundant transition metal in the human body and its bioavailability is stringently controlled. In particular, iron is tightly bound to host proteins such as transferrin to maintain homeostasis, to limit potential damage caused by iron toxicity under physiological conditions and to restrict access by p...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章,评审
doi：10.3389/fcimb.2013.00080
更新日期：2013-11-19 00:00:00
abstract：:Sepsis is a life-threatening health condition caused by infectious pathogens of the respiratory tract, and accounts for 28-50% of annual deaths in the US alone. Current treatment regimen advocates the use of corticosteroids as adjunct treatment with antibiotics, for their broad inhibitory effect on the activity and pr...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2017.00263
更新日期：2017-06-22 00:00:00
abstract：:Metagenomic approaches applied to viruses have highlighted their prevalence in almost all microbial ecosystems investigated. In all ecosystems, notably those associated with humans or animals, the viral fraction is dominated by bacteriophages. Whether they contribute to dysbiosis, i.e., the departure from microbiota c...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章,评审
doi：10.3389/fcimb.2014.00039
更新日期：2014-03-28 00:00:00
abstract：:Chlamydiae are obligate intracellular pathogens of eukaryotes. The bacteria grow in an intracellular vesicle called an inclusion, the membrane of which is heavily modified by chlamydial proteins called Incs (Inclusion membrane proteins). Incs represent 7-10% of the genomes of Chlamydia and, given their localization at...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2015.00013
更新日期：2015-02-11 00:00:00
abstract：:ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanni, Pseudomonas aeruginosa, and Enterobacter species) pathogens have characteristic multiple-drug resistance and cause an increasing number of nosocomial infections worldwide. Peptide-based therapeutics to treat ESKAPE infe...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2017.00041
更新日期：2017-02-15 00:00:00
abstract：:Apicomplexan parasites, such as human malaria parasites, have complex lifecycles encompassing multiple and diverse environmental niches. Invading, replicating, and escaping from different cell types, along with exploiting each intracellular niche, necessitate large and dynamic changes in parasite morphology and cellul...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章,评审
doi：10.3389/fcimb.2020.611801
更新日期：2021-01-08 00:00:00
abstract：:Shiga toxin (Stx)-producing Escherichia coli (STEC) O157:H7 is an enteric pathogen that causes life-threatening disease in humans, with cattle being major natural reservoirs. A group of STEC O157:H7 with a dramatic combination of high virulence potentials and super-shedder bovine origin have been isolated. Here, an ST...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2020.00271
更新日期：2020-06-05 00:00:00
abstract：:Virulent C. difficile toxins TcdA and TcdB invade host intestinal epithelia by endocytosis and use the acidic environment of intracellular vesicles for further processing and activation. We investigated the role of ClC-5, a chloride/proton exchanger expressed in the endosomes of gastrointestinal epithelial cells, in t...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2017.00067
更新日期：2017-03-13 00:00:00
abstract：:The intracellular parasite Toxoplasma gondii can cause chronic infections in most warm-blooded animals, including humans. In the USA, strains belonging to four different Toxoplasma clonal lineages (types 1, 2, 3, and 12) are commonly isolated, whereas strains not belonging to these lineages are predominant in other co...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2019.00408
更新日期：2019-11-29 00:00:00
abstract：:Group A Streptococcus (GAS), also called Streptococcus pyogenes, is a Gram-positive beta-hemolytic human pathogen which causes a wide range of mostly self-limiting but also several life-threatening diseases. Innate immune responses are fundamental for defense against GAS, yet their activation by pattern recognition re...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章,评审
doi：10.3389/fcimb.2014.00140
更新日期：2014-10-02 00:00:00
abstract：:Vibrio alginolyticus is a major cause of Vibriosis in farmed marine aquatic animals and has caused large economic losses to the Asian aquaculture industry in recent years. Therefore, it is necessary to control V. alginolyticus effectively. The virulence mechanism of V. alginolyticus, the Type III secretion system (T3S...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2020.00183
更新日期：2020-04-28 00:00:00
abstract：:Myocarditis, inflammation of the heart muscle, affects all demographics and is a major cause of sudden and unexpected death in young people. It is most commonly caused by viral infections of the heart, with coxsackievirus B3 (CVB3) being among the most prevalent pathogens. To understand the molecular pathogenesis of C...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2019.00265
更新日期：2019-07-24 00:00:00
abstract：:The emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae (GC) underline the need of "antibiotic-free" strategies for the control of gonorrhea. The aim of this study was to assess the anti-gonococcal activity of 14 vaginal Lactobacillus strains, belonging to different species (L. crispatus, L. gass...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2017.00502
更新日期：2017-12-06 00:00:00
abstract：:For centuries, hydrogen sulfide (H2S) was considered primarily as a poisonous gas and environmental hazard. However, with the discovery of prokaryotic and eukaryotic enzymes for H2S production, breakdown, and utilization, H2S has emerged as an important signaling molecule in a wide range of physiological and pathologi...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章,评审
doi：10.3389/fcimb.2020.586923
更新日期：2020-11-10 00:00:00
abstract：:Emerging antibiotic resistance in pathogenic bacteria like Mycobacterium sp., poses a threat to human health and therefore calls for the development of novel antibacterial strategies. We have recently discovered that bacterial membrane peptides, such as KdpF, possess anti-virulence properties when overproduced in path...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2017.00115
更新日期：2017-04-06 00:00:00
abstract：:Toxoplasma gondii is an important human and animal pathogen that causes life-threatening toxoplasmosis. The host immune system produces interferon-γ (IFN-γ) to inhibit T. gondii proliferation. IFN-γ-inducible indole-2,3-dioxygenase 1 (IDO1), which mediates tryptophan degradation, has a major role in anti-T. gondii imm...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2019.00140
更新日期：2019-05-01 00:00:00
abstract：:Streptococcus pyogenes is a significant pathogen of humans, annually causing over 700,000,000 infections and 500,000 deaths. Virulence in S. pyogenes is closely linked to mobile genetic elements like phages and chromosomal islands (CI). S. pyogenes phage-like chromosomal islands (SpyCI) confer a complex mutator phenot...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章,评审
doi：10.3389/fcimb.2014.00109
更新日期：2014-08-12 00:00:00
abstract：:Solid-state fermentation of feedstuffs by Bacillus subtilis MA139 can reduce insoluble dietary fiber content in vitro and improve growth performance in pigs. This study was conducted to investigate the effects of dietary corn bran (CB) fermented by B. subtilis on growth performance and gut microbiota composition in fi...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2017.00526
更新日期：2017-12-22 00:00:00
abstract：:Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease, a chronic granulomatous enteritis in ruminants. Furthermore, infections of humans with MAP have been reported and a possible association with Crohn's disease and diabetes type I is currently discussed. MAP owns large sequence polymorphisms (...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2014.00110
更新日期：2014-08-14 00:00:00
abstract：:Anopheles female mosquitoes can transmit Plasmodium, the malaria parasite. During their aquatic life, wild Anopheles mosquito larvae are exposed to a huge diversity of microbes present in their breeding sites. Later, adult females often take successive blood meals that might also carry different micro-organisms, inclu...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2017.00508
更新日期：2017-12-07 00:00:00
abstract：:Objectives:Pneumocystis jirovecii pneumonia (PCP) is an AIDS-defining illness. In patients with HIV, the benefit of PCP prophylaxis is well-defined when the CD4 T-cell count decreases below 200 cells/μL. In other immunocompromised patients, the value of PCP prophylaxis is not always as well-established. This study aim...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2020.00224
更新日期：2020-05-15 00:00:00
abstract：:Histoplasmosis is one of the most frequent systemic mycosis in HIV patients. In these patients, histoplasmosis has high rates of morbidity/mortality if diagnosis and treatment are delayed. Despite its relevance, there is a paucity of information concerning the interaction between Histoplasma capsulatum and the human h...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2020.591121
更新日期：2020-10-29 00:00:00
abstract：:Pediculus humanus is an obligate bloodsucking ectoparasite of human that includes two ecotypes, head louse and body louse, which differ slightly in morphology and biology, but have distinct ecologies. Phylogenetically, they are classified on six mitochondrial clades (A, B, C, D, E, and F), head louse encompasses the f...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章,评审
doi：10.3389/fcimb.2019.00474
更新日期：2020-01-21 00:00:00
abstract：:Burkholderia cenocepacia is an opportunistic respiratory pathogen of individuals with cystic fibrosis (CF). Some strains of B. cenocepacia are highly transmissible and resistant to almost all antibiotics. Approximately one-third of B. cenocepacia infected CF patients go on to develop fatal "cepacia syndrome." During t...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章,评审
doi：10.3389/fcimb.2011.00025
更新日期：2012-01-11 00:00:00
abstract：:Objectives: To evaluate metagenomic next-generation sequencing (mNGS) as a diagnostic tool in detecting pathogens from osteoarticular infection (OAI) samples. Methods: 130 samples of joint fluid, sonicate fluid, and tissue were prospectively collected from 92 patients with OAI. The performance of mNGS and microbiology...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2020.00471
更新日期：2020-09-17 00:00:00
abstract：:The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in immune compromised individuals. This pathogen is typically acquired via inhalation, and enters the respiratory tract. Innate immune cells such as macrophages and dendritic cells (DCs) are the first host cells that encounter C. neoform...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章,评审
doi：10.3389/fcimb.2020.00037
更新日期：2020-02-11 00:00:00
abstract：:Iron is an absolute requirement for both the host and most pathogens alike and is needed for normal cellular growth. The acquisition of iron by biological systems is regulated to circumvent toxicity of iron overload, as well as the growth deficits imposed by iron deficiency. In addition, hosts, such as humans, need to...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章,评审
doi：10.3389/fcimb.2018.00185
更新日期：2018-06-05 00:00:00
abstract：:Cerebral malaria is characterized by permanent cognitive impairments in Plasmodium-infected children. Antimalarial therapies show little effectiveness to avoid neurological deficits and brain tissue alterations elicited by severe malaria. Melatonin is a well-recognized endogenous hormone involved in the control of bra...
journal_title：Frontiers in cellular and infection microbiology
pub_type： 杂志文章
doi：10.3389/fcimb.2020.541624
更新日期：2020-09-30 00:00:00
