The Mycobacterium avium ssp. paratuberculosis specific mptD gene is required for maintenance of the metabolic homeostasis necessary for full virulence in mouse infections.

abstract：:The ability to efficiently scavenge nutrients in the host is essential for the viability of any pathogen. All catabolic pathways must begin with the transport of substrate from the environment through the cytoplasmic membrane, a role executed by membrane transporters. Although several classes of cytoplasmic membrane t...

journal_title：Frontiers in cellular and infection microbiology

authors： Rosa LT,Bianconi ME,Thomas GH,Kelly DJ

更新日期：2018-02-12 00:00:00

abstract：:The endosymbiotic origin of eukaryotes brought together two disparate genomes in the cell. Additionally, eukaryotic natural history has included other endosymbiotic events, phagotrophic consumption of organisms, and intimate interactions with viruses and endoparasites. These phenomena facilitated large-scale lateral g...

journal_title：Frontiers in cellular and infection microbiology

authors： Aravind L,Anantharaman V,Zhang D,de Souza RF,Iyer LM

更新日期：2012-06-29 00:00:00

abstract：:Pertussis is a respiratory infectious disease that has been resurged during the last decades. The change from the traditional multi-antigen whole-cell pertussis (wP) vaccines to acellular pertussis (aP) vaccines that consist of a few antigens formulated with alum, appears to be a key factor in the resurgence of pertus...

journal_title：Frontiers in cellular and infection microbiology

authors： Zurita ME,Wilk MM,Carriquiriborde F,Bartel E,Moreno G,Misiak A,Mills KHG,Hozbor D

更新日期：2019-04-26 00:00:00

abstract：:Campylobacter jejuni (CJ) is the most prevalent zoonotic pathogen of chicken meat and related products, which may lead to gastroenteritis and autoimmune diseases in humans. Although controlling this bacterium is important, CJ strains resistance against traditional antibiotic therapy has been increased. Vegetable oils ...

journal_title：Frontiers in cellular and infection microbiology

authors： Ribeiro LNM,de Paula E,Rossi DA,Martins FA,de Melo RT,Monteiro GP,Breitkreitz MC,Goulart LR,Fonseca BB

更新日期：2021-01-08 00:00:00

abstract：:Streptococcus pyogenes is a significant pathogen of humans, annually causing over 700,000,000 infections and 500,000 deaths. Virulence in S. pyogenes is closely linked to mobile genetic elements like phages and chromosomal islands (CI). S. pyogenes phage-like chromosomal islands (SpyCI) confer a complex mutator phenot...

journal_title：Frontiers in cellular and infection microbiology

authors： Nguyen SV,McShan WM

更新日期：2014-08-12 00:00:00

abstract：:Despite decades of dedicated research, there remains a dire need for new drugs against tuberculosis (TB). Current therapies are generations old and problematic. Resistance to these existing therapies results in an ever-increasing burden of patients with disease that is difficult or impossible to treat. Novel chemical ...

journal_title：Frontiers in cellular and infection microbiology

authors： Butman HS,Kotzé TJ,Dowd CS,Strauss E

更新日期：2020-12-15 00:00:00

abstract：:The Gram-negative bacterial cell envelope consists of an inner membrane (IM) that surrounds the cytoplasm and an asymmetrical outer-membrane (OM) that forms a protective barrier to the external environment. The OM consists of lipopolysaccahride (LPS), phospholipids, outer membrane proteins (OMPs), and lipoproteins. Ox...

journal_title：Frontiers in cellular and infection microbiology

authors： Piek S,Kahler CM

更新日期：2012-12-20 00:00:00

abstract：:In 2019, the United States Food and Drug Administration accorded restricted approval to Sanofi Pasteur's Dengvaxia, a live attenuated vaccine (LAV) for dengue fever, a mosquito-borne viral disease, caused by four antigenically distinct dengue virus serotypes (DENV 1-4). The reason for this limited approval is the conc...

journal_title：Frontiers in cellular and infection microbiology

authors： Shukla R,Ramasamy V,Shanmugam RK,Ahuja R,Khanna N

更新日期：2020-10-22 00:00:00

abstract：:To define the bottlenecks that restrict antigen expression after oral administration of viral-vectored vaccines, we tracked vectors derived from the human adenovirus type 5 at whole body, tissue, and cellular scales throughout the digestive tract in a murine model of oral delivery. After intragastric administration of...

journal_title：Frontiers in cellular and infection microbiology

authors： Revaud J,Unterfinger Y,Rol N,Suleman M,Shaw J,Galea S,Gavard F,Lacour SA,Coulpier M,Versillé N,Havenga M,Klonjkowski B,Zanella G,Biacchesi S,Cordonnier N,Corthésy B,Ben Arous J,Richardson JP

更新日期：2018-01-25 00:00:00

abstract：:Amoeba-associated microorganisms (AAMs) are frequently isolated from water networks. In this paper, we report the isolation and characterization of Protochlamydia massiliensis, an obligate intracellular Gram-negative bacterium belonging to the Parachlamydiaceae family in the Chlamydiales order, from a cooling water to...

journal_title：Frontiers in cellular and infection microbiology

authors： Benamar S,Bou Khalil JY,Blanc-Tailleur C,Bilen M,Barrassi L,La Scola B

更新日期：2017-08-31 00:00:00

abstract：:The type VI secretion system (T6SS) secretes numerous toxins for bacteria-bacteria competition. TplE is a newly identified trans-kingdom toxin secreted by the T6SS in Pseudomonas aeruginosa, while TplEi neutralizes the toxic effect of TplE to protect bacteria autointoxication. Blocking the interaction of TplE-TplEi co...

journal_title：Frontiers in cellular and infection microbiology

authors： Gao X,Mu Z,Qin B,Sun Y,Cui S

更新日期：2017-09-20 00:00:00

abstract：:Background: Increasing evidence has shown that Helicobacter pylori is associated with coronary heart disease (CHD); however, the underlying mechanism remains unclear. Methods: The expression of miR-25 and mRNAs was measured using qRT-PCR. Protein levels were detected using western blotting and exosomes were assessed w...

journal_title：Frontiers in cellular and infection microbiology

authors： Li N,Liu SF,Dong K,Zhang GC,Huang J,Wang ZH,Wang TJ

更新日期：2019-10-29 00:00:00

abstract：:Staphylococcus aureus is the leading etiologic agent of orthopedic implant infections. Here a ribocluster of 27 S. aureus strains underwent further molecular characterization and subtyping by multilocus sequence typing (MLST) and spa-typing. This cluster had been detected by automated ribotyping (with the EcoRI restri...

journal_title：Frontiers in cellular and infection microbiology

authors： Montanaro L,Ravaioli S,Ruppitsch W,Campoccia D,Pietrocola G,Visai L,Speziale P,Allerberger F,Arciola CR

更新日期：2016-02-16 00:00:00

abstract：:Chronic otitis media with effusion (COME) is a common childhood disease characterized by an accumulation of fluid behind the eardrum. COME often requires surgical intervention and can also lead to significant hearing loss and subsequent learning disabilities. Recent characterization of the middle ear fluid (MEF) micro...

journal_title：Frontiers in cellular and infection microbiology

authors： Kolbe AR,Castro-Nallar E,Preciado D,Pérez-Losada M

更新日期：2019-10-04 00:00:00

abstract：:Non-typeable Haemophilus influenzae (NTHI) is an opportunistic bacterial pathogen of the human respiratory tract and is a leading cause of respiratory infections in children and adults. NTHI is considered to be an extracellular pathogen, but has consistently been observed within and between human respiratory epithelia...

journal_title：Frontiers in cellular and infection microbiology

authors： Clementi CF,Murphy TF

更新日期：2011-11-18 00:00:00

abstract：:Microsporidia are a group of intracellular pathogens causing self-limited and severe diseases in immunocompetent and immunocompromised individuals, respectively. A cellular type 1 adaptive response, mediated by IL-12, IFNγ, CD4+, and CD8+ T cells has been shown to be essential for host resistance, and dendritic cells ...

journal_title：Frontiers in cellular and infection microbiology

authors： Bernal CE,Zorro MM,Sierra J,Gilchrist K,Botero JH,Baena A,Ramirez-Pineda JR

更新日期：2016-02-02 00:00:00

abstract：:Prompt and effective elicitation of protective immunity is highly relevant for cases of rapidly deteriorating fatal diseases, such as plague, which is caused by Yersinia pestis. Here, we assessed the potential of a live vaccine to induce rapid protection against this infection. We demonstrated that the Y. pestis EV76 ...

journal_title：Frontiers in cellular and infection microbiology

authors： Zauberman A,Vagima Y,Tidhar A,Aftalion M,Gur D,Rotem S,Chitlaru T,Levy Y,Mamroud E

更新日期：2017-06-21 00:00:00

abstract：:Protein secretion systems are vital for prokaryotic life, as they enable bacteria to acquire nutrients, communicate with other species, defend against biological and chemical agents, and facilitate disease through the delivery of virulence factors. In this review, we will focus on the recently discovered type IX secre...

journal_title：Frontiers in cellular and infection microbiology

authors： Lasica AM,Ksiazek M,Madej M,Potempa J

更新日期：2017-05-26 00:00:00

abstract：:Vibrio parahaemolyticus elicits gastroenteritis by deploying Type III Secretion Systems (TTSS) to deliver effector proteins into epithelial cells of the human intestinal tract. The bacteria must adhere to the human cells to allow colonization and operation of the TTSS translocation apparatus bridging the bacterium and...

journal_title：Frontiers in cellular and infection microbiology

authors： O'Boyle N,Boyd A

更新日期：2014-01-10 00:00:00

abstract：:Pathogenic fungi have developed many strategies to evade the host immune system. Multiple escape mechanisms appear to function together to inhibit attack by the various stages of both the adaptive and the innate immune response. Thus, after entering the host, such pathogens fight to overcome the immune system to allow...

journal_title：Frontiers in cellular and infection microbiology

authors： Marcos CM,de Oliveira HC,de Melo WC,da Silva JF,Assato PA,Scorzoni L,Rossi SA,de Paula E Silva AC,Mendes-Giannini MJ,Fusco-Almeida AM

更新日期：2016-11-15 00:00:00

abstract：:In this study, a next-generation sequencing strategy on 16S ribosomal RNA (16S rRNA) gene was employed to analyze 70 oral samples from 32 patients with throat cancer, nine patients with vocal cord polyp, and 29 healthy individuals (normal controls). Using this strategy, we demonstrated, for the first time, that the sa...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang L,Yin G,Guo Y,Zhao Y,Zhao M,Lai Y,Sui P,Shi T,Guo W,Huang Z

更新日期：2019-07-03 00:00:00

abstract：:Systemic and endemic mycoses are considered life-threatening respiratory diseases which are caused by a group of dimorphic fungal pathogens belonging to the genera Histoplasma, Coccidioides, Blastomyces, Paracoccidioides, Talaromyces, and the newly described pathogen Emergomyces. T-cell mediated immunity, mainly T hel...

journal_title：Frontiers in cellular and infection microbiology

authors： Puerta-Arias JD,Mejía SP,González Á

更新日期：2020-12-14 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) O157:H7 EspF is an important multifunctional protein that destroys the tight junctions of intestinal epithelial cells and promotes host cell apoptosis. However, its molecular mechanism remains elusive. We knocked out the espF sequence (747 bp, ΔespF), N-terminal sequence (219 ...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang X,Du Y,Hua Y,Fu M,Niu C,Zhang B,Zhao W,Zhang Q,Wan C

更新日期：2017-09-21 00:00:00

abstract：:Preservation of health from infectious diseases depends upon both mucosal and systemic immunity via the collaborative effort of innate and adaptive immune responses. The proficiency of host immunity stems from robust defense mechanisms--physical barriers and specialized immune cells--and a failure of these mechanisms ...

journal_title：Frontiers in cellular and infection microbiology

authors： Denny JE,Powell WL,Schmidt NW

更新日期：2016-04-11 00:00:00

abstract：:Understanding the systems biology approaches for promoting the development of new therapeutic drugs is attaining importance nowadays. The threat of COVID-19 outbreak needs to be vanished for global welfare, and every section of research is focusing on it. There is an opportunity for finding new, quick, and accurate to...

journal_title：Frontiers in cellular and infection microbiology

authors： Jaiswal S,Kumar M,Mandeep,Sunita,Singh Y,Shukla P

更新日期：2020-10-28 00:00:00

abstract：:Stress granules (SGs) are sites of mRNA storage that are formed in response to various conditions of stress, including viral infections. Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has been devastating the swine industry worldwide since the late 1980s. In this study, we found tha...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhou Y,Fang L,Wang D,Cai K,Chen H,Xiao S

更新日期：2017-04-04 00:00:00

abstract：:Candida albicans is one of the most common fungal pathogens. Our previous study demonstrated that concomitant use of berberine (BBR) and fluconazole (FLC) showed a synergistic action against FLC-resistant C. albicans in vitro and BBR had a major antifungal effect in the synergism, while FLC played a role of increasing...

journal_title：Frontiers in cellular and infection microbiology

authors： Xu Y,Quan H,Wang Y,Zhong H,Sun J,Xu J,Jia N,Jiang Y

更新日期：2017-11-29 00:00:00

abstract：:Eradication of Helicobacter pylori has been found to be effective for gastric cancer prevention, but uncertainties remain about the possible adverse consequences such as the potential microbial dysbiosis. In our study, we investigated the association between gut microbiota and H. pylori-related gastric lesions in 47 s...

journal_title：Frontiers in cellular and infection microbiology

authors： Gao JJ,Zhang Y,Gerhard M,Mejias-Luque R,Zhang L,Vieth M,Ma JL,Bajbouj M,Suchanek S,Liu WD,Ulm K,Quante M,Li ZX,Zhou T,Schmid R,Classen M,Li WQ,You WC,Pan KF

更新日期：2018-06-19 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis, a rare disease of biodefense concern with high mortality and extreme difficulty in treatment. No human vaccines are available that protect against B. pseudomallei infection, and with the current limitations of antibiotic treatment, the development of new...

journal_title：Frontiers in cellular and infection microbiology

authors： Van Zandt KE,Tuanyok A,Keim PS,Warren RL,Gelhaus HC

更新日期：2012-09-26 00:00:00

abstract：:Salmonellae are facultative intracellular pathogens that cause globally distributed diseases with massive morbidity and mortality in humans and animals. In the past decades, numerous studies were focused on host defenses against Salmonella infection. Autophagy has been demonstrated to be an important defense mechanism...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang L,Yan J,Niu H,Huang R,Wu S

更新日期：2018-03-14 00:00:00