Host Iron Nutritional Immunity Induced by a Live Yersinia pestis Vaccine Strain Is Associated with Immediate Protection against Plague.

abstract：:Intracellular bacterial pathogens (IBPs) invade and replicate in different cell types including immune cells, in particular of the innate immune system (IIS) during infection in the acute phase. However, immune cells primarily function as essential players in the highly effective and integrated host defense systems co...

journal_title：Frontiers in cellular and infection microbiology

authors： Eisenreich W,Rudel T,Heesemann J,Goebel W

更新日期：2017-07-13 00:00:00

abstract：:To investigate the parameters associated with post-treatment recurrence of bacterial vaginosis (BV), clinical factors and vaginal microbiota were examined and analyzed for BV patients who received standard metronidazole therapy. The variables associated with BV recurrence included clinical factors of past BV history, ...

journal_title：Frontiers in cellular and infection microbiology

authors： Xiao B,Wu C,Song W,Niu X,Qin N,Liu Z,Xu Q

更新日期：2019-06-11 00:00:00

abstract：:Periodontal microorganisms not only colonize subgingival pockets, but also are detected on various mucous membranes in patients with periodontitis. The object of this pilot study was, using the next-generation sequencing of 16S RNA gene, to characterize the microbiota in two oral habitats (buccal mucosas and subgingiv...

journal_title：Frontiers in cellular and infection microbiology

authors： Wei Y,Shi M,Zhen M,Wang C,Hu W,Nie Y,Wu X

更新日期：2019-03-11 00:00:00

abstract：:Schistosomes, a class of parasitic trematode worms, cause schistosomiasis. Accumulating evidence suggests that microRNAs (miRNAs)-small, non-coding RNAs that are known to play critical regulatory roles in many organisms-may be involved in schistosome development and sexual maturation, as well as the pathogenesis of sc...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhu L,Liu J,Cheng G

更新日期：2014-11-11 00:00:00

abstract：:The emergence of antimicrobial-resistant (AR) Salmonella has a major concern worldwide. This study was designed to determine the AR profiles and serovars distribution of Salmonella enterica isolated from different breeds of breeder chickens in the province of Henan, China. For this, 2,139 dead embryo samples were coll...

journal_title：Frontiers in cellular and infection microbiology

authors： Xu Y,Zhou X,Jiang Z,Qi Y,Ed-Dra A,Yue M

更新日期：2020-09-15 00:00:00

abstract：:To discern if there was a particular genotype associated with clinical enteroaggregative Escherichia coli (EAEC) strains isolated from deployed military personnel (DMP) with travelers' diarrhea (TD), we characterized a collection of EAEC from DMP deployed to Afghanistan, Djibouti, Kenya, or Honduras. Although we did n...

journal_title：Frontiers in cellular and infection microbiology

authors： Petro CD,Duncan JK,Seldina YI,Allué-Guardia A,Eppinger M,Riddle MS,Tribble DR,Johnson RC,Dalgard CL,Sukumar G,Connor P,Boisen N,Melton-Celsa AR

更新日期：2020-05-20 00:00:00

abstract：:The SaeRS two-component system plays important roles in regulation of key virulence factors and pathogenicity. In this study, however, we found that the deletion mutation of saeRS enhanced bacterial survival in human blood, whereas complementation of the mutant with SaeRS returned survival to wild-type levels. Moreove...

journal_title：Frontiers in cellular and infection microbiology

authors： Guo H,Hall JW,Yang J,Ji Y

更新日期：2017-05-29 00:00:00

abstract：:An important component in host resistance to malaria infection are inherited mutations that give rise to abnormalities and deficiencies in erythrocyte proteins and enzymes. Understanding how such mutations confer protection against the disease may be useful for developing new treatment strategies. A mouse ENU-induced ...

journal_title：Frontiers in cellular and infection microbiology

authors： Schnider CB,Yang H,Starrs L,Ehmann A,Rahimi F,Di Pierro E,Graziadei G,Matthews K,De Koning-Ward T,Bauer DC,Foote SJ,Burgio G,McMorran BJ

更新日期：2020-09-03 00:00:00

abstract：:Staphylococcus aureus is the leading etiologic agent of orthopedic implant infections. Here a ribocluster of 27 S. aureus strains underwent further molecular characterization and subtyping by multilocus sequence typing (MLST) and spa-typing. This cluster had been detected by automated ribotyping (with the EcoRI restri...

journal_title：Frontiers in cellular and infection microbiology

authors： Montanaro L,Ravaioli S,Ruppitsch W,Campoccia D,Pietrocola G,Visai L,Speziale P,Allerberger F,Arciola CR

更新日期：2016-02-16 00:00:00

abstract：:The ability to efficiently scavenge nutrients in the host is essential for the viability of any pathogen. All catabolic pathways must begin with the transport of substrate from the environment through the cytoplasmic membrane, a role executed by membrane transporters. Although several classes of cytoplasmic membrane t...

journal_title：Frontiers in cellular and infection microbiology

authors： Rosa LT,Bianconi ME,Thomas GH,Kelly DJ

更新日期：2018-02-12 00:00:00

abstract：:Chlamydia trachomatis is the leading cause of preventable blindness and the most common bacterial sexually transmitted infection. Different strains are associated with ocular or urogenital infections, and a proposed mechanism that may explain this tissue tropism is the active tryptophan biosynthesis pathway encoded by...

journal_title：Frontiers in cellular and infection microbiology

authors： O'Neill CE,Skilton RJ,Pearson SA,Filardo S,Andersson P,Clarke IN

更新日期：2018-12-14 00:00:00

abstract：:Stapylococcus aureus is a common infectious agent in e.g. sepsis, associated with both high mortality rates and severe long-term effects. The cytolytic protein α-hemolysin has repeatedly been shown to enhance the virulence of S. aureus. Combined with an unhindered spread of multi drug-resistant strains, this has trigg...

journal_title：Frontiers in cellular and infection microbiology

authors： Andersson T,Bläckberg A,Lood R,Ertürk Bergdahl G

更新日期：2020-11-20 00:00:00

abstract：:Porphyromonas gingivalis is a major etiological agent in chronic and aggressive forms of periodontal disease. The organism is an asaccharolytic anaerobe and is a constituent of mixed species biofilms in a variety of microenvironments in the oral cavity. P. gingivalis expresses a range of virulence factors over which i...

journal_title：Frontiers in cellular and infection microbiology

authors： Hirano T,Beck DA,Demuth DR,Hackett M,Lamont RJ

更新日期：2012-06-12 00:00:00

abstract：:Pathogenic fungi have developed many strategies to evade the host immune system. Multiple escape mechanisms appear to function together to inhibit attack by the various stages of both the adaptive and the innate immune response. Thus, after entering the host, such pathogens fight to overcome the immune system to allow...

journal_title：Frontiers in cellular and infection microbiology

authors： Marcos CM,de Oliveira HC,de Melo WC,da Silva JF,Assato PA,Scorzoni L,Rossi SA,de Paula E Silva AC,Mendes-Giannini MJ,Fusco-Almeida AM

更新日期：2016-11-15 00:00:00

abstract：:The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in immune compromised individuals. This pathogen is typically acquired via inhalation, and enters the respiratory tract. Innate immune cells such as macrophages and dendritic cells (DCs) are the first host cells that encounter C. neoform...

journal_title：Frontiers in cellular and infection microbiology

authors： Nelson BN,Hawkins AN,Wozniak KL

更新日期：2020-02-11 00:00:00

abstract：:Radiation enteritis (RE) is a common complication in cancer patients receiving radiotherapy. Although studies have shown the changes of this disease at clinical, pathological and other levels, the dynamic characteristics of local microbiome and metabolomics are hitherto unknown. We aimed to examine the multi-omics fea...

journal_title：Frontiers in cellular and infection microbiology

authors： Li Y,Yan H,Zhang Y,Li Q,Yu L,Li Q,Liu C,Xie Y,Chen K,Ye F,Wang K,Chen L,Ding Y

更新日期：2020-10-21 00:00:00

abstract：:Iron is an absolute requirement for both the host and most pathogens alike and is needed for normal cellular growth. The acquisition of iron by biological systems is regulated to circumvent toxicity of iron overload, as well as the growth deficits imposed by iron deficiency. In addition, hosts, such as humans, need to...

journal_title：Frontiers in cellular and infection microbiology

authors： Fourie R,Kuloyo OO,Mochochoko BM,Albertyn J,Pohl CH

更新日期：2018-06-05 00:00:00

abstract：:We have previously demonstrated that Candida albicans induces differentiation of hematopoietic stem and progenitor cells (HSPCs) toward the myeloid lineage both in vitro and in vivo in a TLR2- and Dectin-1-dependent manner, giving rise to functional macrophages. In this work, we used an ex vivo model to investigate th...

journal_title：Frontiers in cellular and infection microbiology

authors： Martínez A,Bono C,Megías J,Yáñez A,Gozalbo D,Gil ML

更新日期：2018-09-03 00:00:00

abstract：:Group B Streptococcus (GBS) is a major cause of invasive disease in neonates worldwide. Monitoring data have revealed a continuing trend toward an increase in neonatal GBS infections, despite the introduction of preventive measures. We investigated this trend, by performing the first ever characterization of the proph...

journal_title：Frontiers in cellular and infection microbiology

authors： Renard A,Barbera L,Courtier-Martinez L,Dos Santos S,Valentin AS,Mereghetti L,Quentin R,van der Mee-Marquet NL

更新日期：2019-05-28 00:00:00

abstract：:Clostridium difficile infections (CDI) are a major cause of antibiotic-associated diarrhea. It is hypothesized that CDI develops due to the antibiotic-induced disruption of the intestinal microbial community structure, which allows C. difficile to flourish. Here, we pre-treated weaned pigs with the antibiotics Clindam...

journal_title：Frontiers in cellular and infection microbiology

authors： Jurburg SD,Cornelissen JJBWJ,de Boer P,Smits MA,Rebel JMJ

更新日期：2019-08-06 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) O157:H7 EspF is an important multifunctional protein that destroys the tight junctions of intestinal epithelial cells and promotes host cell apoptosis. However, its molecular mechanism remains elusive. We knocked out the espF sequence (747 bp, ΔespF), N-terminal sequence (219 ...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang X,Du Y,Hua Y,Fu M,Niu C,Zhang B,Zhao W,Zhang Q,Wan C

更新日期：2017-09-21 00:00:00

abstract：:Solid-state fermentation of feedstuffs by Bacillus subtilis MA139 can reduce insoluble dietary fiber content in vitro and improve growth performance in pigs. This study was conducted to investigate the effects of dietary corn bran (CB) fermented by B. subtilis on growth performance and gut microbiota composition in fi...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu P,Zhao J,Guo P,Lu W,Geng Z,Levesque CL,Johnston LJ,Wang C,Liu L,Zhang J,Ma N,Qiao S,Ma X

更新日期：2017-12-22 00:00:00

abstract：:Pneumonia and meningitis continue to present an enormous public health burden and pose a major threat to young children. Among the causative organisms of pneumonia and meningitis, bacteria are the most common causes of serious disease and deaths. It is challenging to accurately and rapidly identify these agents. To so...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhang C,Xiu L,Xiao Y,Xie Z,Ren L,Peng J

更新日期：2018-04-05 00:00:00

abstract：:Enterobacteriaceae cause different types of community- and hospital-acquired infections. Moreover, the spread of multidrug-resistant Enterobacteriaceae is a public health problem and the World Health Organization pointed them among the pathogens in which the search of new antibiotics is critical. The objective of this...

journal_title：Frontiers in cellular and infection microbiology

authors： Cebrero-Cangueiro T,Álvarez-Marín R,Labrador-Herrera G,Smani Y,Cordero-Matía E,Pachón J,Pachón-Ibáñez ME

更新日期：2018-10-18 00:00:00

abstract：:The formation of biofilms by Staphylococcus aureus and Staphylococcus epidermidis is an important aspect of many staphylococcal infections, most notably endocarditis, osteomyelitis and infections associated with indwelling medical devices. The major constituents of staphylococcal biofilms are polysaccharides, such as ...

journal_title：Frontiers in cellular and infection microbiology

authors： Cue D,Lei MG,Lee CY

更新日期：2012-03-26 00:00:00

abstract：:Cleavage and activation of hemagglutinin (HA) by trypsin-like proteases in influenza A virus (IAV) are essential prerequisites for its successful infection and spread. In host cells, some transmembrane serine proteases such as TMPRSS2, TMPRSS4 and HAT, along with plasmin in the bloodstream, have been reported to cleav...

journal_title：Frontiers in cellular and infection microbiology

authors： Hayashi H,Kubo Y,Izumida M,Takahashi E,Kido H,Sato K,Yamaya M,Nishimura H,Nakayama K,Matsuyama T

更新日期：2018-03-23 00:00:00

abstract：:In the present study, we determined the in vitro characteristics and binding interactions of chicken PD-1 (chPD-1) and PD-L1 (chPD-L1) and developed a panel of specific monoclonal antibodies against the two proteins. ChPD-1 and chPD-L1 sequence identities and similarities were lower compared with those of humans and o...

journal_title：Frontiers in cellular and infection microbiology

authors： Reddy VRAP,Mwangi W,Sadigh Y,Nair V

更新日期：2019-12-19 00:00:00

abstract：:Different species inhabit different sensory worlds and thus have evolved diverse means of processing information, learning and memory. In the escalated arms race with host defense, each pathogenic bacterium not only has evolved its individual cellular sensing and behavior, but also collective sensing, interbacterial c...

journal_title：Frontiers in cellular and infection microbiology

authors： Steinert M

更新日期：2014-01-31 00:00:00

abstract：:Virulent C. difficile toxins TcdA and TcdB invade host intestinal epithelia by endocytosis and use the acidic environment of intracellular vesicles for further processing and activation. We investigated the role of ClC-5, a chloride/proton exchanger expressed in the endosomes of gastrointestinal epithelial cells, in t...

journal_title：Frontiers in cellular and infection microbiology

authors： Ruhe F,Olling A,Abromeit R,Rataj D,Grieschat M,Zeug A,Gerhard R,Alekov A

更新日期：2017-03-13 00:00:00

abstract：:In this study, a next-generation sequencing strategy on 16S ribosomal RNA (16S rRNA) gene was employed to analyze 70 oral samples from 32 patients with throat cancer, nine patients with vocal cord polyp, and 29 healthy individuals (normal controls). Using this strategy, we demonstrated, for the first time, that the sa...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang L,Yin G,Guo Y,Zhao Y,Zhao M,Lai Y,Sui P,Shi T,Guo W,Huang Z

更新日期：2019-07-03 00:00:00