Structure-Based Prototype Peptides Targeting the Pseudomonas aeruginosa Type VI Secretion System Effector as a Novel Antibacterial Strategy.

abstract：:Rheumatoid Arthritis (RA) has been increasingly associated with perturbations to the microbial communities that reside in and on the body (the microbiome), in both human and animal studies. To date, such studies have mainly focused on the microbial communities that inhabit the gut and oral cavity. Mounting evidence su...

journal_title：Frontiers in cellular and infection microbiology

authors： Hammad DBM,Hider SL,Liyanapathirana VC,Tonge DP

更新日期：2020-01-22 00:00:00

abstract：:Cerebral malaria is a severe neuropathological complication of Plasmodium falciparum infection. It results in high mortality and post-recovery neuro-cognitive disorders in children, even after appropriate treatment with effective anti-parasitic drugs. While the complete landscape of the pathogenesis of cerebral malari...

journal_title：Frontiers in cellular and infection microbiology

authors： Sahu PK,Satpathi S,Behera PK,Mishra SK,Mohanty S,Wassmer SC

更新日期：2015-10-27 00:00:00

abstract：:Rickettsia rickettsii is a tick-borne obligate intracellular bacterium that causes Rocky Mountain Spotted Fever (RMSF). In Brazil, two species of ticks in the genus Amblyomma, A. sculptum and A. aureolatum, are incriminated as vectors of this bacterium. Importantly, these two species present remarkable differences in ...

journal_title：Frontiers in cellular and infection microbiology

authors： Martins LA,Galletti MFBM,Ribeiro JM,Fujita A,Costa FB,Labruna MB,Daffre S,Fogaça AC

更新日期：2017-04-28 00:00:00

abstract：:Proton pump inhibitors (PPIs) are the standard therapy for gastroesophageal reflux disease. In adults, PPI treatment is associated with Clostridium difficile infections (CDI). In contrast to adults the microbiome of infants develops from sterility at birth toward an adult-like profile in the first years of life. The e...

journal_title：Frontiers in cellular and infection microbiology

authors： Castellani C,Singer G,Kashofer K,Huber-Zeyringer A,Flucher C,Kaiser M,Till H

更新日期：2017-10-11 00:00:00

abstract：:Genital tract infections with Chlamydia trachomatis (C. trachomatis) are the most frequent sexually transmitted disease worldwide. Severe clinical sequelae such as pelvic inflammatory disease (PID), tubal occlusion, and tubal infertility are linked to inflammatory processes of chronically infected tissues. The oxygen ...

journal_title：Frontiers in cellular and infection microbiology

authors： Jerchel S,Kaufhold I,Schuchardt L,Shima K,Rupp J

更新日期：2014-04-16 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), which leads to an estimated 1. 5 million deaths worldwide each year. Although the immune correlates of protection against Mtb infection and TB disease have not been well-defined, natural killer (NK) cells are increasingly recognized as a key...

journal_title：Frontiers in cellular and infection microbiology

authors： Harris LD,Khayumbi J,Ongalo J,Sasser LE,Tonui J,Campbell A,Odhiambo FH,Ouma SG,Alter G,Gandhi NR,Day CL

更新日期：2020-03-24 00:00:00

abstract：:Non-optimal vaginal microbiota, as observed in bacterial vaginosis (BV), is typically characterized by a depletion of beneficial lactobacilli and an abundance of numerous anaerobes. These non-optimal conditions are associated with subclinical cervicovaginal inflammation and an increased risk of HIV infection compared ...

journal_title：Frontiers in cellular and infection microbiology

authors： Delgado-Diaz DJ,Tyssen D,Hayward JA,Gugasyan R,Hearps AC,Tachedjian G

更新日期：2020-01-10 00:00:00

abstract：:Neutrophils are the first cells recruited to the dermal site of Leishmania infection following injection by needle or sand fly bite. The role of neutrophils in either promoting or suppressing host immunity remains controversial. We discuss the events driving neutrophil recruitment, their interaction with the parasite ...

journal_title：Frontiers in cellular and infection microbiology

authors： Ribeiro-Gomes FL,Sacks D

更新日期：2012-05-04 00:00:00

abstract：:The Toxoplasma gondii parasitophorous vacuole membrane (PVM) offers protection from the host immune system but is also a barrier for uptake of nutrients from the host. Previously, we showed that GRA17 mediates the tachyzoite PVM permeability to small molecules. During the conversion from tachyzoites to encysted bradyz...

journal_title：Frontiers in cellular and infection microbiology

authors： Paredes-Santos T,Wang Y,Waldman B,Lourido S,Saeij JP

更新日期：2019-09-12 00:00:00

abstract：:Francisella tularensis is the causative agent of tularemia and a Tier I bioterrorism agent. In the 1900s, several vaccines were developed against tularemia including the killed "Foshay" vaccine, subunit vaccines comprising F. tularensis protein(s) or lipoproteins(s) in an adjuvant formulation, and the F. tularensis Li...

journal_title：Frontiers in cellular and infection microbiology

authors： Jia Q,Horwitz MA

更新日期：2018-05-15 00:00:00

abstract：:Flavobacterium psychrophilum is the etiological agent of bacterial coldwater disease and the rainbow trout fry syndrome in salmonid aquaculture worldwide. However, there have been few studies into the capacity of F. psychrophilum to form biofilms and how these cellular accretions differ from planktonic cells or how th...

journal_title：Frontiers in cellular and infection microbiology

authors： Levipan HA,Avendaño-Herrera R

更新日期：2017-03-15 00:00:00

abstract：:The intracellular pathogen Burkholderia pseudomallei, the etiological agent of melioidosis in humans and various animals, is capable of survival and movement within the cytoplasm of host cells by a process known as actin-based motility. The bacterial factor BimA is required for actin-based motility through its direct ...

journal_title：Frontiers in cellular and infection microbiology

authors： Srinon V,Chaiwattanarungruengpaisan S,Korbsrisate S,Stevens JM

更新日期：2019-03-22 00:00:00

abstract：:Background and Purpose: Early life microbiota plays a crucial role in human health by acting as a barrier from pathogens' invasion and maintaining the intestinal immune homoeostasis. Altered fecal microbiota (FM) ecology was reported in newborns affected by intestinal ischemia. Our purpose was to describe, in these pa...

journal_title：Frontiers in cellular and infection microbiology

authors： Romani L,Del Chierico F,Chiriaco M,Foligno S,Reddel S,Salvatori G,Cifaldi C,Faraci S,Finocchi A,Rossi P,Bagolan P,D'Argenio P,Putignani L,Fusaro F

更新日期：2020-02-25 00:00:00

abstract：:Brucella is a facultative intracellular pathogen that causes zoonotic infection known as brucellosis which results in abortion and infertility in natural host. Humans, especially in low income countries, can acquire infection by direct contact with infected animal or by consumption of animal products and show high mor...

journal_title：Frontiers in cellular and infection microbiology

authors： Ahmed W,Zheng K,Liu ZF

更新日期：2016-03-15 00:00:00

abstract：:The mechanism by which microRNAs (miRNAs) modulate innate immunity and autophagy has not been fully elucidated in Mycobacterium bovis (M. bovis) infections. In this study, we identified that miR-199a inhibited key innate immune responses and autophagy in murine macrophages infected with M. bovis. Using ex vivo and in ...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang J,Hussain T,Yue R,Liao Y,Li Q,Yao J,Song Y,Sun X,Wang N,Xu L,Sreevatsan S,Zhao D,Zhou X

更新日期：2018-07-10 00:00:00

abstract：:A cohort study was conducted to evaluate oral microbial diversity among toddlers aged 12-24 months, and to describe the dynamic processes of colonization, development, and stabilization of the oral microflora during tooth eruption using high-throughput sequencing technology. A total of 20 healthy toddlers aged 12 mont...

journal_title：Frontiers in cellular and infection microbiology

authors： Li F,Tao D,Feng X,Wong MCM,Lu H

更新日期：2018-12-04 00:00:00

abstract：:In this study, a next-generation sequencing strategy on 16S ribosomal RNA (16S rRNA) gene was employed to analyze 70 oral samples from 32 patients with throat cancer, nine patients with vocal cord polyp, and 29 healthy individuals (normal controls). Using this strategy, we demonstrated, for the first time, that the sa...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang L,Yin G,Guo Y,Zhao Y,Zhao M,Lai Y,Sui P,Shi T,Guo W,Huang Z

更新日期：2019-07-03 00:00:00

abstract：:Despite ongoing efforts, sub-Saharan Africa faces a higher cervical cancer burden than anywhere else in the world. Besides HPV infection, definitive factors of cervical cancer are still unclear. Particular states of the cervicovaginal microbiota and viral infections are associated with increased cervical cancer risk. ...

journal_title：Frontiers in cellular and infection microbiology

authors： Klein C,Kahesa C,Mwaiselage J,West JT,Wood C,Angeletti PC

更新日期：2020-02-12 00:00:00

abstract：:Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocat...

journal_title：Frontiers in cellular and infection microbiology

authors： Salcedo SP,Marchesini MI,Degos C,Terwagne M,Von Bargen K,Lepidi H,Herrmann CK,Santos Lacerda TL,Imbert PR,Pierre P,Alexopoulou L,Letesson JJ,Comerci DJ,Gorvel JP

更新日期：2013-07-08 00:00:00

abstract：:To discern if there was a particular genotype associated with clinical enteroaggregative Escherichia coli (EAEC) strains isolated from deployed military personnel (DMP) with travelers' diarrhea (TD), we characterized a collection of EAEC from DMP deployed to Afghanistan, Djibouti, Kenya, or Honduras. Although we did n...

journal_title：Frontiers in cellular and infection microbiology

authors： Petro CD,Duncan JK,Seldina YI,Allué-Guardia A,Eppinger M,Riddle MS,Tribble DR,Johnson RC,Dalgard CL,Sukumar G,Connor P,Boisen N,Melton-Celsa AR

更新日期：2020-05-20 00:00:00

abstract：:Human coronaviruses, which can cause a range of infectious diseases, have been studied for nearly 60 years. The field has gained renewed interest from researchers around the world due to the COVID-19 outbreak in late 2019. Despite a large amount of research, little is known about the knowledge structure and developing...

journal_title：Frontiers in cellular and infection microbiology

authors： Deng Z,Chen J,Wang T

更新日期：2020-09-23 00:00:00

abstract：:Melioidosis is a neglected tropical disease with high mortality rate. It is caused by the Gram-negative, CDC category B select agent Burkholderia pseudomallei (B. ps) that is intrinsically resistant to first-line antibiotics. An antibody-based vaccine is likely to be the most effective control measure. Previous studie...

journal_title：Frontiers in cellular and infection microbiology

authors： Chaichana P,Kronsteiner B,Rongkard P,Teparrukkul P,Limmathurotsakul D,Chantratita N,Day NPJ,Fletcher HA,Dunachie SJ

更新日期：2020-08-26 00:00:00

abstract：:Streptococcus dentisani 7746, isolated from dental plaque of caries-free individuals, has been shown to have several beneficial effects in vitro which could contribute to promote oral health, including an antimicrobial activity against oral pathogens by the production of bacteriocins and a pH buffering capacity throug...

journal_title：Frontiers in cellular and infection microbiology

authors： Ferrer MD,López-López A,Nicolescu T,Perez-Vilaplana S,Boix-Amorós A,Dzidic M,Garcia S,Artacho A,Llena C,Mira A

更新日期：2020-08-31 00:00:00

abstract：:Dermatophytoses account for nearly a quarter of all fungal infections worldwide. These difficult to treat infections of the skin, hair, and nails, are growing more resistant to conventional antifungal treatments, and when treatable, often require prolonged therapeutic regimens. For centuries, essential oils have been ...

journal_title：Frontiers in cellular and infection microbiology

authors： Parrish N,Fisher SL,Gartling A,Craig D,Boire N,Khuvis J,Riedel S,Zhang S

更新日期：2020-10-16 00:00:00

abstract：:Cell death can be critical for host defense against intracellular pathogens because it eliminates a crucial replicative niche, and pro-inflammatory cell death can alert neighboring cells to the presence of pathogenic organisms and enhance downstream immune responses. Pyroptosis is a pro-inflammatory form of cell death...

journal_title：Frontiers in cellular and infection microbiology

authors： Casson CN,Shin S

更新日期：2013-12-27 00:00:00

abstract：:Natural killer (NK) cells are critical for targeting and killing tumor, virus-infected and stressed cells as a member of the innate immune system. Recently, NK cells have also emerged as key regulators of adaptive immunity and have become a prominent therapeutic target for cancer immunotherapy and infection control. N...

journal_title：Frontiers in cellular and infection microbiology

authors： Pierce S,Geanes ES,Bradley T

更新日期：2020-05-19 00:00:00

abstract：:Murid and cricetid rodents were previously believed to be the principal reservoir hosts of hantaviruses. Recently, however, multiple newfound hantaviruses have been discovered in shrews, moles, and bats, suggesting a complex evolutionary history. Little is known about the genetic diversity and geographic distribution ...

journal_title：Frontiers in cellular and infection microbiology

authors： Kikuchi F,Aoki K,Ohdachi SD,Tsuchiya K,Motokawa M,Jogahara T,Sơn NT,Bawm S,Lin KS,Thwe TL,Gamage CD,Ranorosoa MC,Omar H,Maryanto I,Suzuki H,Tanaka-Taya K,Morikawa S,Mizutani T,Suzuki M,Yanagihara R,Arai S

更新日期：2020-08-27 00:00:00

abstract：:HIGHLIGHTS What is already known about this subject?Celiac disease (CD) has a high clinical and histological diversity and the mechanisms underlying this phenomenon remain elusive.H. pylori is a bacterium that chronically infect gastric and duodenal mucosa activating both a Th1/Th17 and T-reg pathways.The role of H. p...

journal_title：Frontiers in cellular and infection microbiology

authors： Lucero Y,Oyarzún A,O'Ryan M,Quera R,Espinosa N,Valenzuela R,Simian D,Alcalde E,Arce C,Farfán MJ,Vergara AF,Gajardo I,Mendez J,Carrasco J,Errázuriz G,Gonzalez M,Ossa JC,Maiza E,Perez-Bravo F,Castro M,Araya M

更新日期：2017-08-23 00:00:00

abstract：:Relapsing fever still remains a neglected disease and little is known on its reservoir, tick vector and physiopathology in the vertebrate host. The disease occurs in temperate as well as tropical countries. Relapsing fever borreliae are spirochaetes, members of the Borreliaceae family which also contain Lyme disease s...

journal_title：Frontiers in cellular and infection microbiology

authors： Talagrand-Reboul E,Boyer PH,Bergström S,Vial L,Boulanger N

更新日期：2018-04-04 00:00:00

abstract：:Chronic otitis media with effusion (COME) is a common childhood disease characterized by an accumulation of fluid behind the eardrum. COME often requires surgical intervention and can also lead to significant hearing loss and subsequent learning disabilities. Recent characterization of the middle ear fluid (MEF) micro...

journal_title：Frontiers in cellular and infection microbiology

authors： Kolbe AR,Castro-Nallar E,Preciado D,Pérez-Losada M

更新日期：2019-10-04 00:00:00