The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability.

abstract：:Ten bacteriophages were isolated from faeces and their lytic effects assayed on 103 pathogenic and non-pathogenic Enterobacteriaceae. Two phages (DT1 and DT6) were selected based on their host ranges, and their lytic effects on pathogenic E. coli strains inoculated on pieces of beef were determined. We evaluated the r...

journal_title：Frontiers in cellular and infection microbiology

authors： Tomat D,Migliore L,Aquili V,Quiberoni A,Balagué C

更新日期：2013-06-06 00:00:00

abstract：:Clostridium difficile is a toxin-producing bacterium that is a frequent cause of hospital-acquired and antibiotic-associated diarrhea. The incidence, severity, and costs associated with C. difficile associated disease are substantial and increasing, making C. difficile a significant public health concern. The two prim...

journal_title：Frontiers in cellular and infection microbiology

authors： Pruitt RN,Lacy DB

更新日期：2012-03-16 00:00:00

abstract：:Vaccination remains a major tool for prevention and progression of Johne's disease, a chronic enteritis of ruminants worldwide. Currently there is only one licensed vaccine within the United States and two vaccines licensed internationally against Johne's disease. All licensed vaccines reduce fecal shedding of Mycobac...

journal_title：Frontiers in cellular and infection microbiology

authors： Lamont EA,Talaat AM,Coussens PM,Bannantine JP,Grohn YT,Katani R,Li LL,Kapur V,Sreevatsan S

更新日期：2014-06-30 00:00:00

abstract：:Rheumatoid Arthritis (RA) has been increasingly associated with perturbations to the microbial communities that reside in and on the body (the microbiome), in both human and animal studies. To date, such studies have mainly focused on the microbial communities that inhabit the gut and oral cavity. Mounting evidence su...

journal_title：Frontiers in cellular and infection microbiology

authors： Hammad DBM,Hider SL,Liyanapathirana VC,Tonge DP

更新日期：2020-01-22 00:00:00

abstract：:In 2019, the United States Food and Drug Administration accorded restricted approval to Sanofi Pasteur's Dengvaxia, a live attenuated vaccine (LAV) for dengue fever, a mosquito-borne viral disease, caused by four antigenically distinct dengue virus serotypes (DENV 1-4). The reason for this limited approval is the conc...

journal_title：Frontiers in cellular and infection microbiology

authors： Shukla R,Ramasamy V,Shanmugam RK,Ahuja R,Khanna N

更新日期：2020-10-22 00:00:00

abstract：:Bacterial persisters are a small proportion of phenotypically heterogeneous variants with the transient capability to survive in high concentrations of antibiotics, causing recurrent infections in both human and aquatic animals. Transfer-messenger RNA (tmRNA), which was encoded by the ssrA gene, was identified as a de...

journal_title：Frontiers in cellular and infection microbiology

authors： Yu W,Li D,Li H,Tang Y,Tang H,Ma X,Liu Z

更新日期：2020-02-28 00:00:00

abstract：:Dengue virus (DENV) threatens almost 70% of the world's population, with no therapeutic currently available. The severe, potentially lethal forms of DENV disease (dengue hemorrhagic fever/dengue shock syndrome) are associated with the production of high level of cytokines, elicited as part of the host antiviral respon...

journal_title：Frontiers in cellular and infection microbiology

authors： Giovannoni F,Ladelfa MF,Monte M,Jans DA,Hemmerich P,García C

更新日期：2019-08-13 00:00:00

abstract：:Lipids are essential players in parasites pathogenesis. In particular, the highly phagocytic trophozoites of Entamoeba histolytica, the causative agent of amoebiasis, exhibit a dynamic membrane fusion and fission, in which lipids strongly participate; particularly during the overstated motility of the parasite to reac...

journal_title：Frontiers in cellular and infection microbiology

authors： Castellanos-Castro S,Bolaños J,Orozco E

更新日期：2020-03-10 00:00:00

abstract：:Objectives:Citrobacter freundii is a frequent cause of nosocomial infections and a known cause of diarrheal infections, and has increasingly become multidrug resistant (MDR). In this study, we aimed to determine the genetic diversity, the antimicrobial resistance profiles and in vitro virulence properties of C. freund...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu L,Chen D,Liu L,Lan R,Hao S,Jin W,Sun H,Wang Y,Liang Y,Xu J

更新日期：2018-07-10 00:00:00

abstract：:Despite decades of dedicated research, there remains a dire need for new drugs against tuberculosis (TB). Current therapies are generations old and problematic. Resistance to these existing therapies results in an ever-increasing burden of patients with disease that is difficult or impossible to treat. Novel chemical ...

journal_title：Frontiers in cellular and infection microbiology

authors： Butman HS,Kotzé TJ,Dowd CS,Strauss E

更新日期：2020-12-15 00:00:00

abstract：:Mycoplasma hyopneumoniae (M. hyopneumoniae) is the causative agent of pandemic pneumonia among pigs, namely, swine enzootic pneumonia. Although M. hyopneumoniae was first identified in 1965, little is known regarding its metabolic pathways, which might play a pivotal role during disease pathogenesis. Lipoate is an ess...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhu K,Chen H,Jin J,Wang N,Ma G,Huang J,Feng Y,Xin J,Zhang H,Liu H

更新日期：2020-04-21 00:00:00

abstract：:Myocarditis, inflammation of the heart muscle, affects all demographics and is a major cause of sudden and unexpected death in young people. It is most commonly caused by viral infections of the heart, with coxsackievirus B3 (CVB3) being among the most prevalent pathogens. To understand the molecular pathogenesis of C...

journal_title：Frontiers in cellular and infection microbiology

authors： Hanson PJ,Hossain AR,Qiu Y,Zhang HM,Zhao G,Li C,Lin V,Sulaimon S,Vlok M,Fung G,Chen VH,Jan E,McManus BM,Granville DJ,Yang D

更新日期：2019-07-24 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) O157:H7 EspF is an important multifunctional protein that destroys the tight junctions of intestinal epithelial cells and promotes host cell apoptosis. However, its molecular mechanism remains elusive. We knocked out the espF sequence (747 bp, ΔespF), N-terminal sequence (219 ...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang X,Du Y,Hua Y,Fu M,Niu C,Zhang B,Zhao W,Zhang Q,Wan C

更新日期：2017-09-21 00:00:00

abstract：:Nocardia is one of the causing agents of bovine mastitis and increasing prevalence of nocardial mastitis in shape of serious outbreaks has been reported from many countries. However, the mechanisms by which this pathogen damages the bovine mammary epithelial cells (bMECs) is not yet studied. Therefore, this study was ...

journal_title：Frontiers in cellular and infection microbiology

authors： Chen W,Liu Y,Zhang L,Gu X,Liu G,Shahid M,Gao J,Ali T,Han B

更新日期：2017-05-18 00:00:00

abstract：:Cryptosporidium spp. and Enterocytozoon bieneusi are two important zoonotic pathogens that can infect humans and a broad range of animal hosts. However, few studies have been conducted to study infection of the two pathogens in domestic geese until now. The aims of the present study were to determine the prevalence of...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhao W,Zhou HH,Ma TM,Cao J,Lu G,Shen YJ

更新日期：2019-12-04 00:00:00

abstract：:Apicomplexan parasites, such as human malaria parasites, have complex lifecycles encompassing multiple and diverse environmental niches. Invading, replicating, and escaping from different cell types, along with exploiting each intracellular niche, necessitate large and dynamic changes in parasite morphology and cellul...

journal_title：Frontiers in cellular and infection microbiology

authors： Ferreira JL,Heincke D,Wichers JS,Liffner B,Wilson DW,Gilberger TW

更新日期：2021-01-08 00:00:00

abstract：:Leptospira are emerging zoonotic pathogens transmitted from animals to humans typically through contaminated environmental sources of water and soil. Regulatory pathways of pathogenic Leptospira spp. underlying the adaptive response to different hosts and environmental conditions remains elusive. In this study, we pro...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhukova A,Fernandes LG,Hugon P,Pappas CJ,Sismeiro O,Coppée JY,Becavin C,Malabat C,Eshghi A,Zhang JJ,Yang FX,Picardeau M

更新日期：2017-01-19 00:00:00

abstract：:The intracellular pathogen Burkholderia pseudomallei, the etiological agent of melioidosis in humans and various animals, is capable of survival and movement within the cytoplasm of host cells by a process known as actin-based motility. The bacterial factor BimA is required for actin-based motility through its direct ...

journal_title：Frontiers in cellular and infection microbiology

authors： Srinon V,Chaiwattanarungruengpaisan S,Korbsrisate S,Stevens JM

更新日期：2019-03-22 00:00:00

abstract：:Response regulators are a critical part of the two-component system of gene expression regulation in bacteria, transferring a signal from a sensor kinase into DNA binding activity resulting in alteration of gene expression. In this study, we investigated a previously uncharacterized response regulator in Francisella n...

journal_title：Frontiers in cellular and infection microbiology

authors： Dean SN,Milton ME,Cavanagh J,van Hoek ML

更新日期：2020-03-13 00:00:00

abstract：:Platycodin D, extract from the root of Platycodon grandiflorum, is one of the most important monomers of the Qinbaiqingfei pellets (Qinbai) that has already been approved as the first Traditional Chinese Medicine for clinic use as an anti-M. pneumoniae agent. Qinbai constituents Scutellaria baicalensis and Platycodon ...

journal_title：Frontiers in cellular and infection microbiology

authors： Meng Y,Yang Y,Lu W,Wang Y,Qian F,Wang X,Zhang Z,Wang W

更新日期：2015-01-13 00:00:00

abstract：:Enteropathogenic Escherichia coli and enterohemorrhagic E. coli are diarrheagenic bacterial human pathogens that cause severe gastroenteritis. These enteric pathotypes, together with the mouse pathogen Citrobacter rodentium, belong to the family of attaching and effacing pathogens that form a distinctive histological ...

journal_title：Frontiers in cellular and infection microbiology

authors： Gaytán MO,Martínez-Santos VI,Soto E,González-Pedrajo B

更新日期：2016-10-21 00:00:00

abstract：:Vibrio parahaemolyticus elicits gastroenteritis by deploying Type III Secretion Systems (TTSS) to deliver effector proteins into epithelial cells of the human intestinal tract. The bacteria must adhere to the human cells to allow colonization and operation of the TTSS translocation apparatus bridging the bacterium and...

journal_title：Frontiers in cellular and infection microbiology

authors： O'Boyle N,Boyd A

更新日期：2014-01-10 00:00:00

abstract：:Non-typeable Haemophilus influenzae (NTHI) is an opportunistic bacterial pathogen of the human respiratory tract and is a leading cause of respiratory infections in children and adults. NTHI is considered to be an extracellular pathogen, but has consistently been observed within and between human respiratory epithelia...

journal_title：Frontiers in cellular and infection microbiology

authors： Clementi CF,Murphy TF

更新日期：2011-11-18 00:00:00

abstract：:Radiation enteritis (RE) is a common complication in cancer patients receiving radiotherapy. Although studies have shown the changes of this disease at clinical, pathological and other levels, the dynamic characteristics of local microbiome and metabolomics are hitherto unknown. We aimed to examine the multi-omics fea...

journal_title：Frontiers in cellular and infection microbiology

authors： Li Y,Yan H,Zhang Y,Li Q,Yu L,Li Q,Liu C,Xie Y,Chen K,Ye F,Wang K,Chen L,Ding Y

更新日期：2020-10-21 00:00:00

abstract：:Chlamydia trachomatis is the leading cause of preventable blindness and the most common bacterial sexually transmitted infection. Different strains are associated with ocular or urogenital infections, and a proposed mechanism that may explain this tissue tropism is the active tryptophan biosynthesis pathway encoded by...

journal_title：Frontiers in cellular and infection microbiology

authors： O'Neill CE,Skilton RJ,Pearson SA,Filardo S,Andersson P,Clarke IN

更新日期：2018-12-14 00:00:00

abstract：:Stress granules (SGs) are sites of mRNA storage that are formed in response to various conditions of stress, including viral infections. Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has been devastating the swine industry worldwide since the late 1980s. In this study, we found tha...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhou Y,Fang L,Wang D,Cai K,Chen H,Xiao S

更新日期：2017-04-04 00:00:00

abstract：:Overwhelming cardiac inflammation has been reported to be the pathogenic mechanism of Coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC), while the detailed molecular mechanisms remain unknown. Membrane-bound dipeptidases (MBD, also known as Dpep) have been shown to be involved in inflammatory diseases. However,...

journal_title：Frontiers in cellular and infection microbiology

authors： Yang X,Yue Y,Xiong S

更新日期：2019-03-07 00:00:00

abstract：:Hundred-thousands of fungal species are present in our environment, including normal colonizers that constitute part of the human microbiota. The homeostasis of host-fungus interactions encompasses efficient fungal sensing, tolerance at mucosal surfaces, as well as antifungal defenses. Decrease in host immune fitness ...

journal_title：Frontiers in cellular and infection microbiology

authors： Bourgeois C,Kuchler K

更新日期：2012-11-22 00:00:00

abstract：:Cross talk occurs between the human gut and the lung through a gut-lung axis involving the gut microbiota. However, the signatures of the human gut microbiota after active Mycobacterium tuberculosis infection have not been fully understood. Here, we investigated changes in the gut microbiota in tuberculosis (TB) patie...

journal_title：Frontiers in cellular and infection microbiology

authors： Hu Y,Feng Y,Wu J,Liu F,Zhang Z,Hao Y,Liang S,Li B,Li J,Lv N,Xu Y,Zhu B,Sun Z

更新日期：2019-04-03 00:00:00

abstract：:Cleavage and activation of hemagglutinin (HA) by trypsin-like proteases in influenza A virus (IAV) are essential prerequisites for its successful infection and spread. In host cells, some transmembrane serine proteases such as TMPRSS2, TMPRSS4 and HAT, along with plasmin in the bloodstream, have been reported to cleav...

journal_title：Frontiers in cellular and infection microbiology

authors： Hayashi H,Kubo Y,Izumida M,Takahashi E,Kido H,Sato K,Yamaya M,Nishimura H,Nakayama K,Matsuyama T

更新日期：2018-03-23 00:00:00