Genetic manipulation of Staphylococci-breaking through the barrier.

abstract：:ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanni, Pseudomonas aeruginosa, and Enterobacter species) pathogens have characteristic multiple-drug resistance and cause an increasing number of nosocomial infections worldwide. Peptide-based therapeutics to treat ESKAPE infe...

journal_title：Frontiers in cellular and infection microbiology

authors： Du H,Puri S,McCall A,Norris HL,Russo T,Edgerton M

更新日期：2017-02-15 00:00:00

abstract：:In 2019, the United States Food and Drug Administration accorded restricted approval to Sanofi Pasteur's Dengvaxia, a live attenuated vaccine (LAV) for dengue fever, a mosquito-borne viral disease, caused by four antigenically distinct dengue virus serotypes (DENV 1-4). The reason for this limited approval is the conc...

journal_title：Frontiers in cellular and infection microbiology

authors： Shukla R,Ramasamy V,Shanmugam RK,Ahuja R,Khanna N

更新日期：2020-10-22 00:00:00

abstract：:Apicomplexan parasites, such as human malaria parasites, have complex lifecycles encompassing multiple and diverse environmental niches. Invading, replicating, and escaping from different cell types, along with exploiting each intracellular niche, necessitate large and dynamic changes in parasite morphology and cellul...

journal_title：Frontiers in cellular and infection microbiology

authors： Ferreira JL,Heincke D,Wichers JS,Liffner B,Wilson DW,Gilberger TW

更新日期：2021-01-08 00:00:00

abstract：:Salmonella is a facultative intracellular Gram-negative bacterium, responsible for a wide range of food- and water-borne diseases ranging from gastroenteritis to typhoid fever depending on hosts and serotypes. Salmonella thus represents a major threat to public health. A key step in Salmonella pathogenesis is the inva...

journal_title：Frontiers in cellular and infection microbiology

authors： Mambu J,Virlogeux-Payant I,Holbert S,Grépinet O,Velge P,Wiedemann A

更新日期：2017-12-08 00:00:00

abstract：:Burkholderia mallei (Bm) is a highly infectious intracellular pathogen classified as a category B biological agent by the Centers for Disease Control and Prevention. After respiratory exposure, Bm establishes itself within host macrophages before spreading into major organ systems, which can lead to chronic infection,...

journal_title：Frontiers in cellular and infection microbiology

authors： Bozue JA,Chaudhury S,Amemiya K,Chua J,Cote CK,Toothman RG,Dankmeyer JL,Klimko CP,Wilhelmsen CL,Raymond JW,Zavaljevski N,Reifman J,Wallqvist A

更新日期：2016-02-26 00:00:00

abstract：:Non-typeable Haemophilus influenzae (NTHI) is an opportunistic bacterial pathogen of the human respiratory tract and is a leading cause of respiratory infections in children and adults. NTHI is considered to be an extracellular pathogen, but has consistently been observed within and between human respiratory epithelia...

journal_title：Frontiers in cellular and infection microbiology

authors： Clementi CF,Murphy TF

更新日期：2011-11-18 00:00:00

abstract：:Chronic otitis media with effusion (COME) is a common childhood disease characterized by an accumulation of fluid behind the eardrum. COME often requires surgical intervention and can also lead to significant hearing loss and subsequent learning disabilities. Recent characterization of the middle ear fluid (MEF) micro...

journal_title：Frontiers in cellular and infection microbiology

authors： Kolbe AR,Castro-Nallar E,Preciado D,Pérez-Losada M

更新日期：2019-10-04 00:00:00

abstract：:Studying how arthropod-borne viruses interact with their arthropod vectors is critical to understanding how these viruses replicate and are transmitted. Until recently, these types of studies were limited in scale because of the lack of classical tools available to study virus-host interaction for non-model viruses an...

journal_title：Frontiers in cellular and infection microbiology

authors： Petit MJ,Shah PS

更新日期：2019-01-07 00:00:00

abstract：:Half of invasive fungal infections lead to death. Amongst pathogenic fungi, the most widespread species belong to the Candida genus and vary in their susceptibility to antifungal drugs. The emergence of antifungal resistance has become a major clinical problem. Therefore, the definition of susceptibility patterns is c...

journal_title：Frontiers in cellular and infection microbiology

authors： Delavy M,Dos Santos AR,Heiman CM,Coste AT

更新日期：2019-02-07 00:00:00

abstract：:More than a decade ago a short tandem repeat-based typing method was developed for the fungus Aspergillus fumigatus. This STRAf assay is based on the analysis of nine short tandem repeat markers. Interpretation of this STRAf assay is complicated when there are only one or two differences in tandem repeat markers betwe...

journal_title：Frontiers in cellular and infection microbiology

authors： de Groot T,Meis JF

更新日期：2019-03-29 00:00:00

abstract：:The worldwide increase in antibiotic-resistant pathogens means that identification of alternative antibacterial drug targets and the subsequent development of new treatment strategies are urgently required. One such new target is the quorum sensing (QS) system. Coral microbial consortia harbor an enormous diversity of...

journal_title：Frontiers in cellular and infection microbiology

authors： Ma ZP,Song Y,Cai ZH,Lin ZJ,Lin GH,Wang Y,Zhou J

更新日期：2018-05-08 00:00:00

abstract：Background:Disseminated histoplasmosis remains a major killer of immunocompromised patients in Latin America. Cytological and histological methods are usually present in most hospitals and may represent a precious diagnostic method. We report 15 years of experience of the department of pathology of the Centre Hospitali...

journal_title：Frontiers in cellular and infection microbiology

authors： Drak Alsibai K,Couppié P,Blanchet D,Adenis A,Epelboin L,Blaizot R,Louvel D,Djossou F,Demar M,Nacher M

更新日期：2020-10-29 00:00:00

abstract：:Response regulators are a critical part of the two-component system of gene expression regulation in bacteria, transferring a signal from a sensor kinase into DNA binding activity resulting in alteration of gene expression. In this study, we investigated a previously uncharacterized response regulator in Francisella n...

journal_title：Frontiers in cellular and infection microbiology

authors： Dean SN,Milton ME,Cavanagh J,van Hoek ML

更新日期：2020-03-13 00:00:00

abstract：:Extracellular vesicles (EVs) have garnered much interest in the cell biology and biomedical research fields. Many studies have reported the existence of EVs in all types of living cells, including in fifteen different fungal genera. EVs play diverse biological roles, from the regulation of physiological events and res...

journal_title：Frontiers in cellular and infection microbiology

authors： Rizzo J,Rodrigues ML,Janbon G

更新日期：2020-07-15 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fcimb.2017.00464.]. ...

journal_title：Frontiers in cellular and infection microbiology

authors： Meuskens I,Michalik M,Chauhan N,Linke D,Leo JC

更新日期：2020-06-03 00:00:00

abstract：:Escherichia coli carrying prophage with genes that encode for Shiga toxins are categorized as Shiga toxin-producing E. coli (STEC) pathotype. Illnesses caused by STEC in humans, which are often foodborne, range from mild to bloody diarrhea with life-threatening complications of renal failure and hemolytic uremic syndr...

journal_title：Frontiers in cellular and infection microbiology

authors： Ludwig JB,Shi X,Shridhar PB,Roberts EL,DebRoy C,Phebus RK,Bai J,Nagaraja TG

更新日期：2020-07-29 00:00:00

abstract：:The NLRP3 inflammasome and IL-1β release have recently been suggested to be important for the progression of urinary tract infection (UTI). However, much is still unknown regarding the interaction of UPEC and the NLRP3 inflammasome. The purpose of this study was to elucidate what virulence factors uropathogenic Escher...

journal_title：Frontiers in cellular and infection microbiology

authors： Demirel I,Persson A,Brauner A,Särndahl E,Kruse R,Persson K

更新日期：2018-03-14 00:00:00

abstract：:The plasma membrane of mammalian cells is susceptible to disruption by mechanical and biochemical damages that frequently occur within tissues. Therefore, efficient and rapid repair of the plasma membrane is essential for maintaining cellular homeostasis and survival. Excessive damage of the plasma membrane and defect...

journal_title：Frontiers in cellular and infection microbiology

authors： Pathak-Sharma S,Zhang X,Lam JGT,Weisleder N,Seveau SM

更新日期：2017-07-14 00:00:00

abstract：:Background: Increasing evidence has shown that Helicobacter pylori is associated with coronary heart disease (CHD); however, the underlying mechanism remains unclear. Methods: The expression of miR-25 and mRNAs was measured using qRT-PCR. Protein levels were detected using western blotting and exosomes were assessed w...

journal_title：Frontiers in cellular and infection microbiology

authors： Li N,Liu SF,Dong K,Zhang GC,Huang J,Wang ZH,Wang TJ

更新日期：2019-10-29 00:00:00

abstract：:Under unfavorable conditions such as host immune responses and environmental stresses, human pathogen Mycobacterium tuberculosis may acquire the dormancy phenotype characterized by "non-culturability" and a substantial decrease of metabolic activity and global transcription rates. Here, we found that the transition of...

journal_title：Frontiers in cellular and infection microbiology

authors： Salina EG,Grigorov AS,Bychenko OS,Skvortsova YV,Mamedov IZ,Azhikina TL,Kaprelyants AS

更新日期：2019-07-30 00:00:00

abstract：:Streptococcus pneumoniae is a leading cause of bacterial pneumonia worldwide. Given the critical role of dendritic cells (DCs) in regulating and modulating the immune response to pathogens, we investigated here the role of DCs in S. pneumoniae lung infections. Using a well-established transgenic mouse line which allow...

journal_title：Frontiers in cellular and infection microbiology

authors： Rosendahl A,Bergmann S,Hammerschmidt S,Goldmann O,Medina E

更新日期：2013-06-21 00:00:00

abstract：:Nosocomial pathogens that develop multidrug resistance present an increasing problem for healthcare facilities. Due to its rapid rise in antibiotic resistance, Acinetobacter baumannii is one of the most concerning gram-negative species. A. baumannii typically infects immune compromised individuals resulting in a varie...

journal_title：Frontiers in cellular and infection microbiology

authors： Waack U,Johnson TL,Chedid K,Xi C,Simmons LA,Mobley HLT,Sandkvist M

更新日期：2017-08-28 00:00:00

abstract：:Toxoplasma gondii is a prevalent parasite of mammals and birds including up to 30% of humans world-wide. Primary infection of immunocompetent hosts leads to a robust cell-mediated immune response, which controls but does not clear the infection, thus enabling long-term parasite persistence in brain and muscle tissues....

journal_title：Frontiers in cellular and infection microbiology

authors： Ehmen HG,Lüder CGK

更新日期：2019-06-28 00:00:00

abstract：:Differentiation between mitis group streptococci (MGS) bacteria in routine laboratory tests has become important for obtaining accurate epidemiological information on the characteristics of MGS and understanding their clinical significance. The most reliable method of MGS species identification is multilocus sequence ...

journal_title：Frontiers in cellular and infection microbiology

authors： Imai K,Nemoto R,Kodana M,Tarumoto N,Sakai J,Kawamura T,Ikebuchi K,Mitsutake K,Murakami T,Maesaki S,Fujiwara T,Hayakawa S,Hoshino T,Seki M,Maeda T

更新日期：2020-01-30 00:00:00

abstract：:Streptococcus pyogenes is a significant pathogen of humans, annually causing over 700,000,000 infections and 500,000 deaths. Virulence in S. pyogenes is closely linked to mobile genetic elements like phages and chromosomal islands (CI). S. pyogenes phage-like chromosomal islands (SpyCI) confer a complex mutator phenot...

journal_title：Frontiers in cellular and infection microbiology

authors： Nguyen SV,McShan WM

更新日期：2014-08-12 00:00:00

abstract：:The emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae (GC) underline the need of "antibiotic-free" strategies for the control of gonorrhea. The aim of this study was to assess the anti-gonococcal activity of 14 vaginal Lactobacillus strains, belonging to different species (L. crispatus, L. gass...

journal_title：Frontiers in cellular and infection microbiology

authors： Foschi C,Salvo M,Cevenini R,Parolin C,Vitali B,Marangoni A

更新日期：2017-12-06 00:00:00

abstract：:Burkholderia cenocepacia is an opportunistic respiratory pathogen of individuals with cystic fibrosis (CF). Some strains of B. cenocepacia are highly transmissible and resistant to almost all antibiotics. Approximately one-third of B. cenocepacia infected CF patients go on to develop fatal "cepacia syndrome." During t...

journal_title：Frontiers in cellular and infection microbiology

authors： Ganesan S,Sajjan US

更新日期：2012-01-11 00:00:00

abstract：:Proton pump inhibitors (PPIs) are the standard therapy for gastroesophageal reflux disease. In adults, PPI treatment is associated with Clostridium difficile infections (CDI). In contrast to adults the microbiome of infants develops from sterility at birth toward an adult-like profile in the first years of life. The e...

journal_title：Frontiers in cellular and infection microbiology

authors： Castellani C,Singer G,Kashofer K,Huber-Zeyringer A,Flucher C,Kaiser M,Till H

更新日期：2017-10-11 00:00:00

abstract：:Campylobacter jejuni (CJ) is the most prevalent zoonotic pathogen of chicken meat and related products, which may lead to gastroenteritis and autoimmune diseases in humans. Although controlling this bacterium is important, CJ strains resistance against traditional antibiotic therapy has been increased. Vegetable oils ...

journal_title：Frontiers in cellular and infection microbiology

authors： Ribeiro LNM,de Paula E,Rossi DA,Martins FA,de Melo RT,Monteiro GP,Breitkreitz MC,Goulart LR,Fonseca BB

更新日期：2021-01-08 00:00:00

abstract：:Clostridium difficile is a toxin-producing bacterium that is a frequent cause of hospital-acquired and antibiotic-associated diarrhea. The incidence, severity, and costs associated with C. difficile associated disease are substantial and increasing, making C. difficile a significant public health concern. The two prim...

journal_title：Frontiers in cellular and infection microbiology

authors： Pruitt RN,Lacy DB

更新日期：2012-03-16 00:00:00