Eucalyptal D Enhances the Antifungal Effect of Fluconazole on Fluconazole-Resistant Candida albicans by Competitively Inhibiting Efflux Pump.

abstract：:Non-encapsulated Streptococcus pneumoniae often possess two genes, aliB-like ORF 1 and aliB-like ORF 2, in place of capsule genes. AliB-like ORF 1 is thought to encode a substrate binding protein of an ABC transporter which binds peptide SETTFGRDFN, found in 50S ribosomal subunit protein L4 of Enterobacteriaceae. Here...

journal_title：Frontiers in cellular and infection microbiology

authors： Nasher F,Kwun MJ,Croucher NJ,Heller M,Hathaway LJ

更新日期：2019-09-10 00:00:00

abstract：:Chronic otitis media with effusion (COME) is a common childhood disease characterized by an accumulation of fluid behind the eardrum. COME often requires surgical intervention and can also lead to significant hearing loss and subsequent learning disabilities. Recent characterization of the middle ear fluid (MEF) micro...

journal_title：Frontiers in cellular and infection microbiology

authors： Kolbe AR,Castro-Nallar E,Preciado D,Pérez-Losada M

更新日期：2019-10-04 00:00:00

abstract：:The mechanism by which microRNAs (miRNAs) modulate innate immunity and autophagy has not been fully elucidated in Mycobacterium bovis (M. bovis) infections. In this study, we identified that miR-199a inhibited key innate immune responses and autophagy in murine macrophages infected with M. bovis. Using ex vivo and in ...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang J,Hussain T,Yue R,Liao Y,Li Q,Yao J,Song Y,Sun X,Wang N,Xu L,Sreevatsan S,Zhao D,Zhou X

更新日期：2018-07-10 00:00:00

abstract：:Esophageal microbiota plays important roles in esophageal cancer. Esophagectomy, as the most important therapeutic way, contributes to changes of esophageal microbiome. However, there are few studies examining the esophageal microbiome and the metabolic changes before and after esophagectomy. The present study charact...

journal_title：Frontiers in cellular and infection microbiology

authors： Li D,He R,Hou G,Ming W,Fan T,Chen L,Zhang L,Jiang W,Wang W,Lu Z,Feng H,Geng Q

更新日期：2020-06-26 00:00:00

abstract：:Toxoplasma gondii is a prevalent parasite of mammals and birds including up to 30% of humans world-wide. Primary infection of immunocompetent hosts leads to a robust cell-mediated immune response, which controls but does not clear the infection, thus enabling long-term parasite persistence in brain and muscle tissues....

journal_title：Frontiers in cellular and infection microbiology

authors： Ehmen HG,Lüder CGK

更新日期：2019-06-28 00:00:00

abstract：:Vibrio parahaemolyticus, autochthonous to estuarine, marine, and coastal environments throughout the world, is the causative agent of food-borne gastroenteritis. More than 80 serotypes have been described worldwide, based on antigenic properties of the somatic (O) and capsular (K) antigens. Serovar O3:K6 emerged in In...

journal_title：Frontiers in cellular and infection microbiology

authors： Ceccarelli D,Hasan NA,Huq A,Colwell RR

更新日期：2013-12-11 00:00:00

abstract：:Toxoplasma gondii is an important human and animal pathogen that causes life-threatening toxoplasmosis. The host immune system produces interferon-γ (IFN-γ) to inhibit T. gondii proliferation. IFN-γ-inducible indole-2,3-dioxygenase 1 (IDO1), which mediates tryptophan degradation, has a major role in anti-T. gondii imm...

journal_title：Frontiers in cellular and infection microbiology

authors： Bando H,Lee Y,Sakaguchi N,Pradipta A,Sakamoto R,Tanaka S,Ma JS,Sasai M,Yamamoto M

更新日期：2019-05-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) represents the etiological agent for several human malignancies, including Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD), which are mostly seen in immunocompromised patients. In fact, KSHV has developed many strategies ...

journal_title：Frontiers in cellular and infection microbiology

authors： Barrett L,Chen J,Dai L,Plaisance-Bonstaff K,Del Valle L,Qin Z

更新日期：2020-10-30 00:00:00

abstract：:Preservation of health from infectious diseases depends upon both mucosal and systemic immunity via the collaborative effort of innate and adaptive immune responses. The proficiency of host immunity stems from robust defense mechanisms--physical barriers and specialized immune cells--and a failure of these mechanisms ...

journal_title：Frontiers in cellular and infection microbiology

authors： Denny JE,Powell WL,Schmidt NW

更新日期：2016-04-11 00:00:00

abstract：:The ability of the opportunistic pathogen, Staphylococcus aureus, to form biofilms is increasingly being viewed as an important contributor to chronic infections. In vitro methods for analyzing S. aureus biofilm formation have focused on bacterial attachment and accumulation on abiotic surfaces, such as in microtiter ...

journal_title：Frontiers in cellular and infection microbiology

authors： Walker JN,Horswill AR

更新日期：2012-03-27 00:00:00

abstract：:MicroRNAs (miRNAs), a group of small molecule non-encoding RNAs, are key post-transcriptional regulators of gene expression that are implicated in many biological processes. In the current study, miR-217 from Eriocheir sinensis was selected for studying its roles during host-virus interaction. Overexpression or silenc...

journal_title：Frontiers in cellular and infection microbiology

authors： Huang Y,Han K,Wang W,Ren Q

更新日期：2017-05-04 00:00:00

abstract：:Neutrophils are the first cells recruited to the dermal site of Leishmania infection following injection by needle or sand fly bite. The role of neutrophils in either promoting or suppressing host immunity remains controversial. We discuss the events driving neutrophil recruitment, their interaction with the parasite ...

journal_title：Frontiers in cellular and infection microbiology

authors： Ribeiro-Gomes FL,Sacks D

更新日期：2012-05-04 00:00:00

abstract：:The spirochete endoflagellum is a unique motility apparatus among bacteria. Despite its critical importance for pathogenesis, the full composition of the flagellum remains to be determined. We have recently reported that FcpA is a novel flagellar protein and a major component of the sheath of the filament of the spiro...

journal_title：Frontiers in cellular and infection microbiology

authors： Wunder EA Jr,Slamti L,Suwondo DN,Gibson KH,Shang Z,Sindelar CV,Trajtenberg F,Buschiazzo A,Ko AI,Picardeau M

更新日期：2018-05-08 00:00:00

abstract：:The NLRP3 inflammasome and IL-1β release have recently been suggested to be important for the progression of urinary tract infection (UTI). However, much is still unknown regarding the interaction of UPEC and the NLRP3 inflammasome. The purpose of this study was to elucidate what virulence factors uropathogenic Escher...

journal_title：Frontiers in cellular and infection microbiology

authors： Demirel I,Persson A,Brauner A,Särndahl E,Kruse R,Persson K

更新日期：2018-03-14 00:00:00

abstract：:Brucella spp. are intracellular vacuolar pathogens that causes brucellosis, a worldwide zoonosis of profound importance. We previously demonstrated that the activity of host unfolded protein response (UPR) sensor IRE1α (inositol-requiring enzyme 1) and ER-associated autophagy confer susceptibility to Brucella melitens...

journal_title：Frontiers in cellular and infection microbiology

authors： Pandey A,Lin F,Cabello AL,da Costa LF,Feng X,Feng HQ,Zhang MZ,Iwawaki T,Rice-Ficht A,Ficht TA,de Figueiredo P,Qin QM

更新日期：2018-04-20 00:00:00

abstract：:Salmonella is a facultative intracellular Gram-negative bacterium, responsible for a wide range of food- and water-borne diseases ranging from gastroenteritis to typhoid fever depending on hosts and serotypes. Salmonella thus represents a major threat to public health. A key step in Salmonella pathogenesis is the inva...

journal_title：Frontiers in cellular and infection microbiology

authors： Mambu J,Virlogeux-Payant I,Holbert S,Grépinet O,Velge P,Wiedemann A

更新日期：2017-12-08 00:00:00

abstract：:Human coronaviruses, which can cause a range of infectious diseases, have been studied for nearly 60 years. The field has gained renewed interest from researchers around the world due to the COVID-19 outbreak in late 2019. Despite a large amount of research, little is known about the knowledge structure and developing...

journal_title：Frontiers in cellular and infection microbiology

authors： Deng Z,Chen J,Wang T

更新日期：2020-09-23 00:00:00

abstract：:Caprine parainfluenza virus type 3 (CPIV3) is a newly emerging pathogenic respiratory agent infecting both young and adult goats, and it was identified in eastern China in 2013. Cellular microRNAs (miRNAs) have been reported to be important modulators of the intricate virus-host interactions. In order to elucidate the...

journal_title：Frontiers in cellular and infection microbiology

authors： Li J,Mao L,Li W,Hao F,Zhong C,Zhu X,Ji X,Yang L,Zhang W,Liu M,Jiang J

更新日期：2018-03-29 00:00:00

abstract：:Objectives:Citrobacter freundii is a frequent cause of nosocomial infections and a known cause of diarrheal infections, and has increasingly become multidrug resistant (MDR). In this study, we aimed to determine the genetic diversity, the antimicrobial resistance profiles and in vitro virulence properties of C. freund...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu L,Chen D,Liu L,Lan R,Hao S,Jin W,Sun H,Wang Y,Liang Y,Xu J

更新日期：2018-07-10 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is a significant cause of serious human gastrointestinal disease worldwide. EHEC strains contain a pathogenicity island called the locus of enterocyte effacement (LEE), which encodes virulence factors responsible for damaging the gut mucosa. The Cpx envelope stress response of...

journal_title：Frontiers in cellular and infection microbiology

authors： De la Cruz MA,Morgan JK,Ares MA,Yáñez-Santos JA,Riordan JT,Girón JA

更新日期：2016-02-05 00:00:00

abstract：:Non-typeable Haemophilus influenzae (NTHI) is an opportunistic bacterial pathogen of the human respiratory tract and is a leading cause of respiratory infections in children and adults. NTHI is considered to be an extracellular pathogen, but has consistently been observed within and between human respiratory epithelia...

journal_title：Frontiers in cellular and infection microbiology

authors： Clementi CF,Murphy TF

更新日期：2011-11-18 00:00:00

abstract：:Iron is the most abundant transition metal in the human body and its bioavailability is stringently controlled. In particular, iron is tightly bound to host proteins such as transferrin to maintain homeostasis, to limit potential damage caused by iron toxicity under physiological conditions and to restrict access by p...

journal_title：Frontiers in cellular and infection microbiology

authors： Caza M,Kronstad JW

更新日期：2013-11-19 00:00:00

abstract：:Relapsing fever still remains a neglected disease and little is known on its reservoir, tick vector and physiopathology in the vertebrate host. The disease occurs in temperate as well as tropical countries. Relapsing fever borreliae are spirochaetes, members of the Borreliaceae family which also contain Lyme disease s...

journal_title：Frontiers in cellular and infection microbiology

authors： Talagrand-Reboul E,Boyer PH,Bergström S,Vial L,Boulanger N

更新日期：2018-04-04 00:00:00

abstract：:Vaccination has had a major impact on the control of infectious diseases. However, there are still many infectious diseases for which the development of an effective vaccine has been elusive. In many cases the failure to devise vaccines is a consequence of the inability of vaccine candidates to evoke appropriate immun...

journal_title：Frontiers in cellular and infection microbiology

authors： Gregory AE,Titball R,Williamson D

更新日期：2013-03-25 00:00:00

abstract：:Owing to the genetic similarities and conserved pathways between a fruit fly and mammals, the use of the Drosophila model as a platform to unveil novel mechanisms of infection and disease progression has been justified and widely instigated. Gaining proper insight into host-pathogen interactions and identifying chief ...

journal_title：Frontiers in cellular and infection microbiology

authors： Younes S,Al-Sulaiti A,Nasser EAA,Najjar H,Kamareddine L

更新日期：2020-06-23 00:00:00

abstract：:Eradication of Helicobacter pylori has been found to be effective for gastric cancer prevention, but uncertainties remain about the possible adverse consequences such as the potential microbial dysbiosis. In our study, we investigated the association between gut microbiota and H. pylori-related gastric lesions in 47 s...

journal_title：Frontiers in cellular and infection microbiology

authors： Gao JJ,Zhang Y,Gerhard M,Mejias-Luque R,Zhang L,Vieth M,Ma JL,Bajbouj M,Suchanek S,Liu WD,Ulm K,Quante M,Li ZX,Zhou T,Schmid R,Classen M,Li WQ,You WC,Pan KF

更新日期：2018-06-19 00:00:00

abstract：:Chronic HCV infection is characterized by several immunological alterations, such as the accumulation of suppressor cells and of hyperactivated T lymphocytes. However, it is unclear whether direct-acting antiviral (DAA)-mediated HCV clearance restores immune dysfunctions. We performed a phenotypic characterization by ...

journal_title：Frontiers in cellular and infection microbiology

authors： Telatin V,Nicoli F,Frasson C,Menegotto N,Barbaro F,Castelli E,Erne E,Palù G,Caputo A

更新日期：2019-06-14 00:00:00

abstract：:Enterococcus faecium is a clinically important pathogen associated with opportunistic infection and multi-drug resistance. E. faecium has been shown to produce membrane vesicles (MVs), but MV production by E. faecium under antibiotic stress conditions and the pathogenic traits thereof have yet to be determined. This s...

journal_title：Frontiers in cellular and infection microbiology

authors： Kim MH,Kim SY,Son JH,Kim SI,Lee H,Kim S,Shin M,Lee JC

更新日期：2019-08-14 00:00:00

abstract：:For centuries, hydrogen sulfide (H2S) was considered primarily as a poisonous gas and environmental hazard. However, with the discovery of prokaryotic and eukaryotic enzymes for H2S production, breakdown, and utilization, H2S has emerged as an important signaling molecule in a wide range of physiological and pathologi...

journal_title：Frontiers in cellular and infection microbiology

authors： Rahman MA,Glasgow JN,Nadeem S,Reddy VP,Sevalkar RR,Lancaster JR Jr,Steyn AJC

更新日期：2020-11-10 00:00:00

abstract：:Cytokinesis, or the division of the cytoplasm, following the end of mitosis or meiosis, is accomplished in animal cells, fungi, and amoebae, by the constriction of an actomyosin contractile ring, comprising filamentous actin, myosin II, and associated proteins. However, despite this being the best-studied mode of cyto...

journal_title：Frontiers in cellular and infection microbiology

authors： Hammarton TC

更新日期：2019-11-21 00:00:00